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Volumn 95, Issue 11, 2000, Pages 3435-3441

Antibodies to the FVIII light-chain that neutralize FVIII procoagulant activity are present in plasma of nonresponder patients with severe hemophilia A and in normal polyclonal human IgG

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8 ANTIBODY; EPITOPE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN LIGHT CHAIN;

EID: 0034210622     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.11.3435     Document Type: Article
Times cited : (57)

References (40)
  • 1
    • 0028268941 scopus 로고
    • Incidence of factor VIII inhibitor development in hemophilia A patients treated with less pure plasma derived concentrates
    • De Biasi R, Rocino A, Papa ML, Salerno E, Mastrullo L, De Biasi D. Incidence of factor VIII inhibitor development in hemophilia A patients treated with less pure plasma derived concentrates. Thromb Haemost. 1994;7:544-547.
    • (1994) Thromb Haemost. , vol.7 , pp. 544-547
    • De Biasi, R.1    Rocino, A.2    Papa, M.L.3    Salerno, E.4    Mastrullo, L.5    De Biasi, D.6
  • 2
    • 0024995967 scopus 로고
    • Viral safety and inhibitor development associated with factor VIIIC ultrapurified from plasma in hemophiliacs previously unexposed to factor VIII concentrates
    • Lusher J, Salzman P. Viral safety and inhibitor development associated with factor VIIIC ultrapurified from plasma in hemophiliacs previously unexposed to factor VIII concentrates. Semin Hematol. 1990;27:1-7.
    • (1990) Semin Hematol. , vol.27 , pp. 1-7
    • Lusher, J.1    Salzman, P.2
  • 3
    • 0027473752 scopus 로고
    • Recombinant FVIII for the treatment of previously untreated patients with hemophilia A
    • Lusher J, Arkin S, Abilgaard C, Schwartz R. Recombinant FVIII for the treatment of previously untreated patients with hemophilia A. N Engl J Med. 1993;328:453-459.
    • (1993) N Engl J Med. , vol.328 , pp. 453-459
    • Lusher, J.1    Arkin, S.2    Abilgaard, C.3    Schwartz, R.4
  • 4
    • 0028266130 scopus 로고
    • A multicenter study of recombinant factor VIII (recombinate): Safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A
    • The Recombinate Study Group
    • Bray GL, Gomparts ED, Courter S, et al. A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group. Blood. 1994;83:2428-2435.
    • (1994) Blood , vol.83 , pp. 2428-2435
    • Bray, G.L.1    Gomparts, E.D.2    Courter, S.3
  • 5
    • 0019501541 scopus 로고
    • A survey of 215 non-hemophilic patients with inhibitors to factor VIII
    • Green D, Lechner K. A survey of 215 non-hemophilic patients with inhibitors to factor VIII. Thromb Haemast. 1981;45:200-203.
    • (1981) Thromb Haemast. , vol.45 , pp. 200-203
    • Green, D.1    Lechner, K.2
  • 7
    • 0027938488 scopus 로고
    • Healthy subjects produce both anti-factor VIII and specific anti-idiotypic antibodies
    • Gilles JG, Saint-Remy JM. Healthy subjects produce both anti-factor VIII and specific anti-idiotypic antibodies. J Clin Invest. 1994;94:1496-1505.
    • (1994) J Clin Invest. , vol.94 , pp. 1496-1505
    • Gilles, J.G.1    Saint-Remy, J.M.2
  • 8
    • 0027488655 scopus 로고
    • Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction
    • Gilles JGG, Arnout J, Vermylen J, Saint-Remy JM. Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction. Blood. 1993;82:2452-2461.
    • (1993) Blood , vol.82 , pp. 2452-2461
    • Gilles, J.G.G.1    Arnout, J.2    Vermylen, J.3    Saint-Remy, J.M.4
  • 9
    • 0024451521 scopus 로고
    • Localization of epitopes for human factor VIII inhibitior antibodies by immunoblotting and antibody neutralization
    • Scandella D, Mattingly M, de Graaf S, Fulcher CA. Localization of epitopes for human factor VIII inhibitior antibodies by immunoblotting and antibody neutralization. Blood. 1989;74:1618-1626.
    • (1989) Blood , vol.74 , pp. 1618-1626
    • Scandella, D.1    Mattingly, M.2    De Graaf, S.3    Fulcher, C.A.4
  • 10
    • 0029554015 scopus 로고
    • Epitope specificity and functional characterization of factor VIII inhibitors
    • Aledort LM, ed. New York, NY: Plenum Press
    • Scandella D, Kessler C, Esmon P, et al. Epitope specificity and functional characterization of factor VIII inhibitors. In: Aledort LM, ed. Inhibitors to Coagulation Factors. New York, NY: Plenum Press; 1995:47-63.
