Metabolism of some radiolabeled essential fatty acids in isolated rat hepatocytes is affected by dietary ethanol

Alcohol

Volumn 21, Issue 1, 2000, Pages 19-26

  Retterstøl, Kjetil ^a   Lund, Anne Marie ^a   Tverdal, Siri ^a   Cristophersen, Bjørn O ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Essential fatty acids; Ethanol; Fatty acid composition; Isolated hepatocytes; Rat

Indexed keywords

ALCOHOL; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ESSENTIAL FATTY ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; OLEIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID;

ALCOHOL CONSUMPTION; ANIMAL CELL; ARTICLE; ESTERIFICATION; FATTY ACID DESATURATION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; ISOTOPE LABELING; LIPID COMPOSITION; LIPID DIET; LIVER METABOLISM; MALE; NONHUMAN; RAT;

ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DIETARY FATS; DOCOSAHEXAENOIC ACIDS; ETHANOL; FATTY ACIDS, ESSENTIAL; LIVER; MALE; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0034190215     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0741-8329(99)00097-X     Document Type: Article

References (36)

1. Altman D.G. Practical Statistics for Medical Research. 1994;211 Chapman & Hall, London.
2. Arvidson G.A. Structural and metabolic heterogeneity of rat liver glycerophosphatides. Eur J Biochem. 4:1968;478-486.
3. Borkenhagen L.F., Kennedy E.P. The enzymatic synthesis of cytidine diphosphate choline. J Biol Chem. 227:1957;951-962.
4. Burdge G.C., Postle A.D. Effect of maternal ethanol consumption during pregnancy on the phospholipid molecular species composition of fetal guinea-pig brain, liver and plasma. Biochim Biophys Acta. 1256:1995;346-352.
5. Carrasco M.P., Sanchez-Amate M.C., Segovia J.L., Marco C. Studies on phospholipid biosynthesis in hepatocytes from alcoholic rats by using radiolabeled exogenous precursors. Lipids. 31:1996;393-397.
6. Christiansen R., Borrebaeck B., Bremer J. The effect of (-) carnitine on the metabolism of palmitate in the liver cells isolated from fasted and refed rats. FEBS Lett. 62:1976;313-317.
7. Corbett R., Menez J.F., Floch H.H., Leonard B.E. The effects of chronic ethanol administration on rat liver and erythrocyte lipid composition: modulatory role of `evening primrose oil'. Alcohol Alcohol. 26:1991;459-464.
8. Curstedt T. Biosynthesis of molecular species of hepatic glycerophosphatides during metabolism of [1,1-2H2]ethanol in rats. Biochim Biophys Acta. 713:1982;589-601.
9. Folch J.M., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem. 226:1957;497-509.
10. Gomez-Tubio A., Pita M.L., Tavares E., Murillo M.L., Delgado M.J., Carreras O. Changes in the fatty acid profile of plasma and adipose tissue in rats after long-term ethanol feeding. Alcohol Clin Exp Res. 19:1995;747-752.
11. Hagve T.A., Christophersen B.O. Linolenic acid desaturation and chain elongation and rapid turnover of phospholipid n-3 fatty acids in isolated rat liver cells. Biochim Biophys Acta. 753:1983;339-349.
12. Hirosue T., Hosogai Y. Changes of hepatic lipid and fatty acid profiles in rats administered iron-deficient diet and ethanol. Food Chem Toxicol. 31:1993;651-654.
13. Holmsen H., Glomset J.A. Acyl specificity and diacylglycerol recycling in fibroblast phospholipid metabolism stimulated with platlet-derived growth factor (PDGF). The 16th Scandinavian Symposium on Lipids, Hardanger, Norway. 1:1991;285-290 Lobo Grafisk, Oslo.
