Spinal modulation of the muscle pressor reflex by nitric oxide and acetylcholine

Brain Research Bulletin

Volumn 53, Issue 1, 2000, Pages 51-58

  Wilson, L Britt ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

Cholinergic; Dorsal horn; Excitatory amino acids; Exercise; Muscle afferents; NMDA

Indexed keywords

ACETYLCHOLINE; EXCITATORY AMINO ACID; N METHYL DEXTRO ASPARTIC ACID; N(G) NITROARGININE METHYL ESTER; NEUROTRANSMITTER; NITRIC OXIDE; OPIATE; OXYTOCIN; RECEPTOR; SEROTONIN; VASOPRESSIN;

EXERCISE; MUSCLE; MUSCLE SPINDLE AFFERENT NERVE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; REVIEW; SPINAL CORD DORSAL HORN;

EID: 0034281861     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(00)00308-7     Document Type: Article

References (74)

1. Aceto M.D., Bagley R.S., Dewey W.L., Fu T.C., Martin B.R. The spinal cord as a major site for the antinociceptive action of nicotine in the rat. Neuropharmacology. 25:1986;1031-1036.
2. Adreani C.M., Hill J.M., Kaufman M.P. Intrathecal blockade of both NMDA and non-NMDA receptors attenuates the exercise pressor reflex in cats. J. Appl. Physiol. 80:1996;315-322.
3. Ally A., Meintjes A.F., Mitchell J.H., Wilson L.B. Effects of clonidine on the reflex cardiovascular responses and release of substance P during muscle contraction. Circ. Res. 75:1994;567-575.
4. Barber R.P., Phelps P.E., Houser C.R., Crawford G.D., Salvaterra P.M., Vaughn J.E. The morphology and distribution of neurons containing choline acetyltransferase in the adult rat spinal cord. J. Comp. Neurol. 229:1984;329-346.
5. Barnes J.M., Henley J.M. Molecular characteristics of excitatory amino acid receptors. Prog. Neurobiol. 39:1992;113-133.
6. Bauer M.B., Murphy S., Gebhart G.F. Muscarinic cholinergic stimulation of the nitric oxide-cyclic GMP signaling system in cultured rat sensory neurons. Neuroscience. 62:1994;351-359.
7. Bleazard L., Morris R. The effects of cholinoceptor agonists and antagonists on C-fiber evoked responses in the substantia gelatinosa of neonatal rat spinal cord slices. Br. J. Pharmacol. 110:1993;1061-1066.
8. Blottner D., Grozdanovic Z., Gossrau R. Histochemistry of nitric oxide synthase in the nervous system. Histochem. J. 27:1995;785-811.
9. Bredt D.S., Glatt C.E., Hwang P.M., Fotuhi M., Dawson T.M., Snyder S.H. Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron. 7:1991;615-624.
10. Cajal, S. R. The spinal cord. In: Histology of the nervous system, vol. I. New York: Oxford University Press; 1995:246-284.
11. Coote J.H., Hilton S.M., Perez-Gonzalez J.F. The reflex nature of the pressor response to muscular exercise. J. Physiol. (Lond.). 214:1971;789-804.
12. Fitzgerald M. The course and termination of primary afferent fibers. Wall P.D. Textbook of pain. 1989;63-81 Churchill Livingstone, Inc, New York.
13. Garthwaite J., Charles S.L., Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intracellular messenger in the brain. Nature. 326:1988;385-387.
14. Gillberg P.G., Askmark H. Changes in cholinergic and opioid receptors in the rat spinal cord, dorsal root, and sciatic nerve after ventral and dorsal root lesion. J. Neural Transm. 85:1991;31-39.
15. Gillberg P.G., Wikstein B. Effect of spinal cord lesions and rhizotomies on cholinergic and opiate receptor binding sites in rat spinal cord. Acta Physiol. Scand. 126:1986;575-582.
