Neural transplants in Parkinson's disease: Clinical results after 10 years' experience;Trasplantes neurales en la enfermedad de Parkinson: Resultados clinicos tras 10 anos de experiencia

Revista de Neurologia

Volumn 30, Issue 11, 2000, Pages 1077-1083

  Lopez Lozano J J ^a   Mata, M ^a   Bravo, G ^a   Brera, B ^a   De La Torres, C ^a   Moreno, R ^a   Sanchez P ^a   Pajaron A ^a   Martinez R ^a   Uria J ^a   Abascal, J ^a   Millan I ^a   Dargallo, J L ^b   Salmean J ^b   Insausti, C ^b  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b HOSPITAL SEVERO OCHOA   (Spain)

Author keywords

Adrenal medulla; Caudate nucleus; Chromaffin; Implant; Parkinson's disease; Substantia nigra

Indexed keywords

CATECHOLAMINE;

ADRENAL MEDULLA; CATECHOLAMINE SYNTHESIS; CAUDATE NUCLEUS; CHROMAFFIN CELL; CONFERENCE PAPER; DOPAMINERGIC NERVE CELL; FETAL TISSUE TRANSPLANTATION; HUMAN; MESENCEPHALON; NERVE TRANSPLANTATION; PARKINSON DISEASE; PERIPHERAL NERVE; SUBSTANTIA NIGRA; ARTICLE; BRAIN; PRENATAL DEVELOPMENT; TRANSPLANTATION;

ADRENAL MEDULLA; BRAIN; FETAL TISSUE TRANSPLANTATION; HUMANS; MESENCEPHALON; PARKINSON DISEASE; SUBSTANTIA NIGRA;

EID: 0034210659     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3011.99664     Document Type: Conference Paper

References (81)

