Amplification of spinal nociceptive transmission depends on the generation of nitric oxide in normal and carrageenan rats

Brain Research

Volumn 737, Issue 1-2, 1996, Pages 92-98

  Stanfa, Louise C ^a   Misra, Charu ^a   Dickenson, Anthony H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

7 Nitro indazole; Inflammation; Intrathecal; Nitric oxide; Nociception; Spinal cord; Wind up

Indexed keywords

7 NITROINDAZOLE; ARGININE; CARRAGEENAN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; INFLAMMATION; INTRATHECAL DRUG ADMINISTRATION; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN;

EID: 0030597067     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00629-4     Document Type: Article

References (40)

1. [1] Bernardi, P.S., Valtschanoff, J.G., Weinberg, R.J., Schmidt, H.H.H.W. and Rustioni, A., Synaptic interactions between primary afferent terminals and GABA and nitric oxide-synthesizing neurons in the superficial laminae of the rat spinal cord, J. Neurosci., 15 (1995) 1363-1371.
2. [2] Bliss, T.V.P. and Collingridge, G.L., A synaptic model of memory: long-term potentiation in the hippocampus. Nature, 361 (1993) 31-39.
3. [3] Coderre, T.J. and Melzack, R., The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury, J. Neurosci., 12 (1992) 3665-3670.
4. [4] Davies, S.N. and Lodge, D., Evidence for involvement of N-methyl-D-aspartate receptors in wind-up of class 2 neurones in the dorsal horn of the rat, Brain Res., 424 (1987) 402-406.
5. [5] Dickenson, A.H., NMDA receptor antagonists as analgesics. In H.L. Fields and J.C. Liebeskind (Eds.), Progress in Pain Research and Management, Vol. 1, IASP Press, Seattle, 1994, pp. 173-187.
6. [6] Dickenson, A.H. and Aydar, E., Antagonism at the glycine site on the NMDA receptor reduces spinal nociception in the rat, Neurosci. Lett., 121 (1991) 263-266.
7. [7] Dickenson, A.H. and Sullivan, A.F., Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn, Pain, 24 (1986) 211-222.
8. [8] Dickenson, A.H. and Sullivan, A.F., Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation, Neuropharmacology, 26 (1987) 1235-1238.
9. [9] Dickenson, A.H. and Sullivan, A.F., Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat, Brain Res., 506 (1990) 31-39.
10. [10] Garry, M.G., Richardson, J.D. and Hargreaves, K.M., Sodium nitroprusside evoked the release of immunoreactive calcitonin gene-related peptide and substance P from dorsal horn slices via nitric oxide-dependent and nitric oxide-independent mechanisms, J. Neurosci., 14 (1994) 4329-4337.
11. [11] Haley, J.E., Dickenson, A.H. and Schachter, M., Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat, Neuropharmacology, 31 (1992) 251-258.
12. [12] Haley, J.E., Sullivan, A.F. and Dickenson, A.H., Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat, Brain Res., 518 (1990) 218-226.
13. [13] Kawabata, A., Fukuzumi, Y., Fukushima, Y. and Takagi, H., Antinociceptive effect of L-arginine on the carrageenin-induced hyperalgesia of the rat: possible involvement of central opioidergic systems, Eur. J. Pharmacol., 218 (1992) 153-158.
14. [14] Kitto, K.F., Haley, J.E. and Wilcox, G.L., Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse, Neurosci. Lett., 148 (1992) 1-5.
15. [15] Li, P., Tong, C., Eisenach, J.C. and Figueroa, J.P., NMDA causes release of nitric oxide from rat spinal cord in vitro, Brain Res., 637 (1994) 287-291.
16. [16] Malmberg, A.B. and Yaksh, T.L., Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats, Pain, 54 (1993) 291-300.
17. [17] Meller, S.T., Cummings, C.P., Traub, R.J. and Gebhart, G.F., The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat, Neuroscience, 60 (1994) 367-374.
18. [18] Meller, S.T., Dykstra, C. and Gebhart, G.F., Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for NMDA-produced facilitation of the nociceptive tail-flick reflex, Eur. J. Pharmacol., 214 (1992) 93-96.
19. [19] Meller, S.T. and Gebhart, G.F., Nitric oxide (NO) and nociceptive processing in the spinal cord, Pain, 52 (1993) 127-136.
