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Volumn 70, Issue 2, 1996, Pages 139-148

Leukopenia-inducing effect of a combination of a new 5-fluorouracil (5-FU)-derived drug, BOF-A2 (Emitefur), with other 5-FU-derived drugs or BV-araU (Sorivudine) in rats

Author keywords

5 fluorouracil derived drug; Emitefur (BOF A2); Leukopenia; Sorivudine (BV araU)

Indexed keywords

2,6 DIHYDROXYNICOTINONITRILE; CARMOFUR; DOXIFLURIDINE; DRUG METABOLITE; EMITEFUR; FLUCYTOSINE; FLUOROURACIL; FLUOROURACIL DERIVATIVE; SORIVUDINE; TEGAFUR; UFT; URACIL;

EID: 0029965890     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.70.139     Document Type: Article
Times cited : (5)

References (20)
  • 1
    • 0018757734 scopus 로고
    • Effect of coadministration of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents
    • Fujii S, Kitano S, Ikenaka K and Shirasaka T: Effect of coadministration of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodents. Gann 70, 209-214 (1979)
    • (1979) Gann , vol.70 , pp. 209-214
    • Fujii, S.1    Kitano, S.2    Ikenaka, K.3    Shirasaka, T.4
  • 2
    • 0027135995 scopus 로고
    • 5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo
    • Spector T, Harrington JA and Porter DJT: 5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo. Biochem. Pharmacol 46, 2243-2248 (1993)
    • (1993) Biochem. Pharmacol , vol.46 , pp. 2243-2248
    • Spector, T.1    Harrington, J.A.2    Porter, D.J.T.3
  • 3
    • 0027959812 scopus 로고
    • Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor 5-benzoyloxybenzyl uracil
    • Naguib FNM, Hao SN and Kouni MH: Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor 5-benzoyloxybenzyl uracil. Cancer Res 54, 5166-5170 (1994)
    • (1994) Cancer Res , vol.54 , pp. 5166-5170
    • Naguib, F.N.M.1    Hao, S.N.2    Kouni, M.H.3
  • 6
    • 0027431466 scopus 로고
    • Synthesis of 5-fluorouracil derivatives containing an inhibitor of 5-fluorouracil degradation
    • Hirohashi M, Kido M, Yamamoto Y, Kojima Y, Jitukawa K and Fujii S: Synthesis of 5-fluorouracil derivatives containing an inhibitor of 5-fluorouracil degradation. Chem Pharm Bull (Tokyo) 41, 1498-1506 (1993)
    • (1993) Chem Pharm Bull (Tokyo) , vol.41 , pp. 1498-1506
    • Hirohashi, M.1    Kido, M.2    Yamamoto, Y.3    Kojima, Y.4    Jitukawa, K.5    Fujii, S.6
  • 8
    • 0028260484 scopus 로고
    • Oral administration of BOF-A2 to rats with lung transplanted tumors results in increased 5-fluorouracil levels
    • Miyauchi S, Imaoka T, Utsunomiya T, Hayashi K, Kubo M, Kawaguchi T and Matsui Y: Oral administration of BOF-A2 to rats with lung transplanted tumors results in increased 5-fluorouracil levels. Jpn J Cancer Res 85, 665-668 (1994)
    • (1994) Jpn J Cancer Res , vol.85 , pp. 665-668
    • Miyauchi, S.1    Imaoka, T.2    Utsunomiya, T.3    Hayashi, K.4    Kubo, M.5    Kawaguchi, T.6    Matsui, Y.7
  • 9
    • 0027964405 scopus 로고
    • Efficacy of a new 5-fluorouracil derivative, BOF-A2, in advanced non-small cell cancer. A multicenter phase II study
    • Nakai Y, Furuse K, Ohta M, Yamaguchi Y, Fujii M, Asakawa M, Fukuoka M, Yoshida K and Niitani H: Efficacy of a new 5-fluorouracil derivative, BOF-A2, in advanced non-small cell cancer. A multicenter phase II study. Acta Oncol 33, 523-526 (1994)
    • (1994) Acta Oncol , vol.33 , pp. 523-526
    • Nakai, Y.1    Furuse, K.2    Ohta, M.3    Yamaguchi, Y.4    Fujii, M.5    Asakawa, M.6    Fukuoka, M.7    Yoshida, K.8    Niitani, H.9
  • 10
    • 0028338361 scopus 로고
    • Deaths bring clinical trials under scrutiny in Japan
    • David S: Deaths bring clinical trials under scrutiny in Japan. Nature 369, 697 (1994)
    • (1994) Nature , vol.369 , pp. 697
    • David, S.1
  • 11
    • 0024833789 scopus 로고
    • Effects of the plasma concentration of 5-fluorouracil and the duration of continous venous infusion of 5-fluorouracil with an inhibitor of 5-fluorouracil degradation on Yoshida sarcoma in rats
    • Fujii S, Shimamoto Y, Ohshimo H, Imaoka T, Motoyama M, Fukushima M and Shirasaka T: Effects of the plasma concentration of 5-fluorouracil and the duration of continous venous infusion of 5-fluorouracil with an inhibitor of 5-fluorouracil degradation on Yoshida sarcoma in rats. Jpn J Cancer Res 80, 167-172 (1989)
