Working at the cutting edge: The creation of allosteric ribozymes

Structure

Volumn 8, Issue 11, 2000, Pages R207-R212

  Warashina, M ^a   Kuwabara, T ^a,b   Taira, K ^a,b  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOZYME; RNA;

ALLOSTERISM; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; BIOSENSOR; CATALYSIS; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME STRUCTURE; GENE INACTIVATION; KINETICS; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CATALYSIS; DIMERIZATION; DNA; FLAVIN MONONUCLEOTIDE; FUSION PROTEINS, BCR-ABL; GENES, ABL; HUMANS; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; MICE; MICE, INBRED NOD; MICE, SCID; MODELS, MOLECULAR; NEOPLASM TRANSPLANTATION; NUCLEIC ACID CONFORMATION; PLASMIDS; RNA; RNA, CATALYTIC; RNA, TRANSFER; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0034435423     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00517-7     Document Type: Review

References (43)

1. The structure, function and application of the hammerhead ribozyme
2. The hydrolysis of RNA: From theoretical calculations to the hammerhead ribozyme-mediated cleavage of RNA
3. Ribozymes: The hammerhead swings into action
4. The hairpin ribozyme: Structure, assembly and catalysis
5. Nucleic acid enzymes
6. Structure, folding and catalysis of the small nucleolytic ribozymes
7. RNA structure, metal ions, and catalysis
8. Ribozyme structure and function
9. Differences among mechanisms of ribozyme-catalyzed reactions
10. Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against human immunodeficiency virus type 1
11. The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization
12. Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation
13. Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors
14. Effective inhibition of influenza virus production in cultured cells by external guide sequences and ribonuclease P
15. Val-driven short ribozymes
16. A novel allosterically trans-activated ribozyme, the maxizyme, with exceptional specificity in vitro and in vivo
17. Val-heterodimeric maxizymes with high potential as gene inactivating agents: Simultaneous cleavage at two sites in HIV-1 tat mRNA in cultured cells
18. Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III
19. Extremely high and specific activity of DNA enzymes in cells with a Philadelphia chromosome
20. Maxizymes, novel allosterically controllable ribozymes, can be designed to cleave various substrates
21. Oncogene inactivation in a mouse model: Tissue invasion by leukaemic cells is stalled by loading them with a designer ribozyme
22. Allosterically controllable maxizymes cleave mRNA with high efficiency and specificity
23. Training ribozymes to switch
24. Nucleic acid molecular switches
25. Allosterically controllable ribozymes with biosensor functions
26. An allosteric hammerhead ribozyme
27. In vitro selection of an allosteric ribozyme that transduces analytes to amplicons
28. Rational design of allosteric ribozymes
29. Allosteric regulation of a ribozyme activity through ligand-induced conformational change
30. Design of allosteric hammerhead ribozymes activated by ligand-induced structure stabilization
31. Engineering precision RNA molecular switches
32. Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP
33. Hammerhead minizymes with high cleavage activity: A dimeric structure as the active conformation of minizymes
34. Characterization of several kinds of dimer minizyme: Simultaneous cleavage at two sites in HIV-1 tat mRNA by dimer minizymes
35. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
36. Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line
37. Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA
38. Chemical and enzymatic probing of effector-mediated changes in the conformation of a maxizyme
39. Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against human immunodeficiency virus type 1
40. The hairpin ribozyme: Discovery, two-dimensional model, and development for gene therapy