Viral-encoded G-protein coupled receptors: new targets for drug research?

Pharmaceutica Acta Helvetiae

Volumn 74, Issue 2-3, 2000, Pages 299-304

  Smit, Martine J ^a   Timmerman, Henk ^a   Verzijl, Dennis ^a   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

CMV; GPCR; Herpes virus; KSHV; Viral encoded G protein coupled receptor

Indexed keywords

CHEMOKINE RECEPTOR; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; RECEPTOR SUBTYPE;

CARCINOGENESIS; CEBIDAE; CONFERENCE PAPER; CYTOMEGALOVIRUS; DRUG TARGETING; ENZYME ACTIVITY; HEPATITIS B VIRUS; HERPES VIRUS; HUMAN; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 7; HUMAN HERPESVIRUS 8; PAPILLOMA VIRUS; POXVIRUS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN STRUCTURE; RETROVIRUS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ANIMALS; GTP-BINDING PROTEINS; HUMANS; RECEPTORS, CELL SURFACE; RECEPTORS, CHEMOKINE; RECEPTORS, VIRUS;

EID: 0034125551     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(99)00039-4     Document Type: Conference Paper

References (43)

1. Allen L.F., Lefkowitz R.J., Caron M.G., Cotecchia S. G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc. Natl. Acad. Sci. U.S.A. 88:1991;11354-11358.
2. Arvanitakis L., Geras-Raaka E., Varma A., Gershengorn M.C., Cesarman E. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature. 385:1997;347-350.
3. Baggiolini M. Chemokines and leukocyte traffic. Nature. 392:1998;565-568.
4. Bais C., Santomasso B., Coso O., Arvanitakis L., Raaka E.G., Gutkind J.S., Asch A.S., Cesarman E., Gerhengorn M.C., Mesri E.A. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature. 391:1998;86-89.
5. Bazan J.F., Bacon K.B., Hardiman G., Wang W., Soo K., Rossi D., Greaves D.R., Zlotnik A., Schall T.J. A new class of membrane-bound chemokine with a CX3C motif. Nature. 385:1997;640-644.
6. Beisser P.S., Vink C., Van Dam J.G., Grauls G., Vanherle S.J., Bruggeman C.A. The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an essential role in the pathogenesis of viral infection. J. Virol. 72:1998;2352-2363.
7. Beisser P.S., Grauls G., Bruggeman C.A., Vink C. Deletion of the R78 G protein-coupled receptor gene from rat cytomegalovirus results in an attenuated, syncytium-inducing mutant strain. J. Virol. 73:1999;7218-7230.
8. Bourne H.R. How receptors talk to trimeric G proteins. Curr. Opin. Cell Biol. 9:1997;134-142.
9. Campbell J.J., Bowman E.P., Murphy K., Youngman K.R., Siani M.A., Thompson D.A., Wu L., Zlotnik A., Butcher E.C. 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7. J. Cell Biol. 141:1998;1053-1059.
10. Cao J.X., Gershon P.D., Black D.N. Sequence analysis of HindIII Q2 fragment of capripoxvirus reveals a putative gene encoding a G-protein-coupled chemokine receptor homologue. Virology. 209:1995;207-212.
11. Chaudhuri A., Polyakova J., Zbrzezna V., Williams K., Gulati S., Pogo A.O. Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. Proc. Natl. Acad. Sci. U.S.A. 90:1993;10793-10797.
12. Danesh J., Newton R., Beral V. Epidemiology. A human germ project? Nature. 389:1997;21-24.
13. Davis-Poynter N.J., Lynch D.M., Vally H., Shellam G.R., Rawlinson W.D., Barrell B.G., Farrell H.E. Identification and characterization of a G protein-coupled receptor homolog encoded by murine cytomegalovirus. J. Virol. 71:1997;1521-1529.
14. Fauci A.S. Host factors and the pathogenesis of HIV-induced disease. Nature. 384:1996;529-534.
15. Ganem D. KSHV and Kaposi's sarcoma: the end of the beginning? Cell. 91:1997;157-160.
16. Gao J.L., Murphy P.M. Human cytomegalovirus open reading frame US28 encodes a functional beta chemokine receptor. J. Biol. Chem. 269:1994;28539-28542.
17. Gompels U.A., Nicholas J., Lawrence G., Jones M., Thomson B.J., Martin M.E., Efstathiou S., Craxton M., Macaulay H.A. The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution. Virology. 209:1995;29-51.
18. Grundy J.E., Lawson K.M., MacCormac L.P., Fletcher J.M., Yong K.L. Cytomegalovirus-infected endothelial cells recruit neutrophils by the secretion of C-X-C chemokines and transmit virus by direct neutrophil-endothelial cell contact and duringneutrophil transendothelial migration. J. Infect. Dis. 177:1998;1465-1474.
19. Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., Williams L.T. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature. 391:1998;799-803.
20. Gutkind J.S. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J. Biol. Chem. 273:1998;1839-1842.
21. Horuk R. Molecular properties of the chemokine receptor family. Trends Pharmacol. Sci. 15:1994;159-165.
22. Horuk R., Martin A., Hesselgesser J., Hadley T., Lu Z.H., Wang Z.X., Peiper S.C. The Duffy antigen receptor for chemokines: structural analysis and expression in the brain. J. Leukocyte Biol. 59:1996;29-38.
23. Isegawa Y., Ping Z., Nakano K., Sugimoto N., Yamanishi K. Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor. J. Virol. 72:1998;6104-6112.
24. Kirshner J.R., Staskus K., Haase A., Lagunoff M., Ganem D. Expression of the open reading frame 74 (G-protein-coupled receptor) gene of Kaposi's sarcoma (KS)-associated herpesvirus: implications for KS pathogenesis. J. Virol. 73:1999;6006-6014.
25. Kledal T.N., Rosenkilde M.M., Schwartz T.W. Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broad-spectrum receptor US28. FEBS Letters. 441:1998;209-214.
26. Leurs R., Smit M.J., Alewijnse A.E., Timmerman H. Agonist-independent regulation of constitutively active G-protein-coupled receptors. Trends Biochem. Sci. 23:1998;418-422.
27. Levy J.A. Three new human herpesviruses (HHV6, 7 and 8). Lancet. 349:1997;558-563.
28. Margulies B.J., Browne H., Gibson W. Identification of the human cytomegalovirus G protein-coupled receptor homologue encoded by UL33 in infected cells and enveloped virus particles. Virology. 225:1996;111-125.
29. Massung R.F., Jayarama V., Moyer R.W. DNA sequence analysis of conserved and unique regions of swinepox virus: identification of genetic elements supporting phenotypic observations including a novel G protein-coupled receptor homologue. Virology. 197:1993;511-528.
30. Murphy P. Pirated genes in Kaposi's sarcoma. Nature. 385:1997;296-299.
31. Nicholas J. Determination and analysis of the complete nucleotide sequence of human herpesvirus. J. Virol. 70:1996;5975-5989.
32. Nicholas J., Cameron K.R., Honess R.W. Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins. Nature. 355:1992;362-365.
33. Persoons M.C., Daemen M.J., Bruning J.H., Bruggeman C.A. Active cytomegalovirus infection of arterial smooth muscle cells in immunocompromised rats. A clue to herpesvirus-associated atherogenesis? Circ. Res. 75:1994;214-220.
34. Pleskoff O., Treboute C., Alizon M. The cytomegalovirus-encoded chemokine receptor US28 can enhance cell-cell fusion mediated by different viral proteins. J. Virol. 72:1998;6389-6397.
35. Premont R.T., Inglese J., Lefkowitz R.J. Protein kinases that phosphorylate activated G protein-coupled receptors. FASEB J. 9:1995;175-182.
36. Rawlinson W.D., Farrell H.E., Barrell B.G. Analysis of the complete DNA sequence of murine cytomegalovirus. J. Virol. 70:1996;8833-8849.
37. Rosenkilde M.M., Kledal T.N., Brauner-Osborne H., Schwartz T.W. Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74. J. Biol. Chem. 274:1999;956-961.
38. Sgadari C., Angiolillo A.L., Cherney B.W., Pike S.E., Farber J.M., Koniaris L.G., Vanguri P., Burd P.R., Sheikh N., Gupta G., Teruya-Feldstein J., Tosato G. Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo. Proc. Natl. Acad. Sci. U.S.A. 93:1996;13791-13796.
39. Spiegel A.M. Defects in G protein-coupled signal transduction in human disease. Annu. Rev. Physiol. 58:1996;143-170.
40. Tensen C.P., Flier J., Van Der Raaij-Helmer E.M., Sampat-Sardjoepersad S., Van Der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R. Human IP-9: a keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3) J. Invest. Dermatol. 112:1999;716-722.
41. van Biesen T., Luttrell L.M., Hawes B.E., Lefkowitz R.J. Mitogenic signaling via G protein-coupled receptors. Endocr. Rev. 17:1996;698-714.
42. Westphal R.S., Sanders-Bush E. Differences in agonist-independent and -dependent 5-hydroxytryptamine2C receptor-mediated cell division. Mol. Pharmacol. 49:1996;474-480.
43. Yoshida R., Imai T., Hieshima K., Kusuda J., Baba M., Kitaura M., Nishimura M., Kakizaki M., Nomiyama H., Yoshie O. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 272:1997;13803-13809.