A possible mechanism of TPA-mediated downregulation of neurotrophin-3 gene expression in rat cultured vascular smooth muscle cells

Molecular Brain Research

Volumn 68, Issue 1-2, 1999, Pages 186-189

  Nemoto, Kiyomitsu ^a   Sekimoto, Masashi ^a   Fukamachi, Katsumi ^a   Nemoto, Fumiko ^a   Miyata, Shingo ^a   Nakamura, Yoshiyuki ^a   Hamada, Masanori ^b   Senba, Emiko ^b   Ueyama, Takashi ^b   Degawa, Masakuni ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

AP 1; Gene expression; Neurotrophin 3; Phorbol ester; Reverse transcription PCR; Vascular smooth muscle cell

Indexed keywords

CYCLOHEXIMIDE; DEXAMETHASONE; NEUROTROPHIN 3; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR AP 1;

ANIMAL TISSUE; AORTA MEDIA; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELLS, CULTURED; CYCLOHEXIMIDE; DEXAMETHASONE; DOWN-REGULATION; GENE EXPRESSION REGULATION; GENETIC VECTORS; MUSCLE, SMOOTH, VASCULAR; NERVE GROWTH FACTORS; NEUROTROPHIN 3; PROTEIN SYNTHESIS INHIBITORS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, INBRED WKY; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

ANIMALIA;

EID: 0033532319     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00088-1     Document Type: Article

References (17)

1. Beato M., Herrlich P., Schutz G. Steroid hormone receptors: many actors in search of a plot. Cell. 83:1995;851-857.
2. Bois-Joyeaux B., Denissenko M., Thomassin H., Guesdon S., Ikonomova R., Bernuau D., Feldmann G., Danan J.L. The c-jun proto-oncogene down-regulates the rat α-fetoprotein promoter in HepG2 hepatoma cells without binding to DNA. J. Biol. Chem. 270:1995;10204-10211.
3. Castren E., Pitkanen M., Sirvio J., Parsadanian A., Lindholm D., Thoenen H., Riekkinen P.J. The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus. Neuroreport. 4:1993;895-898.
4. Chiu R., Boyle W.J., Meek J., Smeal T., Hunter T., Karin M. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell. 54:1988;541-552.
5. Delhase M., Castrillo J.L., de la Hoya M., Rajas F., Hooghe-Peters E.L. AP-1 and Oct-1 transcription factors down-regulate the expression of the human PIT1/GHF1 gene. J. Biol. Chem. 271:1996;32349-32358.
6. Hohn A., Leibrock J., Bailey K., Barde Y.A. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature. 344:1990;339-341.
7. Kokaia Z., Zhao Q., Kokaia M., Elmer E., Metsis M., Smith M.L., Siesjo B.K., Lindvall O. Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage. Exp. Neurol. 136:1995;73-88.
8. Leibrock J., Lottspeich F., Hohn A., Hofer M., Hengerer B., Masiakowski P., Thoenen H., Barde Y.A. Molecular cloning and expression of brain-derived neurotrophic factor. Nature. 341:1989;149-152.
9. Leingartner A., Lindholm D. Two promoters direct transcription of the mouse NT-3 gene. Eur. J. Neurosci. 6:1994;1149-1159.
10. Lindholm D., Castren E., Tsoulfas P., Kolbeck R., Berzaghi M.d.P., Leingartner A., Heisenberg C.P., Tesarollo L., Parada L.F., Thoenen H. Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. J. Cell Biol. 122:1993;443-450.
11. Lindvall O., Ernfors P., Bengzon J., Kokaia Z., Smith M.L., Siesjo B.K., Persson H. Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proc. Natl. Acad. Sci. U.S.A. 89:1992;648-652.
12. Nemoto K., Fukamachi K., Nemoto F., Miyata S., Hamada M., Nakamura Y., Senba E., Ueyama T. Gene expression of neurotrophins and their receptors in cultured rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 245:1998;284-288.
13. Sassone-Corsi P., Lamph W.W., Kamps M., Verma I.M. fos-associated cellular p39 is related to nuclear transcription factor AP-1. Cell. 54:1988;553-560.
14. Scott J., Selby M., Urdea M., Quiroga M., Bell G.I., Rutter W.J. Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. Nature. 302:1983;538-540.
15. Smith M.A., Makino S., Altemus M., Michelson D., Hong S.K., Kvetnansky R., Post R.M. Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus. Proc. Natl. Acad. Sci. U.S.A. 92:1995;8788-8792.
16. Smith M.A., Makino S., Kvetnansky R., Post R.M. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J. Neurosci. 15:1995;1768-1777.
17. Ueyama T., Hamada M., Hano T., Nishio I., Masuyama Y., Ooshima A. Release of nerve growth factor from cultured aortic smooth-muscle cells. Blood Vessels. 28:1991;532-536.