    • (1995) Inhibitors to Coagulation Factors , pp. 47-63
    • Scandella, D.1    Kessler, C.2    Esmon, P.3
  • 12
    • 0029008056 scopus 로고
    • Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults
    • Mouthon L, Nobrega A, Nicolas N, et al. Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults. Proc Natl Acad Sci U S A. 1995; 92:3839-3843.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3839-3843
    • Mouthon, L.1    Nobrega, A.2    Nicolas, N.3
  • 13
    • 0027250069 scopus 로고
    • A recombinant factor VIII A2 domain polypeptide quantitatively neutralizes human inhibitor antibodies that bind to A2
    • Scandella D, Mattingly M, Prescott R. A recombinant factor VIII A2 domain polypeptide quantitatively neutralizes human inhibitor antibodies that bind to A2. Blood. 1993;82:1767-1775.
    • (1993) Blood , vol.82 , pp. 1767-1775
    • Scandella, D.1    Mattingly, M.2    Prescott, R.3
  • 14
    • 0019507155 scopus 로고
    • Natural antibodies against tubulin, actin, myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera and monoclonal immunoglobulins from multiple myeloma and Waldenström's macroglobulinemia may express similar antibody specificities
    • Avrameas S, Guilbert B, Dighiero G. Natural antibodies against tubulin, actin, myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera and monoclonal immunoglobulins from multiple myeloma and Waldenström's macroglobulinemia may express similar antibody specificities. Ann Immunol (Paris). 1981;132C:231-236.
    • (1981) Ann Immunol (Paris) , vol.132 C , pp. 231-236
    • Avrameas, S.1    Guilbert, B.2    Dighiero, G.3
  • 15
    • 0020040257 scopus 로고
    • Naturally occurring antibodies against nine common antigens in normal human sera. I. Detection, isolation, and characterization
    • Guilbert B, Dighiero G, Avrameas S. Naturally occurring antibodies against nine common antigens in normal human sera. I. Detection, isolation, and characterization. J Immunol. 1982;128: 2779-2787.
    • (1982) J Immunol. , vol.128 , pp. 2779-2787
    • Guilbert, B.1    Dighiero, G.2    Avrameas, S.3
  • 16
    • 0020626714 scopus 로고
    • Auto-antibodies specific for β2-microglobulin in normal human serum
    • Vincent C, Revillard J-P. Auto-antibodies specific for β2-microglobulin in normal human serum. Mol Immunol. 1983;20:877-884.
    • (1983) Mol Immunol. , vol.20 , pp. 877-884
    • Vincent, C.1    Revillard, J.-P.2
  • 17
    • 0032124204 scopus 로고    scopus 로고
    • Self-reactive antibodies (natural autoantibodies) in healthy individuals
    • Lacroix-Desmazes S, Kaveri SV, Mouthon L, et al. Self-reactive antibodies (natural autoantibodies) in healthy individuals. J Immunol Methods. 1998;216:117-137.
    • (1998) J Immunol Methods. , vol.216 , pp. 117-137
    • Lacroix-Desmazes, S.1    Kaveri, S.V.2    Mouthon, L.3
  • 18
    • 0033564904 scopus 로고    scopus 로고
    • Normal human serum contains natural antibodies reactive with autologous ABO blood group antigens
    • Spalter SH, Kaveri S, Bonnin E, Mani JC, Kazatchkine MD. Normal human serum contains natural antibodies reactive with autologous ABO blood group antigens. Blood. 1999;93:4418-4424.
    • (1999) Blood , vol.93 , pp. 4418-4424
    • Spalter, S.H.1    Kaveri, S.2    Bonnin, E.3    Mani, J.C.4    Kazatchkine, M.D.5
  • 20
    • 0033516689 scopus 로고    scopus 로고
    • Positive selection of natural autoreactive B cells
    • Hayakawa K, Asano M, Shinton SA, et al. Positive selection of natural autoreactive B cells. Science. 1999;285:113-116.
    • (1999) Science , vol.285 , pp. 113-116
    • Hayakawa, K.1    Asano, M.2    Shinton, S.A.3
  • 22
    • 0025905663 scopus 로고
    • Natural autoantibodies: From "horror autotoxicus" to "gnothi seauton."
    • Avrameas S. Natural autoantibodies: from "horror autotoxicus" to "gnothi seauton." Immunol Today. 1991;12:154-159.