14. Lieber C.S., DeCarli L.M. The feeding of alcohol in liquid diets: two decades of applications and 1982 update. Alcohol Clin Exp Res. 6:1982;523-531.
15. Lieber C.S., DeCarli L.M. The feeding of ethanol in liquid diets. Alcohol Clin Exp Res. 10:1986;550-553.
16. Lieber C.S., Savolainen M. Ethanol and lipids. Alcohol Clin Exp Res. 8:1984;409-423.
17. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J Biol Chem. 193:1951;262-275.
18. Nanji A.A., Sadrzadeh S.M., Dannenberg A.J. Liver microsomal fatty acid composition in ethanol-fed rats: effect of different dietary fats and relationship to liver injury. Alcohol Clin Exp Res. 18:1994;1024-1028.
19. Nervi A.M., Peluffo R.O., Brenner R.R., Leikin A.I. Effect of ethanol administration on fatty acid desaturation. Lipids. 15:1980;263-268.
20. Okita M., Suzuki K., Sasagawa T., Yamamoto J., Miyamoto A., Wakabayashi H., Watanabe A. Effect of arachidonate on lipid metabolism in ethanol-treated rats fed with lard. J Nutr Sci Vitaminol (Tokyo). 43:1997;311-326.
21. Pittner R.A., Fain J.N. Ethanol is a potent stimulator of phosphatidylcholine breakdown in cultured rat hepatocytes. Biochim Biophys Acta. 1133:1992;316-320.
22. Reitz R.C. The effects of ethanol ingestion on lipid metabolism. Prog Lipid Res. 18:1979;87-115.
23. Reitz R.C. Dietary fatty acids and alcohol: effects on cellular membranes. Alcohol Alcohol. 28:1993;59-71.
24. Renkonen O. Mono- and dimethyl phosphatidates from different subtypes of choline and ethanolamine glycerophosphatides. Biochim Biophys Acta. 152:1968;114-135.
25. 14C]5,8,11-eicosatrienoic (Mead) acid in rat hepatocytes. Biochim Biophys Acta. 1259:1995;82-88.
26. Retterstol K., Woldseth B., Christophersen B.O. The metabolism of 22:5(-6) and of docosahexaenoic acid [22:6(-3)] compared in rat hepatocytes. Biochim Biophys Acta. 1303:1996;180-186.
27. Ristic V., Vrbaski S., Lalic Z., Miric M. The effect of ethanol and diazepam on the fatty acid composition of plasma and liver phospholipids in the rat. Biol Pharm Bull. 18:1995;842-845.
28. Salem N. Jr., Ohlsson N.U., Ward G., Denkins Y., Pawlosky R.J. Alcoholism and essential fatty acids. 2nd International Congress of ISSFAL. vol. 1:1995;38-39.
29. Salem N. Jr., Reyzer M., Karanian J. Losses of arachidonic acid in rat liver after alcohol inhalation. Lipids. 31:1996;S153-S156. Suppl.
30. Seenaiah B., Bichenkov E., Ellingson J.S. The effects of chronic ethanol consumption on the formation of phosphatidylethanolamine molecular species and their appearance at the plasma membrane. Alcohol Clin Exp Res. 22:1998;1245-1254.
31. Seglen P.O. Preparation of rat liver cells: 3. Enzymatic requirements for tissue dispersion. Exp Cell Res. 82:1973;391-398.
32. Sprecher H. The influence of dietary alterations, fasting and competitive interactions on the microsomal chain elongation of fatty acids. Biochim Biophys Acta. 360:1974;113-123.
33. Sprecher H. New advances in fatty-acid biosynthesis. Nutrition. 12:1996;S5-S7.
34. Venkatesan S., Rideout J.M., Simpson K.J. Microsomal delta 9, delta 6 and delta 5 desaturase activities and liver membrane fatty acid profiles in alcohol-fed rats. Biomed Chromatogr. 4:1990;234-238.
35. Wang D.L., Reitz R.C. Ethanol ingestion and polyunsaturated fatty acids: effects on the acyl-CoA desaturases. Alcohol Clin Exp Res. 7:1983;220-226.
36. Woldseth B., Christensen E., Christophersen B.O. Incorporation of stearic acid (18:0) and palmitic acid (16:0) in phospholipid molecular species studied in isolated rat liver cells. Biochim Biophys Acta. 1167:1993;296-302.