Heteroduplex DNA and ATP induced conformational changes of a MutS mismatch repair protein from Thermus aquaticus

Biochemical Journal

Volumn 347, Issue 3, 2000, Pages 881-886

  Biswas, Indranil ^a,b   Vijayvargia, Ravi ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Cross linking; DNA binding; Nucleotide cofactors; Proteolysis; TaqMutS

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; DNA; HETERODUPLEX; MUTANT PROTEIN; SUCCINIMIDE DERIVATIVE;

ARTICLE; BASE MISPAIRING; CONTROLLED STUDY; DNA REPAIR; GEL FILTRATION; HYDROLYSIS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; THERMUS AQUATICUS;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BASE PAIR MISMATCH; CHROMATOGRAPHY, GEL; CHYMOTRYPSIN; COENZYMES; CROSS-LINKING REAGENTS; DIMERIZATION; DNA; DNA REPAIR; DNA-BINDING PROTEINS; ESCHERICHIA COLI PROTEINS; HYDROLYSIS; MOLECULAR WEIGHT; MUTATION; MUTS DNA MISMATCH-BINDING PROTEIN; NUCLEIC ACID HETERODUPLEXES; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; SOLUTIONS; SUCCINIMIDES; THERMUS;

EID: 0034193259     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3470881     Document Type: Article

References (26)

1. 1 Modrich, P. and Lahue, R. (1996) Mismatch repair in replication fidelity, genetic recombination and cancer biology. Annu. Rev. Biochem. 65, 101-133
2. 2 Lahue, R. S., Au, K. G. and Modrich, P. (1989) DMA mismatch correction in a defined system. Science 245, 160-164
3. 3 Au, K. G., Welsh, K. and Modrich, P. (1992) Initiation of methyl directed mismatch repair. J. Biol. Chem. 267, 12142-12148
4. 4 Su, S. and Modrich, P. (1986) Escherichia coli mutS encoded protein binds to mismatched DNA base pairs. Proc. Natl. Acad. Sci. U.S.A. 83, 5057-5061
5. 5 Haber, L.-T. and Walker, G. C. (1991) Altering the conserved nucleotide binding motif in the Salmonella thyphimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities. EMBO J. 10, 2707-2715
6. 6 Welsh, K. M., Lu, A.-L., Clark, S. and Modrich, P. (1987) Isolation and characterization of Escherichia coli mutH gene product. J. Biol. Chem. 262, 15624-15629
7. 7 Alani, E. (1996) The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs. Mol. Cell Biol. 16, 5604-5615
8. 8 Alani, E., Sokolsky, T., Studamire, B., Miret, J. J. and Lahue, R. S. (1997) Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition. Mol. Cell. Bioi. 17, 2436-2447
9. 9 Studamire, B., Quach, T. and Alani, E. (1998) Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair. Mol. Cell. Biol. 18, 7590-7601
10. 10 Iaccarino, I., Marra, G., Palombo, F. and Jirieny, J. (1998) hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of the hMutSα. EMBO J. 17, 2677-2686
11. 11 Allen, D. J., Makhov, A., Grilley, M., Taylor, J., Thresher, R., Modrich, P. and Griffith, J. D. (1997) MutS mediates heteroduplex loop formation by a translocation mechanism. EMBO J. 16, 4467-4476
12. 12 Yamaguchi, M., Dao, V. and Modrich, P. (1998) MutS and MutL activates DNA helicase II in a mismatch dependent manner. J. Biol. Chem. 273, 9197-9201
13. 13 Dao, V. and Modrich, P. (1998) Mismatch. MutS, MutL and helicase II dependent unwinding from the single-strand break of an incised heteroduplex. J. Biol. Chem. 273, 9202-9207
14. 14 Blackwell, L. J., Martik, D., Bjornson, K., Bjornson, E. S. and Modrich, P. (1998) Nucleotide promoted release of hMutSα from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism. J. Biol. Chem. 273, 32055-32062
15. 15 Gradia, S., Acharya, S. and Fishel, R. (1997) The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch. Cell 91, 995-1005
16. 2-terminal region of Taq.MutS protein to the major groove of a heteroduplex DNA. J. Biol. Chem. 272, 23811-23817
17. 17 Biswas, I. and Hsieh, P. (1996) Identification and characterization of a thermostable MutS homolog from Thermus aquaticus. J. Biol. Chem. 271, 5040-5048
18. 18 Drummond, J. T., Li, G.-M., Longley, M. J. and Modrich, P. (1995) Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science 268, 1909-1912
19. 19 Biswas, I., Ban, C., Fleming, K. G., Qin, J., Lary, J. W., Yphantis, D. A., Yang, W. and Hsieh, P. (1999) Oligomerization of MutS mismatch repair protein from Thermus aquaticus. J. Biol. Chem. 274, 23673-23678
20. 20 Grilley, M., Welsh, K. M., Su, S.-S. and Modrich, P. (1989) Isolation and characterization of the Escherichia coli mutL gene product. J. Biol. Chem. 264, 1000-1004
21. 21 Schneider, E., Wilken, S. and Schmid, R. (1994) Nucleotide induced conformational changes of MalK, a bacterial ATP binding cassette transporter protein. J. Biol. Chem. 269, 20456-20461
22. 22 Csermely, P., Kagtar, J., Hollosi, M., Jalsovszky, G., Holly, S., Kahn, C., Gergehy, P., Soti, C., Mihaty, K. and Somogyi, J. (1993) ATP induces a conformational change of the 90k-Da heat shock protein (hsp90). J. Biol. Chem. 268, 1901-1907
23. 23 Sekiguchi, J. and Shuman, S. (1995) Proteolytic footprinting of Vaccinia topoisomerase bound to DNA. J. Biol. Chem. 270, 11636-11645
24. 24 Nakagawa, N., Masui, R., Kato, R. and Kuramitsu, S. (1997) Domain structure of Thermus thermophilus UvrB protein: Similarity in domain structure to a helicase. J. Biol. Chem. 272, 22703-22713
25. 25 Tachiki, H., Kato, R., Masui, R., Hasegawa, K., Itakura, H., Fukuyama, K. and Kuramitsu, S. (1998) Domain organization and functional analysis of Thermus thermophilus MutS protein. Nucleic Acid Res. 26, 4153-4159
26. 26 Wu, T.-H. and Marinus, M. G. (1994) Dominent negative mutator mutations in the mutS gene of Escherichia coli. J. Bacteriol. 176, 5393-5400