Specific amino acid changes enhance the anti-recombination activity of the UmuD'C complex

Molecular Microbiology

Volumn 35, Issue 6, 2000, Pages 1443-1453

  Sommer, Suzanne ^a   Coste, Geneviève ^a   Bailone, Adriana ^a  

^a INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACTERIAL PROTEIN; MITOMYCIN;

ARTICLE; CELL KILLING; DNA DAMAGE; GENE MUTATION; GENETIC RECOMBINATION; PRIORITY JOURNAL;

AMINO ACIDS; BACTERIAL PROTEINS; DNA DAMAGE; DNA REPAIR; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MITOMYCIN; MUTATION; PLASMIDS; REC A RECOMBINASES; RECOMBINATION, GENETIC; ULTRAVIOLET RAYS;

BACTERIA (MICROORGANISMS);

EID: 0034120803     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.01809.x     Document Type: Article

References (40)

1. Attfield, P.V., and Pinney, R.J. (1984) Comparison of the Escherichia coli umu' -encoded function with plasmid R46-mediated error-prone repair in DNA-damaged cells. Mutat Res 139: 101-105.
2. Bacher Reuven, N., Tomer, G., and Livneh, Z. (1998) The mutagenesis proteins UmuD′ and UmuC prevent lethal frame-shifts while increasing base substitution mutations. Mol Cell 2: 191-199.
3. Bailone, A., Sommer, S., Knezevic, J., Dutreix, M., and Devoret, R. (1991) A RecA protein mutant deficient in its interaction with the UmuDC complex. Biochimie 73: 479-484.
4. Boudsocq, F., Campbell, M., Devoret, R., and Bailone, A. (1997) Quantitation of the inhibition of Hfr × F recombination by the mutagenesis complex UmuD'C. J Mol Biol 270: 201-211.
5. Bruck, I., Woodgate, R., McEntee, K., and Goodman, M.F. (1996) Purification of a soluble UmuD'C complex from Escherichia coli. Cooperative binding of UmuD'C to single-stranded DNA. J Biol Chem 271: 10767-10774.
6. Churchward, G., Belin, D., and Nagamine, Y. (1984) A pSC101-derived plasmid which shows no sequence homology to other commonly used cloning vectors. Gene 31: 165-171.
7. Clark, A.J., and Low, K.B. (1988) Pathways and systems of homologous recombination in Escherichia coli. In The Recombination of Genetic Material. Low, K.B. (ed.). San Diego: Academic Press, pp. 155-215.
8. Dri, A.M., Rouvière-Yaniv, J., and Moreau, P.L. (1991) Inhibition of cell division in hupA hupB mutant bacteria lacking HU protein. J Bacteriol 173: 2852-2863.
9. Dutreix, M., Moreau, P.L., Bailone, A., Galibert, F., Battista, J.R., Walker, G.C., et al. (1989) New recA mutations that dissociate the various RecA protein activities in Escherichia coli provide evidence for an additional role for RecA protein in UV-mutagenesis. J Bacteriol 171: 2415-2423.
10. Ferentz, A.E., Opperman, T., Walker, G.C., and Wagner, G. (1997) Dimerization of the UmuD′ protein in solution and its implications for regulation of SOS mutagenesis. Nature Struct Biol 4: 979-983.
11. Frank, E.G., Hauser, J., Levine, A.S., and Woodgate, R. (1993) Targeting of the UmuD, UmuD′ and MucA′ mutagenesis proteins to DNA by RecA protein. Proc Natl Acad Sci USA 90: 8169-8173.
12. Freitag, N., and McEntee, K. (1989) "Activated"-RecA protein affinity chromatography of LexA repressor and other SOS-regulated proteins. Proc Natl Acad Sci USA 86: 8363-8367.
13. Goodman, M.F. (1998) Purposeful mutations. Nature 395: 221-223.
14. Howard-Flanders, P., Rupp, W.D., Wilkins, B.M., and Cole, R.S. (1968) DNA replication and recombination after UV-irradiation. Cold Spring Harbor Symp Quant Biology 33: 195-305.
15. Iyer, V.N., and Szybalski, W. (1963) A molecular mechanism of mitomycin action: linking of complementary DNA strands. Proc Natl Acad Sci USA 50: 355-362.
16. Leach, D.R.F., Okely, E.A., and Pinder, D.J. (1997) Repair by recombination of DNA containing a palindromic sequence. Mol Microbiol 26: 597-606.
17. Little, J.W. (1993) LexA cleavage and other self-processing reactions. J Bacteriol 175: 4943-4950.
18. Manis, J.J., and Kline, B.C. (1977) Restriction endonuclease mapping and mutagenesis of the F sex factor replication region. Mol Gen Genet 152: 175-182.
