Microdialysis of a non-NMDA receptor antagonist into the L7 dorsal horn attenuates the pressor response to static muscle contraction but not passive stretch in cats

Experimental Physiology

Volumn 81, Issue 2, 1996, Pages 225-238

  Hand, Gregory A ^a   Ordway, George A ^a   Wilson, L Britt ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE;

ANIMAL EXPERIMENT; ARTICLE; CAT; CONTROLLED STUDY; HEART RATE; HINDLIMB; LUMBAR SPINAL CORD; MEAN ARTERIAL PRESSURE; MICRODIALYSIS; MUSCLE ISOMETRIC CONTRACTION; MUSCLE STRETCHING; MUSCLE TONE; NONHUMAN; PRESSOR RESPONSE; SENSORY NERVE; SPINAL CORD DORSAL HORN; TRICEPS SURAE MUSCLE;

EID: 0029984311     PISSN: 09580670     EISSN: None     Source Type: Journal    
DOI: 10.1113/expphysiol.1996.sp003927     Document Type: Article

References (32)

1. BROWN, P. B. & CULBERSON, J. L. (1981). Somatotopic organization of the hindlimb cutaneous dorsal root projections to cat dorsal horn. Journal of Neurophysiology 45, 137-145.
2. COOTE, J. H., HILTON, S. M. & PEREZ-GONZALEZ, J. F. (1971). The reflex nature of the pressor response to muscular exercise. Journal of Physiology 214, 789-804.
3. DAVIES, J., FRANCES, A. A., JONES, A. W. & WATKINS, J. C. (1981). 2-Amino-5-phosphonovalerate (2 APV), a potent and selective antagonist of amino acid-induced and synaptic excitation. Neuroscience Letters 21, 77-81.
4. DEVOR, M. & WALL, P. D. (1976). Dorsal horn cells with proximal receptive fields. Brain Research 118, 325-328.
5. DOUGHERTY, P. M., PALACEK, J., PALECKOVA, V., SORKIN, L. S. & WILLIS, W. D. (1992). The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli. Journal of Neuroscience 12, 3025-3041.
6. DOUGHERTY, P. M. & WILLIS, W. D. (1991). Modification of the response of primate spinothalamic neurons to mechanical stimulation by EAAs and an N-methyl-D-aspartate antagonist. Brain Research 542, 15-22.
7. GERBER, G. & RANDIĆ, M. (1989a). Excitatory amino acid-mediated components of synaptically evoked input from dorsal roots to deep dorsal horn neurons in the rat spinal cord slice. Neuroscience Letters 106, 211-219.
8. GERBER, G. & RANDIĆ, M. (1989b). Participation of excitatiory amino acid receptors in the slow excitatory synaptic transmission in the rat spinal dorsal horn in vitro. Neuroscience Letters 106, 220-228.
9. 3]glutamate-binding sues in rat central nervous system. Journal of Neuroscience 4, 2133-2144.
10. HAND, G. A., MEINTJES, A. F., KEISTER, A. W., ALLY, A. & WILSON, L. B. (1996). NMDA receptor blockade in cat dorsal horn blunts the reflex pressor response to muscle contraction and stretch. American Journal of Physiology 270, H500-505.
11. HERRLING, P. L. (1985). Pharmacology of the corticocaudate excitatory post-synaptic potential in the cat: evidence for its mediation by quis- or kainate-receptors. Neuroscience 14, 417-426.
12. HILL, J. M., PICKAR, J. G. & KAUFMAN, M. P. (1994). Blockade of non-NMDA receptors attenuates reflex pressor response to static contraction. American Journal of Physiology 266, H1769-1776.
13. HOKFELT, T., MILLHORN, D. E., SEROOGY, K., TSURUO, Y., CECCATELLI, S., LINDH, B., MEISTER, B., MELANDER, T., SCHALLING, M. & TERENIUS, L. (1987). Coexistence of peptides with classical neurotransmitters. Experientia 43, 768-779.
14. IMAI, Y. & KUSAMA, T. (1969). Distribution of the dorsal root fibres in the cat. An experimental study with the Nauta method. Brain Research 13, 338-359.