16. Hand G.A., Kramer G.L., Petty F., Ordway G.A., Wilson L.B. Extracellular excitatory amino acid concentrations in the spinal dorsal horn of cats during static muscle contraction. J. Appl. Physiol. 81:1996;368-372.
17. Hand G.A., Meintjes A.F., Keister A.W., Ally A., Wilson L.B. NMDA receptor blockade in cat dorsal horn blunts the reflex pressor response to muscle contraction and stretch. Am. J. Physiol. 270:1996;H500-H508.
18. Hand G.A., Ordway G.A., Wilson L.B. Microdialysis of CNQX into the L7 dorsal horn attenuates the pressor response to static muscle contraction but not passive stretch in cats. Exp. Physiol. 81:1996;225-238.
19. Hand G.A., Vrettakos P.J., Treuhaft B.S., Shealy W.D., Wilson L.B. Spinal cholinergic inhibition of the pressor response to skeletal muscle activation. Brain Res. 837:1999;143-151.
20. Hill J.M., Kaufman M.P. Attenuation of reflex pressor and ventilatory responses to static muscular contraction by intrathecal opioids. J. Appl. Physiol. 68:1990;2466-2472.
21. Hill J.M., Kaufman M.P. Attenuating effects of intrathecal clonidine on the exercise pressor reflex. J. Appl. Physiol. 70:1991;516-522.
22. Hill J.M., Kaufman M.P. Intrathecal serotonin attenuates the pressor response to static contraction. Brain Res. 550:1991;157-160.
23. Hill J.M., Pickar J.G., Kaufman M.P. Attenuation of reflex pressor and ventilatory responses to static contraction by an NK-1 receptor antagonist. J. Appl. Physiol. 73:1992;1389-1395.
24. Hill J.M., Pickar J.G., Kaufman M.P. Blockade of non-NMDA receptors attenuates reflex pressor response to static contraction. Am. J. Physiol. 266:1994;H1769-H1776.
25. Kaufman M.P., Forster H.V. Reflexes controlling circulatory, ventilatory and airway responses to exercise. Rowell L.B., Shepherd J.T. Handbook of physiology, section 12 Exercise: Regulation and integration of multiple systems . 1996;381-447 Oxford University Press, New York.
26. Kaufman M.P., Kozlowski G.P., Rybicki K.J. Attenuation of the reflex pressor response to muscular contraction by a substance P antagonist. Brain Res. 333:1985;182-184.
27. Kaufman M.P., Longhurst J.C., Rybicki K.J., Wallach J.H., Mitchell J.H. Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats. J. Appl. Physiol. 55:1983;105-112.
28. Kaufman M.P., Rybicki K.J., Kozlowski G.P., Iwamoto G.A. Immunoneutralization of substance P attenuates the reflex pressor response to muscular contraction. Brain Res. 377:1986;199-203.
29. Kaufman M.P., Waldrop T.G., Rybicki K.J., Ordway G.A., Mitchell J.H. Effects of static and rhythmic twitch contractions on the discharge of group III and IV muscle afferents. Cardiovasc. Res. 18:1984;663-668.
30. Kniffki K.D., Mense S., Schmidt R.F. Muscle receptors with fine afferent fibers which may evoke circulatory reflexes. Circ. Res. 48:1981;125-131.
31. Li P., Tong C., Eisenach J.C., Figueroa J.P. NMDA causes release of nitric oxide from rat spinal cord in vitro. Brain Res. 637:1994;287-291.
32. Lin Q., Palecek J., Paleckova V., Peng Y.B., Wu J., Cui M., Willis W.D. Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons. J. Neurophysiol. 81:1999;1075-1085.
33. Malmberg A.B., Yaksh T.L. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain. 54:1993;291-300.
34. Matsukawa K., Wall P.T., Wilson L.B., Mitchell J.H. Reflex responses in renal nerve activity during isometric contraction in cats. Am. J. Physiol. 259:1990;H1380-H1388.
