Early onset of CD8 transgene expression inhibits the transition from DN3 to DP thymocytes

Journal of Immunology

Volumn 165, Issue 3, 2000, Pages 1236-1242

  Wack, Andreas ^a,b   Coles, Mark ^b   Norton, Trisha ^b   Hostert, Arnd ^b   Kioussis, Dimitris ^b  

^a CHIRON VACCINES   (Italy)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL COMPOSITION; CELL MATURATION; CELL SIZE; FLOW CYTOMETRY; GENE EXPRESSION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; TRANSGENE;

EID: 0034254680     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.3.1236     Document Type: Article

References (42)

1. Wu, L., R. Scollay, M. Egerton, M. Pearse, G. J. Spangrude, and K. Shortman. 1991. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349:71.
2. Shimonkevitz, R. P., L. A. Husmann, M. J. Bevan, and I. N. Crispe. 1987. Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes. Nature 329:157.
3. Pearse, M., L. Wu, M. Egerton, A. Wilson, K. Shortman, and R. Scollay. 1989. An early thymocyte development sequence marked by transient expression of the IL-2 receptor. Proc. Natl. Acad. Sci. USA 86:1614.
4. -CD8 triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150:4244.
5. Groettrup, M., K. Ungewiss, O. Azogui, R. Palacios, M. J. Owen, A. C. Hayday, and H. von Boehmer. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein. Cell 75:283.
6. Fehling, H. J., A. Krotkowa, C. Saint-Ruf, and H. von Boehmer. 1995. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ cells. Nature 375:795.
7. Hoffman, E. S., L. Passoni, T. Crompton, T. M. J. Leu, D. G. Schatz, A. Koff, M. J. Owen, and A. C. Hayday. 1996. Productive T cell receptor β-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 10:948.
8. Mombaerts, P., A. R. Clarke, M. A. Rudnicki, J. Iacomini, S. Itohara, J. J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M. L. Hooper, et al. 1992. Mutations in T cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360:225.
9. Malissen, B., L. Ardouin, S.-Y. Lin, A. Gillet, and M. Malissen. 1999. Function of the CD3 subunits of the pre-TCR and TCR complexes during T cell development. Adv. Immunol. 72:103.
10. Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannous. 1992. Rag-1-deficient mice have no mature B and T lymphocytes. Cell 68:869.
11. Shinkai, Y., G. Rathbun, K.-P. Lam, E. M. Oltz, V. Steward, M. Mendelson, J. Charron, M. Dalla, F. Young, A. M. Stall, et al. 1992. Rag-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
12. lck. Nature 357: 161.
13. Pivniouk, V., E. Tsitsikov, P. Swinton, G. Rathbun, F. W. Alt, and R. S. Geha. 1998. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell 94:229.
14. Clements, J. L., B. Yang, S. E. Ross-Barta, S. L. Eliason, R. F. Hrstka, R. A. Williamson, and G. A. Koretzky. 1998. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281:416.
15. Zhang, W., C. L. Sommers, D. N. Burshtyn, C. C. Stebbins, J. B. DeJarnette, R. P. Trible, A. Grinberg, H. C. Tsay, H. M. Jacobs, C. M. Kessler, et al. 1999. Essential role of LAT in T cell development. Immunity 10:323.
16. lck in thymopoiesis. EMBO J. 4:1671.
17. Cheng, A. M., I. Negishi, S. J. Anderson, A. C. Chan, J. Bolen, D. Y. Loh, and T. Pawson. 1997. The syk and Zap-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc. Natl. Acad. Sci. USA 94:1707.
18. Groves, T., P. Smiley, M. P. Cooke, K. Forbush, R. M. Perlmutter, and C. J. Guidos. 1996. Fyn can partially substitute for Lck in T lymphocyte development. Immunity 5:417.
19. van Oers, N. S., B. Lowin-Kropf, D. Finlay, K. Connolly, and A. Weiss. 1996. αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 5:429.
