The active site region of the vitamin K-dependent carboxylase includes both the amino-terminal hydrophobic and carboxy-terminal hydrophilic domains of the protein

FEBS Letters

Volumn 413, Issue 1, 1997, Pages 1-6

  Maillet, Magali ^a,b   Morris, Daniel ^b   Gaudry, Michel ^a   Marquet, André ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Catalytic site; Enzyme inactivation; P Benzoylphenylalanine; Photolabeling; Propeptide binding site; Vitamin K dependent carboxylase

Indexed keywords

VITAMIN K DEPENDENT CARBOXYLASE;

AMINO ACID ANALYSIS; ANIMAL TISSUE; ARTICLE; BINDING SITE; CATTLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; LIVER; NONHUMAN; PHOTOAFFINITY LABELING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARBON-CARBON LIGASES; CATTLE; FACTOR IX; KINETICS; LIVER; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHOTOCHEMISTRY; PROTEIN BINDING; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

ANIMALIA; BOS TAURUS;

EID: 0030787398     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00831-4     Document Type: Article

References (29)

1. Wright, D.J., Morris, D.P. and Stafford, D.W. (1995) in: Molecular Basis of Thrombosis and Hemostasis (High, K.A., and Roberts, H.R., Eds.), pp. 309-329, Marcel Dekker, Inc., New York.
2. Suttie J.W. FASEB J. 7:1993;445-452.
3. Suttie J.M. Biofactors. 1:1988;55-60.
4. Price P.A. Annu. Rev. Nutr. 8:1988;565.
5. Suttie J.W. Annu. Rev. Biochem. 54:1985;459-477.
6. Pan L.C., Price P.A. Proc. Natl. Acad. Sci. U.S.A. 82:1985;6109-6113.
7. Jorgensen M.J., Cantor A.B., Furie B.C., Brown C.L., Shoemaker C.B., Furie B. Cell. 48:1987;185-191.
8. Foster D.C., Rudinski M.S., Schach B.G., Berkner K.L., Kumar A.A., Hagen F.S., Sprechner C.A., Insley M.Y., Davie E.W. Biochemistry. 26:1987;7003-7011.
9. Wu S.-M., Morris D.P., Stafford D.W. Proc. Natl. Acad. Sci. U.S.A. 88:1991;2236-2240.
10. Wu S.-M., Cheung W.F., Frazier D.F., Stafford D.W. Science. 254:1991;1634-1636.
11. Roth D.A., Rehemtulla A., Kaufman R.J., Walsh C.T., Furie B., Furie B.C. Proc. Natl. Acad. Sci. U.S.A. 90:1993;8372-8376.
12. Sugiura I., Furie B., Walsh C.T., Furie B.C. J. Biol. Chem. 271:1996;17837-17844.
13. Dubois J., Gaudry M., Bory S., Azerad R., Marquet A. J. Biol. Chem. 258:1983;7897.
14. Decottignies-Le Marechal P., Ducrocq C., Marquet A., Azerad R. J. Biol. Chem. 259:1984;15010.
15. Vidal-Cros A., Gaudry M., Marquet A. Biochem. J. 260:1990;749.
16. Dubois J., Dugave C., Bory S., Gaudry M., Marquet A. Biochemistry. 30:1991;10506.
17. Kuliopulos A., Nelson N.P., Yamada M., Walsh C.T., Furie B., Furie B.C., Roth D.A. J. Biol. Chem. 269:1994;21364-21370.
18. Yamada M., Kuliopulos A., Nelson N.P., Roth D.A., Furie B., Furie B.C., Walsh C.T. Biochemistry. 34:1995;481-489.
19. Wu, S.-M., Morris, D.P. and Stafford, D.W. Enzymes: Mechanisms of Action III A1414, 904.
20. Wright, D.J., Morris, D.P. and Stafford, D.W. (1995) in: Molecular Basis of Thrombosis and Hemostasis (High, K.A., and Roberts, H.R., Eds.), pp. 323-324, Marcel Dekker, Inc., New York.
21. Hubbard B., Jacobs M., Ulrich M., Walsh C.T., Furie B., Furie B.C. J. Biol. Chem. 264:1989;14145-14150.
22. Kauer J.C., Erickson-Viitnamin S., Wolfe H.R., Degrado W.F. Jr. J. Biol. Chem. 261:1986;10695-10700.
23. Josien H., Martin A., Chassaing G. Tetrahedron Lett. 32:1991;6547-6550.
24. Josien H., Chassaing G. Tetrahedron Asym. 3:1992;1351-1354.
25. Merrifield R.B. J. Am. Chem. Soc. 85:1963;2149-2154.
26. Heald S.L., Jeffs P.W., Lavin T.N., Nambi P., Lefkowitz R.J., Caron M.G. J. Med. Chem. 26:1983;832-838.
27. Morris D.P., Soute B.A.M., Vermeer C., Stafford D.W. J. Biol. Chem. 268:1993;8735-8742.
28. Laemmli U.K. Nature. 227:1970;1940.
29. Suttie J.W., Hageman J.M., Lehrman S.R., Rich D.H. J. Biol. Chem. 251:1976;5827-5830.