Signaling mechanisms of glucagon-like peptide 2-induced intestinal epithelial cell proliferation

Journal of Surgical Research

Volumn 90, Issue 1, 2000, Pages 13-18

  Jasleen, Jasleen ^a   Shimoda, Naoshi ^a   Shen, E Robert ^a   Tavakkolizadeh, Ali ^a   Whang, Edward E ^a   Jacobs, Danny O ^a   Zinner, Michael J ^a   Ashley, Stanley W ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Glucagon like peptide 2; Mitogen activated protein kinase; Mitogen activated extracellular signal regulated kinase; Phosphatidylinositide 3 kinase; Signal transduction; Tyrosine kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; GENISTEIN; GLUCAGON LIKE PEPTIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

CELL PROLIFERATION; CELL STRAIN CACO 2; CONFERENCE PAPER; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0034192694     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2000.5818     Document Type: Conference Paper

References (34)

1. Drucker D. J. Epithelial cell growth and differentiation. I. Intestinal growth factors. Am. J. Physiol. 273:1997;G3.
2. Hodin R. A., Meng S., Nguyen D. Immediate-early gene expression in EGF-stimulated epithelial cells. J. Surg. Res. 56:1994;500.
3. Filmus J., Shi W., Spencer T. Role of transforming growth factor alpha in the transformation of ras-transfected rat intestinal epithelial cells. Oncogene. 8:1993;1017.
4. Ko T. C., Beauchamp R. D., Townsend C. M., Thompson E. A., Thompson J. C. Transforming growth factor-β inhibits rat intestinal cell growth by regulating cell cycle specific gene expression. Am. J. Surg. 167:1994;14.
5. Dignass A. U., Tsunekawa S., Podolsky D. K. Fibroblast growth factors modulate intestinal epithelial cell growth and migration. Gastroenterology. 106:1994;1254.
6. Drucker D. J., Ehrlich P., Asa S. L., Brubaker P. L. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc. Natl. Acad. Sci. USA. 93:1996;7911.
7. Tsai C., Hill M., Asa S. L., Brubaker P. L., Drucker D. J. Intestinal growth-promoting properties of glucagon-like peptide-2 in mice. Am. J. Physiol. 273:1997;E77.
8. Drucker D. J., Ehrlich P., Asa S. L., Brubaker P. L. Induction of intestinal epithelial proliferation by glucagon like peptide 2. Proc. Natl. Acad. Sci. USA. 93:1996;7911.
9. Litvak D. A., Hellmich M. R., Evers M., Banker N. A., Townsend C. M. Glucagon-like peptide-2 is a potent growth factor for small intestine and colon. J. Gastrointest. Surg. 2:1998;146.
10. Drucker D. J., Yusta B., Boushey R. P., DeForest L., Brubaker P. L. Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis. Am. J. Physiol. 276:1999;G79.
11. Robin B. Y. B., Drucker D. J. GLP-2 reduces the mortality and morbidity in NSAID-induced murine enteritis. Gastroenterology. 116:1999;A922.
12. Bernard N., MacNaughton W., Scott R., Kirk D., Meddings J. B. Glucagon-like peptide-2 (GLP-2) accelerates healing of indomethacin-induced enteritis. Gastroenterology. 116:1999;A122.
13. Scott R. B., Kirk D., MacNaughton W. K., Meddings J. B. GLP-2 augments the adaptive response to massive intestinal resection in rat. Am. J. Physiol. 275:1998;G911.
14. Jasleen J., Severy P. B., Jacobs D. O., Zinner M. J., Ashley S. W. Glucagon-like peptide-2 stimulates intestinal epithelial cell cycle progression in vitro. Surg. Forum. 49:1998;131.
15. Dudley D., Pang L., Decker S., Bridges A., Saltiel A. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA. 92:1995;7686.
