Four novel non-random chromosome rearrangements in B-cell chronic lymphocytic leukaemia: 6p24-25 and 12p12-13 translocations, 4q21 anomalies and monosomy 21

British Journal of Haematology

Volumn 108, Issue 3, 2000, Pages 559-564

  Cuneo, Antonio ^b   Roberti, Maria Grazia ^c   Bigoni, Renato ^c   Minotto, Claudia ^c   Bardi, Antonella ^c   Milani, Raffaella ^c   Tieghi, Alessia ^c   Campioni, Diana ^c   Cavazzini, Francesco ^c   De Angeli, Cristiano ^c   Negrini, Massimo ^a   Castoldi, Gianluigi ^c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF FERRARA   (Italy)

^c NONE

Author keywords

12p anomaly; 4q anomaly; 6p anomaly; Chromosome 21; Chronic lymphocytic leukemia

Indexed keywords

ARTICLE; B LYMPHOCYTE; CHROMOSOME 12P; CHROMOSOME 4Q; CHROMOSOME 6P; CHROMOSOME ANALYSIS; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; IMMUNOPHENOTYPING; MONOSOMY; PHENOTYPE; PRIORITY JOURNAL;

AGED; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 21; CHROMOSOMES, HUMAN, PAIR 4; CHROMOSOMES, HUMAN, PAIR 6; FEMALE; HUMANS; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, B-CELL; MALE; MIDDLE AGED; MONOSOMY; TRANSLOCATION, GENETIC;

EID: 0034117226     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.01898.x     Document Type: Article

References (35)

1. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Gralnick, H.R., Sultan, C. & The French-American-British (FAB) Cooperative Group (1989) Proposals for the classification of chronic (mature) B and T lymphoid leukemias. Journal of Clinical Pathology, 42, 567-584.
2. Bentz, M., Stilgenbauer, S., Lichter, P. & Dohner, H. (1999) Interphase FISH in chronic lymphoproliferative disorders and comparative genomic hybridisation in the study of lymphomas. Haematologica, 84, 102-106.
3. Bigoni, R., Negrini, M., Veronese, M.L., Cuneo, A., Castoldi, G. & Croce, C.M. (1996) Characterization of t(11,14) translocation in mantle cell lymphoma by fluorcscent in situ hybridization. Oncogene, 13, 797-802.
4. Brito-Babapulle, V., Garcia-Marco, J., Maljaie, S.H., Hiorns, L., Coignet, L., Conchon, M. & Catovsky, D. (1997) The impact of molecular cytogenetics on chronic lymphoid leukaemia. Acta Haematologica, 98, 175-186.
5. Bullrich, F., Veronese, M.L., Kitada, S., Jurlander, J., Caligiuri, M.A., Reed, J.C. & Croce, C.M. (1996) Minimal region of loss at 13q14 in B-CLL. Blood, 88, 3109-3115.
6. Castoldi, G.L., Lanza, F. & Cuneo, A. (1987) Cytogenetic aspects of B cell chronic lymphatic leukemia: their correlation with clinical stage and different polyclonal mitogens. Cancer Genetics and Cytogenetics, 26, 75-84.
7. Cheson, B.D., Bennett, J.M., Grever, M., Kay, N., Keating, M.J., O'Brien, S. & Rai, K.R. (1996) National Cancer Institute-sponsored working group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood, 87, 4990-4997.
8. Criel, A., Verhoef, G., Vlietinck, R., Mecucci, C., Billiet, J., Michaux, L., Meeus, P., Louwagie, A., Van Orshoven, A., Van Hoof, A., Boogaerts, M., Van den Berghe, H. & De Wolf-Peeters, C. (1997) Further characterization of morphologically defined typical and atypical CLL: a clinical, immunophenolypic, cytogenetic and prognostic study. British Journal of Haematology, 97, 383-391.
9. Cuneo, A., Wlodarska, I., Sayed Aly, M., Piva, N., Carli, M.G., Fagioli, F., Tallarico, A., Pazzi, I., Ferrari, L., Cassiman, J.J., Van Den Berghe, H. & Castoldi, G.L. (1992) Non radioactive in situ hybridization for the detection and monitoring of trisomy 12 in B cell chronic lymphocytic leukaemia. British Journal of Haematology, 81, 192-196.
10. Cuneo, A., De Angeli, C., Roberti, M.G., Piva, N., Bigoni, R., Gandini, D., Rigolin, G.M., Moretti, S., Cavazzini, P., del Senno, L. & Castoldi, G. (1996) Richter's syndrome in a case of atypical chronic lymphocytic leukaemia with the t(11: 14) (q13: q32): role for a p53 exon 7 gene mutation. British Journal of Haematology, 92, 375-381.
11. Cuneo, A., Bigoni, R., Negrini, M., Bullrich, F., Veronese, M.L., Roberti, M.G., Bardi, A., Rigolin, G.M., Cavazzini, P., Croce, C.M. & Castoldi, G. (1997) Cytogenetic and interphase cytogenetic characterization of atypical chronic lymphocytic leukemia carrying BCL1 translocation. Cancer Research, 57, 1144-1150.
12. Cuneo, A., Bigoni, R. & Castoldi, G. (1998) Towards a clinically relevant cytogenetic classification of chronic lymphocytic leukemia and related disorders. Haematologica, 83, 577-579.
13. Dohner, H., Stilgenbauer, S., Fisher, K., Bentz, M. & Lichter, P. (1997a) Cytogenetic and molecular cytogenetic analysis of B cell chronic lymphocytic leukemia: specific chromosome aberrations identify prognostic subgroups of patients and point to loci of candidate genes. Leukemia, 11, 19-24.
14. Dohner, H., Stilgenbauer, S., James, M.R., Benner, A., Weilguni, T., Bentz, M., Fisher, K., Hunstein, W. & Lichter, P. (1997b) 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood, 89, 2516-2522.
15. Escudier, S., Pereira-Leahy, J.M., Drach, J.W., Weier, H.U., Goodacre, A.M., Cork, A.M., Trujillo, J.M., Keating, M.J. & Andreef, M. (1993) Fluorescence in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia. Blood 81, 2702-2707.
16. Gardiner, A.C., Corcoran, M.M. & Oscier, D.G. (1997) Citogenetic, fluorescence in situ hybridisation, and clinical evaluation of translocations with concomitant deletion at 13q14 in chronic lymphocytic leukaemia. Genes Chromosomes and Cancer, 20, 73-81.