1. Backlund EO, Grandberg PO, Hamberger B, Kuntsson E, Martensson A, Goran S, et al. Transplantation of adrenal medullary tissue to striarum in parkinsonism: first clinical trials. J Neurosurg 1985; 62: 169-73.
2. Madrazo I, Drucker-Colin R, Díaz V, Martínez-Mata J, Torres C, Becerril J. Open microsurgical autograft of the adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson's disease. N Engl J Med 1987; 316: 831-4.
3. Freed WJ, Morihisa J, Spoor E, Hoffer B, Olson L, Seiger Å. Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behavior. Nature 1981; 292: 351-2.
4. Perlow MJ, Freed WJ, Hoffer BJ, Seiger Å, Olson L, Wyatt RJ. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 1979; 204: 643-7.
5. Jiao SS, Zhang WC, Cao JK. Transplantation to the caudate nucleus in Parkinson's disease. Initial clinical results in 18 patients. Arch Neurol 1989; 46: 487-91.
6. Allen GS, Burns RS, Tulipan NE, Parker RB. Adrenal medullary transplantation to the caudate nucleus in Parkinson's disease. Initial clinical results in 18 patients. Arch Neurol 1989; 46: 487-91.
7. Apuzzo ML, Neal JH, Waters CH, Appley AJ, Boyd SD, Couldwell WT, et al. Utilization of unilateral and bilateral stereotactically placed adrenomedullary-striatal autografts in parkinsonian humans: rationale techniques, and observations. Neurosurgery 1990; 26: 746-57.
8. Goetz CG, Olanow CW, Koller WC, Penn RD, Cahilll D, Morantz R, et al. Multicenter study of autologous adrenal medullary transplantation to the corpus striatum in patients with advanced Parkinson's disease. N Engl J Med 1989; 320: 337-41.
9. Lindvall O, Backlund E, Farde L, Freedman R, Hoffer B, Seiger A. Transplantation in Parkinson's disease: two cases of adrenal medullary grafts to the putamen. Ann Neurol 1987; 22: 457-68.
10. López-Lozano JJ, Bravo G, Abascal J, and the Clínica Puerta de Hierro Neural Transplantation Group. Grafting of perfused adrenal medullary tissue into the caudate nucleus of patients with Parkinson's disease. J Neurosurg 1991; 75: 234-43.
11. Kelly P, Ahlskog E, van Heerden J, Carmichael SW, Studdard SL, Bell GN. Adrenal medullary autograft transplantation into the striatum of patients with Parkinson's disease. Mayo Clin Proc 1989; 64: 282-90.
12. López-Lozano JJ, Brera B, Abascal J, Bravo G. Preparation of adrenal medullary tissue for transplantation in Parkinson's disease: a new procedure. J Neurosurg 1989; 71: 452-4.
13. Rafael H, Moromizato P, Espinoza M, Ayulo V, González-Portillo M. Transplantation of adrenal medulla and omentum to the putamen by a transinsular pathway for Parkinson's disease. Neurosurgery 1990; 28: 481.
14. Stellar S. Transplantation of adrenal medulla and omentum to the putamen by a transinsular pathway for the Parkinson's disease. Neurosurgery 1992; 30: 143-4.
15. Frank F, Sturiale C, Gaist G, Manetto V. Adrenal medullary autograft in human brain for Parkinson's disease. Acta Neurochir (Wien) 1988; 94: 162-3.
16. Goetz CG, Stebbins GT, Klawans HL, Koller WC, Grossman RG, Bakay RAE, et al. United Parkinson-Foundation Neurotransplantation Registry. Multicenter United States and Canadian data base, presurgical and 12 months follow-up. Prog Brain Res 1990; 82: 611-7.
17. Jiao SS, Ding YJ, Zhang WC, Cao JK, Zhang GF, Zhang ZM, et al. Adrenal medullaryautografts in patients with Parkinson's disease. N Engl J Med 1989; 321: 324-5.
18. Watts RL, Bakay RAE, Iuvone PM, Watts N, Graham S. Autologous adrenal-caudate transplantation in Parkinson's disease. Neurology 1988; 38 (Suppl 1): S143.
19. Pezzoli G, Motti E, Zecchinelli A, Ferrante C, Silani V, Falini A, et al. Adrenal medulla autograft in 3 parkinsonian patients. Results using 2 different approaches. Prog Brain Res 1990; 82: 677-82.
20. Lieberman A, Ransohoff J, Berczeller P, Goldstein M. Adrenal medullary transplants as a treatment for advanced Parkinson's disease. Prog Brain Res 1990; 82: 665-9.