15. KALIA, M., MEI, S. S. & KAO, F. F. (1981). Central projections from ergoreceptors (C fibers) in muscle involved in cardiopulmonary responses to static exercise. Circulation Research 48, 148-162.
16. KANGRGA, I. & RANDIĆ, M. (1991). Outflow of endogenous aspartate and glutamate from the rat spinal dorsal horn in vitro by activation of low- and high-threshold primary afferent fibres. Modulation by μ-opioids. Brain Research 553, 347-352.
17. KAUFMAN, M. P. & RYBICKI, K. J. (1987). Discharge properties of group III and IV muscle afferents: their responses to mechanical and metabolic stimuli. Circulation Research 61, 160-165.
18. MCCLOSKEY, D. I. & MITCHELL, J. H. (1972). Reflex cardiovascular and respiratory responses originating in exercising muscle. Journal of Physiology 224, 173-186.
19. MCNEIL, D. L., WESTLUND, K. N. & COGGESHALL, R. E. (1989). Peptide immunoreactivity of unmyelinated primary afferent axons in rat lumbar dorsal roots. Journal of Histochemistry and Cytochemistry 37, 1047-1052.
20. MATSUKAWA, K., WALL, P. T., WILSON, L. B. & MITCHELL, J. H. (1990). Reflex responses of renal nerve activity during isometric muscle contraction in cats. American Journal of Physiology 259, H1380-1388.
21. MAYER, M. L. & WESTBROOK, G. L. (1985). The action of W-methyl-D-aspartic acid on mouse spinal neurones in culture. Journal of Physiology 361, 65-90.
22. SCHNEIDER, S. P. & PERL, E. R. (1988). Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn. Journal of Neuroscience 8, 2062-2073.
23. SMULLIN, D. H., SKILLING, S. R. & LARSON, A. A. (1990). Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord. Pain 42, 93-101.
24. SPAGUE, J. M. & HA, H. (1964). The terminal fields of dorsal root fibres in the lumbosacral spinal cord of the cat and the dendritic organization of the motor nuclei. In Organization of the Spinal Cord, ed. ECCLES, J. C. & SCHADE, J. P., p. 133. Elsevier Publishing Co., Amsterdam, New York.
25. STEBBINS, C. L., BROWN, B., LEVIN, D. & LONGHURST, J. C. (1988). Reflex effect of skeletal muscle mechano-receptor stimulation on the cardiovascular system. Journal of Applied Physiology 65, 1539-1547.
26. WALL, P. D. & SHORTLAND, P. (1991). Long range afferents in the cat spinal cord. 1. Numbers, distances, and conduction velocities. Philosophical Transactions of the Royal Society B 334, 85-93.
27. WALL, P. D. & WERMAN, R. (1976). The physiology and anatomy of long ranging afferent fibres within the spinal cord. Journal of Physiology 255, 321-334.
28. WILSON, L. B., FUCHS, I. E., MATSUKAWA, K., MITCHELL, J. H. & WALL, P. T. (1993a). Substance P release in the spinal cord during the exercise pressor reflex in anaesthetized cats. Journal of Physiology 460, 79-90.
29. WILSON, L. B., FUCHS, I. E. & MITCHELL, J. H. (1993b). Influence of muscle tension on the contraction-induced release of substance P in the spinal cord of anesthetized cats. Circulation Research 73, 1024-1031.
30. WILSON, L. B., WALL, P. T., MATSUKAWA, K. & MITCHELL, J. H. (1992). Effect of microinjections of an antagonist to substance P or somatostatin on the exercise pressor reflex. Circulation Research 70, 213-222.
31. YOSHIMURA, M. & JESSELL, T. (1990). Amino acid-mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cord. Journal of Physiology 430, 315-333.
32. ZAR, J. H. (1984). Biostatistical Analysis, pp. 190-191. Prentice Hall, Inc., Englewood Cliffs, NJ, USA.