Canadian Biotechnology Start-Ups, 1991-1997: The Role of Incumbents' Patents and Strategic Alliances in Controlling Competition

Social Science Research

Volumn 29, Issue 4, 2000, Pages 503-534

  Calabrese, Tony ^a   Baum, Joel A C ^a   Silverman, Brian S ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HARVARD UNIVERSITY   (United States)

Author keywords

biotechnology; Canada; control of competition; organizational founding; Patents; strategic alliances

Indexed keywords

ARTICLE; BIOTECHNOLOGY; CANADA; ECONOMIC ASPECT; HISTORY; INDUSTRY; PATENT;

BIOTECHNOLOGY; CANADA; ECONOMIC COMPETITION; HISTORY, 20TH CENTURY; INDUSTRY; PATENTS;

EID: 0034363430     PISSN: 0049089X     EISSN: None     Source Type: Journal    
DOI: 10.1006/ssre.2000.0679     Document Type: Article

References (85)

1. Aldrich H. E. Using an ecological perspective to study organizational founding rates. Entrepreneurship Theory and Practice. 14:1990;7-24.
2. Amburgey T. L., Dacin T., Singh J. Learning races, patent races, and capital races: Strategic interaction and embeddedness within organizational fields. Baum J. A. C., Dutton J. E. Advances in Strategic Management. 1996;303-322 JAI Press, Greenwich.
3. Argyres N. S., Liebeskind J. P. Privatizing the intellectual commons: Universities and the commercialization of biotechnology. Journal of Economic Behavior & Organization. 35:1998;427-454.
4. Austin D. H. An event study approach to measuring innovative output: The case of biotechnology. American Economic Review. 83:1993;253-258.
5. Bain J. S. Barriers to New Competition. 1956;Harvard Univ. Press, Cambridge.
6. Barley S., Freeman J., Hybels R. Strategic alliances in commercial biotechnology. Nohria N., Eccles R. Networks and Organizations: Structure, Form and Action. 1992;311-347 HBS Press, Boston.
7. Barnett W. P. The organizational ecology of a technological system. Administrative Science Quarterly. 35:1990;31-60.
8. Barnett W. P., Carroll G. R. How institutional constraints affected the organization of early American telephony. Journal of Law, Economics and Organization. 9:1993;98-126.
9. Barron D. N. Analysis of count data: Overdispersion and autocorrelation. Sociological Methodology. 22:1992;179-220.
10. Baum J. A. C. Organizational ecology. Clegg S., Hardy C., Nord W. Handbook of Organization Studies. 1996;77-114 Sage, London.
11. Baum J. A. C., Calabrese T., Silverman B. S. Don't go it alone: Alliance network composition and startups' performance in Canadian biotechnology. Strategic Management Journal. 21:2000;267-294.
12. Baum J. A. C., Korn H. J., Kotha S. Dominant designs and population dynamics in telecommunications services: Founding and failure of facsimile transmission service organizations. Social Science Research. 24:1995;1965-1992.
13. Baum J. A. C., Oliver C. Institutional linkages and organizational mortality. Administrative Science Quarterly. 36:1991;187-218.
14. Baum J. A. C., Oliver C. Institutional embeddedness and the dynamics of organizational populations. American Sociological Review. 57:1992;540-559.
15. Baum J. A. C., Oliver C. Toward an institutional ecology of organizational founding. Academy of Management Journal. 39:1996;1378-1427.
16. Baum J. A. C., Powell W. W. Cultivating an institutional ecology of organizations: Comment on Hannan, Carroll, Dundon, and Torres. American Sociological Review. 60:1995;529-538.
17. Baum, J. A. C, and, Silverman, B. S. 1998, Alliance and patent-based competition in the Canadian biotechnology industry, paper presented at the Academy of Management, San Diego CA, August.
18. Baum J. A. C., Singh J. V. Organizational niches and the dynamics of organizational founding. Organization Science. 5:1994;483-501.
19. Biotech '97, Ernst & Young, San Francisco, CA.
20. Canadian Biotech, various years, Ernst & Young, Toronto.
21. Canadian Biotechnology, various years, (, F. Haynes, Ed.), Contact Canada, Toronto.
22. Canadian Biotechnology Handbook, various years, (, P. Winter, Ed.), Canadian Biotech News, Nepean, Ontario.
23. Carroll G. R., Huo Y. P. Organizational task and institutional environments in ecological perspective: Findings from the local newspaper industry. American Journal of Sociology. 91:1986;838-873.
24. Caves R. M., Porter M. E. From entry barriers to mobility barriers: Conjectural decisions and contrived deterrence to new competition. Quarterly Journal of Economics. 91:1977;241-261.