16. Alessi D. R., Cuenda A., Cohen P., Dudley D., Saltiel A. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro. J. Biol. Chem. 270:1995;27489.
17. Payne D. M., Rossomando A. K., Martino P., Ericksson A. K., Her J-H., Shabanowitz J., Hunt D. F., Weber M. J., Surgill T. W. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). EMBO J. 10:1991;885.
18. Ray L. B., Surgill T. W. Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo. Proc. Natl. Acad. Sci. USA. 85:1988;3753.
19. Neary J. T. MAPK cascades in cell growth and death. News Physiol. Sci. 12:1997;286.
20. Watanabe N., Matsuyama T., Namba M., Miuagawa J., Itoh H., Komatsu R., Kono N., Tarui S. Trophic effect of glucagon-(1-21)-peptide on the isolated rat ileal mucosal cells. Biochem. Biophys. Res. Commun. 152:1988;1038.
21. Lund P. K., Hoyt E., Simmons J. G., Ulshen M. H. Regulation of intestinal glucagon gene expression during adaptive growth of small intestine. Digestion. 54:1993;371.
22. Drucker D. J., Shi Q., Crivici A., Sumner-Smith M., Tavares W., Hill M., DeForest L., Cooper S., Brubaker P. L. Regulation of the biological activity of glucagon-like peptide-2 in vivo by dipeptidyl peptidase IV. Nat. Biotechnol. 15:1997;673.
23. Auger K. R., Serunian L. A., Soltoff S. P., Libby P., Cantley L. C. PDGF-dependent tyrosine phosphorylation stimulates production of novel phosphoinositides in intact cells. Cell. 57:1989;167.
24. Carpenter, C. L, Duckworth, B. C, Auger, K. R, Cohen, B, Schaffhausen, B. S, and, Cantley, L. C. Purification and characterization of phosphoinositide 3-kinase from rat liver, J. Biol. Chem. 265, 19704, 1990.
25. Whitman M., Downes C. P., Keller M., Keller T., Cantley L. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol 3-kinase. Nature. 332:1988;644.
26. Lane H. A., Fernandez A., Lamb N. J., Thomas G. p70s6k function is essential for G1 progression. Nature. 363:1993;170.
27. Franke T. F., Kaplan D. R., Cantley L. C. PI3K: Downstream AKTion blocks apoptosis. Cell. 88:1997;435.
28. Marais R., Wynne J., Treisman R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell. 73:1993;381.
29. Rhoads J. M., Argenzio R. A., Chen W., Rippe R. A., Westwick J. K., Cox A. D., Berschneider H. M., Brenner D. A. l-Glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Am. J. Physiol. 272:1997;G943.
30. Oliver B. L., Sha'afi R. I., Hajjar J-J. Transforming growth factor-α and epidermal growth factor activate mitogen-activated protein kinase and its substrates in intestinal epithelial cells. Exp. Bio. Med. 210:1995;162.
31. Meloche S., Seuwen K., Pages G., Pouyssegur J. Biphasic synergistic activation of p44mapk (ERK1) by growth factors: Correlation between late phase activation and mitogenicity. Mol. Endocrinol. 6:1992;845.
32. Munroe D. G., Gupta A. K., Kooshesh F., Vyas T. B., Fizkalla G., Wang H., Demchyshyn L., Yang Z., Kamboj R. K., Chen H., McCallum K., Sumner-Smith M., Drucker D. J., Crivici A. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide-2. Proc. Natl. Acad. Sci. USA. 96:1996;1569.
33. Shen K. R., Ashely S. W., Jasleen J., Tavakkolizadeh A., Zinner M. J., Whang E. E. Glucagon-like peptide-2 stimulates intestinal epithelial proliferation by decreasing intracellular cyclic AMP concentration. Surg. Forum. 50:1999;50.
34. Yusta, B, Somwar, R, Wan, F, Munroe, D, Grinstein, S, Klip, A, and, Drucker, D. J. Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor, J. Biol. Chem. 274, 30459, 1999.