Inactivation of p53 by HTLV type 1 and HTLV type 2 Tax trans-activators

AIDS Research and Human Retroviruses

Volumn 16, Issue 16, 2000, Pages 1677-1681

  Mahieux, R ^a,d   Pise Masison, C A ^a   Nicot, C ^a   Green, P ^b   Hall, W W ^c   Brady, J N ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; TAX PROTEIN;

ARTICLE; CONTROLLED STUDY; FIBROBLAST; GAMMA IRRADIATION; GENE INACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS 2; LYMPHOCYTE TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; VIRUS TYPING;

ANIMALS; CELL LINE, TRANSFORMED; GENE PRODUCTS, TAX; HTLV-I INFECTIONS; HTLV-II INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMAN T-LYMPHOTROPIC VIRUS 2; HUMANS; MICE; T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034331209     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/08892220050193137     Document Type: Article

References (30)

1. A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia
2. Human T lymphotropic virus type II (HTLV-II): Epidemiology; molecular properties, and clinical features of infection
3. Lack of evidence of HTLV-I/II infection in T CD8 malignant or reactive lymphoproliferative disorders in France: A serological and/or molecular study of 169 cases
4. Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector
5. Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro
6. HTLV-I transgenic models: An overview
7. Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation
8. In vitro mutagenesis of the human T-cell leukemia virus types I and II tax genes
9. The x gene is essential for HTLV replication
10. HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes
11. African origin of human T-lymphotropic virus type 2 (HTLV-2) supported by a potential new HTLV-2d subtype in Congolese Bambuti Efe Pygmies
12. Mutational analysis of human T-cell leukemia virus type 2 Tax
13. How phosphorylation regulates the activity of p53
14. Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1
15. p53 Functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells
16. Functional inactivation of wild-type p53 protein correlates with loss of IL-2 dependence in HTLV-I transformed human T lymphocytes
17. Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain
18. Phosphorylation of p53: A novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells
19. Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein
20. Aberrant expression of the p53 tumor suppressor gene in adult T-cell leukemia and HTLV-I-infected cells
21. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor
22. The p53 tumor suppressor protein: Meeting review
23. Multiple isolates and characteristics of human T-cell leukemia virus type II
24. Incidence of hairy cell leukemia, mycosis fungoides, and chronic lymphocytic leukemia in first known HTLV-II-endemic population
25. Identification and characterization of an extended Tax protein in human T-cell lymphotropic virus type II subtype b isolates
26. Differential trans-activation of the intercellular adhesion molecule 1 gene promoter by Tax1 and Tax2 of human T-cell leukemia viruses
27. Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail To transform primary human T cells
28. Cell-type-specific trans-activation of the parathyroid hormone-related protein gene promoter by the human T-cell leukemia virus type I (HTLV-I) tax and HTLV-II tax proteins
29. Activation of the GM-CSF promoter by HTLV-I and -II tax proteins
30. HTLV-I and HTLV-II tax trans-activate the human EGR-1 promoter through different cis-acting sequences