NF-κB modulates TNF-α production by alveolar macrophages in asymptomatic HIV-seropositive individuals

Journal of Immunology

Volumn 164, Issue 3, 2000, Pages 1588-1594

  Mathys, Jean Marie ^a   Melanson, Suzanne M ^a   Schiffer Alberts, Deborah J ^a   Ioannidis, John P A ^b   Koziel, Henry ^c   Skolnik, Paul R ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOMODULATION; MACROPHAGE; MALE; PATHOGENESIS; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS REPLICATION;

ADULT; CELL ADHESION; DNA-BINDING PROTEINS; FEMALE; HIV SEROPOSITIVITY; HUMANS; I-KAPPA B PROTEINS; MACROPHAGES, ALVEOLAR; MALE; MIDDLE AGED; NF-KAPPA B; PHOSPHOLIPASE C; POLYMERASE CHAIN REACTION; PRIMED IN SITU LABELING; PROSPECTIVE STUDIES; RNA, MESSENGER; SERINE PROTEINASE INHIBITORS; SIGNAL TRANSDUCTION; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 0034142379     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Murray, J. P., and J. Mills. 1990. Pulmonary injections complications of human immunodeficiency virus infection. Part I. Am. J. Respir. Dis. 141:1356.
2. Murray, J. F., and J. Mills. 1990. Pulmonary infectious complications of human immunodeficiency virus infection. Part II. Am. J. Respir. Dis. 141:1582.
3. Wallace, J. M., N. I. Hansen, L. Lavange, J. Glassroth, B. L. Browdy, M. J. Rosen, P. A. Kvale, B. T. Mangura, L. B. Reichman, P. C. Hopewell, et al. 1997. Respiratory disease trends in the pulmonary complications of HIV infection study cohort. Am. J. Respir. Crit. Care Med. 155:72.
4. Murray, J. F. 1984. Pulmonary complications of the acquired immunodeficiency syndrome. N. Engl. J. Med. 310:1682.
5. Lu, W., and D. Israel-Biet. 1993. Virion concentration in bronchoalveolar lavage fluids of HIV infected patients. Lancet 342:298.
6. Agostini, C., R. Sancetta, A. Cerutti, and G. Semenzato. 1995. Alveolar macrophages as a cell source of cytokine hyperproduction in HIV-related interstitial lung diseases. J. Leukocyte Biol. 58:495.
7. Israel-Biet, D., J. Cadranel, K. Bedjord, J. M. Andrieu, A. Jeffrey, and P. Even. 1991 Tumor necrosis factor production in HIV-seropositive subjects: relationship with lung opportunistic infections and HIV expression in alveolar macrophages J. Immunol. 147:490.
8. Lebargy, F., A. Branellec, L. Deforges, J. Bignon, and J. F. Bernaudin. 1994. HIV-1 in human alveolar macrophages from infected patients is latent in vivo but replicates after in vitro stimulation. Am. J. Res. Cell Mol. Biol. 10:72.
9. Nakata, K., M. Weiden, T. Harkin, D. Ho, and W. N. Rom. 1995. Low copy number and limited variability of proviral DNA in alveolar macrophages from HIV-infected patients; evidence for genetic differences in HIV-1 between lung and blood macrophages. Mol. Med. 1:744.
10. Nakata, K., W. N. Rom, Y. Honda, R. Condos, S. Kanegasali, Y. Cao, and M. Weiden. 1997. Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication in the lung. Am. J. Respir. Crit. Care Med. 55:996.
11. Pearce, T. E., M. Nowakowski, E. Eden, Z. B. Hung, P. Steiner, M. Shahabuddin, M. J. Potash, and D, J. Volsky. 1993. Uniform detection of HIV-1 in alveolar macrophages of pediatric but not adult AIDS patients. J. Leukocyte Biol. 53:722.
12. Cox, R. A., G. T. Anders, P. J. Cappelli, J. E. Johnson, H. M. Blanton, B. J. Seaworth, and R. L. Treasure. 1990. Production of tumor necrosis factor-α and interleukin-1 by alveolar macrophages from HIV-1 infected persons. AIDS Res. Hum. Retroviruses 6:431.
13. Du, E. J., W. J. Maury, T. M. Folks, A, S. Fauci, and A. B. Rabson. 1989. Tumor necrosis factor α activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-κB sites in the long terminal repeal. Proc. Natl. Acad. Sci. USA 86:5974.
14. Baldwin, A. S. 1996. The NFκB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14: 649.
15. Baeuerle, P. A., and D. Baltimore. 1996. NF-κB ten years after. Cell 87:13.
16. Liou, H. C., and D. Baltimore. 1993. Regulation of the NF-kappa B/Rel transcription factor and IκB inhibitor system. Curr. Opin. Cell Biol. 5:477.
17. Miyamoto, S., M. Maki, M. J. Schmitt, M. Hatanaka, and I. M. Verma. 1994. Tumor necrosis factor α-induced phosphorylation of IκBα is a signal for its degradation but not dissociation from NF-κB. Proc. Natl. Acad. Sci. USA 91: 12740.
18. Harper, J. W., K, Hemmi, and J. C. Powers. 1985. Reaction of serine proteases with isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism-based serine protease inhibitor. Biochemistry 4:2219.
19. Henkel, T., T. Machleidt, I. Alkalay, M Kronke, Y. Ben-Neriah, and P. A. Baeuerle. 1993, Rapid proteolysis of IκB-α is necessary for activation of transeription factor NF-κB. Nature 365:182.
20. Abate, A., and H. Schroder. 1998. Protease inhibitors protect macrophages from lipopolysaccharride-induced toxicity: possible role of NF-κB. Life Sci. 62:1081.
21. Pinkston, P., N. Pelletier, C. Arena, J. Schock, R. Garland, and R. M. Rose. 1995. Quantitative culture of HIV-1 from bronchoalveolar lavage cells. Am. J. Respir. Crit. Care Med. 152:254.
22. Andrews, N. C., D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limited numbers of mammalian cells. Nuc. Acids Res. 19:2499.
23. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
24. Schwartz, M. D., E. E. Moore, F. A. Moore, R. Shankar, P. Moine, J. B. Haemel, and E. Abraham. 1996. Nuclear factor-κB is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit. Care Med. 24:1285.
25. Donald, R., D. W. Ballard, and J. Hawiger. 1995. Proteolytic processing of NF-κB/IκB in human monocytes. J. Biol. Chem. 270:9.
26. Yao, J., N. Mackman, T. S. Edgington, S. T. Fan. 1997. Lipopolysaccharide induction of the tumor necrosis factor-α promoter in human monocytie cells. J. Biol. Chem. 272:17795.
27. Lo, C. J., M. Fu, and B. Kim. 1997. Macrophage TNFα mRNA expression is modulated by protease inhibitors. J. Surg. Res. 69:408.
28. Finco, T.S., A. A. Beg, and A. S. Baldwin, Jr. 1094. Inducible phosphorylation of IκB-α is not sufficient for its dissociation from NF-κB and is inhibited by protease inhibitors. Proc. Natl. Acad. Sci. USA 91:11884.
29. Cheng, J. D., R. P. Ryseck, R. M. Attar, D. Dambach, and R. Bravo. 1998. Functional redundancy of the nuclear factor KB inhibitors IκBα and IκBβ. J. Exp. Med. 188:1055.
30. Johnson, D. R., I. Douglas, A. Jahnke, S. Ghosh, and J. S. Pober. 1996. A sustained reduction in IκB-β may contribute to persistent NF-κB activation in human endothelial cells. J. Biol. Chem. 271:16317.
31. Thompson, J. E., R. J. Phillips, H. Erdjument-Bromage, P. Tempst, and S. Ghosh. 1995. IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 80:573.
32. Haas, M., S. Page, M. Page, F. J. Neumann, N. Marx, M. Adam, H. M. Ziegler-Heitbrock, D. Neumeier, and K. Brand. 1998. Effect of proteasome inhibitors on monocytie IκB-α, -β depletion, NFκB activation, and cytokine production. J. Leukoyte Biol. 63:395.
33. Lo, C. J., I. Garcia, H. G. Cryer, and R. V. Maier. 1996. Calcium and calmodulin regulate lipopolysaccharide-induced alveolar macrophage production of tumor necrosis factor and procoagulant activity. Arch. Surg. 131:44
34. Wiegmann, K., S. Schutze, T. Machleidt, D. Witte, and M. Kronke. 1994. Functional dichotomy of neutral and acidic shingomyelinases in tumor necrosis factor signaling. Cell 78:1005.
35. Carter, A. B., M. M. Monick, and G. W. Hunninghake. 1998. Lipopolysaccharide-induced NF-κB activation and cytokine release in human alveolar macrophages is PKC-independent and TK-and PLC-dependent. Am. J. Respir. Cell Mol. Biol. 18:384.
36. Tschaikowsky, K. 1994. Protein kinase C inhibitors suppress LPS-induced TNF production in AM and in whole blood: the role of encapsulation into liposomes. Biochim. Biophys. Acta 1222:113.
37. Schutze, S., K. Potthoff, T. Machleidt, D. Berkovic, K. Wiegmann, and M. Kronke. 1992. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 77:765.