Activation-induced cell death in B lymphocytes

Cell Research

Volumn 10, Issue 3, 2000, Pages 179-192

  Donjerković, Dubravka ^a   Scott, David W ^a  

^a HOLLAND LABORATORY   (United States)

Author keywords

Activation induced cell death; B cell receptor; B lymphocytes

Indexed keywords

CASPASE; INTERLEUKIN 4 RECEPTOR; ISOENZYME; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA;

ANIMAL; APOPTOSIS; B LYMPHOCYTE; CELL CYCLE G1 PHASE; HUMAN; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CASPASES; G1 PHASE; HUMANS; ISOENZYMES; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; RECEPTORS, INTERLEUKIN-4; SIGNAL TRANSDUCTION;

EID: 0034280923     PISSN: 10010602     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cr.7290047     Document Type: Review

References (77)

1. Monroe JG. Tolerance sensitivity of immature-stage B cells: can developmentally regulated B cell antigen receptor (BCR) signal transduction play a role? J Immunol 1996; 156:2657-60.
2. Pennell CA, Scott DW. Lymphoma models for B cell activation and tolerance. IV. Growth inhibition by anti-Ig of CH31 and CH33 B lymphoma cells. Eur J Immunol 1986; 16:1577-81.
3. Scott DW, Livnat D, Pennell CA et al. Lymphoma models for B cell activation and tolerance. III. Cell cycle dependence for negative signalling of WEHI-231 B lymphoma cells by anti-mu. J Exp Med 1986; 164:156-64.
4. Benhamou LE, Cazenave PA, Sarthou P. Anti-immunoglobulins induce death by apoptosis in WEHI-231 B lymphoma cells. Eur J Immunol 1990; 20:1405-7.
5. Hasbold J, Klaus GG. Anti-immunoglobulin antibodies induce apoptosis in immature B cell lymphomas. Eur J Immunol 1990; 20:1685-90.
6. Muthuswamy SK, Muller WJ. Activation of the Src family of tyrosine kinases in mammary tumorigenesis. Adv Cancer Res 1994; 64:111-23.
7. Vihinen M, Smith CI. Structural aspects of signal transduction in B-cells. Crit Rev Immunol 1996; 16:251-75.
8. Yao XR, Scott DW. Antisense oligodeoxynucleotides to the Blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma. Proc Natl Acad Sci USA 1993; 90:7946-50.
9. Blk kinase in signaling growth arrest and apoptosis. Immunol Rev 1993; 132:163-86.
10. Reth M. The B-cell antigen receptor complex and co-receptors. Immunol Today 1995; 16:310-3.
11. Yao XR, Flaswinkel H, Reth M et al. Immunoreceptor tyrosine-based activation motif is required to signal pathways of receptor-mediated growth arrest and apoptosis in murine B lymphoma cells. J Immunol 1995; 155:652-61.
12. Yao XR, Scott DW. Independent signaling for growth arrest and apoptosis by Ig alpha and Ig beta subunits of the B-cell antigen eptor complex. Ann N Y Acad Sci 1995; 766:96-8
13. Berridge MJ. Lymphocyte activation in health and disease. Crit Rev Immunol 1997; 17:155-78.
14. Yamada H, June CH, Finkelman F et al. Persistent calcium elevation correlates with the induction of surface immunoglobulin-mediated B cell DNA synthesis. J Exp Med 1993; 177:1613-21.
15. Rothstein TL, Baeker TR, Miller RA et al. Stimulation of murine B cells by the combination of calcium ionophore plus phorbol ester. Cell Immunol 1986; 102:364-73.
16. Scott DW, Livnat D, Whitin J et al. Lymphoma models for B cell activation and tolerance. V. Anti-Ig mediated growth inhibition is reversed by phorbol myristate acetate but does not involve changes in cytosolic free calcium. J Mol Cell Immunol 1987; 3:109-20.
17. Gold MR, DeFranco AL. Phorbol esters and dioctanoylglycerol block anti-IgM-stimulated phosphoinositide hydrolysis in the murine B cell lymphoma WEHI-231. J Immunol 1987; 138:868-76.
18. Muthukkumar S, Udhayakumar V, Bondada S. Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma. Eur J Immunol 1993; 23:2419-26.
19. Genestier L, Dearden-Badet MT, Bonnefoy-Berard N et al. Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line. Cell Immunol 1994; 155:283-91.
20. Bonnefoy-Berard N, Genestier L, Flacher M et al. The phosphoprotein phosphatase calcineurin controls calcium-dependent apoptosis in B cell lines. Eur J Immunol 1994; 24:325-9.
21. Graves JD, Draves KE, Craxton A et al. Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. Proc Natl Acad Sci USA 1996; 93:13814-8.
22. Sigal NH, Dumont FJ. Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu Rev Immunol 1992; 10:519-60.
23. Higashigawa M, Komada Y, Shimono Y et al. FK506 inhibits anti-IgM antibody-induced apoptosis and 17 kD endonuclease activity in the human B-cell line, MBC-1, established from Burkitt's lymphoma. Br J Haematol 1997; 99:908-13.
