Axonal transport of tubulin and actin

Journal of Neurocytology

Volumn 29, Issue 11-12, 2000, Pages 889-911

  Galbraith, James A ^a   Gallant, Paul E ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; TUBULIN;

ARTICLE; CELL TYPE; CYTOSKELETON; FLUORESCENCE MICROSCOPY; ISOTOPE LABELING; MICROTUBULE; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NERVE FIBER TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ACTINS; AGING; ANIMALS; AXONAL TRANSPORT; MICROSCOPY, FLUORESCENCE; MOLECULAR MOTOR PROTEINS; NERVE REGENERATION; NEURONS; POLYMERS; RADIOISOTOPES; TIME FACTORS; TUBULIN;

EID: 0034433063     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010903710160     Document Type: Article

References (122)

1. Microtubules released from the neuronal centrosome are transported into the axon
2. Cytoplasmic dynein and dynactin are required for the transport of microtubules into the axon
3. Inhibition of microtubule nucleation at the neuronal centrosome compromises axon growth
4. Phosphorylation-dependent immunoreactivity of neurofilaments and the rate of slow axonal transport in the central and peripheral axons of the rat dorsal root ganglion
5. Mobility measurement by analysis of fluorescence photobleaching recovery kinetics
6. The transport properties of axonal microtubules establish their polarity orientation
7. Assembly of microtubules at the tip of growing axons
8. Actin in emerging neurites is recruited from a monomer pool
9. Axonal transport of actin: Slow component B is the principal source of actin for the axon
10. Slow components of axonal transport: Two cytoskeletal networks
11. A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasm
12. Newly assembled microtubules are concentrated in the proximal and distal regions of growing axons
13. Composite microtubules of the axon: Quantitative analysis of tyrosinated and acetylated tubulin along individual axonal microtubules
14. Posttranslational processing of alpha-tubulin during axoplasmic transport in CNS axons
15. Axonal transport in the garfish optic nerve: Comparison with the olfactory system
16. Transport and turnover of microtubules in frog neurons depend on the pattern of axonal growth
17. Speckle microscopic evaluation of microtubule transport in growing nerve processes
18. Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis
19. Altered slow axonal transport and regeneration in a myelin-deficient mutant mouse: The trembler as an in vivo model for Schwann cell-axon interactions
20. Local control of axonal properties by Schwann cells: Neurofilaments and axonal transport in homologous and heterologous nerve grafts
21. Differential axonal transport of isotubulins in the motor axons of the rat sciatic nerve
22. Reorganization and movement of microtubules in axonal growth cones and developing interstitial branches
23. Functional analysis of dynactin and cytoplasmic dynein in slow axonal transport
24. Cytoplasmic dynein is associated with slow axonal transport
25. Synthesis and fast axonal transport of proteins in the isolated Aplysia nervous system
26. Migration of proteins along the axons of the sciatic nerve
27. Axonal migration of proteins in the central nervous system and peripheral nerves as shown by radiography
28. FRAP analysis of the stability of the microtubule population along the neurites of chick sensory neurons
29. Quantitative analysis of axonal transport of cytoskeletal proteins in chicken oculomotor nerve
30. Active transport of photoactivated tubulin molecules in growing axons revealed by a new electron microscopic analysis
31. Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon
32. Different contributions of microtubule dynamics and transport to the growth of axons and collateral sprouts
33. Axonal transport of neurotubule protein
34. Intracellular transport in neurons
35. Axonal transport and the neuronal cytoskeleton
36. Protein synthesis and transport in the regenerating goldfish visual system
37. Axonal transport and the cytoskeleton
38. The mechanisms of fast and slow transport in neurons: Identification and characterization of the new kinesin superfamily motors
39. The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons
40. Axonal transport of the cytoskeleton in regenerating motor neurons: Constancy and change
41. Axonal transport of class II and III beta-tubulin: Evidence that the slow component wave represents the movement of only a small fraction of the tubulin in mature motor axons
42. Changes in the isotype composition of beta-tubulin delivered to regenerating sensory axons by slow axonal transport
43. Axotomy accelerates slow component B of axonal transport
44. The effect of colchicine on the axonal transport of protein in the optic nerve and tract of the rabbit
45. Transport of microtubular protein in axons of retinal ganglion cells
46. Slow transport of tubulin in the neurites of differentiated PC12 cells
47. Microtubule behavior in PC12 neurites: Variable results obtained with photobleach technology
48. Recovery of slow axonal transport after colchicine treatment in rat sciatic nerve
49. Changes of fast axonal transport by taxol injected subepineurally into the rat sciatic nerve
50. Preferential blockade of the tubulin transport by colchicine
51. Effects of taxol on slow and fast axonal transport
52. Polymer sliding in axons
53. The structural hypothesis of axonal transport: Two classes of moving elements
54. Axonal transport of the cytoplasmic matrix
55. Slow axonal transport mechanisms move neurofilaments relentlessly in mouse optic axons
56. Microtubule assembly and turnover in growing axons
57. Progressive and spatially differentiated stability of microtubules in developing neuronal cells
58. A test of microtubule translocation during neurite elongation
