EGF receptor activation of the human gastrin gene: A tale of two zinc finger transcription factor families

Keio Journal of Medicine

Volumn 49, Issue 3, 2000, Pages 106-110

  Merchant, Juanita L ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

gERE; HB EGF; Ras; Sp1; ZBP 89

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GASTRIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ADULT; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; REVIEW;

ADULT; GASTRINS; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 0034265782     PISSN: 00229717     EISSN: None     Source Type: Journal    
DOI: 10.2302/kjm.49.106     Document Type: Review

References (40)

1. Sumii M, Sumii K, Tari A, Kawaguchi H, Yamamoto G, Takehara Y, Fukino Y, Kamiyasu T, Hamada M, Tsuda T, et al.: Expression of antral gastrin and somatostatin mRNA in Helicobacter pylori-infected subjects. Am J Gastroenterol 1994; 89: 1515-1519
2. Godley JM, Brand SJ: Regulation of the gastrin promoter by epidermal growth factor and neuropeptides. Proc Natl Acad Sci USA 1989; 86: 3036-3040
3. Wu V, Sumii K, Tari A, Sumii M, Walsh JH: Regulation of rat antral gastrin and somatostatin gene expression during starvation and after refeeding. Gastroenterology 1991; 101: 1552-1558
4. Brand SJ, Stone D: Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. J Clin Invest 1988; 82: 1059-1066
5. Finley GG, Koski RA, Melhem MF, Pipas JM, Meisler AI: Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma. Cancer Res 1993; 53: 2919-2926
6. Merchant JL, Demediuk B, Brand SJ: A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter. Mol Cell Biol 1991; 11: 2686-2696
7. Ford MG, Valle JD, Soroka CJ, Merchant JL: EGF receptor activation stimulates endogenous gastrin gene expression in canine G cells and human gastric cell cultures. J Clin Invest 1997; 99: 2762-2771
8. Jackson RL, Busch SJ, Cardin AD: Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes. Physiol Rev 1991; 71: 481-539
9. Murayama Y, Miyagawa J, Higashiyama S, Kondo S, Yabu M, Isozaki K, Kayanoki Y, Kanayama S, Shinomura Y, Taniguchi N, et al.: Localization of heparin-binding epidermal growth factor-like growth factor in human gastric mucosa. Gastroenterology 1995; 109: 1051-1059
10. Merchant JL, Shiotani A, Mortensen ER, Shumaker DK, Abraczinskas DR: Epidermal growth factor stimulation of the human gastrin promoter requires Sp1. J Biol Chem 1995; 270: 6314-6319
11. Merchant JL, Du M, Todisco A: Sp1 phosphorylation by Erk 2 stimulates DNA binding. Biochem Biophys Res Commun 1999; 254: 454-461
12. Merchant JL, Iyer GR, Taylor BR, Kitchen JR, Mortensen ER, Wang Z, Flintoft RJ, Michel JB, Bassel-Duby R: ZBP-89, a Kruppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter. Mol Cell Biol 1996; 16: 6644-6653
13. Lania L, Majello B, De Luca P: Transcriptional regulation by the Sp family proteins. Int J Biochem Cell Biol 1997; 29: 1313-1323
14. Hagen G, Muller S, Beato M, Suske G: Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J 1994; 13: 3843-3851
15. Kennett SB, Udvadia AJ, Horowitz JM: Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription. Nucleic Acids Res 1997; 25: 3110-3117
16. Majello B, De Luca P, Lania L: Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains. J Biol Chem 1997; 272: 4021-4026
17. Nakata H, Wang SL, Chung DC, Westwick JK, Tillotson LG: Oncogenic ras induces gastrin gene expression in colon cancer. Gastroenterology 1998; 115: 1144-1153
18. Mortensen ER, Marks PA, Shiotani A, Merchant JL: Epidermal growth factor and okadaic acid stimulate Sp1 proteolysis. J Biol Chem 1997: 272: 16540-16547
19. Chupreta S, Du M, Todisco A, Merchant JL: EGF stimulates gastrin promoter through activation of Sp1 kinase activity. Am J Physiol Cell Physiol 2000; 278: C697-C708