21. Drucker-Colín R, Madrazo I, Ostrosky-Solís F, Shkurovich M, Franco R, Torres C. Adrenal medullary tissue transplants in the caudate nucleus of Parkinson's patients. Prog Brain Res 1988; 78: 567-74.
22. Madrazo I, León V, Torres C, Aguilera M, Varela G, Álvarez F, et al. Transplantation of fetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson's disease. N Engl J Med 1988; 318: 51.
23. Lieberman A, Ransohoff J, Berczeller P, Brous P, Eng K, Goldstein M, et al. Adrenal medullary transplants as a treatment for advanced Parkinson's disease. Acta Neurol Scand 1989; 80 (Suppl 126): 189-96.
24. López-Lozano JJ, Abascal J, Bravo G, and the Clínica Puerta de Hierro Neural Transplantation Group. A year follow-up of autoimplants of perfused adrenal medulla into parkinsonian patients. Prog Brain Res 1990; 82: 657-63.
25. López-Lozano JJ, Bravo G, Abascal J, and the Clínica Puerta de Hierro Neural Transplantation Group. A long-term study of Parkinson's patients subjected to autoimplants of perfused adrenal medulla into the caudate nucleus. Transplant Proc 1990; 22: 2243-6.
26. Madrazo I, Franco-Bourland RE, Ostrosky-Solís F, Aguilera M, Cuevas C, Álvarez F, et al. Neural transplantation (auto-adrenal, fetal nigral and fetal adrenal) in Parkinson's disease: the Mexican experience. Prog Brain Res 1990; 82: 593-602.
27. Madrazo I, Franco-Bourland RE, Aguilera M, Ostrosky-Solís F. Hispanic registry of graft procedures for Parkinson'disease. Lancet 1989; ii: 751-2.
28. Date I, Felten SY, Felten DL. Cografts of adrenal medulla with peripheral nerve enhance the survivability of transplanted adrenal chromaffin cells ans recovery of the host nigrostriatal dopaminergic system in MPTP treated yound adult mice. Brain Res 1990; 537: 33-9.
29. Kordower JH, Fiandaca MS, Notter MFD. Peripheral nerve provodes NGF-like support from peripheral nerve for grafted rhesus adrenal chromaffin cells. J Neurosurg 1990; 73: 418-28.
30. Stromberg I, Herrera-Marchitz M, Ungerstendt U. Chronic implants of chromaffin tissue into dopamine denervated striatum. Effects of NGF on graft survival, fiber outgrowth and rotational behaviour. Exp Brain Res 1985; 60: 335-49.
31. Doering LC. Peripheral nerve segments promote consistent long-term survival of adrenal medulla transplants in the brain. Exp Neurol 1992; 118: 253-60.
32. Bing G, Notter MFD, Hansen JT, Kellogg C, Kordower JH, Gash DM. Cografts of adrenal medulla with C6 glioma cells in rat with 6-hydroxydopamine-induced lesions. Neuroscience 1990; 34: 687-97.
33. Olson L, Backlund EO, Ebendal T, Freedman R, Hamberger B, Hansson P, et al. Intraputaminal infusion of nerve growth factor to support adrenal medullary autografts in Parkinson's disease: one-year follow-up of first clinical trial. Arch Neurol 1991; 48: 373-81.
34. López-Lozano JJ, Bravo G, Abascal J, Brera B, Pascual ML, et al. Clinical experience with cotransplantation of peripheral nerve and adrenal medulla in patients with Parkinson's disease. Transpl Int 1996; 9: 485-91.
35. López-Lozano JJ, Bravo G, Abascal J, Brera B, Santos H, Gómez-Angulo JC, and the Clínica Puerta de Hierro Neural Transplantation Group. Co-transplantation of peripheral nerve and adrenal medulla in Parkinson's disease. Lancet 1992; 339: 430.
36. López Lozano JJ, Bravo G, Brera B, Dargallo J, Saleman J and the Clínica Puerta de Hierro Neural Transplantation Group. Alloimplants of fetal ventral mesencephalon into a cavity of caudate nucleus cause a chronic improvement in severe Parkinson's patients: five years of follow-up in 10 patients. J Neurosurg 1997; 86: 931-42.
37. López Lozano JJ, Bravo G, Abascal J, Brera B, Millan I, and the Clinica Puerta de Hierro Neural Transplantation Group. Clinical outcome of cotransplantation of peripheral nerve and adrenal medulla in patients with Parkinson's disease. J Neurosurg 1999; 90: 875-82.
38. Bakay RAE, Barrow DL, Fiandaca MS, Iuvone PM, Schiff A, Collins DC. Biochemical and behavioral correction of MPTP-like syndrome by fetal cell transplantation. Ann N Y Acad Sci 1987; 495: 623-38.