20. [20] Millan, M.J. and Seguine, L., (+)-HA 966, a partial agonist at the glycine site coupled to NMDA receptors, blocks formalin-induced pain in mice, Eur. J. Pharmacol., 238 (1993) 445-447.
21. [21] Moore, P.K., Babbedge, R.C., Wallace, P., Gaffen, Z.A. and Hart, S.L., 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure, Br. J. Pharmacol., 108 (1993) 296-297.
22. G-nitro arginine methyl ester exhibits antinociceptive activity in the mouse, Br. J. Pharmacol., 102 (1991) 198-202.
23. [23] Moore, P.K., Wallace, P., Gaffen, Z., Hart, S.L. and Babbedge, R.C., Characterization of the novel nitric oxide synthase inhibitor 7-nitro-indazole and related indazoles: antinociceptive and cardiovascular effects, Br. J. Pharmacol., 110 (1993) 219-224.
24. [24] Radhakrishnan, V. and Henry, J.L., L-NAME blocks responses to NMDA, substance P and noxious cutaneous stimuli in cat dorsal horn, NeuroReport, 4 (1993) 323-326.
25. [25] Ren, K. and Dubner, R., NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflamation of the hindpaw, Neurosci. Lett., 163 (1993) 22-26.
26. [26] Ren, K., Hylden, J.L.K., Williams, G.M., Ruda, M.A. and Dubner, R., The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioural hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation, Pain, 50 (1992) 331-344.
27. [27] Ren, K., Williams, G.M., Hylden, J.L.K., Ruda, M.A. and Dubner, R., The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioural hyperalgesia in rats, Eur. J. Pharmacol., 219 (1992) 235-243.
28. [28] Semos, M.L. and Headley, P.M., The role of nitric oxide in spinal nociceptive reflexes in rats with neurogenic and non-neurogenic peripheral inflammation, Neuropharmacology, 33 (1994) 1487-1497.
29. [29] Sorkin, L.S., NMDA evokes an L-NAME sensitive spinal release of glutamate and citrulline, NeuroReport, 4 (1993) 479-482.
30. [30] Spike, R.C., Todd, A.J. and Johnston, H.M., Coexistence of NADPH diaphorase with GABA, glycine, and acetylcholine in rat spinal cord, J. Comp. Neurol., 335 (1993) 320-333.
31. [31] Stanfa, L.C., Sullivan, A.F. and Dickenson, A.H., Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan inflammation, Pain, 50 (1992) 345-354.
32. [32] Thompson, S.W.N., Babbedge, R., Levers, T., Dray, A. and Urban, L., No evidence for contribution of nitric oxide to spinal reflex activity in the rat spinal cord in vitro, Neurosci. Lett., 188 (1995) 121-124.
33. [33] Traub, R.J., Solodkin, A., Meller, S.T. and Gebhart, G.F., Spinal cord NADPH-diaphorase histochemical staining but not nitric oxide synthase immunoreactivity increases following carrageenan-produced hindpaw inflammation in the rat, Brain Res., 668 (1994) 204-210.
34. [34] Valtschanoff, J.G., Weinberg, R.J., Kharazia, V.N., Nakane, M. and Schmidt, H.H.H., Neurons in rat hippocampus that synthesize nitric oxide, J. Comp. Neurol., 331 (1993) 111-121.
35. [35] Valtschanoff, J.G., Weinberg, R.J., Rustioni, A. and Schmidt, H.H., Nitric oxide synthase and GABA colocalize in lamina II of rat spinal cord, Neurosci. Lett., 148 (1992) 6-10.
36. [36] Yaksh, T.L., Behavioural and anatomical correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists, Pain, 37 (1989) 111-123.
37. [37] Yamamoto, T., Shimoyama, N. and Mizuguchi, T., Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw, Anesth. Analg., 77 (1993) 886-890.
38. [38] Yamamoto, T., Shimoyama, N. and Mizuguchi, T., The effects of morphine, MK-801, an NMDA antagonist, and CP-96,345, an NK1 antagonist, on the hyperesthesia evoked by carrageenan injection in the rat paw, Anesthesiology, 78 (1993) 124-133.
39. [39] Yamamoto, T. and Yaksh, T.L., Comparison of the antinociceptive effects of pre- and post-treatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat, Anesthesiology, 77 (1992) 757-763.
40. [40] Yamamoto, T. and Yaksh, T.L., Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists, Pain, 49 (1992) 121-128.