Mechanisms of cytotoxicity of major anti-tumor agents and the sphingomyelin-ceramide signalling pathway;La voie sphingomyeline-ceramide dans la reponse cellulaire aux effecteurs antitumoraux

Medecine/Sciences

Volumn 12, Issue 11, 1996, Pages 1219-1227

  Levade, Thierry ^a   Jaffrézou, Jean Pierre ^b   Andrieu, Nathalie ^a   Laurent, Guy ^b  

^a CHU RANGUEIL   (France)

^b INSTITUT CLAUDIUS REGAUD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; CERAMIDE; CYTARABINE; CYTOKINE; DIACYLGLYCEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN KINASE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; TRANSCRIPTION FACTOR AP 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CELL DIFFERENTIATION; CELL METABOLISM; CELL PROLIFERATION; CYTOTOXICITY; DRUG RESISTANCE; ENZYME ACTIVATION; GENOTYPE; HYDROLYSIS; IONIZING RADIATION; NONHUMAN; ONCOGENE C JUN; RADIOSENSITIVITY; REVIEW; SIGNAL TRANSDUCTION;

EID: 0029966180     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.4267/10608/654     Document Type: Review

References (66)

1. Kolesnick RN. Sphingomyelin and derivatives as cellular signals. Prog Lipid Res 1991; 30: 1-38.
2. Devaux P, Zachowski A. Maintenance and consequences of membrane phospholipid asymmetry. Chem Phys Lipids 1994; 73: 107-20.
3. Schuchman EH, Desnick RJ. Niemann-Pick disease types A and B: acid sphingomyelinase deficiencies. In: Scriver CR, Beaudet AL, Sly WS, Valle D. The metabolic and molecular bases of inherited disease, 7th ed. New York: McGraw Hill, 1995: 2601-24.
4. Levade T, Salvayre R, Douste-Blazy L. Sphingomyelinases and Niemann-Pick disease. J Chem Clin Biochem 1986; 24: 205-20.
5. 2+-dependent, neutral sphingomyelinase in nuclei of rat ascites hepatoma cells. J Biochem 1989; 106: 593-8.
6. 3-induced HL-60 cell differentiation. J Biol Chem 1994; 269: 4070-7.
7. Obeid LM, Linardic CM, Karolak LA, Hannun YA. Programmed cell death induced by ceramide. Science 1993; 259: 1769-71.
8. Wiegmann K, Schütze S, Machleidt T, Witte D, Krönke M. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 1994; 78: 1005-15.
9. Andrieu N, Salvayre R, Levade T. Evidence against the involvement of the acid lysosomal sphingomyelinase in the tumor necrosis factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibrobasts. Biochem J 1994; 303: 341-5.
10. Andrieu N, Salvayre R, Jaffrézou JP, Levade T. Low temperatures and hypertonicity do not block cytokine-induced stimulation of the sphingomyelin pathway but inhibit nuclear factor-κB activation. J Biol Chem 1995; 270: 24518-24.
11. Wright SC, Zheng H, Zhong J. Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24). FASEB J 1996; 10: 325-32.
12. Linardic CM, Hannun YA. Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. J Biol Chem 1994; 269: 23530-7.
13. Andrieu N, Salvayre R, Levade T. Comparative study of the metabolic pools of sphingomyelin and phosphatidylcholine sensitive to tumor necrosis factor. Eur J Biochem 1996; 236: 738-45.
14. Bettaieb A, Record M, Côme MG, Bras AC, Chap H, Laurent G, Jaffrézou JP. Opposite effects of TNFα on the sphingomyelin-ceramide pathway in two myeloid leukemia cell lines: role of transverse sphingomyelin distribution in the plasma membrane. Blood 1996; 88: 1465-72.
15. Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z, Kolesnick R. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 1994; 180: 525-35.
16. Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MT, Szabo E, Zon LI, Kyriakis IM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 1996; 380: 75-9.
17. Quillet-Mary A, Mansat V, Duchayne E, Come MG, Allouche M, Bailly JD, Bordier C, Laurent G. Daunorubicin-induced inter-nucleosomal DNA fragmentation in acute myeloid cells. Leukemia 1995; 10: 417-25.