39. Doucet G, Brundin P, Descarries L, Björklund A. Effect of prior denervation on survival and fiber outgrowth from intrastriatal fetal mesencephalic grafts. Eur J Neurosci 1990; 2: 279-90.
40. Rioux L, Gayudin DP, Gagnon C, Di Paolo T, Bédard PJ. Decrease of behavioral and biochemical denervation supersensitivity of rat striaturn by nigral transplants. Neuroscience 1991; 44: 75-83.
41. Sladek JR, Redmond DE, Collier TJ, Haber SN, Elsworth JD, Deutch AY, et al. Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Prog Brain Res 1987; 71: 309-22.
42. Freed CR. Transplantation of fetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson's disease. N Engl J Med 1988; 319: 370-1.
43. Henderson BTH, Clough CG, Hughes RC, Hitchcock ER, Kenny BG. Implantation of human fetal ventral mesencephalon to the right caudate nucleus in advanced Parkinson's disease. Arch Neurol 1991; 48: 822-7.
44. Hitchcock ER, Henderson BTH, Kenny BG, Clough CG, Hughes RC, Detta A. Stereotactic implantation of foetal mesencephalon. Restor Neurol 1991; 4: 79-86.
45. Iacono RP, Tang ZS, Mazziotta JC, Grafton S, Hoehn M. Bilateral fetal grafts for Parkinson's disease: 22 months' results. Stereotact Funct Neurosurg 1992; 58: 84-7.
46. Lindval O, Widner H, Rehncrona S, Brundin P, Odin P, Gustavi B, et al. Transplantation of fetal dopamine neurons in Parkinson's disease: one-year clinical and ncurophysiological observations in two patients with putaminal implants. Ann Neurol 1992; 31: 155-65.
47. Widner H, Tetrud J, Rehncrona S, Snow BJ, Brundin P, Björklund A, et al. Fifteen months' follow-up on bilateral embryonic grafts in two cases of severe MPTP-induced parkinsonism. Adv Neurol 1993; 60: 729-33.
48. Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Wells TH, Barrett JN, et al. Transplantation of human fetal dopamine cells for Parkinson's disease. Results at 1 year. Arch Neurol 1990; 47: 505-12.
49. Wenning GK, Odin P, Morrish P, Rehncrona S, Wjdner H, et al. Short-and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease. Ann Neurol 1997; 42: 95-107.
50. Widner H, Tetrud J, Rehncrona S, Snow BJ, Brundin P, Gustavi B, et al. Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by MPTP. N Engl J Med 1992; 26: 1556-63.
51. Freed CR, Breeze RE, Rosemberg NL, Schneck SA, Kriek E, Qi JX, et al. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. N Engl J Med 1992; 327: 1549-55.
52. Lindvall O, Brundin P, Widner H, Rehncrona S, Gustavii B, Frackowiak R, et al. Grafts of fetal dopamine neurons survive motor function in Parkinson's disease. Science 1990; 247: 574-7.
53. Sawle GV, Bloomfield PM, Björklund A, Brooks DJ, Brundin P, Leenders KL, et al. Transplantation of fetal dopamine neurons in Parkinson's disease: PET[18F] 6-L-fluorodopa studies in two patients with putaminal implants. Ann Neurol 1992; 31: 166-73.
54. Spencer DD, Robbins RJ, Naftolin F, Marek KL, Vollmer T, Leranth C, et al. Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease. N Engl J Med 1992; 327: 1541-8.
55. Hitchcock ER, Henderson BTH, Kenny BG, Clough CG, Hughes RC, Detta A. Stereotactic implantation of foetal mesencephalon. Restor Neurol 1991; 4: 79-86.
56. Hitchcock ER, Clough C, Hughes R, Kenny B. Embryos and Parkinson's disease. Lancet 1988; 1: 1274.
57. Lindvall O, Rehncrona S, Brundin P, Gustavii B, Åstedt B, Widner H, et al. Neural transplantalion in Parkinson disease. The Swedish experience. Prog Brain Res 1990; 82: 729-34.
58. Freed CR, Beeze RE, Rosenberg NL, Schneck SA, Wells TH, Barrett JN, et al. Therapeutic effects of human fetal dopamine cells transplanted in a patient with Parkinson's disease. Prog Brain Res 1990; 82: 715-21.
59. Hagell P, Schrag A, Piccini P, Jahanshahi M, Brown R, Rehncrona S, et al. Sequential bilateral transplantation in Parkinson's disease: effects of the second graft. Brain 1999; 122: 1121-32