59. Multiple forms of tubulin: Different gene products and covalent modifications
60. Slow transport rates of cytoskeletal proteins change during regeneration of axotomized retinal neurons in adult rats
61. Slow transport of the cytoskeleton after axonal injury
62. Transport of cytoskeletal elements from parent axons into regenerating daughter axons
63. Conditioning nerve crush accelerates cytoskeletal protein transport in sprouts that form after a subsequent crush
64. Diversity in the axonal transport of structural proteins: Major differences between optic and spinal axons in the rat
65. Retardation in the slow axonal transport of cytoskeletal elements during maturation and aging
66. Experimental diabetic neuropathy: Impairment of slow transport with changes in axon cross-sectional area
67. Changes in axon size and slow axonal transport are related in experimental diabetic neuropathy
68. Experimental diabetic neuropathy: Similar changes of slow axonal transport and axonal size in different animal models
69. Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: Evidence for dynamic interactions of tau with microtubules in vivo
70. Tubulin transport in neurons
71. Slow axonal transport of soluble actin with actin depolymerizing factor, cofilin, and profilin suggests actin moves in an unassembled form
72. Polewards microtubule flux in the mitotic spindle: Evidence from photoactivation of fluorescence
73. Impaired slow axonal transport in wobbler mouse motor neuron disease
74. Slowly migrating axonal polypeptides. Inequalities in their rate and amount of transport between two branches of bifurcating axons
75. Monomer-polymer equilibria in the axon: Direct measurement of tubulin and actin as polymer and monomer in axoplasm
76. Sensory neurons selectively upregulate synthesis and transport of the beta III-tubulin protein during axonal regeneration
77. Multiple fates of newly synthesized neurofilament proteins: Evidence for a stationary neurofilament network distributed nonuniformly along axons of retinal ganglion cell neurons
78. Slow axonal transport
79. Biochemical composition and dynamics of the axonal cytoskeleton in the corticospinal system of the adult hamster
80. A unitary concept of axoplasmic transport based on the transport filament hypothesis
81. Microtubule dynamics in nerve cells: Analysis using microinjection of biotinylated tubulin into PC12 cells
82. Turnover of fluorescently labelled tubulin and actin in the axon
83. Differential behavior of photoactivated microtubules in growing axons of mouse and frog neurons
84. Do photobleached fluorescent microtubules move?: Re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon
85. Changes in protein content of goldfish optic nerve during degeneration and regeneration following nerve crush
86. Animal models of ALS
87. Fast transport of neurofilament protein along microtubules in squid axoplasm
88. Microtubule polymer assembly and transport during axonal elongation
89. Neurofilaments are transported rapidly but intermittently in axons: Implications for slow axonal transport
90. Axonal transport of tubulin in Ti1 pioneer neurons in situ
91. Detection of single fluorescent microtubules and methods for determining their dynamics in living cells
92. Assembly of actin-containing cortx occurs at distal regions of growing neurites in PC12 cells
93. Tubulin dynamics in cultured mammalian cells
94. Microtubule transport from the cell body into axons of growing neurons
95. Neuroplasmic transport in the nervous system of the cockroach Periplaneta americana
96. Hypothyroidism reduces the rate of slow component A (SCa) axonal transport and the amount of transported tubulin in the hyt/hyt mouse optic nerve
97. Hypothyroidism selectively reduces the rate and amount of transport for specific SCb proteins in the hyt/hyt mouse optic nerve
98. Tubulin dynamics in neuronal axons of living zebrafish embryos
99. Microtubule behavior in the growth cones of living neurons during elongation
100. Protein transport in intact and severed (anucleate) crayfish giant axons
101. Subunit composition specific to axonally transported tubulin
102. Maturation and aging of the axonal cytoskeleton: Biochemical analysis of transported tubulin
103. Changes in organization and axonal transport of cytoskeletal proteins during regeneration
104. Organization and slow axonal transport of cytoskeletal proteins under normal and regenerating conditions
105. Impairment of cytoskeletal protein transport due to aging or beta, beta′-iminodipropionitrile intoxication in the rat sciatic nerve
106. Two populations of axonally transported tubulin differentiated by their interactions with neurofilaments
107. Oligomeric tubulin in large transporting complex is transported via kinesin in squid giant axons
108. Transport of cytoskeletal elements in the squid giant axon
109. Axonal transport: Each major rate component reflects the movement of distinct macromolecular complexes
110. Fluorescent microtubules break up under illumination
111. Microtubule assembly in growing dendrites
112. Rapid movement of axonal neurofilaments filaments interrupted by prolonged pauses
113. Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover is associated with microtubule breakage and treadmilling
114. How microtubules get fluorescent speckles
115. The cold stability of microtubules increases during axonal maturation
116. Experiments on the mechanism of nerve growth
117. Axonal transport of actin in rabbit retinal ganglion cells
118. Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons
119. Microtubule nucleation and release from the neuronal centrosome
120. Microtubule transport and assembly during axon growth
121. Axonal transport studied in a single vertebrate neuron: The giant electromotor neuron of the electric catfish, Malapterurus electricus