(+)-MCPG induces PKCε translocation in cortical synaptosomes through a PLD-coupled mGluR

European Journal of Neuroscience

Volumn 12, Issue 4, 2000, Pages 1310-1318

  Pastorino, Lucia ^c   Colciaghi, F ^c   Gardoni, F ^c   Albani Torregrossa, S ^a   Pellegrini Giampietro, D E ^a   Moroni, F ^a   De Graan, P N E ^b   Cattabeni, F ^c   Di Luca, M ^c  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Cortex; Nerve terminal; Rat; Signal transduction

Indexed keywords

(2[2'' CARBOXY 3' PHENYLCYCLOPROPYL]GLYCINE)13; 1 AMINO 1,5 INDANDICARBOXYLIC ACID; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; CALCIUM; CYCLOLEUCINE; GLUTAMATE RECEPTOR; ISOENZYME; MEMBRANE RECEPTOR; METABOTROPIC RECEPTOR; PHOSPHOLIPASE D; PROTEIN KINASE C; TRITIUM; UNCLASSIFIED DRUG; 1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; 1-AMINO-1,3-DICARBOXYCYCLOPENTANE; 2 (2' CARBOXY 3' PHENYLCYCLOPROPYL)GLYCINE; 2-(2'-CARBOXY-3'-PHENYLCYCLOPROPYL)GLYCINE; ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE; AMINO ACID RECEPTOR BLOCKING AGENT; BENZOIC ACID DERIVATIVE; CHELATING AGENT; CYCLOPROPANE DERIVATIVE; DRUG DERIVATIVE; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLYCINE; NEUROPROTECTIVE AGENT; PRKCE PROTEIN, RAT; PROTEIN KINASE C BETA; PROTEIN KINASE C EPSILON;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; SYNAPTOSOME; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; NERVE CELL; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BENZOATES; CEREBRAL CORTEX; CHELATING AGENTS; CYCLOLEUCINE; CYCLOPROPANES; EGTAZIC ACID; ENZYME ACTIVATION; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; ISOENZYMES; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHOLIPASE D; PRESYNAPTIC TERMINALS; PROTEIN KINASE C; PROTEIN KINASE C-EPSILON; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; SYNAPTOSOMES;

EID: 0034168998     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00023.x     Document Type: Article

References (45)

