Deletion of chromosomes 9p and 17 associated with abnormal expression of p53, p16/MTS1 and p15/MTS2 gene protein in hepatocellular carcinomas

Chinese Medical Journal

Volumn 113, Issue 9, 2000, Pages 817-822

  Shao, Jianyong ^a   Li, Yuhong ^a   Li, Hiuming ^b   Wu, Qiuliang ^a   Hou, Jinghui ^a   Liew, ChoongTsek ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Chromosome; Hepatitis virus; Hepatocellular carcinoma; Loss of heterozygosity; Tumor suppressor gene

Indexed keywords

CDKN2B PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2B; PROTEIN; PROTEIN P16INK4A; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; CHROMOSOME 17; CHROMOSOME 9; CHROMOSOME DELETION; COMPARATIVE STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETICS; HEPATITIS B; HEPATITIS C; HETEROZYGOSITY LOSS; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; VIROLOGY;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 9; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FREQUENCY; HEPATITIS B; HEPATITIS C; HUMANS; LIVER NEOPLASMS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0034286049     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Wang BN. Problems in the primary hepatocellular carcinoma research. Natl J Med 1994;74:459-460.
2. Harris CC. Hepatocellular carcinogenesis: recent advances and speculations. Cancer Cells 1990;2:146-148.
3. Piao Z, Park C, Park JH, et al. Allelotype analysis of hepatocellular carcinoma. Int J Cancer 1998;75:29-33.
4. Fujimato Y, Hampton LL, Wirth PJ, et al. Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China. Cancer Res 1994;54:281-285.
5. Walker GJ, Hayward NK, Falvey S, et al. Loss of somatic heterozygosity in hepatocellular carcinoma. Cancer Res 1991;51:4367-4370.
6. Biden K, Young J, Buttenshaw R, et al. Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population. Hepatology 1997;25:593-597.
7. Yeh SH, Chen PJ, Chen HL, et al. Frequent genetic alteration at the distal region of chromosome 9p in human hepatocellular carcinomas. Cancer Res 1994;54:4188-4192.
8. Tusda H, Zhang W, Shimosato Y, et al. Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Natl Acad Sci U S A 1990;87:6791-6794.
9. Piao Z, Kim H, Jeon BK, et al. Relationship between loss of heterozygosity of tumor suppressor genes and histologic differentiation in hepatocellular carcinoma. Cancer 1997;80:865-872.
10. INK4A/MTS1 genes in biliary tract cancers. Cancer Res 1995;55:2756-2760.
11. Nobori T, Miura K, Wu DJ, et al. Deletion of the cyclindependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994;368:753-756.
12. Edmondson HA, Steiner PE. Primary carcinoma of the liver. A study of 100 cases among 48900 necopsies. Cancer 1954;7:462-503.
13. Shao JY, Li HM, Liew CT, et al. A preliminary study of loss of heterozygosity on chromosome 1p in primary hepatocellular carcinoma. Chin J Pathol 1999;28:28-30.
14. Shao JY, Liew CT, Liang XM, et al. Study of loss of heterozygosity on chromosome 9 in primary hepatocellular carcinoma. Chin J Cancer 1999;18:16-19.
15. Moskaluk CA, Kern SE. Microdissection and polymerase chain reaction amplification of genomic DNA from histologic tissue sections. Am J Pathol 1997;150:1547-1552.
16. INK4A cyclin-dependent kinase inhibitor in malignant mesothelioma. J Natl Cancer Inst 1995;87:1870-1875.
17. Olopdo OI, Pomykata WM, Hagos F, et al. Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene frame the tumor suppressor region on 9p21. Proc Natl Acad Sci U S A 1995;92:6489-6493.
18. Kim SK, Ro JY, Kemp RB, et al. Identification of three distinct tumor suppressor loci on the short arm of chromosome 9 in small cell lung cancer. Cancer Res 1997;57:400-403.
19. van Der RP, Nawroz HRH, Corio R, et al. Frequent loss of chromosome 9p21-22 early in head and neck cancer progression. Cancer Res 1994;54:1156-1158.
20. Eriksdotti G, Siguesson A, Jonasson A, et al. Loss of heterozygosity on chromosome 9 in human breast cancer: association with clinical variables and genetic changes at other chromosome regions. Int J Cancer 1995;64:378-382.
21. Huang DP, Lo KW, van Hasselt CA, et al. A region of homozygous deletion on chromosome 9p21-22 in primary nasopharyngeal carcinoma. Cancer Res 1994;54:4003-4006.
22. INK4A transcript. Cancer Res 1995;55:2995-2997.
23. INK4A is a potential effector of TGF-β-induced cell cycle arrest. Nature 1994;371:257-261.
24. INK4A/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res 1995;55:1448-1451.
25. Reed AL, Califano J, Cairns P, et al. High frequency of p16 (CDKN2/MTS1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 1996;56:3630-3633.
26. Piao Z, Park C, Lee JS, et al. Homozygous deletion of the CDKN2 gene and loss of heterozygosity of 9p in primary hepatocellular carcinoma. Cancer Lett 1998;122:201-207.
27. INK4A gene in liver cancer. Int J Cancer 1996;67:176-180.
28. Slagle BL, Zhou YZ, Butel JS. Hepatitis B virus integration event in human chromosome 17p near the P53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas. Cancer Res 1991;51:49-54.
29. Tadashisa T, Satonaka K, Kitazawa S, et al. P53 gene abnormalities are closely related to hepatoviral infections and occur at the late stage of hepatocarcinogenesis. Cancer Res 1994;54:231-235.
30. Volgestein B, Kinzler KW. p53 function and dysfunction. Cell 1992;70:523-526.
31. Cornelis RS, van Vliet M, Vos CBJ, et al. Evidence for a gene on 17p13.3, distal to p53, as a target for allele loss in breast tumors without p53 mutation. Cancer Res 1994;54:4200-4206.
32. Scorsone KA, Zhou YZ, Butel JS, et al. P53 mutation cluster at codon 249 in hepatitis B virus positive hepatocellular carcinoma. Cancer Res 1992;52:1635-1638.
33. Hsu IC, Metcalf RA, Sun T, et al. Mutation hotpot in the p53 gene in human hepatocellular carcinomas. Nature 1991;350:428-429.
34. Hsu IC, Peng SY, Shen JC, et al. Allelotype and loss of heterozygosity of p53 in primary and recurrent hepatocellular carcinomas. Cancer 1994;73:42-47.
35. Luisa B, Giovanna F, Noventa F, et al. Concurrent hepatitis B and C virus infection and risk of hepatocellular carcinoma in cirrhosis. Cancer 1994;74:2442-2448.