Enrichment of threonine content in Saccharomyces cerevisiae by pathway engineering

Enzyme and Microbial Technology

Volumn 26, Issue 9-10, 2000, Pages 763-770

  Farfán, María José ^a   Calderón, Isabel L ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Amino acid production; Gene amplification; Genetic engineering; Threonine biosynthesis; Yeast

Indexed keywords

AMINO ACIDS; DEGRADATION; GENES; GENETIC ENGINEERING; GROWTH KINETICS; METABOLISM;

AMINO ACID PRODUCTION; GENE AMPLIFICATION; SACCHAROMYCES CEREVISIAE; THREONINE BIOSYNTHESIS;

YEAST;

THREONINE;

ALLELE; AMINO ACID SYNTHESIS; BIOSYNTHESIS; CONFERENCE PAPER; GENE AMPLIFICATION; GENE CLUSTER; GENE MUTATION; GENETIC ENGINEERING; NONHUMAN; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0034214105     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0141-0229(00)00169-1     Document Type: Conference Paper

References (35)

1. Leuchtenberger W. Amino acids. Technical Production and Use. Roehr M. Biotechnology. Products of primary metabolism. 1996;465-502 VCH, Weinheim.
2. Kleemann A., Leuchtenberger W., Hoppe B., Tanner H. Amino acids. Bartholomé E., Bierket E., Hellman H. Ullmann's encyclopedia of industrial chemistry A2. 1985;57-97 VCH, Weinheim.
3. Sulser H., DePizzol J., Büchi W. A probable flavoring principle in vegetable-protein hydrolysates. J Food Sci. 32:1967;611-615.
4. Debabov VG, Kozlov JI, Khurges EM, Livshits VA, Zhdanova NI, Gusyatiner MM, Sokolov AK, Bachina TA, Chistoserdov AJ, Tsigankov JD, Yankovsky NK, Mashko SV, Lapidus AL, Gavrilova OF, Radionov OA. Novel L-threonine-producing microbacteria and a method for the production of L-threonine. Eur Patent Appl 1994;593-792.
5. Martín-Rendón E., Farfán M.J., Ramos C., Calderón I.L. Isolation of a mutant allele that deregulates the threonine biosynthesis in Saccharomyces cerevisiae. Curr Genet. 24:1993;465-471.
6. Farfán M.J., Martín-Rendón E., Calderón I.L. Effect of gene amplification on threonine production by yeast. Biotechnol Bioeng. 49:1996;667-674.
7. Seibold M., Nill K., Poralla K. Homoserine and threonine pools of borrelidin resistant Saccharomyces cerevisiae mutants with altered aspartokinase. Arch Microbiol. 129:1981;368-370.
8. Delgado M.A., Guerrero J., Conde J. Genetic and biochemical study of threonine-overproducing mutants of Saccharomyces cerevisiae. Mol Cell Biol. 2:1982;731-736.
9. Ramos C., Calderón I.L. Overproduction of threonine by yeast mutants resistant to hydroxynorvaline. Appl Environ Microbiol. 58:1992;1677-1682.
10. Martínez-Force E., Benítez T. Selection of amino-acid overproducer yeast mutants. Curr Genet. 21:1992;191-196.
11. Arévalo-Rodríguez M. Aislamiento y caracterización de mutaciones del gen HOM3 que alteran la regulación de la síntesis de treonina y metionina en Saccharomyces cerevisiae. Ph.D. Thesis, University of Seville, Spain, 1996.
12. Farfán M.J., Aparicio L., Calderón I.L. Threonine overproduction in yeast strains carrying the HOM3-R2 mutant allele under the control of different inducible promoters. Appl Environ Microbiol. 65:1999;110-116.
13. Mountain H.A., Byström A.S., Larsen J.T., Korch C. Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast. 7:1991;781-803.
14. Gietz D., St. Jean A., Woods R.A., Schiestl R.H. Improved method for high efficiency transformation of intact yeast cells. Nucl Acids Res. 20:1992;1425.
15. Hanahan D. Techniques for transformation of E. coli. In: Glover DM, editor. DNA cloning. A practical approach Oxford: IRL Press, 1985. p. 109-14.