25. Cohen J., Cohen P. Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences, Second Edition. 1983;Erlbaum, Hillsdale.
26. Coleman J. S. Longitudinal Data Analysis. 1981;Basic Books, New York.
27. Davis L. E., North D. C. Institutional Change and American Economic Growth. 1971;Cambridge Univ. Press, Cambridge.
28. Delacroix J., Carroll G. R. Organizational foundings: An ecological study of the newspaper industries of Argentina and Ireland. Administrative Science Quarterly. 28:1983;274-291.
29. DiMaggio P. J., Powell W. W. The iron cage revisited: Institutional isomorphism and collective rationality in organizational fields. American Sociological Review. 48:1983;148-160.
30. Dobbin F., Dowd T. J. How policy shapes competition: Early railroad foundings in Massachusetts. Administrative Science Quarterly. 42:1997;501-529.
31. Eisenhardt K. M., Schoonhoven K. Organizational growth: Linking founding team, strategy, environment, and growth among U.S. semiconductor ventures. Administrative Science Quarterly. 35:1990;1978-1988.
32. Fligstein N. Markets as politics: A political-cultural approach to market institutions. American Sociological Review. 61:1996;656-673.
33. Fligstein N. The Transformation of Corporate Control. 1990;Harvard Univ. Press, Cambridge.
34. Gartner W. B. Some suggestions for research on entrepreneurial traits and characteristics. Entrepreneurship: Theory and Practice. 14:1989;27-37.
35. Gompers, P. A., and Lerner, J.1998. What drives venture capital fundraising?Brookings Papers on Economic Activity; Microeconomics, 149-192.
36. Greene W. H. Econometric Analysis. 1990;Macmillan, New York.
37. Grindley P. C., Mowery D. C., Silverman B. SEMATECH and collaborative research: Lessons in the design of high-technology consortia. Journal of Policy Analysis and Management. 13:1994;723-758.
38. Grindley P. C., Teece D. J. Managing intellectual capital: Licensing and cross-licensing in semiconductors and electronics. California Management Review. 39:1997;8-41.
39. Hannan M. T., Carroll G. R. Dynamics of Organizational Populations: Density, Competition and Legitimation. 1992;Oxford Univ. Press, New York.
40. Haunschild P. R., Miner A. S. Modes of interorganizational imitation: The effects of outcome salience and uncertainty. Administrative Science Quarterly. 42:1997;472-500.
41. Hausman J., Hall B. H., Griliches Z. Economic models for count data with an application to the patents and R&D relationship. Econometrica. 52:1984;909-937.
42. Henderson R. M., Clark K. B. Architectural innovation: The reconfiguration of existing product technologies and the failure of established firms. Administrative Science Quarterly. 35:1990;9-30.
43. Holtzeakin D., Joulfaian D., Rosen H. S. Entrepreneurial decisions and liquidity constraints. Rand Journal of Economics. 25:1994;334-347.
44. Howes P. Patent Protection. PMAC Annual Review, 1996-97, Chapter 2. 1997;Pharmaceuticals Association of Canada, Toronto.
45. Hybels, R. C, Ryan, A. R, and, Barley, S. R. 1994, Alliances, legitimation, and founding rates in the U.S. biotechnology field, 1971-89, paper presented at the Academy of Management National Meetings, Dallas, TX.
46. Katz M. L., Ordover J. A. R&D cooperation and competition. Brookings Papers on Economic Activity. 1990;137-203.
47. Kennedy P. A Guide to Econometric Methods (3rd edition). 1992;MIT Press, Cambridge.
48. Kenney M. Biotechnology: The University-Industry Complex. 1986;Yale Univ. Press, New Haven.
49. Kmenta J. Elements of Econometrics. 1971;Macmillan, New York.
50. Kogut B., Shan W., Walker G. The make-or-cooperate decision in the context of an industry network. Nohria N., Eccles R. G. Networks and Organizations: Structure, Form and Action. 1992;348-365 HBS Press, Boston.
51. Kogut B., Walker G., Kim D. J. Cooperation and entry induction as an extension of technological rivalry. Research Policy. 24:1995;77-95.
52. Kondo E. K. The effect of patent protection on foreign direct investment. Journal of World Trade. 29:1995;97-122.
53. Lerner J. Patenting in the shadow of competitors. Journal of Law and Economics. 38:1995;463-495.
54. Levin R. C., Klevorick A. K., Nelson R. R., Winter S. G. Appropriating the returns from industrial research and development. Brookings Papers on Economic Activity. 3:1987;783-833.
55. Liebeskind J. P., Oliver A. L., Zucker L., Brewer M. Social networks, learning and flexibility: Sourcing scientific knowledge in new biotechnology firms. Organization Science. 7:1996;428-443.
