Rapid lupus autoantigen relocalization and reactive oxygen species accumulation following ultraviolet irradiation of human keratinocytes

Rheumatology

Volumn 39, Issue 3, 2000, Pages 253-261

  Lawley, W ^a   Doherty, A ^a   Denniss, S ^a   Chauhan, D ^a   Pruijn, G ^b   Van Venrooij, W J ^b   Lunec, J ^a   Herbert, K ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis; Autoantigen; Necrosis; Reactive oxygen species; Systemic lupus erythematosus; Ultraviolet light

Indexed keywords

AUTOANTIGEN; HOE 33342; MEMBRANE ANTIGEN; MONOCLONAL ANTIBODY; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; RO52; RO60; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; RADIATION DOSE; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION;

EID: 0034127553     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/39.3.253     Document Type: Article

References (29)

1. Peek R, Pruijn GJM, van der Kemp AJW, van Venrooij WJ. Subcellular distribution of Ro ribonucleoprotein complexes and their constituents. J Cell Sci 1993;106:929 35.
2. Pruijn GJM, Simons FHM, van Venrooij WJ. Intracellular localization and nucleocytoplasmic transport of Ro RNP components. Eur J Cell Biol 1997;74:123-32.
3. LeFeber WP, Norris DA, Ryan SR et al. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J Clin Invest 1984;74:1545-51.
4. Furukawa F, Kashihara-Sawami M, Lyons MB, Norris DA. Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus. J Invest Dermatol 1990;94:77-85.
5. Bachmann M, Chang S, Slor H, Kukulies J, Muller WEG. Shuttling of the autoantigen La between nucleus and cell surface after UV-irradiation of human keratinocytes. Exp Cell Res 1990;191:171-80.
6. Golan TD, Elkon KB, Gharavi A, Krueger JG. Enhanced membrane binding of autoantibodies to cultured human keratinocytes of systemic erythematosus patients after ultraviolet B/ ultraviolet A irradiation. J Clin Invest 1992;90:1067 76.
7. Jones SK. Ultraviolet radiation (UVR) induced cell-surface Ro/SS-A antigen expression by human keratinocytes in vitro: a possible mechanism for the UVR induction of cutaneous lupus. Br J Dermatol 1992; 126:546-53.
8. Baboonian C, Venables PJW, Booth J, Williams DG, Roffe LM, Maini RN. Virus infection induces redistribution and membrane localization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity. Clin Exp Immunol 1989;78:454-9.
9. Dorner T, Hucko M, Mayet WJ, Trefzer U, Burmester GR, Hiepe F. Enhanced membrane expression of the 52kDa Ro (SS-A) and La (SS-B) antigens by human keratinocytes induced by TNFα. Ann Rheum Dis 1995;54:904 9.
10. Zhu J. Ultraviolet B irradiation and cytomegalovirus infection synergize to induce the cell surface expression of 52kD/Ro antigen. Clin Exp Immunol 1996;103:47 53.
11. Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994;179:1317 30.
12. Henseleit U, Zhang J, Wanner R, Haase I, Kolde G, Rosenbach T. Role of p53 in UVB-induced apoptosis in human HaCaT keratinocytes. J Inv Dermatol 1997; 109:722 7.
13. Malorni W, Straface E, Donelli G, Giacomoni PU. UV-induced cytoskeletal damage, surface blebbing and apoptosis are hindered by α-tocopherol in cultured human keratinocytes. Eur J Dermatol 1996;6:414-20.
14. Utz PJ, Hottelet M, Schur PH, Andersen P. Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. J Exp Med 1997; 185:843-54.
15. Miyai E, Yanagida M, Akiyama J-I, Yamamoto I. Ascorbic acid 2-O-α glucoside, a stable form of ascorbic acid, rescues human keratinocyte cell line, SCC, from cytotoxicity of ultraviolet light. Biol Pharm Bull 1996; 19:984-7.
16. O'Connor I, O'Brien N. Modulation of UVA light-induced oxidative stress by β-carotene, lutein and astaxanthin in cultured fibroblasts. J Dermatol Sci 1998;16:226-30.
17. Lopez-Torres M, Thiele JJ, Han D, Packer L. Topical application of α tocopherol modulates the antioxidant network and diminishes ultraviolet-induced oxidative damage in murine skin. Br J Dermatol Sci 1998; 138:207-15.
18. Shindo Y, Hashimoto T. Ultraviolet B-induced cell death in four cutaneous cell lines exhibiting different enzymatic antioxidant defences: involvement of apoptosis. J Dermatol Sci 1998;17:140-50.
19. Lerner EA, Lerner MR, Janeway CA, Steiz JA. Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc Natl Acad Sci USA 1981; 78:2737-41.
20. Smith PR, Williams DG, Venables PJW, Maini RN. Monoclonal antibodies to the Sjögrcn's syndrome associated antigen SS-B (La). J Immunol Meth 1985;77:63-76.
21. Habets WJ, Hoet MH, De Jong BAW, Van Der Kemp A, van Venrooij WJ. Mapping of B cell epitopes on small nuclear ribo-nucleoproteins that react with human autoantibodies as well as with experimentally-induced mouse monoclonal antibodies. J Immunol 1989;143:2560-6.
22. Veldhoven CHA, Pruijn GJM, Meilof JF et al. Characterization of murine monoclonal antibodies against 60kD Ro/SS-A and La/SS-B autoantigens. Clin Exp Immunol 1995;101:45-54.
23. Pruijn GJM, Thijssen JPH, Smith PR, Williams DG, van Venrooij WJ. Anti-La monoclonal antibodies recognizing epitopes within the RNA binding domain of the La protein show differential capacities to immunoprecipitate RNA-associated La protein. Eur J Biochem 1995;232:611-9.
24. Schmitz M, Bachmann M, Laubinger J, Thijssen JPH, Pruijn GJM. Characterization of murine monoclonal antibodies against the Ro52 autoantigen. Clin Exp Immunol 1997;110:53-62.
25. Boyce ST, Ham RG. Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum free serial culture. J Inv Dermatol 1983;81:33s 40s.
26. Norris DA, Bennion SD, David-Bajar K. Pathomechanisms of cutaneous lupus crythematosus. In: Wallace DJ, Hannahs-Hahn B. eds. Dubois' lupus crythematosus. 5th edn. Baltimore, MD, USA: Williams & Wilkins, 1997:549 67.
27. Casiano CA, Ochs RL, Tan EM. Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes. Cell Death Diff 1998;5:183 90.
28. Anonymous. Solar and ultraviolet radiation. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 1992;55:1 290.
29. Honigsmann H, Thody AJ. Protection against ultraviolet radiation. In: Thody AJ, Friedmann PS, eds. Scientific basis of dermatology. London: Churchill Livingstone, 1986:36 57.