1. Alaluf, S., Mulvihill, E.R. & McIlhinney, R.A.J. (1995) Rapid agonist mediated phosphorylation of the metabotropic glutamate receptor 1 alpha by protein kinase C in permanently transfected BHK cells. FEBS Lett., 367, 301-305.
2. Albani-Torregrossa, S., Attucci, S., Marinozzi, M., Pellicciari, R., Moroni, F. & Pellegrini-Giampietro, D.E. (1999) Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase. D activation in adult rat hippocampus: focus on (2R,1′S,2′R,3′S)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine versus 3,5-dihydroxyphenylglycine. Mol. Pharmacol., in press.
3. Arcaro, A. & Wymann, M.P. (1993) Wortmannin is a potent phosphatidylinositol 3-Kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil response. Biochem. J., 296, 297-301.
4. Boss, V.K. & Conn, P.J. (1992) Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices. J. Neurochem., 59, 2340-2343.
5. Boss, V.K., Nutt, M. & Conn, P.J. (1994) L-cysteine sulphinic acid as an endogenous agonist of a novel metabotropic receptor coupled to phospholipase D activity. Mol. Pharmacol., 45, 1177-1182.
6. Bradford, M.M. (1976) A rapid and sensitive method for the quantification of microgram quantities of proteins utilizing the principle of protein dye-binding. Anal. Biochem., 72, 248-252.
7. Breakwell, N.A., Rowan, M.J. & Anwill, R. (1998) (+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor. J. Neurophysiol., 79, 1270-1276.
8. Budd, D.C. & Nicholls, D.G. (1995) Protein kinase C-mediated suppression of the presynaptic adenosine A1 receptor by a facilitatory metabotropic glutamate receptor. J. Neurochem., 65, 615-621.
9. Caputi, A., Rurale, S., Pastorino, L., Cattabeni, F. & Di Luca, M. (1996) Differential translocation of protein kinase C isozymes in rats characterized by a chronic lack of LTP induction and cognitive impairment. FEBS Lett., 393, 121-123.
10. Casabona, G., Knopfel, T., Kuhn, R., Gasparini, F., Baumann, P., Sortino, M.A., Copani, A. & Nicoletti, F. (1997) Expression and coupling to polyphosphoinositide hydrolysis of group I metabotropic glutamate receptors in early postnatal and adult rat brain. Eur. J. Neurosci., 9, 12-17.
11. Coffey, E.T., Herrero, I., Sihra, T.S., Sanchez-Prieto, J. & Nicholls, D.G. (1994) Glutamate exocytosis and MARCKS phosphorylation are enhanced by a metabotropic glutamate receptor coupled to a protein kinase C synergistically activated by diacylglycerol and arachidonic acid. J. Neurochem., 63, 1303-1310.
12. Conn, P.J. & Pin, J.P. (1997) Pharmacology and functions of metabotropic glutamate receptors. Ann. Rev. Pharmacol. Toxicol., 37, 205-237.
13. Conricode, K.M., Brewer, K.A. & Exton, J.H. (1992) Activation of phospholipase D by protein kinase C. J. Biol. Chem., 267, 7199-7202.
14. Di Luca, M., Caputi, A., Cinquanta, M., Cimino, M., Marini, P., Princivalle, A., De Graan, P.N.E., Gispen, W.H. & Cattabeni, F. (1995) Changes in protein kinase C and its presynaptic substrate B-50/GAP-43 after intrauterine exposure to methylazoxy-methanol, a treatment inducing cortical and hippocampal damage and cognitive deficit in rats. Eur. J. Neurosci., 7, 899-906.
15. Di Luca, M., Caputi, A., Cattabeni, F., De Graan, P.N.E., Gispen, W.H., Raiteri, M., Fassio, A., Schmid, G. & Bonanno, G. (1997) Increased presynaptic protein kinase C activity and glutamate release in rats with a prenatally induced hippocampal lesion. Eur. J. Neurosci., 9, 472-479.
16. Dunkley, P.R., Heath, J.W., Harrison, S.M., Jarvie, P.E., Glenfield, P.J. & Rostas, J.A. (1988) A rapid Percoll gradient procedure for isolation of synaptosomes directly from an SI fraction: homogeneity and morphology of subcellular fractions. Brain Res., 441, 59-71.
17. Exton, J.H. (1994) Phosphatidylcholine breakdown and signal transduction. Biochemica Biophysica Acta, 1212, 26-42.
18. Fitzjohn, S.M., Bortolotto, S.A., Palmer, M.J., Doherty, A.J., Ornstein, P.L., Schoepp, D.D., Kingston, A.E., Lodge, D. & Collingridge, G.L. (1998) The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology, 37, 1445-1458.
19. Fotuhi, M., Sharp, A.H., Glatt, C.E., Hwang, P.M., von Krosigk, M., Snider, S.H. & Dawson, T.M. (1993) Differential localization of phosphoinositide-linked metabotropic glutamate receptor (mGluR1) and the inositol 1,4,5-trisphosphate receptor in rat brain. J. Neurosci., 13, 2001-2012.
20. Gereau, R.W. & Heinemann, S.F. (1998) Role of protein kinase C phosphorylation I rapid desensitization of metabotropic glutamale receptor 5. Neuron, 20, 143-151.
21. Herrero, I., Miras-Portugal, M.T. & Sanchez Prieto, J. (1992) Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation. Nature, 360, 163-166.
22. 2+]c but not in cAMP mediates L-AP4 inhibition of glutamate release: PKC mediated suppression of this inhibitory pathway. Eur. J. Neurosci., 8, 700-709.