19. McLenigan, M., Peat, T.S., Frank, E.G., McDonald, J.P., Gonzalez, M., Levine, A.S., et al. (1998) Novel Escherichia coli umuD÷ mutants: structure-function insights into SOS mutagenesis. J Bacteriol 180: 4658-4666.
20. Ohta, T., Sutton, M.D., Guzzo, A., Cole, S., Ferentz, A.E., and Walker, G.C. (1999) Mutations affecting the ability of the Escherichia coli UmuD′ protein to participate in SOS mutagenesis. J Bacteriol 181: 177-185.
21. Peat, T.S., Frank, E.G., McDonald, J.P., Levine, A.S., Woodgate, R., and Hendrickson, W.A. (1996a) Structure of the UmuD′ protein and its regulation in response to DNA damage. Nature 380: 727-730.
22. Peat, T.S., Frank, E.G., Woodgate, R., and Hendrickson, W.A. (1996b) Production and crystallization of a selenomethionyl variant of UmuD'C, an Escherichia coli SOS response protein. Proteins: Structure, Function and Genetics 25: 506-509.
23. Perry, K.L, Elledge, S.J., Mitchell, B.B., Marsh, L., and Walker, G.C. (1985) umuDC and mucAB operons whose products are required for UV light-and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. Proc Natl Acad Sci USA 82: 4331-4335.
24. Petit, M.A., Bedale, W., Osipiuk, J., Lu, C., Rajagopalan, M., McInerney, P., et al. (1994) Sequential folding of UmuC by the Hsp70 and Hsp60 chaperone complexes of Escherichia coli. J Biol Chem 269: 23824-23829.
25. Rehrauer, W.M., Bruck, I., Woodgate, R., Goodman, M.F., and Kowalczykowski, S.C. (1998) Modulation of RecA nucleoprotein function by the mutagenic UmuD'C protein complex. J Biol Chemistry 273: 32384-32387.
26. Roca, A.I., and Cox, M.M. (1997) RecA protein: structure, function, and role in recombinational DNA repair. Prog Nucleic Acids Res Mol Biol 56: 129-223.
27. Sinden, R.R., and Cole, R.S. (1978) Repair of cross-linked DNA and survival of Escherichia coli treated with psoralen and light: effects of mutations influencing genetic recombination and DNA metabolism. J Bacteriol 136: 538-547.
28. Sommer, S., Bailone, A., and Devoret, R. (1993) The appearance of the UmuD'C protein complex in Escherichia coli switches repair from homologous recombination to SOS mutagenesis. Mol Microbiol 10: 963-971.
29. Sommer, S., Boudsocq, F., Devoret, R., and Bailone, A. (1998) Specific RecA amino acid changes affect RecA-UmuD'C interaction. Mol Microbiol 28: 281-291.
30. Story, R.M., Weber, I.T., and Steitz, T.A. (1992) The structure of the E. coli recA protein monomer and polymer. Nature 355: 318-325.
31. Sweasy, J.B., Witkin, E.M., Sinha, N., and Roegner-Maniscalco, V. (1990) RecA protein of Escherichia coli bas a third essential role in SOS mutator activity. J Bacteriol 172: 3030-3036.
32. 2C mutagenic complex and RecA protein. Proc Natl Acad Sci USA 95: 9755-9760.
33. 2C is an error-prone DNA polymerase, Escherichia coli pol V. Proc Natl Acad Sci USA 96: 8919-8924.
34. Venderbure, C., Chastanet, A., Boudsocq, F., Sommer, S., and Bailone, A. (1999) Inhibition of homologous recombination by the plasmid MucA'B complex. J Bacteriol 181: 1249-1255.
35. Walker, G.C. (1984) Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. Microbiol Rev 48: 60-93.
36. Walker, G.C. (1995) SOS-regulated proteins in translesion DNA synthesis and mutagenesis. Trends Biochem Sci 20: 416-420.
37. Woodgate, R. (1992) Construction of a umuDC operon substitution mutation in Escherichia coli. Mutat Res 281: 221-225.
38. Woodgate, R., and Levine, A.S. (1996) Damage inducible mutagenesis: recent insights into the activities of the Umu family of mutagenesis proteins. Cancer Surveys 28: 117-140.
39. Woodgate, R., Rajagopalan, M., Lu, C., and Echols, H. (1989) UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD′. Proc Natl Acad Sci USA 86: 7301-7305.
40. Woodgate, R., Singh, M., Kulaeva, O.I., Frank, E.G., Levine, A.S., and Koch, W.H. (1994) Isolation and characterization of novel plasmis-encoded umuC mutants. J Bacteriol 176: 5011-5021.