Neutralizing antiidiotypic antibodies to factor VIII inhibitors after desensitization in patients with hemophilia A

Journal of Clinical Investigation

Volumn 97, Issue 6, 1996, Pages 1382-1388

  Gilles, Jean Guy ^a   Desqueper, Benoît ^a   Lenk, Harald ^b   Vermylen, Jozef ^a   Saint Remy, Jean Marie ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

antiidiotypic antibodies; desensitization; Factor VIII; inhibitors; tolerance

Indexed keywords

BLOOD CLOTTING FACTOR 8 CONCENTRATE; BLOOD CLOTTING FACTOR 8 CRYOPRECIPITATE; IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PROFILATE SD 1000; RECOMBINANT BLOOD CLOTTING FACTOR 7A; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CASE REPORT; DESENSITIZATION; HEMOPHILIA A; HUMAN; IMMUNOLOGICAL TOLERANCE; INFANT; PRIORITY JOURNAL;

EID: 0029920320     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118558     Document Type: Article

References (15)

1. Schwarzinger, I., I. Pabinger, C. Korninger, F. Hasckeke, M. Kundi, H. Niessner, and K Lechner. 1987. Incidence of inhibitors in patients with severe and moderate hemophilia A treated with factor VIII concentrates. Am J. Hematol. 24:241-245.
2. McMillan, C W., S.S Shapiro, D. Whitehurst, L.W. Hoyer, A. Vijaya Rao, J. Layerson, and the hemophilia study group. 1988. The natural history of factor VII: c inhibitors in patients with hemophilia A: a national cooperative study IL Observations on the initial development of factor VIII: c inhibitors. Blood. 71:344-348.
3. Kasper, C.K., L.M. Aledort, R.B. Counts, J.R. Edson, J. Fratantone, D Green, J.W. Hempton, M.N. Hilgartner, J. Lazarson, P.H Levin, et al. 1975. A more uniform measurement of factor VIII inhibitors. Thromb. Res. 34:869-872.
4. Mariani, G., A. Ghirardini, and R. Bellocco. 1994. Immune tolerance in hemophilia: principal results from the international registry. Thromb Haemostasis. 72:155-158.
5. Gilles, J.G., and J.M.R. Saint-Remy. 1994. Healthy subjects produce both anti-factor VIII and specific antiidiotypic antibodies. J. Clin. Invest. 94:1496-1505.
6. Rossi, F., Y. Sultan, and M.D. Kazatchkine 1988. Anti-idiotypes against autoantibodies and alloantibodies to VIII.C (anti-haemophilic factor) are present in therapeutic polyspecific normal immunoglobulins. Clin. Exp. Immunol. 74:311-316
7. Sultan, Y., M.D. Kazatchkine, P. Maisonneuve, and U F. Nydegger. 1984. Anti-idiotypic suppression of auto-antibodies to factor VIII (anti-hemophilic factor) by high dose intravenous gammaglobulin. Lancet. ii:765-768.
8. Gilles, J.G G , J Arnout, J. Vermylen, and J.M.R. Saint-Remy. 1993 Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction. Blood 82:2452-2461.
9. Svendsen, L., M. Brogli, G. Lindeberg, and K Stocker. 1984 Differentiation of thrombin- and factor Xa-related amidiolytic activity in plasma by means of synthetic thrombin inhibitor. Thromb Res 34:457-464.
10. Brackmann, H., F. Etzel, P. Hoffmann, and H. Egli 1977. The successful treatment of acquired inhibitors against factor VIII. Thromb. Haemostasis. 38: 369-374.
11. Gomperts, E.D., J. Stanley, J.A. Church, R. Sakai, and J. Lemire, 1984. Induction of tolerance to FVIII in a child with a high-titer inhibitor: in vitro and in vivo observations. J Pediatr. 104.70-75.
12. Van Leeuwen, E., E. Mauser-Bunschoten, P. Van Dijken, A. Kok, E. Sjamsoendin-Visser, and J. Sixma. 1986. Disappearance of factor VIII: C antibodies in patients with haemophilia A upon frequent administration of FVIII in intermediate or low dose. Br. J. Haematol 64.291-297.
13. Mauser-Bunshoten, R., J. Nilsson, and C Kasper. 1991. Immune tolerance, a 1990 approach. In Hemophilia and von Willebrand's Disease in the 1990s. J.M. Lusher and C.M. Kessler, editors. Elsevier Science, New York. 265-271.
14. Sultan, Y., F. Rossi, and M.D. Kazatchkine. 1987. Recovery from antiVIIIc (anti-hemophilic factor) autoimmune disease is dependent on generation of anti-idiotypes against anti-VIIIc autoantibodies. Proc. Natl Acad. Sci. USA. 84:828-831.
15. Kluskens, L., and H. Kohler. 1974. Regulation of immune response by autogenous antibody against receptor Proc Natl. Acad. Sci. USA. 71 5083-5087.