20. Shinkai, Y., S. Koyasu, K.-i. Nakayama, K. M. Murphy, D. Y. Loh, E. L. Reinherz, and F. W. Alt. 1993. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 259:822.
21. Mombaerts, P., S. J. Anderson, R. M. Perlmutter, T. W. Mak, and S. Tonegawa, 1994. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity 1:261.
22. -/- mice by anti-CD3ε treatment or with transgenes encoding activated Lck or tailless pTα. Immunity 6:703.
23. Levelt, C. N., P. Mombaerts, A. Iglesias, S. Tonegawa, and K. Eichman. 1993. Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε. Proc. Natl. Acad. Sci. USA 90:11401.
24. -/- mice in the absence of TCR β chain expression. Int. Immunol. 6:995.
25. Fehling, H. J., and H. von Boehmer. 1997. Early αβ T cell development in the thymus of normal and genetically altered mice. Curr. Opin. Immunol. 9:263.
26. Killeen, N., B. A. Irving, S. Pippig, and K. Zingler. 1998. Signalling checkpoints during the development of T lymphocytes. Curr. Opin. Immunol 10:360.
27. Rodewald, H.-R., and H. J. Fehling. 1998. Molecular and cellular events in early thymocyte development. Adv. Immunol. 69:1.
28. Haks, M. C., P. Krimpenfort, J. H. N. van den Brakel, and A. M. Kruisbeek. 1999. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 11:91.
29. + double positive thymocytes in mice with compromised CD3 complex signaling. J. Immunol. 162: 2741.
30. Robey, E. A., B. J. Fowlkes, J. W. Gordon, D. Kioussis, H. von Boehmer, F. Ramsdell, and R. Axel. 1991. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 64:99.
31. Hostert, A., M. Tolaini, R. Festenstein, L. McNeill, B. Malissen, O. Williams, R. Zamoyska, and D. Kioussis. 1997. A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice. J. Immunol. 158:4270.
32. Itano, A., D. Kioussis, and E. Robey. 1994. Stochastic component to development of class I major histocompatibility complex-specific T cells. Proc. Natl. Acad. Sci. USA 91:220.
33. Corbella, P., D. Moskophidis, E. Spanopoulou, C. Mamalaki, M. Tolaini, A. Itano, D. Lans, D. Baltimore, E. Robey, and D. Kioussis. 1994. Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity. Immunity 1:269.
34. Wack, A., P. Corbella, N. Harker, K. Roderick, T. Norton, K. Williams, O. Williams, and D. Kioussis. 1999. T helper cells and Th2 responses can develop in the absence of MHC class II-CD4 interactions. J. Immunol. 183:1162.
35. Mamalaki, C., T. Elliott, T. Norton, N. Yannoutsos, A. R. Townsend, P. Chandler, E. Simpson, and D. Kioussis. 1993. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev. Immunol. 3:159.
36. Lee, N. A., D. Y. Loh, and E. Lacy. 1992. CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice. J. Exp. Med. 175:1013.
37. Robey, E. A., F. Ramsdell, D. Kioussis, W. Sha, D. Loh, R. Axel, and B. J. Fowlkes. 1992. The level of CD8 expression can determine the outcome of thymic selection. Cell 69:1089.
38. Spanopoulou, E., C. A. J. Roman, L. M. Corcoran, M. S. Schlissel, D. P. Silver, D. Nemazee, M. C. Nussenzweig, S. A. Shinton, R. R. Hardy, and D. Baltimore. 1994. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8:1030.
39. Sarmiento, M., A. L. Glasebrook, and F. W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing lyt-2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665.
40. Irving, B. I., F. W. Alt, and N. Killeen. 1998. Thymocyte development in the absence of pre-T cell receptor extracellular Ig domains. Science 280:905.
41. Norment, A. M., K. A. Forbush, N. Nguyen, M. Malissen, and R. M. Perlmutter. 1997. Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor. J. Exp. Med. 185:121.
42. lck with the pre-T cell receptor during thymocyte development. Eur. J. Immunol. 30:8.