Nitric oxide, glial cells and neuronal degeneration in parkinsonism

Trends in Pharmacological Sciences

Volumn 21, Issue 5, 2000, Pages 163-165

  Hirsch, Etienne C ^a   Hunot, Stéphane ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CYTOKINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

CYTOKINE RELEASE; DOPAMINERGIC NERVE CELL; GLIA CELL; HUMAN; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NONHUMAN; NOTE; PARKINSONISM; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

EID: 0034192229     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01471-1     Document Type: Short Survey

References (12)

1. McGeer P.L.et al. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology. 38:1988;1285-1291.
2. Kurkowska-Jastrzebska I.et al. The inflammatory reaction following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication in mouse. Exp. Neurol. 156:1999;50-61.
3. Liberatore G.T.et al. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat. Med. 5:1999;1403-1409.
4. Hunot S.et al. Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neuroscience. 72:1996;355-363.
5. Good P.F.et al. Protein nitration in Parkinson's disease. J. Neuropathol. Exp. Neurol. 57:1998;338-342.
6. Langston J.W.et al. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 46:1999;598-605.
7. Vingerhoets F.J.et al. Positron emission tomographic evidence for progression of human MPTP-induced dopaminergic lesions. Ann. Neurol. 36:1994;765-770.
8. Grünenwald T., Beal M.F. NOS knockouts and neuroprotection. Nat. Med. 5:1999;1403-1409.
9. Hunot S.et al. FcεRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-α in glial cells. J. Neurosci. 19:1999;3440-3447.
10. Aisen P.et al. Iron metabolism. Curr. Opin. Chem. Biol. 3:1999;200-206.
11. Hirsch E.C., Faucheux B.A. Iron metabolism and Parkinson's disease. Mov. Disord. 13(Suppl. 1):1998;39-45.
12. McGeer E.G., McGeer P.L. Brain inflammation in Alzheimer disease and the therapeutic implications. Curr. Pharm. Des. 5:1999;821-836.