60. Redmond DE, Leranth C, Spencer DD, Robbins R, Vollmer T, Kim JH, et al. Fetal neural graft survival. Lancet 1990; 336: 820-2.
61. Molina H, Quiñones R, Ålvarez L, Galarraga J, Piedra J, Suárez C, et al. Transplantation of human mesencephalic tissue in caudate nucleus as treatment for Parkinson's disease: the Cuban experience. Restor Neurol 1991; 4: 99-110.
62. López Lozano JJ, Brera B. Neural transplants in Parkinson's disease. Transplantation Proc 1993; 25: 1005-11.
63. Peschanski M, Defer G, NeGuyenn JP, Ricoli F, Monfort JC, Remy D, et al. Bilateral motor improvement and alteration of L-Dopa effect inn two patients with PD following intrastriatal transplantation of fetal ventral mesencephalon. Brain 1994; 117: 487-99.
64. Goetz CG, Tanner CM, Penn RL, Stebbins GT, Gilley DW, Shannon KM, et al. Adrenal medullary transplant to the striatum of patients with advanced Parkinson's disease: 1-year motor and psychomotor data. Neurology 1990; 40: 273-6.
65. Lindvall O, Sawe G, Widner H, Rothwell JC, Bjorklund A, Brooks D, et al. Evidence for long-term survival and function of dopaminergic grafts in progresive PD. Ann Neurol 1994; 35: 172-80.
66. Watts RL, Subramanian T, Freeman A, Getz CG, Penn R, Stebbins GT, et al. Cografts of stereotaxic intrastriatal cografts of autologous adrenal medulla and peripheral nerve in Parkinson's disease: two year follow-up study. Exp Neurol 1997; 147: 510-31.
67. Date I, Imaoka T, Miyoshi Y, Ono T, Asari S, Ohmoto T. Chromaffin cell survival and host dopaminergic fiber recovery in a patient with Parkinson's disease treated by cografts of adrenal medulla and pretransected peripheral nerve: case report. J Neurosurg 1994; 84: 685-9.
68. Hirsch EC, Duyckaerts C, Javoy-Agid F, Hauw JJ, Agid Y. Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease? Ann Neurol 1990; 27: 676-82.
69. Ramón y Cajal S. Algunas observaciones favorables a la hipótesis neurotrópica. Trab Lab Invest Biol (Madrid) 1910; 8: 63-134.
70. Tello J. La influencia del neurotropismo en la regeneración de los centres nerviosos. Trab Lab Invest Biol (Madrid) 1911; 9: 123-59.
71. Bohn MC, Cupit L, Marciano F, Gash DM. Adrenal medulla grafts enhance recovery of striatal dopaminergic fibers. Science 1987; 237: 913-6.
72. Kordower JH, Goetz CG, Freeman TB, Olanow CW. Dopaminergic transplants in patients with Parkinson's disease: neuroanatomical correlates of clinical recovery. Exp Neurol 1997; 144: 41-6.
73. Kordower JH, Freeman TB, Chen EY, Mufson EJ, Sanberg PR, Hauser RA, et al. Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease. Mov Disord 1998; 13: 383-93.
74. Kordower JH, Freeman TB, Snow BJ, Vingerhoets FJ, Mufson EJ, Sandberg PR, et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 1995; 332: 118-24.
75. Kopyov OV, Jacques DS, Lieberman A, Duma CM, Rogers RL. Outcome following intrastriatal fetal mesencephalic grafts for Parkinson's patients is directly related to the volume of grafted tissue. Exp Neurol 1997; 146: 536-45.
76. Piccini P, Brooks DJ, Bjorklund A, Gunn RN, Grasby PM, Rimoldi O, et al. Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient. Nat Neurosci 1999; 2: 1137-40.
77. Ross BD, Hoang TQ, Bluml S, Dubowitz D, Kopyov OV, Jacques DB, et al. In vivo magnetic resonance spectroscopy of human fetal neural transplants. NMR Biomed 1999; 12: 221-36.
78. Bluml S, Kopyov O, Jacques S, Ross BD. Activation of neurotransplants in humans. Exp Neurol 1999; 158: 121-5.
79. Freeman TB, Vawter DE, Leaverton PE, Godbold JH, Hauser RA, Goetz CG, et al. Use of placebo surgery in controlled trials of a cellular-based therapy for Parkinson's disease. N Engl J Med 1999; 341: 988-92.
80. Freed CR, Breeze RE, Greene RE. Double-blind placebo-controlled human fetal cell transplants in advanced Parkinson's disease. Soc Neurosci 1999; 1: 212.
81. Fahn S, Greene PE, Tsai W-Y. Bouble-blind controlled trials of human embyonic dopaminergic tissue transplants in advanced Parkinson's disease: clinical outcomes. Neurology 1999; (Suppl2): A405.