Pre-exercise branched-chain amino acid administration increases endurance performance in rats

Medicine and Science in Sports and Exercise

Volumn 29, Issue 9, 1997, Pages 1182-1186

  Calders, Patrick ^b   Pannier, Jean Louis ^a   Matthys, Dirk M ^b   Lacroix, Eric M ^b  

^a GHENT UNIVERSITY   (Belgium)

^b NONE

Author keywords

Ammonia; Branched chain amino acids; Exercise; Time to exhaustion

Indexed keywords

AMMONIA; BRANCHED CHAIN AMINO ACID; FATTY ACID; GLUCOSE; LACTIC ACID; PLACEBO; TRYPTOPHAN;

AMMONIA BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDURANCE; EXERCISE TOLERANCE; EXHAUSTION; FEMALE; GLUCOSE BLOOD LEVEL; INTRAPERITONEAL DRUG ADMINISTRATION; MOTOR PERFORMANCE; NONHUMAN; RAT; REST; SUPPLEMENTATION; TREADMILL EXERCISE;

AMINO ACIDS, BRANCHED-CHAIN; AMMONIA; ANIMALS; EXERCISE TOLERANCE; FEMALE; PHYSICAL CONDITIONING, ANIMAL; PHYSICAL ENDURANCE; RATS; RATS, WISTAR;

EID: 0030930831     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005768-199709000-00010     Document Type: Article

References (20)

1. AHLBORG, G., P. FELIG, L. HAGENFELDT, R. HENDLER, and J. WAHREN. Substrate turnover during prolonged exercise in man: splanchnic and leg metabolism of glucose, free fatty acids and amino acids. J. Clin. Invest. 53:1080-1090, 1974.
2. BLOMSTRAND, E., F. CELSING, and E. A. NEWSHOLME. Changes in plasma concentrations of aromatic and branched-chain amino acids during sustained exercise in man and their possible role in fatigue. Acta Physiol. Scand. 133:115-121, 1988.
3. BLOMSTRAND, E., P. HASSMÉN, B. EKBLOM, and E. A. NEWSHOLME. Administration of branched-chain amino acids during sustained exercise - effects on performance and on plasma concentration of some amino acids. Eur. J. Appl. Physiol. 63:83-88, 1991.
4. BLOMSTRAND, E. Branched-chain amino acids and neurotransmission in intense efforts. In: Branched-chain amino acids: Biochemistry, Physiopathology and Clinical Science, P. Schauder, Wahren, R. Paoletti, R. Bernardi, M. Rinetti (Eds.). New York: Raven Press, 1992. pp. 31-41.
5. BOUCKAERT, J. and J. L. PANNIER. Blood ammonia response to treadmill and bicycle exercise in man. Int. J. Sports Med. 16:141-144, 1995.
6. COACKLEY, J. H., A. J. M. WAGENMAKERS, and R. H. T. EDWARDS. Relationship between ammonia, heart rate and exertion in McArdle's disease. Am. J. Physiol. 262 (Endocrinol:Metab. 25):E167-E172, 1992.
7. DAVIS, J. M., S. P. BAILEY, J. A. WOODS, F. J. GALIANO, M. T. HAMILTON, and W. P. BARTOLI. Effects of carbohydrate feedings on plasma free tryptophan and branched-chain amino acids during prolonged cycling. Eur. J. Appl. Physiol. 65:513-519, 1992.
8. DÉCOMBAZ, J., P. REINHARDT, K. ANANTHARAMAN, G. VON GLUTZ, and J. POORTMANS. Biochemical changes in a 100 km run: free amino acids, urea and creatinine. Eur. J. Appl. Physiol. 41:61-72, 1979.
9. FELIG, P. and J. WAHREN. Amino acid metabolism in exercising man. J. Clin. Invest. 50:2703-2714, 1971.
10. GRAHAM, T. E. and D. A. MACLEAN. Ammonia and amino acid metabolism in human skeletal muscle during exercise. Can. J. Physiol. Pharmacol. 70:132-141, 1992.
11. HENDERSON, S. A., A. L. BLACK, and G. A. BROOKS. Leucine turnover and oxidation in trained rats during exercise. Am. J. Physiol. 249 (Endocrinol:Metab.12): E137-E144, 1985.
12. KNAPIK, J., C. MEREDITH, B. JONES, R. FIELDING, V. YOUNG, and W. EVANS. Leucine metabolism during fasting and exercise. J. Appl. Physiol. 70:43-47, 1991.
13. MACLEAN, D. A. and T. E. GRAHAM. Branched-chain amino acid supplementation augments plasma ammonia responses during exercise in humans. J. Appl. Physiol. 74:2711-2717, 1993.
14. MACLEAN, D. A., T. E. GRAHAM, and B. SALTIN. Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise. Am. J. Physiol. 267 (Endocrinol): Metab.30):E1010-E1022, 1994.
15. MUTCH, B. J. C. and E. W. BANISTER. Ammonia metabolism in exercise and fatigue: a review. Meet. Sci. Sports Exerc. 15:41-50, 1983.
16. NEWSHOLME, E. A., E. BLOMSTRAND, and B. EKBLOM. Physical and mental fatigue: metabolic mechanisms and importance of plasma amino acids. Br. Med. Bull. 48:477-495, 1992.
17. VARNIER, M., P. SARTO, D. MARTINES, et al. Effect of infusing branched-chain amino acid during incremental exercise with reduced muscle glycogen content. Eur. J. Appl. Physiol. 69:26-31, 1994.
18. VERGER, PH., P. AYMARD, L. CYNOBERT, G. ANTON, and R. LUIGI. Effects of administration of branched-chain amino acids versus glucose during acute exercise in the rat. Physiol. Behav. 55:523-526, 1994.
19. WAGENMAKERS, A. J. M. Role of amino acids and ammonia in mechanisms of fatigue. In: Muscle fatigue mechanisms in exercise and training. P. Marconnet, P. V. Komi, B. Saltin, O. M. Sejersted (Eds). Med. Sports Sci. Basel, Karger 34:69-86, 1992.
20. WAGENMAKERS, A. J. M., J. H. COACKLEY, and R. H. T. EDWARDS. Metabolism of branched-chain amino acids and ammonia during exercise: clues from McArdle's disease. Int. J. Sports Med. 11: S101-S113, 1990.