Persistent CD3-crosslinking down-regulates interleukin-2 responsiveness in interleukin-2-competent cloned T cells: The possible involvement of protein kinase C

Scandinavian Journal of Immunology

Volumn 44, Issue 1, 1996, Pages 45-53

  Landewe R B M ^a   Dijkmans, B A C ^a   Verdonk, M J A ^a   Breedveld, F C ^a   Daha, M R ^a   Miltenburg, A M M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CYCLOSPORIN A; INTERLEUKIN 2; MONOCLONAL ANTIBODY; PROTEIN KINASE C; RECOMBINANT INTERLEUKIN 2;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029931506     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1996.d01-280.x     Document Type: Article

References (36)

1. Imboden JB, Weiss A, Stobo JD. Transmembrane signalling by the T-3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. Immunol Today 1985;6:328-31.
2. src in the activation pathway. Mol Cell Biol 1987;7:650-6.
3. Meuer SC, Hussey RE, Cantrell DA et al. Triggering of theT3/Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin-2-dependent autocrine pathway. Proc Natl Acad Sci USA 1984;81:1509-13.
4. Cantrell DA, Collins MKL, Crumpton MJ. Autocrine regulation of T-lymphocyte proliferation: differential induction of IL-2 and IL-2 receptor. Immunology 1988;65:343-9.
5. Mills GB, Stewart DJ, Mellors A, Gelfand EW. Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells. J Immunol 1986;136:3019-24.
6. Kozumbo WJ, Harris DT, Gromkowski S, Cerotinni JC, Cerutti PA. Molecular mechanisms in T cell activation. J Immunol 1987;138:606-12.
7. Tigges MA, Casey LS, Koshland ME. Mechanism of interleukin2 signaling: mediation of different outcomes by a single receptor and transduction pathway. Science 1989;243:781-6.
8. Valge VE, Wong JGP, Datlof BM, Sinskey AJ, Rao A. Protein kinase C is required for responses to T cell receptor ligands but not to interleukin-2 in T cells. Cell 1988;55:101-12.
9. Nisbet-Brown ER, Lee JWW, Cheung RK, Gelfand EW. Antigen-specific and -nonspecific mitogenic signals in the activation of human T cell clones. J Immunol 1987;138:3713-19.
10. Ceredig R, Corradin G. High antigen concentration inhibits T cell proliferation but not interleukin 2 production: examination of limiting dilution microcultures and T cell clones. Eur J Immunol 1986:16:30-4.
11. Matis LA, Glimcher LH, Paul WE, Schwartz RH. Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentration of antigen and Ia molecules. Proc Natl Acad Sc USA 1983;80:6019-23.
12. Suzuki G, Kawase Y, Koyasu S, Yahara I, Kobayashi Y. Schwatz RH. Antigen-induced suppression of the proliferative response of T cell clones. J Immunol 1988;140:1359-65.
13. Ely JM, Fitch FW. Alloreactive cloned T-cell lines. VII. Comparison of the kinetics of IL-2 release stimulated by alloantigen or Con A. J Immunol 1983;131:1274-9.
14. Geppert TD, Lipsky PE. Accessory-cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3. J Immunol 1987;138:1660-6.
15. Manger B, Weiss A, Imboden J, Laing T, Stobo JD. The role of protein kinase C in transmembrane signaling by the T-cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies. J Immunol 1987;139:2755-60.
16. Londeï M, Grubeck-Loebenstein B, de Berardinis P. Greenall C, Feldmann M. Efficient propagation and cloning of human T cells in the absence of antigen by means of OKT3, Interleukin 2, and antigen-presenting cells. Scand J Immunol 1988;27:35-46.
17. Miltenburg AMM, van Laar JM, de Kuiper R, Daha MR, Breedveld FC. T cells cloned from human rheumatoid synovial membrane functionally represent the Th1 subset. Scand J Immunol 1992;35:603-10.
18. Kawamura H, Sharrow SO, Ailing DW, Stephany D. York-Jolley J, Berzofsky JA. Interleukin-2 receptor expression in unstimulated murine splenic T cells. Localization to L3T4 + cells and regulation by non-H-2-linked genes. J Exp Med 1986;63:1376-90.
19. Golstein P, Ojcius DM, Young DE. Cell death mechanisms and the immune system. Immunol Rev 1991;121:29-65.
20. Emmel EA, Verweij CL, Durand DB, Higgins KM, Lacy E, Crabtree GR. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 1989;246:1617-20.
21. Metcalfe S. Cyclosporine does not prevent cytoplasmatic calcium changes associated with lymphocyte activation. Transplantation 1984;38:161-4.
22. Ledbetter JA, June CH, Martin P, Spooner CE, Hansen JA, Meier KE. Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C. cytoplasmic free calcium and proliferation. J Immunol 1986;136:3945-52.
23. Weiss A, Imboden J, Shoback D, Stobo J. Role of T3 surface molecules in human T-cell activation: T3 dependent activation results in an increase in cytoplasmic free calcium. Proc Natl Acad Sci USA 1984;81:4169-73.
24. Gullberg M, Smith KA. Regulation of T cell autocrine growth. T4 + cells become refractory to interleukin 2. J Exp Med 1986;163:270-84.
25. Schwinzer R, Franklin RA, Domenico J, Renz H, Gelfand EW. Monoclonal antibodies directed to different epitopes in the CD3-TCR complex induce different states of competence in resting human T-cells. J Immunol 1992;148:1322-8.
26. Nau GJ, Moldwin RL, Lancki DW, Kim DK, Fitch FW. Inhibition of IL 2-driven proliferation of murine T lymphocyte clones by supraoptimal levels of immobilized anti-T cell receptor monoclonal antibody. J Immunol 1987;139:114-22.
27. Lenardo MJ. Interleukin-2 programs mouse αß T lymphocytes for apoptosis. Nature 1991;353:858-61.
28. Boehme SA, Lenardo MJ. Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Eur J Immunol 1993;23:1552-60.
29. Critchfield JM, Racke MK, Zuniga-Pflücker JC, Cannella B, Raine CS, Goverman J, Lenardo MJ. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 1994;263:1139-43.
30. Bretscher P, Cohn M. A theory of self-nonself discrimination. Science 1970;169:1042-4.
31. Mueller DL, Jenkins MK, Schwartz RH. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Ann Rev Immunol 1989;7:445-80.
32. Schwartz RH. A cell culture model for T lymphocyte clonal anergy. Science 1990;248:1349-56.
33. Mueller DL, Jenkins MK, Schwartz RH. An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness. J Immunol 1989;142:2617-28.
34. Horowitz JB, Kaye J, Conrad PJ, Katz ME, Janeway CA Jr. Autocrine growth inhibition of a cloned line of helper T cells. Proc Natl Acad Sci USA 1986;83:1886-90.
35. lck with CD4 inhibits the induction of growth through the αβ T-cell receptor. Nature 1992;358:328-31.
36. Mueller DL, Jenkins MK, Chiodetti L, Schwartz RH. An intracellular calcium increase in protein kinase C activation and fail to initiate T cell proliferation in the absence of a costimulatory signal. J Immunol 1990;144:3701-9.