35. Matsukawa K., Wall P.T., Wilson L.B., Mitchell J.H. Neurally mediated vasoconstriction during isometric muscle contraction in cats. Am. J. Physiol. 262:1992;H833-H838.
36. Matsukawa K., Wall P.T., Wilson L.B., Mitchell J.H. Reflex stimulation of cardiac sympathetic nerve activity during isometric muscle contraction in cats. Am. J. Physiol. 267:1994;H821-H827.
37. McCloskey D.I., Mitchell J.H. Reflex cardiovascular and respiratory responses originating in exercising muscle. J. Physiol. (Lond.). 224:1972;173-186.
38. McMahon S.B., Lewin G.R., Wall P.D. Central hyperexcitability triggered by noxious inputs. Curr. Opin. Neurobiol. 3:1993;602-610.
39. Meintjes A.F., Nobrega A.C.L., Ally A., Wilson L.B. Attenuation of the exercise pressor reflex Effect of an opioid agonist on substance P release in the L7 dorsal horn of cats . Circ. Res. 77:1995;326-334.
40. Meller S.T., Gebhart G.F. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain. 52:1993;127-136.
41. Meller S.T., Pechman P.S., Gebhart G.F., Maves T.J. Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat. Neuroscience. 50:1992;7-10.
42. Mense S., Stahnke M. Responses in muscle afferent fibres of slow conduction velocity to contractions and ischaemia in the cat. J. Physiol. (Lond.). 342:1983;383-397.
43. Mitchell J.H. Neural control of the circulation during exercise. Med. Sci. Sports Exerc. 22:1990;141-154.
44. Mitchell J.H., Kaufman M.P., Iwamoto G.A. The exercise pressor reflex Its cardiovascular effects, afferent mechanisms, and central pathways . Ann. Rev. Physiol. 45:1983;229-242.
45. Mitchell J.H., Schmidt R.F. Cardiovascular reflex control by afferent fibers from skeletal muscle receptors. Shepherd J.T., Abboud F.M. Handbook of physiology, the cardiovascular system III. 1983;623-658 American Physiological Society, Bethesda, MD.
46. 1A receptors. Am. J. Physiol. 268:1995;H1577-H1585.
47. Rethelyi M., Trevino D.L., Perl E.R. Distribution of primary afferent fibers within the sacrococcygeal dorsal horn An autoradiographic study . J. Comp. Neurol. 185:1979;603-622.
48. 3)Labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine. Proc. Natl. Acad. Sci. 84:1987;7744-7748.
49. Ribiero-Da-Silva A., Cuello A.C. Choline acetyltransferase-immunoreactive profiles are presynaptic to primary sensory fibers in the rat superficial dorsal horn. J. Comp. Neurol. 295:1990;370-384.
50. Snyder S.H. Nitric oxide and neurons. Curr. Opin. Neurobiol. 2:1992;323-327.
51. Stanfa L.C., Misra C., Dickenson A.H. Amplification of spinal nociceptive transmission depends on the generation of nitric oxide in normal and carrageenan rats. Brain Res. 737:1996;92-98.
52. Stebbins C.L., Brown B., Levin D., Longhurst J.C. Reflex effect of skeletal muscle mechanoreceptor stimulation on the cardiovascular system. J. Appl. Physiol. 65:1988;1539-1547.
53. Stebbins C.L., Ortiz-Acevedo A. The exercise pressor reflex is attenuated by intrathecal oxytocin. Am. J. Physiol. 267:1994;R909-R915.
54. Stebbins C.L., Ortiz-Acevedo A., Hill J.M. Spinal vasopressin modulates the reflex cardiovascular response to static contraction. J. Appl. Physiol. 72:1992;731-738.
55. Valtschanoff J.G., Weinberg R.J., Rustioni A., Schmidt H.H.H.W. Nitric oxide synthase and GABA colocalize in lamina II of rat spinal cord. Neurosci. Lett. 148:1992;6-10.
