Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)

Genomics

Volumn 63, Issue 3, 2000, Pages 384-390

  Roth, Christina ^a   Schuierer, Marion ^a   Günther, Kalle ^b   Buettner, Reinhard ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ZINC FINGER PROTEIN;

AMINO ACID ANALYSIS; ARTICLE; CHROMOSOME 13Q; DNA BINDING; EXON; FLUORESCENCE IN SITU HYBRIDIZATION; GENE STRUCTURE; HUMAN; IN VITRO STUDY; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPRESSOR GENE; SEQUENCE ANALYSIS;

MURINAE;

EID: 0034144352     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1999.6084     Document Type: Article

References (26)

1. Bauer R., Pscherer A., Imhof A., Moser M., Kopp H., Seegers S., Kerscher M., Tainsky M. A., Hofstaedter F., Buettner R. The genomic structure of the human AP-2 gene. Nucleic Acids Res. 22:1994;1413-1420.
2. Bosher J. M., Williams T., Hurst H. C. The developmentally regulated transcription factor AP-2 is involved in c-erbB2 overexpression in human mammary carcinoma. Proc. Natl. Acad. Sci. USA. 92:1995;744-747.
3. Buettner R., Kannan P., Imhof A., Bauer R., Yim S. O., Glockshuber R., Van Dyke M. W., Tainsky M. A. An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2. Mol. Cell. Biol. 13:1993;4174-4185.
4. Byrne C., Tainsky M. A., Fuchs E. Programming gene expression in developing epidermis. Development. 120:1994;2369-2383.
5. Chazaud C., Oulad-Abdelghani M., Bouillet P., Decimo D., Chambon P., Dolle P. AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis. Mech. Dev. 54:1996;83-94.
6. Gaubatz S., Imhof A., Dosch R., Werner O., Mitchell P. J., Buettner R., Eilers M. Transcription factor AP-2 negatively regulates gene activation by myc. EMBO J. 14:1995;1508-1519.
7. Hamilton T. B., Borel F., Romaniuk P. J. Comparison of the DNA binding characteristics of the related zinc finger proteins WT-1 and EGR1. Biochemistry. 37:1998;2051-2058.
8. He G. P., Kim S., Ro H. S. Cloning and characterization of a novel zinc finger transcriptional repressor. A direct role of the zinc finger motif in repression. J. Biol. Chem. 274:1999;14678-14684.
9. Huang S., Jean D., Luca M., Tainsky M. A., Bar-Eli M. Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. EMBO J. 17:1998;4358-4369.
10. Imataka H., Sofawa K., Yasumoto K., Kikuchi Y., Sasano K., Kobayashi A., Hayami M., Fujii-Kuriyama Y. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-450 1A1 gene. EMBO J. 11:1992;3663-3671.
11. Imhof A., Schuierer M., Werner O., Moser M., Roth C., Bauer R., Buettner R. Transcriptional regulation of the AP-2α promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. Mol. Cell. Biol. 19:1999;194-204.
12. Kannan P., Buettner R., Chiao P. J., Yim S. O., Sarkiss M., Tainsky M. A. N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation. Genes Dev. 8:1994;1258-1269.
13. Karjalainen J. M., Kellokoski J. K., Eskelinen M. J., Alhava E. M., Kosma V. M. Downregulation of transcription factor AP-2 predicts poor survival in stage I cutaneous malignant melanoma. J. Clin. Oncol. 16:1998;3584-3591.
14. Kim J., Prawitt D., Bardeesy N., Torban E., Vicaner C., Goodyer P., Zabel B., Pelletier J. The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation. Mol. Cell. Biol. 19:1999;2289-2299.
15. Lichter P., Cremer T. Chromosome analysis by nonisotopic in situ hybridization. Rooney D. E., Czepulkowski B. H. Human Cytogenetics: A Practical Approach. 1992;157-192 Oxford Univ. Press, Oxford.
16. Mitchell P. J., Timmons P. M., Hebert J. M., Rigby P. W., Tjian R. Transcription factor AP-2 is expressed in neural crest lineages during mouse embryogenesis. Genes Dev. 5:1991;105-119.
17. Moser M., Pscherer A., Imhof A., Bauer R., Kerscher M., Amselgruber W., Sinowatz F., Hofstaedter F., Schüle R., Buettner R. Molecular cloning and characterization of a second AP-2 transcription activator gene, AP-2β Development. 121:1995;2779-2788.
18. Moser M., Rüschof J., Buettner R. Comparative analysis of AP-2a and AP-2β gene expression during murine embryogenesis. Dev. Dyn. 208:1997a;115-124.
19. Moser M., Pscherer A., Roth C., Becker J., Mücher G., Zerres K., Dixkens C., Weis J., Guay-Woodford L., Buettner R., Fässler R. Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2β Genes Dev. 11:1997b;1938-1948.
20. Oulad-Abdelghani M., Bouillet P., Chazaud C., Dollé P., Chambon P. AP-2.2: A novel AP-2 related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. Exp. Cell Res. 225:1996;338-347.
21. Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
22. Schorle H., Meier P., Buchert M., Jaenisch R., Mitchell P. J. Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature. 381:1996;235-238.
23. Turner B. C, Zhang J., Gumbs A. A., Maher M. G., Kaplan L., Carter D., Glazer P. M., Hurst H. C., Haffty B. G., Williams T. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Res. 58:1998;5466-5472.
24. Turner J., Crossley M. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators. EMBO J. 17:1998;5129-5140.
25. Williams T., Admon A., Lüscher B., Tjian R. Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev. 2:1988;1557-1569.
26. Zhang J., Hagopian-Donaldson S., Serbedzija G., Elsemore J., Plehn-Dujowich D., McMahon A. P., Flavell R. A., Williams T. Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature. 381:1996;238-241.