Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination

Human Molecular Genetics

Volumn 9, Issue 8, 2000, Pages 1239-1244

  Badge, Richard M ^a,c   Yardley, Jane ^b   Jeffreys, Alec J ^b   Armour, John A L ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CROSSING OVER; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC RECOMBINATION; HAPLOTYPE; HUMAN; MALE; PEDIGREE ANALYSIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM REPEAT; UNINDEXED SEQUENCE;

EID: 0034194230     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.8.1239     Document Type: Article

References (33)

1. Oudet, C., Hanauer, A., Clemens, P., Caskey, T. and Mandel, J.-L. (1992) Two holspots of recombination in the DMD gene correlate with the deletion prone regions. Hum. Mol. Genet., 1, 599-603
2. Smith, R.A., Ho, P.J., Clegg, J.B., Kidd, J.R. and Thein, S.L. (1998) Recombination breakpoints in the human β globin cluster. Blood, 92, 4415-4421.
3. Chakravarti, A., Elbein, S.C. and Permutt, MA. (1986) Evidence for increased recombination near the human insulin gene: implication for disease association studies. Proc. Natl Acad. Sci. USA, 83, 1045-1049.
4. Yip, S.P., Lovegrove, J.U., Rana, N.A., Hopkinson, D.A. and Whitehouse, D.B. (1999) Mapping recombination hotspots in human phosphoglucomutase (PGM1). Hum. Mol. Genet., 8, 1699-1706.
5. Cullen, M., Erlich, H., Klitz, W. and Carrington, M. (1995) Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus. Am. J Hum. Genet., 56, 1350-1358.
6. Green, P., Falls, K. and Crooks, S. (1990) Documentation for CRI-MAP, version 2.4.
7. Broman, K.W., Murray, J.C., Sheffield, V.C., White, R.L. and Weber, J.L. (1998) Comprehensive human genetic maps: Individual and sex specific variation in recombination. Am. J. Hum. Genet., 63, 861-869.
8. Panetta, R., Greenwood, M.T., Warszynska, A., Demchyshyn, L.L., Day, R., Niznik, H.B., Srikant, C.B. and Patel, Y.C. (1994) Molecular cloning, functional characterization and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. Mol. Pharmacol., 45, 417-427.
9. 2+ channel gene family. Circ. Res., 83, 103-109.
10. Natale, D.A., Schubert, A.E. and Kowalski, D. (1992) DNA helical stability accounts for mutational defects in a yeast replication origin. Proc. Natl Acad. Sci. USA, 89, 2654-2658.
11. Sinnett, D., Woolf, E., Xie, W., Glatt, K., Kirkness, E.F., Nielsen, T.O., Zannis-Hadjopoulos, M., Price, G.B. and Lalande, M. (1996) Identification of a putative DNA replication origin in the γ-aminobutyric acid receptor subunit β3 and α5 gene cluster on human chromosome 15q11-q13, a region asociated with parental imprinting and allele specific replication timing. Gene, 173, 171-177.
12. Huang, R.-Y. and Kowalski, D. (1996) Multiple DNA elements in ARS305 determine replication origin activity. Nucleic Acids Res., 24, 816-823.
13. Munteanu, M.G., Vlahovicek, K., Parthasaraty, S., Simon, I. and Pongor, S. (1998) Rod models of DNA: sequence-dependent anisotropic elastic modelling of local bending phenomena. Trends Biochem. Sci., 23, 341-346.
14. Aoki, K., Suzuki, K., Sugano, T., Tasaka, T., Nakahara, K., Kuge, O., Omori, A. and Kasai, M. (1995) A novel gene, translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. Nature Genet., 10, 167-174.
15. Hedrick, P.W. (1987) Gametic disequilibrium measures: proceed with caution. Genetics, 117, 331-341.
16. Slatkin, M. (1994) Linkage disequilibrium in growing and stable populations. Genetics, 137, 331-336.
17. Schneider, S., Kueffer, J.-M., Roessli, D. and Excoffier, L. (1997) Arlequin v.1.1: a software for population genetic data analysis. Genetics and Biometry Laboratory, University of Geneva, Geneva, Switzerland.
18. Jeffreys, A.J., Murray, J. and Neumann, R. (1998) High resolution mapping of crossovers in human sperm defines a minisatellite-associated recombination hotspot. Mol. Cell, 2, 267-273.
19. Fullerton, S.M., Bond, J., Schneider, J.A., Hamilton, B.A., Harding, R.M., Boyce, A.J. and Clegg, J.B. (2000) Polymorphism and divergence in the β globin replication origin initiation region. Mol. Biol. Evol., 17, 179-188.
20. Dobbs, D.L., Shaiu, W.L. and Benbow, R.M. (1994) Modular sequence elements associated with origin regions in eukaryotic chromosomal DNA. Nucleic Acids Res., 22, 2479-2489.
21. Yoon, Y., Sanchez, A., Brun, C. and Huberman, J.A. (1995) Mapping of replication initiation sites in human ribosomal DNA by nascent strand abundance analysis. Mol. Cell. Biol., 15, 2482-2489.
22. Eberhart, D. and Warren, S.T. (1996) Nuclease sensitivity of permeabilized cells confirms altered chromatin formation at the fragile X locus. Somat. Cell Mol. Genet., 22, 435-441.
23. Jeffreys, A.J., Ritchie, A. and Neumann, R. (2000) High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot. Hum. Mol. Genet., 9, 725-733.
24. Smith, G.R., Kunes, S.M., Schultz, D.W., Taylor, A. and Triman, K.L. (1981) Structure of chi hotspots of generalized recombination. Cell, 24, 429-436.
25. Schuchert, P., Langsford, M., Kaslin, E. and Kohli, J. (1991) A specific DNA sequence is required for high frequency of recombination in the ade6 gene of fission yeast. EMBO J., 10, 2157-2163.
26. Edelman, W., Kroger, B., Goller, M. and Horak, I. (1989) A recombination hotspot in the LTR of a mouse retrotransposon identified in an in vitro system. Cell, 57, 937-946.
27. Zimmerer, E.J. and Passmore, H.C. (1991) Stuctural and genetic properties of the Eb recombinational hostpot in the mouse. Immunogenetics, 33, 132-140.
28. Rooney, S.M. and Moore, P.D. (1995) Antiparallel, intramolecular triplex NA stimulates homologous recombination in human cells. Proc. Natl Acad. Sci. USA, 92, 2141-2144.
29. Jeffreys, A.J., Wilson, V. and Thein, S.L. (1985) Hypervariable 'minisatellite' regions in human DNA. Nature, 314, 67-73.
30. Wahls, W.P., Wallace, L.J. and Moore, P.D. (1990) Hypervariable minisatellite DNA is a hotspot for homologous recombination in human cells. Cell, 60, 95-103.
31. Bergemann, A.D. and Johnson, E.M. (1992) The HeLa Pur factor binds single stranded DNA at specific elements conserved in gene flanking regions and origins of DNA replication. Mol. Cell. Biol., 12, 1257-1265.
32. Gale, J.M., Tobey, R.A. and D'Anna, J.A. (1992) Localization and DNA sequence of a replication origin in the rhodopsin gene locus of Chinese hamster cells. J. Mol. Biol., 224, 342-358.
33. Sander, M. and Hsieh, T. (1985) Drosophila topoisomerase II double strand cleavage: analysis of DNA sequence homology at the cleavage site. Nucleic Acids Res., 13, 1057-1072.