Molecular mechanisms of platelet exocytosis: Role of SNAP-23 and syntaxin 2 and 4 in lysosome release

Blood

Volumn 96, Issue 5, 2000, Pages 1782-1788

  Chen, Dong ^a   Lemons, Paula P ^a   Schraw, Todd ^a   Whiteheart, Sidney W ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GUANOSINE TRIPHOSPHATE; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 23; SYNTAXIN; SYNTAXIN 2; SYNTAXIN 4; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EXOCYTOSIS; HUMAN; HUMAN CELL; LYSOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEROTONIN RELEASE; THROMBOCYTE RELEASE REACTION;

EID: 0034283702     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.5.1782     Document Type: Article

References (41)

1. Platelet activation
2. The role of protein kinase C in the initial events of platelet activation by thrombin assessed with a selective inhibitor
3. Release of a fluorescent probe as an indicator of lysosomal granule secretion by thrombin-stimulated human platelets
4. The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation: Comparison with thrombin
5. Platelets release their lysosomal content in vivo in humans upon activation
6. Lysosomal concept of platelet secretion - Revisited
7. Secretory lysosomes - A special mechanism of regulated secretion in haemopoietic cells
8. L is for lyric granules: Lysosomes that kill
9. Regulated secretion from hemopoietic cells
10. Role of lysosomal and cytosolic pH in the regulation of macrophage lysosomal enzyme secretion
11. Identification of lysosome-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein
12. Protein sorting and secretion during CTL killing
13. 2+-regulated exocytic vesicles in fibroblasts and epithelial cells
14. A molecular description of synaptic vesicle membrane trafficking
15. The synaptic vesicle cycle: A cascade of protein-protein interactions
16. Mechanisms of intracellular protein transport
17. SNAP receptors implicated in vesicle targeting and fusion
18. SNAREpins: Minimal machinery for membrane fusion
19. Molecular mechanisms of platelet exocytosis: Role of SNAP-23 and syntaxin 2 in dense core granule release
20. Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets
21. Regulated secretion in platelets: Identification of elements of the platelet exocytosis machinery
22. Molecular mechanisms of platelet exocytosis: Requirements for α-granule release
23. A critical role for N-ethylmaleimide-sensitive fusion protein (NSF) in platelet granule secretion
24. Proteins of the exocytotic core complex mediate platelet alpha-granule secretion: Roles of vesicle-associated membrane protein, SNAP-23, and syntaxin 4
25. Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: Effects on GTP/GDP binding and cellular distribution
26. Human platelets contain SNARE proteins and a Sec1 p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: Implications for platelet secretion
27. Organization of the secretory machinery in the rodent brain: Distribution of the t-SNAREs, SNAP-25 and SNAP-23
28. SNAP family of NSF attachment proteins includes a brain-specific isoform
29. Measurement of secretion of lysosomal acid glycosidases
30. Differential effects of G-protein activators on 5-hydroxytryptamine and platelet-derived growth factor release from streptolysin-O-permeabilized human platelets
31. 2+-dependent lysosomal secretion in electropermeabilised human platelets
32. 2+-dependent mechanisms of secretion from streptolysin O-permeabilized platelets: Effects of leakage of cytosolic proteins
33. Zinc-induced platelet aggregation is mediated by the fibrinogen receptor and is not accompanied by release or by thromboxane synthesis
34. The AAA team: Related ATPases with diverse functions
35. Role of two nucleotide-binding regions in an N-ethylmaleimide-sensitive factor involved in vesicle-mediated protein transport
36. N-ethylmaleimide-sensitive fusion protein: A trimeric ATPase whose hydrolysis of ATP is required for membrane fusion
37. GTPgammaS-induced actin polymerisation in vitro: ATP- and phosphoinositide-independent signalling via Rho-family proteins and a plasma membrane-associated guanine nucleotide exchange factor
38. Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets
39. Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers
40. Membrane fusion mediated by coiled coils: A hypothesis