23. Herrero, I., Miras-Portugal, M.T. & Sanchez-Prieto, J. (1998) Functional switch from facilitation to inhibition in the control of glutamate release by metabotropic glutamate receptors. J. Biol. Chem., 273, 1951-1958.
24. Holler, T., Cappel, E., Klein, J. & Loffelholz, K. (1993) Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats. J. Neurochem., 61, 1569-1572.
25. Hollmann, M. & Heinemann, S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci., 17, 31-108.
26. Kinoshita, A., Ohishi, H., Neki, A., Nomura, S., Shigemoto, R., Takada, M., Nakanishi, S. & Mizuno, N. (1996) Presynaptic localization of a metabotropic glutamate receptor, and mGluR8, in the rhinencephalic areas: a light and electron microscope study in the rat. Neurosci. Lett., 207, 61-64.
27. Kinoshita, A., Shigemoto, R., Ohishi, H., Van der Putten, H. & Mizuno, N. (1998) Immunohistochemical localization of metabotropic glutamate receptors, mGluR7α and mGluR7β, in the central nervous system of the adult rat and mouse: a light and electron microscopic study. J. Comp. Neural., 393, 332-352.
28. Klein, J., Iovino, M., Vakil, M., Shinozaki, H. & Loffelholz, K. (1997) Ontogenetic and pharmacological studies on metabotropic glutamate receptors coupled to phospholipase D activation. Neuropharmacology, 36, 305-311.
29. Liu, J.P. (1996) Protein kinase C and its substrates. Mol. Cell. Endocrinol., 116, 1-29.
30. Moroni, F., Lombardi, G., Thomsen, C., Leonardi, P., Attucci, S., Peruginelli, F., Torregrossa, S.A., Pellegrini-Giampietro, D.E., Luneia, R. & Pellicciari, R. (1997) Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. J. Pharmacol. Exp. Therap., 281, 721-729.
31. Moroni, F., Cozzi, A., Lombardi, G., Sourtcheva, S., Leonardi, P., Carfi, M. & Pellicciari, R. (1998) Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex. Eur. J. Pharmacol., 347, 189-195.
32. Ohishi, H., Neki, A. & Mizuno, N. (1998) Distribution of a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat and mouse: an immunohistochemical study with a monoclonal antibody. Neurosci. Res., 30, 65-82.
33. Pachter, J.A., Pai, J.K., Mayer-Ezell, R., Petrin, J.M., Dobek, E. & Bishop, W.R. (1992) Differential regulation of phosphoinositide and phasphatidylcholine hydrolysis by protein kinase C-β1 overexpression. J. Biol. Chem., 267, 9826-9830.
34. Pellegrini-Giampietro, D.E., Albani Torregrossa, S. & Moroni, F. (1996) Pharmacological charactrization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br. J. Pharmacol., 118, 1035-1043.
35. Pellicciari, R., Costantino, G., Marinozzi, M., Natalini, B., Thomsen, C. & Moroni, F. (1998) Metabotropic glutamate receptors: new ligands and molecular modelling studies. In Moroni, F., Nicoletti, F., Pellegrini-Giampietro, D.E., (eds). Metabotropic Glutamate Receptors and Brain Functions. Portland Press, London, pp. 293-303.
36. Pellicciari, R., Luneia, R., Constantino, G., Marinozzi, M., Natalini, B., Jakobsen, P., Kanstrup, A., Lombardi, G., Moroni, F. & Thomsen, C. (1995) 1-aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J. Med. Chem., 38, 3717-3719.
37. Petralia, R.S., Wang, Y.X., Niedzielski, A.S. & Wenthold, R.J. (1996) The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localisation. Neuroscience, 71, 949-976.
38. Phillips, T., Makoff, A., Brown, S., Rees, S. & Emson, P. (1997) Localization of mGluR4 protein in the rat cerebral cortex and hippocampus. Neuroreport, 8, 3349-3354.
39. Pin, J.P. & Duvoisin, R. (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology, 34, 1-26.
40. Ramakers, G.J.M., Pasinelli, P., Di Luca, M., Pastorino, L., Cattabeni, F., Gispen, W.H. & De Graan, P.N.E. (1998) Changes in pre-and post-synaptic protein kinase C substrates phosphorylation after induction of long-term potentiation and glutamate treatment. In Moroni, F., Nicoletti, F., Pellegrini-Giampietro, D.E. (eds), Metabotropic Glutamate Receptors and Brain Functions. Portland Press, London, pp. 191-200.
41. Romano, C., Sesma, M.A., McDonald, C.T., O'Malley, K., Van der Pol, A. & Olney, J.W. (1995) Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. J. Comp. Neurol., 355, 455-469.
42. Sanchez-Prieto, J., Budd, D.C., Herrero, I., Vazquez, E. & Nicholls, D.G. (1996) Presynaptic receptors and the control of glutamate exocytosis. Trends Neurosci., 19, 235-239.
43. Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M., Flor, P.J., Neki, A., Abe, T., Nakanishi, S. & Mizuno, N. (1997) Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J. Neurosci., 17, 7503-7522.
44. Tanaka, C. & Nishizuka, Y. (1994) The protein kinase C family for neuronal signaling. Annu. Rev. Neurosci., 17, 551-567.
45. Young, S.W. (1988) Expression of three (and a putative four) protein kinase C genes in brains of rat and rabbit. J. Chem. Neuroanat., 1, 177-194.