Use of polymer supported thiophenol for the synthesis and purification of a benzimidazol-2-one library

Tetrahedron Letters

Volumn 41, Issue 14, 2000, Pages 2483-2485

  Ermann, Monika ^a   Simkovsky, Nadja M ^a   Roberts, Stanley M ^a   Parry, David M ^b   Baxter, Andy D ^b   Montana, John G ^b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UCB PHARMA   (Belgium)

Author keywords

Alkylation; Molecular recognition; Supported reagents reactions

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; POLYMER; REAGENT; THIOPHENOL; UREA DERIVATIVE;

ALKYLATION; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SYNTHESIS;

EID: 0034175621     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00185-4     Document Type: Article

References (16)

1. Curran, D. P. Angew. Chem., Int. Ed. Engl. 1998, 37, 1174-1196.
2. Cheng, S.; Comer, D. D.; Williams, J. P.; Myers, P. L.; Boger, D. L. J. Am. Chem. Soc. 1996, 118, 2567-2573.
3. Booth, R. J.; Hodges, J. C. J. Am. Chem. Soc. 1997, 119, 4882-4886.
4. Flynn, D. L.; Crich, J. Z.; Devraj, R. V.; Hockerman, S. L.; Parlow, J. J.; South, M. S.; Woodard, S. J. Am. Chem. Soc. 1997, 119, 4874-4881.
5. Parlow, J. J.; Flynn, D. L. Tetrahedron 1998, 54, 4013-4031.
6. Meanwell, N. A.; Seiler, S. M. Drugs Future 1990, 15, 369-390.
7. Olesen, S.-P.; Munch, E.; Moldt, P.; Drejer, J. Eur. J. Pharmacol. 1994, 251, 53-59.
8. Vernin, G.; Domlog, H.; Siv, C.; Metzger, J.; El-Shafei, A. K. J. Heterocycl. Chem. 1981, 18, 85-89.
9. Jarrar, A. A.; Fataftah, Z. A. Tetrahedron 1977, 33, 2127-2129.
10. Pan, P.-C.; Sun, C.-M. Bioorg. Med. Chem. Lett. 1999, 9, 1537-1540.
11. Pan, P.-C.; Sun, C.-M. Tetrahedron Lett. 1999, 40, 6443-6446.
12. Wei, G. P.; Phillips, G. B. Tetrahedron Lett. 1998, 39, 179-182.
13. Meanwell, N. A.; Sit, S. Y.; Gao, J.; Wong, H. S.; Goa, Q.; Laurent, D. R. S.; Balasubramanian, N. J. Org. Chem. 1995, 60, 1565-1582.
14. Supplied by Argonaut Technologies, San Carlos, CA 94070.
15. The resins were filtered off and the solvent evaporated. The residue was acidified with 1N HCl and the resulting precipitate filtered off and dried in vacuo.
16. 4). Evaporation of the solvent yielded the bisalkylated heterocycles.