56. Waldrop T.G., Eldridge F.L., Iwamoto G.A., Mitchell J.H. Central neural control of respiration and circulation during exercise. Rowell L.B., Shepherd J.T. Exercise Regulation and integration of multiple systems . 1996;333-380 Oxford University Press, New York.
57. Wall P.D., Weman R. The physiology and anatomy of long ranging afferent fibres within the spinal cord. J. Physiol. (Lond.). 255:1976;321-334.
58. Wilson L.B. Elimination of the pressor reflex by dorsal horn administration of muscimol. FASEB J. 13:1999;A448.
59. Wilson L.B., Crews A.D. Segmental effect of NMDA block in the dorsal horn on the pressor reflex. Brain Res. 807:1998;222-227.
60. Wilson L.B., Engretson J. Effect of NO in the dorsal horn on the pressor reflex evoked by muscle mechanoreceptor activation. Soc. Neurosci. Abstr. 24:1998;622.
61. Wilson L.B., Engretson J., Crews A.D. The pressor reflex evoked by static muscular contraction Role of nitric oxide in the dorsal horn . Am. J. Physiol. 276:1999;R1639-R1646.
62. Wilson L.B., Fuchs I.E., Matsukawa K., Mitchell J.H., Wall P.T. Substance P release in the spinal cord during the exercise pressor reflex in anesthetized cats. J. Physiol. (Lond.). 460:1993;79-90.
63. Wilson L.B., Fuchs I.E., Mitchell J.H. Effects of graded muscle contractions on spinal cord substance P release, arterial blood pressure, and heart rate. Circ. Res. 73:1993;1024-1031.
64. Wilson L.B., Hand G.A. The pressor reflex evoked by static contraction Neurochemistry at the site of the first synapse . Brain Res. Rev. 23:1997;196-209.
65. Wilson L.B., Hand G.A. Segmental effect of spinal NK-1 receptor blockade on the pressor reflex. Am. J. Physiol. 275:1998;H789-H796.
66. Wilson L.B., Wall P.T., Matsukawa K. Attenuation of the reflex responses to muscle contraction by the co-administration of antagonists to substance P and somatostatin into the dorsal horn. Cardiovasc. Res. 29:1995;379-384.
67. Wilson L.B., Wall P.T., Matsukawa K., Mitchell J.H. Multiplicity of the afferent pathways mediating the exercise pressor reflex. Brain Res. 539:1991;316-319.
68. Wilson L.B., Wall P.T., Matsukawa K., Mitchell J.H. Effect of spinal microinjections of an antagonist to substance P or somatostatin on the exercise pressor reflex. Circ. Res. 70:1992;213-222.
69. Wilson L.B., Wall P.T., Pawelczyk J.A., Matsukawa K. Cardiorespiratory and phrenic nerve responses to graded muscle stretch in anesthetized cats. Respir. Physiol. 98:1994;251-266.
70. Wu J., Lin Q., McAdoo D.J., Willis W.D. Nitric oxide contributes to the central sensitization following intradermal injection of capsaicin. Neuroreport. 9:1998;589-592.
71. Zhuo M., Gebhart G.F. Spinal cholinergic and monoaminergic receptors mediate descending inhibition from the nuclei gigantocellularis and gigantocellularis pars alpha in the rat. Brain Res. 535:1990;67-78.
72. Zhuo M., Gebhart G.F. Inhibition of a cutaneous nociceptive reflex by a noxious visceral stimulus is mediated by spinal cholinergic and descending serotonergic systems in the rat. Brain Res. 585:1992;7-18.
73. Zhuo M., Meller S.T., Gebhart G.F. Endogenous nitric oxide is required for tonic cholinergic inhibition of spinal mechanical transmission. Pain. 54:1993;71-78.
74. Zorumski C.F., Thio L.L. Properties of vertebrate glutamate receptors Calcium mobilization and desensitization . Prog. Neurobiol. 39:1992;295-336.