    • (1991) Immunol Today , vol.12 , pp. 154-159
    • Avrameas, S.1
  • 23
    • 0027391325 scopus 로고
    • Monoclonal IgM and IgG autoantibodies obtained after polyclonal activation show reactivities similar to those of polyclonal natural autoantibodies
    • Adib-Conquy M, Avrameas S, Teminck T. Monoclonal IgM and IgG autoantibodies obtained after polyclonal activation show reactivities similar to those of polyclonal natural autoantibodies. Molec Immunol. 1993;30:119-127.
    • (1993) Molec Immunol. , vol.30 , pp. 119-127
    • Adib-Conquy, M.1    Avrameas, S.2    Teminck, T.3
  • 24
    • 0027984654 scopus 로고
    • Anti-CD4 activity of normal human immunoglobulins G for therapeutic use. (Intravenous immunoglobulin, IVIg)
    • Hurez V, Kaveri SV, Mouhoub A, et al. Anti-CD4 activity of normal human immunoglobulins G for therapeutic use. (Intravenous immunoglobulin, IVIg). Ther Immunol. 1994;1:269-278.
    • (1994) Ther Immunol. , vol.1 , pp. 269-278
    • Hurez, V.1    Kaveri, S.V.2    Mouhoub, A.3
  • 25
    • 0030019996 scopus 로고    scopus 로고
    • Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use (IVIg)
    • Kaveri S, Vassilev T, Hurez V, et al. Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use (IVIg). J Clin Invest. 1996; 97:865-869.
    • (1996) J Clin Invest. , vol.97 , pp. 865-869
    • Kaveri, S.1    Vassilev, T.2    Hurez, V.3
  • 26
    • 0032194166 scopus 로고    scopus 로고
    • Therapeutic preparations of normal polyspecific immunoglobulin G (IVIg) induce apoptosis in human lymphocytes and monocytes: A novel mechanism of action of IVIg involving the Fas apoptotic pathway
    • Prasad N, Papoff G, Zeuner A, et al. Therapeutic preparations of normal polyspecific immunoglobulin G (IVIg) induce apoptosis in human lymphocytes and monocytes: a novel mechanism of action of IVIg involving the Fas apoptotic pathway. J Immunol. 1998;161:3781-3790.
    • (1998) J Immunol. , vol.161 , pp. 3781-3790
    • Prasad, N.1    Papoff, G.2    Zeuner, A.3
  • 27
    • 0032767113 scopus 로고    scopus 로고
    • Normal human immunoglobulin suppresses experimental myasthenia gravis in SCID mice
    • Vassilev T, Yamamoto M, Aissaoui A, et al. Normal human immunoglobulin suppresses experimental myasthenia gravis in SCID mice. Eur J Immunol. 1999;29:2436-2442.
    • (1999) Eur J Immunol. , vol.29 , pp. 2436-2442
    • Vassilev, T.1    Yamamoto, M.2    Aissaoui, A.3
  • 29
    • 0028289949 scopus 로고
    • A role for the C2 domain of factor VIII in binding to von Willebrand factor
    • Saenko EL, Shima M, Rajalakshmi KJ, Scandella D. A role for the C2 domain of factor VIII in binding to von Willebrand factor. J Biol Chem. 1994; 269:11,601-11,605.
    • (1994) J Biol Chem. , vol.269 , pp. 11601-11605
    • Saenko, E.L.1    Shima, M.2    Rajalakshmi, K.J.3    Scandella, D.4
  • 30
    • 0029966328 scopus 로고    scopus 로고
    • Kinetics of factor VIII-von Willebrand factor association
    • Vlot AJ, Koppelman SJ, Meijers JCM, et al. Kinetics of factor VIII-von Willebrand factor association. Blood. 1996;87:1809-1816.
    • (1996) Blood , vol.87 , pp. 1809-1816
    • Vlot, A.J.1    Koppelman, S.J.2    Meijers, J.C.M.3
  • 31
    • 0027457180 scopus 로고
    • A factor VIII neutralizing monoclonal antibody and a human inhibitor alloantibody recognizing epitopes in the C2 domain inhibit factor VIII binding to von Willebrand factor and to phosphatidylserine
    • Shima M, Scandella D, Yoshioka A, et al. A factor VIII neutralizing monoclonal antibody and a human inhibitor alloantibody recognizing epitopes in the C2 domain inhibit factor VIII binding to von Willebrand factor and to phosphatidylserine. Thromb Haemost. 1993;69:240-246.
