Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-GY whole body irradiation

Transplantation

Volumn 61, Issue 3, 1996, Pages 477-485

  Tomita, Yukihiro ^a,b   Khan, Abrar ^a,c   Sykes, Megan ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c HENRY FORD HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OKT 4; OKT 8; T LYMPHOCYTE ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CHIMERA; FEMALE; GRAFT REJECTION; IMMUNOSUPPRESSIVE TREATMENT; IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; WHOLE BODY RADIATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; ANTIGENS, CD8; ANTILYMPHOCYTE SERUM; BONE MARROW TRANSPLANTATION; CHIMERA; FEMALE; GRAFT SURVIVAL; IMMUNE TOLERANCE; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES; THYMUS GLAND; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS; WHOLE-BODY IRRADIATION;

EID: 0030050468     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199602150-00028     Document Type: Article

References (24)

1. Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a non-lethal preparative regimen. J Exp Med 1989; 169: 493.
2. Tomita Y, Khan A, Sykes M. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a non-myeloablative regimen. J Immunol 1994; 153: 1087.
3. Sharabi Y, Abraham VS, Sykes M, Sachs DH. Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance. Bone Marrow Transplant 1992; 9: 191.
4. Dialynas DP, Quan ZS, Wall KA, et al. Characterization of murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to human Leu3/T4 molecule. J Immunol 1983; 131: 2445.
5. Sarmiento M, Glasebrook AL, Fitch FW. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt2 antigen block T cell-mediated cytolysis in the absence of complement. J Immunol 1980; 125: 2665.
6. Ozato K, Mayer NM, Sachs DH. Monoclonal antibodies to mouse major histocompatibility complex antigens IV. A series of hybridoma clones producing anti-H-2d antibodies and an examination of expression of H-2d antigens on the surface of these cells. Transplantation 1982; 34: 113.
7. Unkeless JC. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J Exp Med 1979; 150: 580.
8. Sherman LA, Randolph CP. Monoclonal anti-H-2Kb antibodies detect serological differences between H-2Kb mutants. Immunogenetics 1981; 12: 183.
9. Ozato K, Mayer N, Sachs DH. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J Immunol 1980; 124: 533.
10. b haplotype reveal genetic control of isotype expression. J Immunol 1981; 126: 317.
11. a retrovirus exploits the immune system. Immunol Today 1991; 12: 356.
12. Tomonari K, Fairchild S. The genetic basis of negative selection of Tcrβ-V11+ T cells. Immunogenetics 1991; 33: 157.
13. Dyson PJ, Knight AM, Fairchild S, Simpson E, Tomonari K. Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes. Nature 1991; 349: 531.
14. Bill J, Kanagawa O, Woodland D, Palmer E. The MHC molecule I-E is necessary but not sufficient for the clonal deletion of Vβ11 bearing T cells. J Exp Med 1989; 169: 1405.
15. Scollay R, Jacobs S, Jerabek L, Butcher E, Weissman I. T cell maturation: thymocyte and thymus migrant subpopulations defined with monoclonal antibodies to MHC region antigens. J Immunol 1980; 124: 2845.
16. Vicari A, Abehsira-Amar O, Papiernik M, Boyd RL, Tucek CL. MTS-32 monoclonal antibody defines CD4+CD8- thymocyte subsets that differ in their maturation level, lymphokine secretion, and selection patterns. J Immunol 1994; 152: 2207.
17. Bendelac A, Schwartz RH. CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation. Nature 1991; 353: 68.
18. Lo D, Burkly LC, Flavell RA, Palmiter RD, Brinster RL. Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells. J Exp Med 1989; 170: 87.
19. Gao E-K, Kosaka H, Surh CD, Sprent J. T cell contact with Ia antigens on nonhematopoietic cells in vivo can lead to immunity rather than tolerance. J Exp Med 1991; 174: 435.
20. Ramsdell F, Jenkins M, Dinh Q, Fowlkes BJ. The majority of CD4+CD8- thymocytes are functionally immature. J Immunol 1991; 147: 1779.
21. Inaba M, Inaba K, Hosono M, et al. Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells. J Exp Med 1991; 173: 549.
22. Ardavin C, Wu L, Li C-L, Shortman K. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 1993; 362: 761.
23. Sharabi Y, Sachs DH, Sykes M. T cell subsets resisting induction of mixed chimerism across various histocompatibility barriers. In: Proceedings of the 8th International Congress on Immunology. Heidelberg: Springer-Verlag, 1992: 801.
24. Antica M, Wu L, Shortman K, Scollay R. Thymic stem cells in mouse bone marrow. Blood 1994; 84: 111.