56. Miner A. S., Amburgey T. L., Stearns T. Interorganizational linkages and population dynamics: Buffering and transformational shields. Administrative Science Quarterly. 35:1990;689-713.
57. Mowery D. C., Oxley J. E., Silverman B. S. Strategic alliances and interfirm knowledge transfer. Strategic Management Journal. 17:1996;77-92.
58. Nelson R. R., Winter S. G. An Evolutionary Theory of Economic Change. 1982;Harvard Univ. Press, Cambridge MA.
59. Nonaka I., Takeuchi H. The Knowledge-Creating Company. 1995;Oxford Univ. Press, New York.
60. North D. C. Journal of Economic Perspectives. 5:1991;97-112.
61. Pisano G. P. Institutions, The R&D boundaries of the firm: An empirical analysis. Administrative Science Quarterly. 35:1990;153-176.
62. Podolny J. M. Market uncertainty and the character of economic exchange. Administrative Science Quarterly. 39:1994;458-483.
63. Podolny J., Stuart T. E., Hannan M. T. Networks, knowledge, and niches. American Journal of Sociology. 102:1996;659-689.
64. Powell W. W. Neither market nor hierarchy: Network forms of organization. Research in Organizational Behavior, 12:1990;295-336.
65. Powell W. W., Brantley P. Competitive cooperation in biotechnology: Learning through networks? Nohria N., Eccles R. G. Networks and Organizations: Structure, Form and Action. 1992;366-394 HBS Press, Boston.
66. Powell W. W., Koput K. W., Smith-Doerr L. Interorganizational collaboration and the locus of innovation: Networks of learning in biotechnology. Administrative Science Quarterly. 41:1996;116-145.
67. Powell, W. W, Koput, K. W, Smith-Doerr, L, and, Owen-Smith, J. 1998, Newtork position and firm performance: Organizational returns to collaboration in the biotechnology industry, working paper, University of Arizona.
68. Rosenberg N. Inside the Black Box: Technology and Economics. 1982;Cambridge Univ. Press. Cambridge, UK.
69. Shan W., Walker G., Kogut B. Interfirm cooperation and startup innovation in the biotechnology industry. Strategic Management Journal. 15:1994;387-394.
70. Singh J. V., Tucker D. J., Meinhard A. G. Institutional change and ecological dynamics. Powell W. W., DiMaggio P. J. The New Institutionalism in Organizational Analysis. 1991;390-422 Univ. of Chicago Press, Chicago.
71. Spence A. M. Market Signaling. 1974;Harvard Univ. Press, Cambridge.
72. Stewart J. Drug Development and Approval. PMAC Annual Review, 1996-97, Chapter 7. 1997;Pharmaceuticals Association of Canada, Toronto.
73. Stigler G. J. The theory of economic regulation. Bell Journal of Economics. 2:1971;3-21.
74. Stinchcombe A. L. Social structure and organizations. March J. G. Handbook of Organizations. 1965;142-193 Rand McNally, Chicago.
75. Stuart T. E. Interorganizational alliances and the performance of firms; A study of growth and innovation rates in a high-technology industry, working paper. 1998;Graduate School of Business.
76. Stuart T. E., Hoang H., Hybels R. C. Interorganizational endorsements and the performance of entrepreneurial ventures. Administrative Science Quarterly. 44:1999;315-349.
77. Suarez F. F., Utterback J. M. Dominant designs and the survival of firms. Strategic Management Journal. 16:1995;415-430.
78. Teece D. J. Profiting from technological innovation. Research Policy. 15:1986;285-305.
79. Tushman M. L., Anderson P. Technological discontinuities and organizational environments. Administrative Science Quarterly. 31:1986;439-465.
80. Utterback J. M., Suarez F. F. Innovation, competition, and industry structure. Policy Studies. 22:1993;1-21.
81. Uzzi B. The sources and consequences of embeddedness for the economic performance of organizations: The network effect. American Sociological Review. 61:1996;674-698.
82. Wade J. Dynamics of organizational communities and technological bandwagons: An empirical investigation of community evolution in the microprocessor market. Strategic Management Journal. 16:1995;111-133.
83. Walker G., Kogut B., Shan W. J. Social capital, structural holes and the formation of an industry network. Organization Science. 8:1997;109-125.
84. Williamson O. E. Transaction cost economics and organization theory. Smelser N. J., Swedberg R. The Handbook of Economic Sociology. 1994;77-107 Princeton Univ. Press, Princeton.
85. Zucker L. G., Darby M. R., Brewer M. B. Intellectual human capital and the birth of U.S. biotechnology enterprises. American Economic Review. 88:1998;290-306.