20. Baldwin GS, Casey A, Mantamadiotis T, McBride K, Sizeland AM, Thumwood CM: PCR cloning and sequence of gastrin mRNA from carcinoma cell lines. Biochem Biophys Res Commun 1990; 170: 691-697
21. Singh P, Owlia A, Varro A, Dai B, Rajaraman S, Wood T: Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells. Cancer Res 1996; 56: 4111-4115
22. Van Solinge WW, Nielsen FC, Friis-Hansen L, Falkmer UG, Rehfeld JF: Expression but incomplete maturation of progastrin in colorectal carcinomas. Gastroenterology 1993; 104: 1099-1107
23. Watson SA, Morris TM, Varro A, Michaeli D, Smith AM: A comparison of the therapeutic effectiveness of gastrin neutralisation in two human gastric cancer models: relation to endocrine and autocrine/paracrine gastrin mediated growth. Gut 1999; 45: 812-817
24. Watson SA, Michaeli D, Morris TM, Clarke P, Varro A, Griffin N, Smith A, Justin T, Hardcastle JD: Antibodies raised by gastrimmune inhibit the spontaneous metastasis of a human colorectal tumour, AP5LV. Eur J Cancer 1999; 35: 1286-1291
25. Hasegawa T, Takeuchi A, Miyaishi O, Isobe K, deCrombrugghe B: Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. J Biol Chem 1997; 272: 4915-4923
26. Passantino R, Antona V, Barbieri G, Rubino P, Melchionna R, Cossu G, Feo S, Giallongo A: Negative regulation of beta enolase gene transcription in embryonic muscle is dependent upon a zinc finger factor that binds to the G-rich box within the muscle-specific enhancer. J Biol Chem 1998; 273: 484-494
27. Antona V, Cammarata G, De Gregorio L, Dragani TA, Giallongo A, Feo S: The gene encoding the transcriptional represser BERF-1 maps to a region of conserved synteny on mouse chromosome 16 and human chromosome 3 and a related pseudogene maps to mouse chromosome 8. Cytogenet Cell Genet 1998; 83: 90-92
28. Tommerup N, Vissing H: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Genomics 1995; 27: 259-264
29. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997; 25: 3389-3402
30. Law DJ, Du M, Law GL, Merchant JL: ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. Biochem Biophys Res Commun 1999; 262: 113-120
31. Lisowsky T, Polosa PL, Sagliano A, Roberti M, Gadaleta MN, Cantatore P: Identification of human GC-box-binding zinc finger protein, a new Kruppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence. FEBS Lett 1999; 453: 369-374
32. Law DJ, Tarle SA, Merchant JL: The human ZBP-89 homolog, located at chromosome 3q21, represses gastrin gene expression. Mamm Genome 1998; 9: 165-167
33. Ye S, Whatling C, Watkins H, Henney A: Human stromelysin gene promoter activity is modulated by transcription factor ZBP-89. FEBS Lett 1999; 450: 268-272
34. Wang Y, Kobori JA, Hood L: The ht beta gene encodes a novel CACCC box-binding protein that regulates T-cell receptor gene expression. Mol Cell Biol 1993; 13: 5691-5701
35. Reizis B, Leder P: Expression of the mouse pre-T cell receptor alpha gene is controlled by an upstream region containing a transcriptional enhancer. J Exp Med 1999; 189: 1669-1678
36. Law GL, Itoh H, Law DJ, Mize GJ, Merchant JL, Morris DR: Transcription factor ZBP-89 regulates the activity of the ornithine decarboxylase promoter. J Biol Chem 1998; 273: 19955-19964
37. (WAF) promoter. Biochem Biophys Res Commun 1999; 256: 249-254
38. Wieczorek E, Lin Z, Perkins EB, Law DJ, Merchant JL, Zehner ZE: The zinc finger repressor, ZBP-89, binds to the silencer element of the human vimentin gene and complexes with the transcriptional activator, Sp1. J Biol Chem 2000; 275: 12879-12888
39. Taniuchi T, Mortensen ER, Ferguson A, Greenson J, Merchant JL: Overexpression of ZBP-89, a zinc finger DNA binding protein, in gastric cancer. Biochem Biophys Res Commun 1997; 233: 154-160
40. Remington MC, Tarle SA, Simon B, Merchant JL: ZBP-89, a Kruppel-type zinc finger protein, inhibits cell proliferation. Biochem Biophys Res Commun 1997; 237: 230-234