    • (1989) Jpn J Cancer Res , vol.80 , pp. 167-172
    • Fujii, S.1    Shimamoto, Y.2    Ohshimo, H.3    Imaoka, T.4    Motoyama, M.5    Fukushima, M.6    Shirasaka, T.7
  • 12
    • 0025308777 scopus 로고
    • Hematologic effects of interleukin-1 beta, granulocyte colony-stimulating factor, and granulocyte macrophage colony-stimulating factor in tumor-bearing mice treated with fluorouracil
    • Moure MA, Stolfi RL and Martin DS: Hematologic effects of interleukin-1 beta, granulocyte colony-stimulating factor, and granulocyte macrophage colony-stimulating factor in tumor-bearing mice treated with fluorouracil. J Natl Cancer Inst 82, 1031-1037(1990)
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1031-1037
    • Moure, M.A.1    Stolfi, R.L.2    Martin, D.S.3
  • 13
    • 84969040335 scopus 로고
    • Protection by testosterone from fluorouracil-induced toxicity without loss of anticancer activity against autochthonaus murine breast tumors
    • Stolhi RL, Sawyer RC, Nayak R, Spiegelman S and Martin DS: Protection by testosterone from fluorouracil-induced toxicity without loss of anticancer activity against autochthonaus murine breast tumors. Cancer Res 40, 2730-2735 (1980)
    • (1980) Cancer Res , vol.40 , pp. 2730-2735
    • Stolhi, R.L.1    Sawyer, R.C.2    Nayak, R.3    Spiegelman, S.4    Martin, D.S.5
  • 14
    • 0022550597 scopus 로고
    • Effect of (E)-5-(2-bromovinyl) uracil on the catabolism and antitumor activity of 5-flurorouracil in rats and leukemic mice
    • Desgranges C, Razaka G, Clercq ED, Herdewijn P, Balzarini J, Drouillet F and Bricaud H: Effect of (E)-5-(2-bromovinyl) uracil on the catabolism and antitumor activity of 5-flurorouracil in rats and leukemic mice. Cancer Res 46, 1094-1101 (1986)
    • (1986) Cancer Res , vol.46 , pp. 1094-1101
    • Desgranges, C.1    Razaka, G.2    Clercq, E.D.3    Herdewijn, P.4    Balzarini, J.5    Drouillet, F.6    Bricaud, H.7
  • 15
    • 0026092290 scopus 로고
    • Highly sensitive method for the determination of 5-fluorouracil in biological samples in the presence of 2′-deoxy-5-fluorouridine by gas chromatography-mass spectrometer
    • Kubo M, Sasabe H and Shimizu T: Highly sensitive method for the determination of 5-fluorouracil in biological samples in the presence of 2′-deoxy-5-fluorouridine by gas chromatography-mass spectrometer. J Chromatogr 564, 137-145 (1991)
    • (1991) J Chromatogr , vol.564 , pp. 137-145
    • Kubo, M.1    Sasabe, H.2    Shimizu, T.3
  • 16
    • 0028012826 scopus 로고
    • Inhibition of catabolic pathway of 5-fluorouracil by 3-cyano-2,6-dihydroxypyridine in human lung cancer tissue
    • Okayasu T, Sugiyama T and Miyauchi S: Inhibition of catabolic pathway of 5-fluorouracil by 3-cyano-2,6-dihydroxypyridine in human lung cancer tissue. Jpn J Cancer Res 85, 101-105 (1994)
    • (1994) Jpn J Cancer Res , vol.85 , pp. 101-105
    • Okayasu, T.1    Sugiyama, T.2    Miyauchi, S.3
  • 17
    • 0022400840 scopus 로고
    • Enzymes of uracil catabolism in normal and neoplastic human tissues
    • Naguib FNM, Kouni MHK and Cha S: Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 45, 5405-5412 (1985)
    • (1985) Cancer Res , vol.45 , pp. 5405-5412
    • Naguib, F.N.M.1    Kouni, M.H.K.2    Cha, S.3
  • 18
    • 0025603176 scopus 로고
    • Effect of 1-β-D-arabinofuranosyl(E)-5(2-bromovinyl)uracil against herpes virus type 1 infection in immunosuppressed mice
    • Ijichi K, Ashida N and Machida H: Effect of 1-β-D-arabinofuranosyl(E)-5(2-bromovinyl)uracil against herpes virus type 1 infection in immunosuppressed mice. Antimicrob Agents Chemother 34, 2431-2433 (1990)
    • (1990) Antimicrob Agents Chemother , vol.34 , pp. 2431-2433
    • Ijichi, K.1    Ashida, N.2    Machida, H.3
  • 20
    • 0027137849 scopus 로고
    • Metabolism of 5′-ether prodrugs of 1-β-D-arabinofuranosyol-E-5-(2-bromovinyl)uracil in rats
    • Ashida N, Ijichi K, Watanabe Y and Machida H: Metabolism of 5′-ether prodrugs of 1-β-D-arabinofuranosyol-E-5-(2-bromovinyl)uracil in rats. Biochem Pharmacol 46, 2201-2207 (1993)
    • (1993) Biochem Pharmacol , vol.46 , pp. 2201-2207
    • Ashida, N.1    Ijichi, K.2    Watanabe, Y.3    Machida, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.