18. Jaffrézou JP, Levade T, Bettaïeb A, Andrieu N, Bezombes C, Maestre N, Vermeersch S, Rousse A, Laurent G. Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J 1996; 15: 2417-24.
19. Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z, Kolesnick RN. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signal. Cell 1995; 82: 405-14.
20. Strum JC, Small GW, Pauig SB, Daniel LW. 1-β-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells. J Biol Chem 1994; 269: 15493-7.
21. Zhang J, Alter N, Reed JC, Borner C, Obeid LM, Hannun YA. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci USA 1996; 93: 5325-8.
22. Golstein P. Deux mécanismes moléculaires pour la cytotoxixité T: perforine/ granzymes et Fas. médecine/sciences 1995; 11: 99-104.
23. Gill BM, Nishikata H, Chan G, Delovitch TL, Ochi A. Fas antigen and sphingomyelin-ceramide turnover-mediated signaling: role in life and death of T-lymphocytes. Immunol Rev 1994; 142: 113-25.
24. Cifone MC, De Maria R, Roncaioli P, Rippo MR, Azuma LLM, Lanier LL, Santoni A, Testi R. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med 1994; 177: 1547-52.
25. Tepper CG, Jayadev S, Liu B, Bielawska A, Wolff R, Yonehara S, Hannun YA, Seldin MF. Role of ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci USA 1995; 92: 8443-7.
26. Riboni L, Prinetti A, Bassi R, Caminiti A, Tettamanti G. A mediator role of ceramide in the regulation of neuroblastoma Neuro2a cell differentiation. J Biol Chem 1995; 270: 26868-75.
27. Ohta H, Yatomi Y, Sweeney EA, Hakomori S, Igarashi Y. A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-α in human neutrophils. FEBS Lett 1994; 355: 267-70.
28. Mathias S, Dressler KA, Kolesnick RN. Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor α. Proc Natl Acad Sci USA 1991; 88: 10009-13.
29. Yao B, Zhang Y, Delikat S, Mathias S, Basu S, Rolesnick RN. Phosphorylation of Raf by ceramide-activated protein kinase. Nature 1995; 378: 307-10.
30. Kahn A. La transmission du signal en amont et en aval de Ras. médecine/sciences 1992; 8: 1097-9.
31. Dobrowsky RT, Hannun YA. Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem 1992; 267: 5048-51.
32. Sawai H, Okasaki T, Yamamoto H, Okano H, Takeda Y, Tashima M, Sawada H, Okuma M, Ishikura H, Umehara H, Domae N. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. J Biol Chem 1995; 270: 27326-31.
33. Lozano J, Berra E, Municio MM, Diaz-Meco MT, Dominguez I, Sanz L, Moscat J. Protein kinase C ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase. J Biol Chem 1994; 269: 19200-2.
34. Higuchi M, Singh S, Jaffrézou JP, Aggarwal BB. Acid sphingomyelinase-generated ceramide is needed but not sufficient for tumor necrosis factor-induced apoptosis. J Immunol 1996; 157: 297-304.
35. Martin SJ, Takayama S, McGahon AJ, Miyashita T, Corbeil J, Kolesnick RN, Reed JC, Green DR. Inhibition of ceramide-induced apoptosis by Bcl-2. Cell Death Diff 1995; 26: 253-7.
36. Allouche M, Bettaieb A, Vindis C, Rousse A, Laurent G. Daunorubicin-induced apoptosis of leukemic cells: Bcl-2-mediated protection is effected downstream of the spningomyelin-ceramide pathway. Oncogene 1996 (sous presse).
37. Jarvis WDJ, Fornari FA, Browning JL, Gewirtz DA, Kolesnick RN, Grant SG. Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia Cells J Biol Chem 1994; 269: 31685-92.
38. Kolesnick R, Fuks ZJ. Ceramide: a signal for apoptosis or mitogenesis. J Exp Med 1995; 181: 1949-52.
39. Okazaki T, Bell RM, Hannun YA. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem 1989; 264: 19076-80.
40. Okazaki T, Bielawska A, Bell RM, Hannun YA. Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem 1990; 265: 15823-31.
41. Kim MY, Linardic C, Obeid L, Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J Biol Chem 1991; 266: 484-9.
42. Dressler KA, Mathias S, Kolesnick RN. Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system. Science 1992; 255: 1715-8.