    • (1993) Thromb Haemost. , vol.69 , pp. 240-246
    • Shima, M.1    Scandella, D.2    Yoshioka, A.3
  • 32
    • 0021221197 scopus 로고
    • Anti-idiotypic suppression of autoantibodies to factor VIII (antihaemophilic factor) by high-dose intravenous gammaglobulin
    • Sultan Y, Kazatchkine MD, Maisonneuve P, Nydegger UE. Anti-idiotypic suppression of autoantibodies to factor VIII (antihaemophilic factor) by high-dose intravenous gammaglobulin. Lancet. 1984;2(8406):765-768.
    • (1984) Lancet , vol.2 , Issue.8406 , pp. 765-768
    • Sultan, Y.1    Kazatchkine, M.D.2    Maisonneuve, P.3    Nydegger, U.E.4
  • 33
    • 0023792148 scopus 로고
    • Anti-idiotypes against autoantibodies and alloantibodies to factor VIII:C (anti-haemophilic factor) are present in therapeutic polyspecific normal immunoglobulins
    • Rossi F, Sultan Y, Kazatchkine MD. Anti-idiotypes against autoantibodies and alloantibodies to factor VIII:C (anti-haemophilic factor) are present in therapeutic polyspecific normal immunoglobulins. Clin Exp Immunol. 1988;74:311-316.
    • (1988) Clin Exp Immunol. , vol.74 , pp. 311-316
    • Rossi, F.1    Sultan, Y.2    Kazatchkine, M.D.3
  • 34
    • 0029920320 scopus 로고    scopus 로고
    • Neutralizing anti-idiotypic antibodies to factor VIII inhibitors after desensitization in patients with hemophilia A
    • Gilles JG, Desqueper B, Lenk H, Vermylen J, Saint-Remy JM. Neutralizing anti-idiotypic antibodies to factor VIII inhibitors after desensitization in patients with hemophilia A. J Clin Invest. 1996;97:1382-1388.
    • (1996) J Clin Invest. , vol.97 , pp. 1382-1388
    • Gilles, J.G.1    Desqueper, B.2    Lenk, H.3    Vermylen, J.4    Saint-Remy, J.M.5
  • 35
    • 0023638433 scopus 로고
    • An acquired factor VIII inhibitor responsive to high-dose gammagloblin
    • Green D, Kwaan HC. An acquired factor VIII inhibitor responsive to high-dose gammagloblin. Thromb Haemost. 1987;58:1005-1007.
    • (1987) Thromb Haemost. , vol.58 , pp. 1005-1007
    • Green, D.1    Kwaan, H.C.2
  • 37
    • 0028168261 scopus 로고
    • V region-mediated selection of autoreactive repertoires by intravenous immunoglobulin (IVIg)
    • Kazatchkine MD, Dietrich G, Hurez V, et al. V region-mediated selection of autoreactive repertoires by intravenous immunoglobulin (IVIg). Immunol Rev 1994;139:79-107.
    • (1994) Immunol Rev , vol.139 , pp. 79-107
    • Kazatchkine, M.D.1    Dietrich, G.2    Hurez, V.3
  • 38
    • 0015491722 scopus 로고
    • Specific inhibition of plaque formation to phosphorylcholine by antibody against antibody
    • Cosenza H, Kohler H. Specific inhibition of plaque formation to phosphorylcholine by antibody against antibody. Science. 1972;176: 1027-1029.
    • (1972) Science , vol.176 , pp. 1027-1029
    • Cosenza, H.1    Kohler, H.2
  • 39
    • 0027367810 scopus 로고
    • Selection of the expressed B cell repertoire by infusion of normal immunoglobulin G in a patient with autoimmune thyroiditis
    • Dietrich G, Varela FJ, Hurez V, Bouanani M, Kazatchkine MD. Selection of the expressed B cell repertoire by infusion of normal immunoglobulin G in a patient with autoimmune thyroiditis. Eur J Immunol. 1993;23:2945-2950.
    • (1993) Eur J Immunol. , vol.23 , pp. 2945-2950
    • Dietrich, G.1    Varela, F.J.2    Hurez, V.3    Bouanani, M.4    Kazatchkine, M.D.5
  • 40
    • 0018876848 scopus 로고
    • Circulating immune complexes containing anti-FVIII antibodies in multitransfused patients with haemophilia A
    • Kazatchkine MD, Sultan Y, Burton-Kee EJ, Mowbray JF. Circulating immune complexes containing anti-FVIII antibodies in multitransfused patients with haemophilia A. Clin Exp Immunol. 1980;39:315-320.
    • (1980) Clin Exp Immunol. , vol.39 , pp. 315-320
    • Kazatchkine, M.D.1    Sultan, Y.2    Burton-Kee, E.J.3    Mowbray, J.F.4


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