24. Gottschalk AR, Boise LH, Thompson CB et al. Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc Natl Acad Sci USA 1994; 91:7350-4.
25. Muthukkumar S, Ramesh TM, Bondada S. Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells. Transplantation 1995; 60:264-70.
26. Donjerkovic D, Zhang L, Scott DW. Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium In Process Citation]. Cell Growth Differ 1999; 10:695-704.
27. Sarthou P, Henry-Toulme N, Cazenave PA. Membrane IgM cross-linking is not coupled to protein kinase C translocation in WEHI-231 B lymphoma cells. Eur J Immunol 1989; 19:1247-52.
28. Warner GL, Scott DW. Lymphoma models for B-cell activation and tolerance. VII. Pathways in anti-Ig-mediated growth inhibition and its reversal. Cell Immunol 1988; 115:195-203.
29. Kuwahara K, Kawai T, Mitsuyoshi S et al. Cross-linking of B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphatidylinositol 3-kinase. Int Immunol 1996; 8:1273-85.
30. Maheswaran S, McCormack JE, Sonenshein GE. Changes in phosphorylation of myc oncogene and RB antioncogene protein products during growth arrest of the murine lymphoma WEHI 231 cell line. Oncogene 1991; 6:1965-71.
31. Fruman DA, Meyers RE, Cantley LC. Phosphoinositide kinases. Annu Rev Biochem 1998; 67:481-507.
32. Campbell KS. Signal transduction from the B cell antigen-receptor. Curr Opin Immunol 1999; 11:256-64.
33. Pawson T. SH2 and SH3 domains in signal transduction. Adv Cancer Res 1994; 64:87-110.
34. Brennan P, Babbage JW, Burgering BM et al. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 1997; 7:679-89.
35. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 1994; 372:570-3.
36. Scott DW, Lamers M, Kohler G et al. Role of c-myc and CD45 in spontaneous and anti-receptor-induced apoptosis in adult murine B cells. Int Immunol 1996; 8:1375-85.
37. Parry SL, Hasbold J, Holman M et al. Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40. J Immunol 1994; 152:2821-9.
38. McCormack JE, Pepe VH, Kent RB et al. Specific regulation of c-myc oncogene expression in a murine B-cell lymphoma. Proc Natl Acad Sci USA 1984; 81:5546-50.
39. Tisch R, Roifman CM, Hozumi N. Functional differences between immunoglobulins M and D expressed on the surface of an immature B-cell line. Proc Natl Acad Sci USA 1988; 85:6914-8.
40. Fischer G, Kent SC, Joseph L et al. Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc. J Exp Med 1994; 179:221-8.
41. Kaptein JS, Lin CKE, Wang CL et al. Anti-IgM-mediated regulation of c-myc and its possible relationship to apoptosis. J Biol Chem 1996; 271:18875-84.
42. Wu M, Yang W, Bellas RE et al. c-myc promotes survival of WEHI 231 B lymphoma cells from apoptosis. Curr Top Microbiol Immunol 1997; 224:91-101.
43. Sonenshein GE. Down-modulation of c-myc expression induces apoptosis of B lymphocyte models of tolerance via clonal deletion. J Immunol 1997; 158:1994-7.
44. Scott DW, Donjerkovic D, Maddox B et al. Role of c-myc and p27 in anti-IgM induced B-lymphoma apoptosis. Curr Top Microbiol Immunol 1997; 224:103-12.
45. Wu M, Arsura M, Bellas RE et al. Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells. Mol Cell Biol 1996; 16:5015-25.
46. Potter M, Marcu KB. The c-myc story: where we've been, where we seem to be going. Curr Top Microbiol Immunol 1997; 224:1-17.
47. Lee H, Arsura M, Wu M et al. Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line. J Exp Med 1995; 181:1169-77.
48. Wu M, Lee H, Bellas RE et al. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells. Embo J 1996; 15:4682-90.
49. Baeuerle PA. IkappaB-NF-kappaB structures: at the interface of inflammation control [comment]. Cell 1998; 95:729-31.
50. Hagiyama H, Adachi T, Yoshida T et al. Signaling through the antigen receptor of B lymphocytes activates a p53-independent pathway of c-Myc-induced apoptosis. Oncogene 1999; 18:4091-8.
51. Scott DW, O'Garra A, Warren D et al. Lymphoma models for B cell activation and tolerance. VI. Reversal of anti-Ig-mediated negative signaling by T cell-derived lymphokines. J Immunol 1987; 139:3924-9.
52. Ales-Martinez JE, Silver L, LoCascio N et al. Lymphoma models for B-cell activation and tolerance. IX. Efficient reversal of anti-Ig-mediated growth inhibition by an activated TH2 clone. Cell Immunol 1991; 135:402-9.
53. Ales-Martinez JE, Cuende E, Gaur A et al. Prevention of B cell clonal deletion and anergy by activated T cells and their lymphokines. Semin Immunol 1992; 4:195-202.
