Insulin activation of pyruvate dehydrogenase complex is enhanced by exercise training

Metabolism: Clinical and Experimental

Volumn 48, Issue 7, 1999, Pages 865-869

  Nakai, Naoya ^b   Sato, Yuzo ^b   Oshida, Yoshiharu ^b   Fujitsuka, Noriaki ^b   Yoshimura, Atsushi ^b   Shimomura, Yoshiharu ^a  

^a NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; FATTY ACID; GLUCOSE; INSULIN; PYRUVATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXERCISE; FATTY ACID OXIDATION; FEMALE; GLUCOSE OXIDATION; HORMONE ACTION; INSULIN INFUSION; INSULIN METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

EID: 0033034665     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(99)90220-2     Document Type: Article

References (34)

1. Sugden MC, Holness MJ: Interactive regulation of the pyruvate dehydrogenase complex and the carnitine palmitoyltransferase system. FASEB J 8:54-61, 1994
2. Linn TC, Pettit FH, Reed LJ: Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation. Proc Natl Acad Sci USA 62:234-241, 1969
3. Feldhoff PW, Arnold J, Oesterling B, et al: Insulin-induced activation of pyruvate dehydrogenase complex in skeletal muscle of diabetic rats. Metabolism 42:615-623, 1993
4. Fuller SJ, Randle PJ: Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal-muscle mitochondria. Effects of starvation and diabetes. Biochem J 219:635-646, 1984
5. Holness MJ, Liu Y, Sugden MC: Time courses of the responses of pyruvate dehydrogenase activities to short-term starvation in diaphragm and selected skeletal muscles of rat. Biochem J 264:771-776, 1989
6. Sugden MC, Holness MJ: Effects of re-feeding after prolonged starvation on pyruvate dehydrogenase activities in heart, diaphragm and selected skeletal muscle of the rat. Biochem J 262:669-672, 1989
7. Hagg SA, Taylor SI, Ruderman NB: Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise. Biochem J 158:203-210, 1976
8. Denyer GS, Lam D, Cooney GJ, et al: Effect of starvation and insulin in vivo on the activity of the pyruvate dehydrogenase complex in rat skeletal muscle. FEBS Lett 250:464-468, 1989
9. Houmard JA, Egan PC, Neufer PD, et al: Elevated skeletal muscle glucose transporter levels in exercise-trained middle-aged men. Am J Physiol 261:E437-E443, 1991
10. James DE, Kraegen EW, Chisholm DJ: Effect of exercise training on whole-body insulin sensitivity and responsiveness. J Appl Physiol 56:1217-1222, 1984
11. Yamanouchi K, Nakajima H, Shinozaki T, et al: Effects of daily physical activity on insulin action in the elderly. J Appl Physiol 73:2241-2245, 1992
12. Slentz CA, Gulve EA, Rodnick KJ, et al: Glucose transporters and maximal transport are increased in endurance-trained rat soleus. J Appl Physiol 73:486-492, 1992
13. Mole PA, Oscai LO, Holloszy JO: Adaptation of muscle to exercise. Increase in the levels of palmityl CoA synthetase, carnitine palmityltransferase, and palmityl CoA dehydrogenase, and in the capacity to oxidize fatty acids. J Clin Invest 50:2323-2330, 1971
14. Kerbey AL, Radcliffe PM, Randle PJ: Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A. Biochem J 164:509-519, 1977
15. Pettit FH, Pelley JW, Reed LJ: Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios. Biochem Biophys Res Commun 65:575-582, 1975
16. Harris RA, Paxton R, Parker RA: Activation of the branched-chain α-ketoacid dehydrogenase complex by a broad specificity protein phosphatase. Biochem Biophys Res Commun 107:1497-1503, 1982
17. Nakai N, Sato Y, Oshida Y, et al: Effects of aging on the activities of pyruvate dehydrogenase complex and its kinase in rat heart. Life Sci 60:2309-2314, 1997
18. Nakai N, Shimomura Y, Ohsaki N, et al: Exercise training prevents maturation-induced decrease in insulin sensitivity. J Appl Physiol 80:1963-1967, 1996
19. Morgan CR, Lazarow A: Immunoassay of insulin: Two-antibody system. Diabetes 12:115-126, 1963
20. Tubbs PK, Garland PB: Assay of coenzyme A and some acyl derivatives. Methods Enzymol 13:535-551, 1969
21. Nakai N, Collier GR, Sato Y, et al: Activities of liver pyruvate dehydrogenase complex and 3-hydroxyacyl-CoA dehydrogenase in sand rat (Psammomys obesus). Life Sci 60:51-55, 1997
22. Paxton R, Scislowski PWD, Davis EJ, et al: Role of branchedchain 2-oxo acid dehydrogenase and pyruvate dehydrogenase in 2-oxobutyrate metabolism. Biochem J 234:295-303, 1986
23. Bradshaw RA, Noyes BE: L-3-Hydroxyacyl coenzyme A dehydrogenase from pig heart muscle. Methods Enzymol 105:122-128, 1975
24. Pratt ML, Roche TE: Mechanism of pyruvate inhibition of kidney pyruvate dehydrogenase kinase and synergistic inhibition by pyruvate and ADP. J Biol Chem 254:7191-7196, 1979
25. Randle PJ, Garland PB, Hales CN, et al: The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785-789, 1963
26. Randle PJ, Priestman DA, Mistry SC, et al: Glucose fatty acid interactions and the regulation of glucose disposal. J Cell Biochem 55S:1-11, 1994 (suppl)
27. Collier GR, Traianedes K, Macaulay SL, et al: Effect of fatty acid oxidation inhibition on glucose metabolism in diabetic rats. Horm Metab Res 25:9-12, 1993
28. Holness MJ, Sugden MC: Pyruvate dehydrogenase activities during the fed-to-starved transition and on re-feeding after acute or prolonged starvation. Biochem J 258:529-533, 1989
29. Sugden MC, Orfali KA, Holness MJ: The pyruvate dehydrogenase complex: Nutrient control and the pathogenesis of insulin resistance. J Nutr 125:1746S-1752S, 1995 (suppl)
30. Kruszynska YT, McCormack, McIntyre N: Effects of glycogen stores and non-esterified fatty acid availability on insulin-stimulated glucose metabolism and tissue pyruvate dehydrogenase activity in the rat. Diabetologia 34:205-211, 1991
31. Caterson ID, Fuller SJ, Randle PJ: Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and alloxan-diabetic rats. Biochem J 208:53-60, 1982
32. French TJ, Holness MJ, MacLennan PA, et al: Effects of nutritional status and acute variation in substrate supply on cardiac and skeletal-muscle fructose 2,6-bisphosphate concentrations. Biochem J 250:773-779, 1988
33. DeFronzo RA, Jacot E, Jequier E, et al: The effect of insulin on the disposal of intravenous glucose. Diabetes 30:1000-1007, 1981
34. Thomas AP, Denton RM: Use of toluene-permeabilized mitochondria to study the regulation of adipose tissue pyruvate dehydrogenase in situ. Biochem J 238:93-101, 1986