Interleukin-15 redirects the outcome of a tolerizing T-cell stimulus from apoptosis to anergy

Blood

Volumn 96, Issue 3, 2000, Pages 1006-1012

  Dooms, Hans ^a   Van Belle, Tom ^a   Desmedt, Marjory ^a   Rottiers, Pieter ^a   Grooten, Johan ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b Department of Molecular Biology ^*  (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GROWTH FACTOR; HEMAGGLUTININ; INTERLEUKIN 12; INTERLEUKIN 15; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; CELL ACTIVITY; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL;

EID: 0034254363     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.3.1006.015k27_1006_1012     Document Type: Article

References (39)

1. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
2. A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells
3. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor
4. IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation
5. Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
6. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
7. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
8. Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl- xS) gene expression
9. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
10. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis
11. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice
12. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
13. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
14. + T cell responsiveness to antigen
15. Interleukin-15 protects from lethal apoptosis in vivo
16. Models of T cell anergy: Istherea common molecular mechanism?
17. A cell culture model for T lymphocyte clonal anergy
18. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin
19. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
20. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of co-stimulation
21. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody
22. Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment
23. Induction of apoptosis in mature T ceils by tumour necrosis factor
24. Reactive oxygen species regulate activation-induced T cell apoptosis
25. Dissociation of T cell anergy from apoptosis by blockade of Fas/Apo-1 (CD95) signaling
26. Costimulatory requirements of murine Th1 clones. The role of accessory cell-derived signals in responses to anti-CD3 antibody
27. Induction and maintenance of anergy in mature T cells
28. Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones: Correlation with lymphokine secretion patterns
29. Sensitivity of T cells to anti-CD3-stimulated suicide is independent of functional phenotype
30. 2+ and protein kinase C-independent lethal signaling pathway
31. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens
32. Extinction of IL-12 signaling promotes Fas-mediated apoptosis of antigen-specific T cells
33. Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor
34. Persistent CD3-crosslinking down-regulates interleukin-2 responsiveness in interleukin-2-competent cloned T cells: The possible involvement of protein kinase C
35. + T cell anergy in vitro
36. Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen- induced T cell deletion but does not influence T cell homeostasis after a viral infection
37. Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes
38. Reversal of in vitro T cell clonal anergy by IL-2 stimulation
39. TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells