Synthesis report of the step project detection of germ cell mutagens

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 353, Issue 1-2, 1996, Pages 65-84

  Adler, I D ^a   Anderson, D ^b   Benigni, R ^c   Ehling, U H ^a   Laehdetie, J ^d   Pacchierotti, F ^e   Russo, A ^f   Tates, A D ^g  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b BIBRA INTERNATIONAL   (United Kingdom)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d UNIVERSITY OF TURKU   (Finland)

^e ENEA C R CASACCIA   (Italy)

^f UNIVERSITY OF PADOVA   (Italy)

^g LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Genetic risk; Germ cell mutagen

Indexed keywords

CHLORAMBUCIL; METHYLNITROSOUREA; MITOMYCIN C; MUTAGENIC AGENT;

ANIMAL CELL; ARTICLE; CHROMOSOME ANALYSIS; GENETIC RISK; GERM CELL TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SPERMATID;

ANIMALIA;

EID: 0030010673     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0027-5107(95)00240-5     Document Type: Article

References (76)

1. Adler, I.-D. (1974) Comparative cytogenetic study after treatment of mouse spermatogonia with mitomycin C. Mutation Res., 23, 369-379.
2. Adler, I.-D. (1976) Aberration induction by mitomycin C in early primary spermatocytes of mice. Mutation Res., 35, 247-256.
3. Adler, I.-D. (1980) New approaches to mutagenicity studies in animals for carcinogenic and mutagenic agents. I. Modification of the heritable tranlocation test. Teratogenesis, Carcinogen. Mutagen., 1, 75-86.
4. Adler, I.-D. (1990) Clastogenic effects of acrylamide in different germ-cell stages of male mice, in: J.W. Allen, B.A. Bridges, M.F. Lyon, M.J. Moses and L.B. Russell (Eds.), Biology of Mammalian Germ Cell Mutagenesis, Banbury Report 34, Cold Spring Harbor Laboratory Press, New York, pp. 115-131.
5. Adler, I.-D. and D. Anderson (1994) Dominant lethal effects after inhalation exposure to 1,3-butadiene. Mutation Res., 309, 295-297.
6. Adler, I.-D., and J. Ashby (1989) The present lack of evidence for unique rodent germ cell mutagens. Mutation Res., 212, 55-66.
7. Adler, I.-D., I. Ingwersen, U. Kliesch and A. El Tarras (1988) Clastogenic effects of acrylamide in mouse bone marrow cells. Mutation Res., 206, 379-385.
8. Adler, I.-D., G. Schriever-Schwemmer and U. Kliesch (1994a) Clastogenicity of trophosphamide in somatic and germinal cells of mice. Mutation Res., 307, 229-236.
9. Adler, I.-D., P. Reitmeir, R. Schmöller and G. Schriever-Schwemmer (1994b) Dose response for heritable translocations induced by acrylamide in spermatids of mice. Mutation Res., 309, 285-291.
10. Adler, I.-D., J. Cao, J.G. Filser, P. Gassner, W. Kessler, U. Kliesch, A. Neuhäuser-Klaus and M. Nüsse (1994c) Mutagenicity of 1,3-butadiene inhalation in somatic and germinal cells of mice. Mutation Res., 309, 307-314.
11. Adler, I.-D., J.G. Filser, P. Gassner, W. Kessler, J. Schöneich and G. Schriever-Schwemmer (1995a) Heritable translocations induced by inhalation exposure of male mice to 1,3-butadiene. Mutation Res., 347, 121-127.
12. Adler, I.-D., J. Cochrane, S. Osterman-Golkar, T.R. Skopek, M. Sorsa and E. Vogel (1995b) 1,3-Butadiene working group report. Mutation Res., 330, 101-114.
13. Adler, I.D., U. Kliesch, C. Tiveron and F. Pacchierotti (1995c) Clastogenicity of diepoxibuthane in bone marrow cells and male germ cells of mice, Mutagenesis 10, 535-541.
14. Albrecht, O.E., J.G. Filser and H.G. Neumann (1993) Biological monitoring of 1,3-butadiene: species differences in haemoglobin binding in rat and mouse, in: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (Eds.), Butadiene and Styrene: Assessment of Health Hazards, IARC Scientific Publications No. 127, 135-142.
15. 1 effects in mice exposed to 1,3-butadiene, in: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (Eds.), Butadiene and Styrene: Assessment of Health Hazards. IARC Sci. Publ. No. 127, 171-181.
16. Autio, K., L. Renzi, J. Catalan, O.E. Albrecht and M. Sorsa (1994) Induction of micronuclei in peripheral blood reticulocytes and bone marrow cells of rats and mice exposed to 1,3-butadiene by inhalation. Mutation Res., 309, 315-320.
17. Bateman, A.J. (1967) A failure to detect any mutagenic action of urethane in the mouse. Mutation Res., 4, 710-712.
18. Benigni, R. and C. Andreoli (1993) Rodent carcinogenicity and toxicity, in vitro mutagenicity, and their physical chemical determinants, Mutation Res., 297, 281-292.
19. Benigni, R. and A. Giuliani (1992) QSAR studies in genetic toxicology: congeneric and noncongeneric chemicals, Arch. Toxicol., Suppl. 15, 228-237.
20. Bruce, W.R., and J.A. Heddle (1979) The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays. Can. J. Genet. Cytol., 21, 319-334.
21. Cunningham, M.J., W.N. Choy, G. Theall Arce, L.B. Rickard, D.A. Vlachos, L.A. Kinney and A.M. Sarrif (1986) In vivo sister chromatid exchange and micronucleus induction studies with 1,3-butadiene in B6C3F1 mice and Sprague-Dawley rats. Mutagenesis, 1, 449-452.
22. Dean, B.J. (1969) Chemical-induced chromosome damage. Lab. Anim., 3, 157-174.
23. Dearfield, K.L., G.D. Douglas, U.H. Ehling, M.M. Moore, G.A. Sega and D.J. Brusick (1995) Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk. Mutation Res., 330, 71-99.
24. Ehling, U.H. (1974) Differential spermatogenic response of mice to the induction of mutations by antitumor drugs. Mutation Res., 26, 285-295.
25. Ehling, U.H. and A. Neuhäuser-Klaus (1991) Induction of specific-locus and domiant lethal mutations in male mice by 1-methyl-1-nitrosourea (MNU). Mutation Res., 250, 447-456.
26. Ehling, U.H. and A. Neuhäuser-Klaus (1992) Reevaluation of the induction of specific-locus mutations in spermatogonia of the mouse by acrylamide. Mutation Res., 283, 185-191.
27. Ehling, U.H. and A. Neuhäuser-Klaus (1994) Induction of specific-locus and dominant lethal mutations in male mice by trophosphamide. Mutation Res., 307, 229-236.
28. Fahrig, R. (1977) The mammalian spot test (Fellfleckentest) with mice. Arch. Toxicol., 38, 87-98.
29. Generoso, W.M., K.T. Cain, C.C. Cornett and N.L.A. Cacheiro (1983) DNA target sites associated with chemical induction of dominant-lethal mutations and heritable translocations. In: Genetics: New Frontiers, Oxford and IBH Publ. Co., New Delhi, India, pp. 347-356.
30. Generoso, W.M., K.L. Witt, K.T. Cain, L. Hughes, A.-M.C. Lockhart and M.D. Shelby (1995) Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice. Mutation Res., 345, 167-180.
31. Green, S., A. Auletta, J. Fabricant, R. Kapp, M. Mandahar, C.-J. Sheu, J. Spinger and B. Whitfield (1985) Current status of bioassays in genetic toxicology - the dominant lethal assay. A report of the U.S. EPA GeneTox Program. Mutation Res., 154, 49-67.
32. Irons, R.D., M. Oshimura and J.C. Barrett (1987) Chromosome aberrations in mouse bone marrow cells following in vivo exposure to 1,3-butadiene. Carcinogenesis, 8, 1711-1714.
33. Kallio, M. and J. Lähdetie (1993) Analysis of micronuclei induced in mouse early spermatids by mitomycin C, vinblastine sulfate or etoposide using fluorescence in situ hybridization. Mutagenesis, 8, 561-567.
34. 1 in the male rat meiotic cycle is hypersensitive to N-methyl-N-nitrosourea induced micronucleus formation. Mutagenesis, 10, 279-285.
35. Kliesch, U., N. Danford and I.-D. Adler (1981) Micronucleus test and bone marrow chromosome analysis. A comparison of 2 methods in vivo for evaluating chemically induced chromosome aberrations. Mutation Res., 80, 321-332.
36. Lähdetie, J., A. Suutari and T. Sjöblom (1994) The spermatid micronucleus test with the dissection technique detects the germ cell mutagenicity of acrylamide in rat meiotic cells. Mutation Res,. 309, 255-262.
37. MacGregor, J.T. (1990) The in vivo erythrocyte micronucleus test: measurement at steady state increases the assay efficiency and permits integration with toxicity studies. Fund. Appl. Toxcicol., 14, 513-522.
38. Morrissey, R.E., B.A. Schwetz, P.L. Hackett, M.R. Sikov, B.D. Hardin, B.J. McClanahan, J.R. Decker and T.J. Mast (1990) Overview of reproductive and developmental toxicity studies of 1,3-butadiene in rodents. Environ. Health Perspect., 86, 79-84.
39. Nagao, T. (1987) Frequency of congenital defects and dominant lethals in the offspring of male mice treated with methylnitrosourea. Mutation Res., 177, 171-178.
40. Neuhäuser-Klaus, A. (1981) An approach towards the standardization of the mammalian spot test. Arch. Toxicol., 48, 229-243.
41. Neuhäuser-Klaus, A., and W. Schmahl (1989) Mutagenic and teratogenic effects of acrylamide in the mammalian spot test. Mutation Res., 226, 157-162.
42. Nomura, T. (1974) An analysis of the changing urethane response of the developing mouse embryo in relation to mortality, malformation and neoplasm. Cancer Res., 34, 2217-2231.
43. Nomura T. (1982) Paternal exposure to X-rays and chemicals induces heritable tumors and anomalies in mice. Nature, 296, 575-577.
44. Nomura, T (1983) A method to detect tumors and presumed somatic mutations in mice. Cancer Lett., 18, 131-135.
45. Nomura, T. (1984) Quantitative studies on mutagenesis, teratogenesis and carcinogenesis in mice, in: Y. Tazima (Ed.) Problems of Threshold in Chemical Mutagenesis, The Environmental Mutagen Society of Japan, pp. 27-34.
46. Nomura, T. (1988) X-ray- and chemically induced germ-line mutation causing phenotypical anomalies in mice. Mutation Res., 198, 309-320.
47. Otto, F.J., H. Oldiges and V.K. Jain (1984) Flow cytometry measurement of cellular DNA content dispersion induced by mutagenic treatment, in: W.G. Eisert and M.L. Mendelsohn (Eds.), Biological Dosimetry, Springer, Heidelberg, pp. 37-49.
48. Pacchierotti, F., C. Tiveron, M. D'Archivio, B. Bassani, E. Cordelli, G. Leter and M. Spano (1994) Acrylamide-induced chromosomal damage in male mouse germ cells detected by cytogenetic analysis of one-cell zygotes. Mutation Res., 309, 273-284.
49. Parvinen, M., J. Toppari and J. Lähdetie (1993) Transillumination-phase contrast microscopy techniques for evaluation of male germ cell toxicity and mutagenicity, in: R.E. Chapin and J.J. Heindel (Eds.) Male Reproductive Toxicology, Methods in Reproductive Toxicology, Vol. 3A, Academic Press, Orlando, pp. 142-165.
50. Roberts, G.T. and J.W. Allen (1980) Tissue-specific induction of sister-chromatid exchange by ethyl carbamate in mice. Environ. Mutagen., 2, 17-26.
51. Röhrborn, G., and A. Basler (1977) Cytogenetic investigations of mammals. Comparison of the genetic activity of cytostatics in mammals. Arch. Toxicol., 38, 35-43.
52. Russell, L.B. (1977) Validation of the in vivo somatic mutation method in the mouse as a prescreen for germinal mutations. Arch. Toxicol., 38, 75-85.
53. Russell, L.B., C.S. Aaron, F. de Serres, M.W. Generoso, K.L. Kannan, M. Shelby, J. Springer and P. Voitek (1984) Evaluation of mutagenicity assays for the purposes of genetic risk assessment. Mutation Res., 134, 143-157.
54. Russell, L.B., P.R. Hunsicker, E.F. Oakberg, C.C. Cummings and R.L. Schmoyer (1988) Tests for urethane induction of germ-cell mutations and germ-cell killing in the mouse. Mutation Res.. 188, 335-342.
55. Russell, L.B., P.R. Hunsicker, N.L.A. Cacheiro, J.W. Bangham, W.L. Russell and M.D. Shelby (1990) Chlorambucil is a highly effective inducer of deletion mutations in mouse germ cells. Proc. Natl. Acad. Sci., 87, 1416-1420.
56. Russell, L.B., P.R. Hunsicker, N.L.A. Cacheiro and W.M. Generoso (1991) Induction of specific locus mutations in male germ cells of the mouse by acrylamide monomer. Mutation Res., 262, 101-107.
57. Russell, W.L., and P.R. Hunsicker (1983) Extreme sensitivity of one particular germ-cell stage in male mice to induction of specific-locus mutations by methylnitrosourea. Environ. Mutagen., 5, 498.
58. Russo, A. and A.G. Levis (1992a) Further evidence for the aneuploidogenic properties of chelating agents: induction of micronuclei in mouse male germ cells by EDTA. Environ. Mol. Mutagen., 19, 125-131.
59. Russo, A. and A.G. Levis (1992b) Detection of aneuploidy in male germ cells of mice by means of a meiotic micronucleus assay. Mutation Res., 281, 187-191.
60. Russo, A., G. Gabbani and B. Simoncini (1994) Weak genotoxicity of acrylamide on premeiotic and somatic cells of the mouse. Mutation Res., 309, 263-272.
61. Shelby, M.D. (1990) Results of NTP-sponsored mouse cytogenetic studies on 1,3-butadiene, isoprene and chloroprene. Environ. Health Perspect., 86, 71-73.
62. Shelby, M.D., K.T. Cain, L.A. Hughes, P.W. Braden and W.M. Generoso (1986) Dominant lethal effects of acrylamide in male mice. Mutation Res., 173, 35-40.
63. Shelby, M.D., K.T. Cain, C.V. Cornett and W.M. Generoso, W.M. (1987) Acrylamide: induction of heritable translocations in male mice. Environ. Mol. Mutagen., 9, 362-368.
64. Shibuya, T., Murota, T., Tutikawa, K. (1982) Mouse spot test with alkylnitrosoureas. Mutation Res., 104, 311-315.
65. Smith, K.M., H. Zenick, R.J. Preston, E.L. George and R.E. Long (1986) Dominant lethal effects of subchronic acrylamide administration in the Long-Evans rat. Mutation Res., 173, 273-277.
66. Sorsa, M., K. Autio, N.A. Demopoulos, H. Järventaus, P. Rössner, R.J. Sram, G. Stephanou and D. Vlachodimitripoulos (1994) Human cytogenetic biomonitoring of occupational exposure to 1,3-butadiene. Mutation Res., 309, 321-326.
67. Spano, M., C. Bartoleschi, E. Cordelli, G. Leter, L. Segre, A. Mantovani, P. Fazzi and F. Pacchierotti (1996) Flow cytometric and histological assessment of 1,2:3,4-diepoxybutane toxicity on mouse spermatogenesis. J. Toxicol. Environ. Health, 47, 101-119.
68. Sugiyama, T., N. Veda, S. Maeda, N. Shiraishi, K. Goto-Mimura, S. Muro and C. Chattopadhyay (1981) Chemical carcinogenesis in the rat: common mode of action of carcinogens at the chromosome level. J. Natl. Cancer Inst., 67, 831-839.
69. 1- and S-phase. Mutagenesis, 7, 411-419.
70. Tates, A.D., F.J. Van Dam, F.A. DeZwart, C.M.M. Van Teylingen and A.T. Natarajan (1994) Development of a cloning assay with high cloning efficiency to detect induction of 6-thioguanine-resistant lymphocytes in spleen of adult mice following inhalation exposure to 1,3-butadiene. Mutation Res., 309, 299-306.
71. Tice, R.R., R. Boucher, C.A. Luke and M.D. Shelby (1987) Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by 1,3-butadiene. Environ. Mutagen., 9, 235-250.
72. Tutikawa, K., and Y. Harada (1972) Teratogenicity and non-mutagenicity of urethane. Teratology, 6, 123.
73. Waters, M.D., and C. Nolan (1994) Meeting report of the EC/US workshop on genetic risk assessment: 'Human genetic risk from exposure to chemical, focusing on the feasibility of the parallelogram approach'. Mutation Res., 307, 411-424.
74. West, A., A. Suutari and J. Lähdetie (1995) Detection of germ cell mutagenicity of trophosphamide by the spermatid micronucleus test in the rat. Mutagenesis, 10, 287-290.
75. Xiao, Y. and A.D. Tates (1994) Increased frequencies of micronuclei in early spermatids of rats following exposure of young primary spermatocytes to acrylamide. Mutation Res., 309, 245-254.
76. Xiao, Y. and A.D. Tates (1995) Clastogenic effects of 1,3-butadiene and its metabolites 1,2-epoxybutene and 1,2:3,4-diepoxybutane in splenocytes and germ cells of rats and mice in vivo. Env. Mol. Mutagenesis, 26, 97-108.