Lymphotoxin-α-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activation

Journal of Immunology

Volumn 164, Issue 5, 2000, Pages 2508-2514

  Fu, Yang Xin ^a,b   Huang, Guangming ^a   Wang, Yang ^a   Chaplin, David D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; LYMPHOTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGICAL MEMORY; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHEEP ERYTHROCYTE; SPLEEN CELL; STRAIN DIFFERENCE;

EID: 0034163409     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.5.2508     Document Type: Article

References (28)

1. De Togni, P., J. Goellner, N. H. Ruddle, P. R. Streeter, A. Fick, S. Mariathasan, S. C. Smith, R. Carlson, L. P. Shornick, J. Strauss-Schoenberger, et al. 1994. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264:703.
2. Banks, T. A., B. T. Rouse, M. K. Kerley, P. J. Blair, V. L. Godfrey, N. A. Kuklin, D. M. Bouley, J. Thomas, S. Kanangat, and M. L. Mucenski. 1995. Lymphotoxin-α-deficient mice: effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155:1685.
3. Rennert, P. D., J. L. Browning, R. Mebius, F. Mackay, and P. S. Hochman. 1996. Surface lymphotoxin α/β complex is required for the development of peripheral lymphoid organs. J. Exp. Med. 184:1999.
4. Rennert, P. D., D. James, F. Mackay, J. L. Browning, and P. S. Hochman. 1998. Lymph node genesis is induced by signaling through the lymphotoxin β receptor. Immunity 9:71.
5. Ware, C. F., T. L. VanArsdale, P. D. Crowe, and J. L. Browning. 1995. The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol. 198:175.
6. Beutler, B. 1995. TNF, immunity and inflammatory disease: Lesson of the past decade. J. Invest. Med. 43:227.
7. Matsumoto, M., S. Mariathasan, M. H. Nahm, F. Baranyay, J. J. Peschon, and D. D. Chaplin. 1996. Role of lymphotoxin and type I TNF receptor in the formation of germinal centers. Science 271:1289.
8. Fu, Y.-X., H. Molina, M. Matsumoto, G. Huang, J. Min, and D. D. Chaplin. 1997. Lymphotoxin-α supports development of splenic follicular structure that is required for IgG responses. J. Exp. Med. 185:2111.
9. Koni, P. A., R. Sacca, P. Lawton, J. L. Browning, N. H. Ruddle, and R. A. Flavell. 1997. Distinct roles in lymphoid organogenesis for lymphotoxin α and β revealed in lymphotoxin β-deficient mice. Immunity 6:491.
10. Futterer, A., K. Mink, A. Luz, M. H. Kosco-Vilbois, and K. Pfeffer. 1998. The lympholoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9:59.
11. Fu, Y.-X., G. Huang, Y. Wang, and D. D. Chaplin. 1998. B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin-α-dependent fashion. J. Exp. Med. 187:1009.
12. Liu, Y. J. 1997. Sites of B lymphocyte selection, activation, and tolerance in spleen. J. Exp. Med. 186:625.
13. MacLennan, I. C. 1994. Germinal centers. Annu. Rev. Immunol. 12:117.
14. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature 381:751.
15. Kelsoe, G. 1996. Life and death in germinal centers (redux). Immunity 4:107.
16. Zheng, B., S. Han, and G. Kelsoe. 1996. T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J. Exp. Med. 184:1083.
17. Zheng, B., W. Xue, and G. Kelsoe. 1994. Locus-specific somatic hypermutation in germinal centre T cells. Nature 372:556.
18. Zheng, B., S. Han, Q. Zhu, R. Goldsby, and G. Kelsoe. 1996. Alternative pathways for the selection of antigen-specific peripheral T cells. Nature 384:263.
19. Nossal, G. J. 1997. B lymphocyte physiology: the beginning and the end. Ciba Found. Symp. 204:220.
20. Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493.
21. Matsumoto, M., S. F. Lo, C. J. Carruthers, J. Min, S. Mariathasan, G. Huang, D. R. Plas, S. M. Martin, R. S. Geha, M. H. Nahm, and D. D. Chaplin. 1996. Affinity maturation without germinal centers in lymphotoxin-α (LTα) deficient mice. Nature 382:462.
22. Zinkernagel, R. M., M. F. Bachmann, T. M. Kundig, S. Oehen, H. Pirchet, and H. Hengartner. 1996. On immunological memory. Annu. Rev. Immunol. 14:333.
23. Tew, J. G., J. H. Wu, D. H. Qin, S. Helm, G. F. Burton, and A. K. Szakal. 1997. Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells. Immunol. Rev. 156:39.
24. van Essen, D., H. Kikutani, and D. Gray. 1995. CD40 ligand-transduced costimulation of T cells in the development of helper function. Nature 378:620.
25. Weiss, U., and K. Rajewsky. 1990. The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response. J. Exp. Med. 172:1681.
26. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.
27. Matsumoto, M., Y.-X, Fu, H. Molina, and D. D. Chaplin. 1997. Lymphotoxin-α-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers. Immunol. Rev. 156:137.
28. Torcia, M., L. Bracci-Laudiero, M. Lucibello, L. Nencioni, D. Labardi, A. Rubartelli, F. Cozzolino, L. Aloe, and E. Garaci. 1996. Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Cell 85:345.