43. Schutze S, Potthoff K, Machleidt T, Berkovic D, Wiegmann K, Kronke M. TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced «acidic» sphingomyelin breakdown. Cell 1992; 71: 765-76.
44. Dbaibo GS, Obeid LM, Hannun YA. Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J Biol Chem 1993; 268: 17762-6.
45. Ballou LR, Chao CP, Holness MA, Barker SC, Raghow R. Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J Biol Chem 1992; 267: 20044-50.
46. Mathias S, Younes A, Kan CC, Orlow I, Joseph C, Kolesnick RN. Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta. Science 1993; 259: 519-22.
47. Chen J, Nikolova-Karakashian M, Merrill AH Jr, Morgan ET. Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes. J Biol Chem 1995; 270: 25233-8.
48. Dobrowsky RT, Kamibayashi C, Mumby MC, Hannun YA. Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem 1993; 268: 15523-30.
49. Chan G, Ochi A. Sphingomyelin-ceramide turnover in CD28 costimulatory signaling. Eur J Immunol 1995; 25: 1999-2004.
50. Boucher LM, Wiegmann K, Futterer A, Pfeffer K, Machleidt T, Schulze S, Mak TW, Kronke M. CD28 signals through acidic sphingomyelinase [see comments]. J Exp Med 1995; 181: 2059-68.
51. Cifone MG, Roncaioli P, De Maria R, Camarda G, Santoni A, Ruberti G, Testi R. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J 1995; 14: 5859-68.
52. Niculescu F, Rus H, Shin S, Lang T, Shin ML. Generation of diacylglycerol and ceramide during homologous complement activation. J Immunol 1993; 150: 214-24.
53. Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Pushkareva MY, Obeid LM, Hannun YA. Role for ceramide in cell cycle arrest. J Biol Chem 1995; 270: 2047-52.
54. Linardic CM, Jayadev S, Hannun YA. Brefeldin A promotes hydrolysis of sphingomyelin. J Biol Chem 1992; 267: 14909-11.
55. Augé N, Andrieu N, Nègre-Salvayre A, Thiers JC, Levade T, Salvayre R. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. J Biol Chem 1996; 271: 19251-5.
56. Dobrowsky RT, Kamibayashi C, Mumby MC, Hannun YA. Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem 1993; 268: 15523-30.
57. Muller G, Ayoub M, Storz P, Rennecke J, Fabbro D, Pfizenmaier K. PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic adic. EMBO J 1995; 14: 1961-9.
58. Gulbins E, Coggeshall KM, Baier G, Telford D, Langlet C, Baier-Bitterlich G, Bonnefoy-Bevard N, Burn P, Wiltinghofer A, Altman A. Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides. Mol Cell Biol 1994; 14: 4749-58.
59. Gulbins E, Bissonnette R, Mahboubi A, Martin S, Nishioka W, Brunner T, Baier G, Baier-Bitterlich G, Byrd C, Lang F, et al. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway, Immunity 1995; 2: 341-51.
60. Belka C, Wiegmann K, Adam D, Holland R, Neuloh M, Herrmann F, Kronke M, Brach MA. Tumor necrosis factor (TNF)-alpha activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase. EMBO J 1995; 14: 1156-65.
61. Raines MA, Kolesnick RN, Golde DW. Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells. J Biol Chem 1993; 268: 14572-5.
62. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA, Brenner DA. Ceramide activates the stress-activated protein kinases. J Biol Chem 1995; 270: 22689-92.
63. Yang Z, Costanzo M, Golde DW, Kolesnick RN. Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells. J Biol Chem 1993; 268: 20520-3.
64. Dbaibo GS, Pushkareva MY, Javadev S, Schwarz JK, Horowitz JM, Obeid LM, Hannun YA. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci USA 1995; 92: 1347-51.
65. Laulederkind SJ, Bielawska A, Raghow R, Hannun YA, Ballou LR. Ceramide induces interleukin 6 gene expression in human fibroblasts. J Exp Med 1995; 182: 599-604.
66. Chang Y, Abe A, Shayman JA. Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription. Proc Natl Acad Sci USA 1995; 92: 12275-9.