16. Sherman F., Fink G.R., Hicks J.B. Laboratory course manual for methods in yeast genetics. 1986;Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
17. Grenson M., Crabeel M. Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. J Bacteriol. 103:1970;770-777.
18. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning a laboratory manual . 1989;Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
19. Thomas D, Barbey R, Surdin-Kerjan Y. Evolutionary relationships between yeast and bacterial homoserine dehydrogenases. FEBS Lett 1993;323:298-93.
20. Hill J.E., Myers A.M., Koerner T.J., Tzagoloff A. Yeast/E. coli shuttle vectors with multiple unique restriction sites. Yeast. 2:1986;163-167.
21. Thomas D., Surdin-Kerjan Y. Structure of the HOM2 gene of Saccharomyces cerevisiae and regulation of its expression. Molec Gen Genet. 217:1989;149-154.
22. Scherer S., Davis R.W. Replacement of chromosome segments with altered DNA sequences constructed in vitro. Proc Natl Acad Sci USA. 76:1979;4951-4955.
23. Ramos C., Delgado M.A., Calderón I.L. Inhibition by different amino acids of the aspartate kinase and the homoserine kinase of the yeast Saccharomyces cerevisiae. FEBS Lett. 278:1991;123-126.
24. Kacser H., Burns J.A. The control of flux. Symp Soc Exp Biol. 27:1973;65-104.
25. Fell D. Understanding the control of metabolism. Frontiers in metabolism 2. 1997;Portland Press, London.
26. Prasad R., Niederberger P., Hütter R. Tryptophan accumulation in Saccharomyces cerevisiae under the influence of an artificial yeast TRP gene cluster. Yeast. 3:1987;95-105.
27. Niederberger P., Prasad R., Miozzari G., Kacser H. A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast. Biochem J. 287:1992;473-479.
28. Ramos C., Wiame J.M. Occurence of a catabolic L-serine (L-threonine) deaminase in Saccharomyces cerevisiae. Eur J Biochem. 123:1982;571-576.
29. Petersen J.G.L., Kielland-Brandt M.C., Bornaes C., Holmberg S. Molecular genetics of serine and threonine catabolism in Saccharomyces cerevisiae. Genetics. 119:1988;527-534.
30. Monschau N., Stahmann K.P., Sahm H., McNeil J.B., Bognar A.L. Identification of Saccharomyces cerevisiae GLY1 as a threonine aldolase a key enzyme in glycine biosynthesis . FEMS Microbiol Lett. 1590:1997;55-60.
31. Eggeling L, Sahm H, de Graaf AA. Quantifying and directing metabolite flux: application to amino acid overproduction. In: Sahm H, Ubandry C, editors. Metabolic Engineering. Advances in Biochemical Engineering/Biotechnology, vol. 54. Heidelberg: Springer Verlag, 1996, 1-30.
32. Schrumpf B., Eggeling L., Sahm H. Isolation and prominent characteristics of a lysine hyperproducing strain of Corynebacterium glutamicum. Appl Microbiol Biotechnol. 37:1992;566-571.
33. Malumbres M., Martin J.F. Molecular control mechanisms of lysine and threonine biosynthesis in amino acid-producing corynebacteria redirecting carbon flow . FEMS Microbiol Lett. 143:1996;103-114.
34. Eggeling L., Oberle S., Sahm H. Improved L-lysine yield with Corynebacterium glutamicum use of dapA resulting in increased flux combined with growth limitation . Appl Microbiol Biotechnol. 49:1998;24-30.
35. Menkel E., Thierbach G., Eggeling L., Sahm H. Influence of increased aspartate availability on lysine formation by a recombinant strain of Corynebacterium glutamicum and utilization of fumarate. Appl Environm Microbiol. 55:1989;684-688.