54. Wang H, Grand RJ, Milner AE et al. Repression of apoptosis in human B-lymphoma cells by CD40-ligand and Bcl-2: relationship to the cell-cycle and role of the retinoblastoma protein. Oncogene 1996; 13:373-9.
55. Tsubata T, Wu J, Honjo T. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40. Nature 1993; 364:645-8.
56. Hornung M, Lindemann D, Kraus C et al. The CD40 TRAF family member interacting motif carries the information to rescue WEHI 231 cells from anti-IGM-induced growth arrest [published erratum appears in Eur J Immunol 1999 May; 29(5):1751]. Eur J Immunol 1998; 28:3812-23.
57. Schauer SL, Wang Z, Sonenshein GE et al. Maintenance of nuclear factor-kappa B/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of I kappa B proteins. J Immunol 1996; 157:81-6.
58. Schauer SL, Bellas RE, Sonenshein GE. Dominant signals leading to inhibitor kappaB protein degradation mediate CD40 ligand rescue of WEHI 231 immature B cells from receptor-mediated apoptosis. J Immunol 1998; 160:4398-405.
59. Wang Z, Karras JG, Howard RG et al. Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells. J Immunol 1995; 155:3722-5.
60. Ishida T, Kobayashi N, Tojo T et al. CD40 signaling-mediated induction of Bcl-XL, Cdk4, and Cdk6. Implication of their cooperation in selective B cell growth. J Immunol 1995; 155:5527-35.
61. Choi MS, Boise LH, Gottschalk AR et al. The role of bcl-XL in CD40-mediated rescue from anti-mu-induced apoptosis in WEHI-231 B lymphoma cells. Eur J Immunol 1995; 25:1352-7.
62. Merino R, Grillot DA, Simonian PL et al. Modulation of anti-IgM-induced B cell apoptosis by Bcl-xL and CD40 in WEHI-231 cells. Dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction. J Immunol 1995; 155:3830-8.
63. Fang W, Rivard JJ, Ganser JA et al. Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli. J Immunol 1995; 155:66-75.
64. Reid S, Snow EC. The regulated expression of cell cycle-related proteins as B-lymphocytes enter and progress through the G1 cell cycle stage following delivery of complete versus partial activation stimuli. Mol Immunol 1996; 33:1139-51.
65. Mullins MW, Pittner BT, Snow EC. CD40-mediated induction of p21 accumulation in resting and cycling B cells. Mol Immunol 1998; 35:567-80.
66. Solvason N, Wu WW, Kabra N et al. Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes. J Exp Med 1996; 184:407-17.
67. Warner GL, Ludlow JW, Nelson DA et al. Anti-immunoglobulin treatment of murine B-cell lymphomas induces active transforming growth factor beta but pRB hypophosphorylation is transforming growth factor beta independent. Cell Growth Differ 1992; 3:175-81.
68. Lam EW, Choi MS, van der Sman J et al. Modulation of E2F activity via signaling through surface IgM and CD40 receptors in WEHI-231 B lymphoma cells. J Biol Chem 1998; 273:10051-7.
69. Joseph LF, Ezhevsky S, Scott DW. Lymphoma models for B-cell activation and tolerance: anti-immunoglobulin M treatment induces growth arrest by preventing the formation of an active kinase complex which phosphorylates retinoblastoma gene product in G1. Cell Growth Differ 1995; 6:51-7.
70. Ezhevsky SA, Toyoshima H, Hunter T et al. Role of cyclin A and p27 in anti-IgM induced G1 growth arrest of murine B-cell lymphomas. Mol Biol Cell 1996; 7:553-64.
71. Kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40. Eur J Immunol 1996; 26:2425-32.
72. Wu M, Bellas RE, Shen J et al. Roles of the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in receptor-mediated apoptosis of WEHI 231 B lymphoma cells. J Exp Med 1998; 187:1671-9 rec.
73. Bras A, Ruiz-Vela A, Gonzalez de Buitrago G et al. Caspase activation by BCR cross-linking in immature B cells: differential effects on growth arrest and apoptosis. Faseb J 1999; 13:931-44.
74. Andjelic S, Liou HC. Antigen receptor-induced B lymphocyte apoptosis mediated via a protease of the caspase family. Eur J Immunol 1998; 28:570-81.
75. Rothstein TL, Wang JK, Panka DJ et al. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature 1995; 374:163-5.
76. Bras A, Martinez AC, Baixeras E. B cell receptor cross-linking prevents Fas-induced cell death by inactivating the IL-1 beta-converting enzyme protease and regulating Bcl-2/Bcl-x expression. J Immunol 1997; 159:3168-77.
77. Francis DA, Sen R, Rothstein TL. Receptor-specific regulation of NF-kappa B, c-Myc and Fas-mediated apoptosis in primary B cells. Curr Top Microbiol Immunol 1997; 224:83-90.