17. Geisler, C.H., Philip, P., Egelund Christensen, B., Hou-Jensen, K., Tinggaard Pedersen, N., Myhre Jensen, O., Thorling, K., Andersen, E., Birgens, H.S., Drivsholm, A., Ellegaard, J., Larsen, J.K., Plesner, T., Brown, P., Kragh Andersen, P.M. & Hansen, M. (1997) In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: a cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients. Leukaemia Research, 21, 1011-1023.
18. Hernandez, J.M., Mecucci, C., Criel, A., Meeus, P., Michaux, L., Van Hoof, A., Verhoef, G., Louwagie, A., Scheiff, J.M., Michaux, J.L., Boogaerts, M. & Van Den Berghe, H. (1995) Cytogenetic analysis of B-cell chronic lymphoid leukemias classified according to morphologic and immunophenotypic (FAB) criteria. Leukemia, 9, 2140-2147.
19. ISCN (1995) Guidelines for Cancer Cytogenetics. Supplement to An International System for Human Cytogenetic Nomenclature (ed. by F. Mitelman). Karger, Basel.
20. Juliusson, G. & Gahrton, G. (1993) Cytogenetics in CLL and related disorders. Chronic Lymphocytic Leukaemia. Baillière Clinical Hematology, Vol. 6 (ed. by C. Rozman), pp. 821-848. Baillière-Tindall, London.
21. Juliusson, G. & Merup, M. (1998) Cytogenetics in chronic lymphocytic leukemia. Seminars in Oncology, 25, 19-26.
22. Juliusson, G., Gahrton, G., Oscier, G., Fitchett, M., Ross, E.M., Brito-Babapulle, V., Catovsky, D., Knuutila, S., Elonen, E., Lechleitner, M., Tanzer, J., Schoenwald, M., Castold, G.L., Cuneo, A., Nowell, P., Peterson, L. & Kay, N. (1991) Cytogenetic findings and survival in B cell chronic lymphocytic leukemia. Second international Workshop on chromosomes in CLL. Compilation of data from 662 patients. Leukemia and Lymphoma, 2, 21-25.
23. Lens, D., Dyer, M.J.S., Garcia-Marco, J.M., De Schouwer, P.J.J.C., Hamoudi, R.A., Jones, D., Farahat, N., Matures, E. & Catovsky, D. (1997) p53 abnormalities in CLL are associated with excess of prolymphocytes and poor prognosis. British Journal of Haematology, 99, 848-857.
24. Matutes, E., Owusu-Amkomah, K., Morilla, R., Garcia-Marco, J., Houlian, A., Que, T.H. & Catovsky, D. (1994) The immunological profile of B-Cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia, 10, 1640-1645.
25. Matutes, E., Oscier, D., Garcia-Marco, J., Copplestone, E.A., Gillingham, R., Hamblin, T., Lens, D., Swansbury, G.J. & Catovsky, D. (1996) Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients. British Journal of Haematology, 92, 382-388.
26. Mitelman, F., Johansson, B. & Mertens, F. (1995) Catalog of Chromosome Aberrations in Cancer, 5th edn. Wiley-Liss, New York.
27. O'Connor, S., Su'ut, L., Morgan, G. & Jack, A. (1998) Gain of chromosomes 4 and 12 material is a common finding in typical and atypical B cell chronic lymphocytic leukaemia (abstract). Blood, 92 (Suppl. 1 to no. 10), 226a.
28. Oscier, D.G. (1999) Cytogenetics and molecular genetics of chronic lymphocytic leukemia (EHA-4 educational book). Haematologica, 84, 88-91.
29. Oscier, D.G., Fitchett, M., Herbert, T. & Lambert, R. (1991) Karyotypic evolution in B-cell chronic lymphocytic leukemia. Genes Chromosomes and Cancer, 3, 16-20.
30. Peterson, L.C., Lindquist, L.L., Church, S. & Kay, N.E. (1992) Frequent clonal abnormalities of chromosome band 13q14 in B-cell chronic lymphocytic leukemia: multiple clones, subclones and non clonal alterations in 82 midwestern patients. Genes Chromosomes and Cancer, 4, 273-280.
31. Philip, P., Geisler, C., Hansen, M.M., Hasselbach, H., Christensen, B.E., Drivsholm, A., Lund, B., Nielsen, J.B., Jensen, K.B. & Andersen, E. (1991) Aberrations of chromosome 6 in 193 newly diagnosed untreated cases of chronic lymphocytic leukemia. Cancer Genetics and Cytogenetics, 53, 35-43.
32. Rasio, D., Negrini, M. & Croce, C.M. (1995) Genomic organization of the ATM locus involved in ataxia-telangiectasia. Cancer Research, 55, 6053-6057.
33. Schlegelberger, B., Metzke, S., Harder, S., Zuhlke-Jenisch, R., Zhang, Y. & Siebert, R. (1998) Classical and molecular cytogenetics of tumor cells, laboratory Manual: Diagnostic Cytogenetics (ed. by R.D. Wegner). Springer, Berlin.
34. Takashima, T., Itoh, M., Ueda, Y., Nishida, K., Tamaki, T., Misawa, S., Seto, M., Machii, T. & Taniwaki, M. (1997) Detection of 14q32.33 translocalion and t(11: 14) in interphase nuclei of chronic B-cell leukemia-lymphomas by in situ hybridization. International Journal of Cancer, 72, 31-38.
35. Zhang, Y., Matthiesen, P., Harder, S., Siebert, R., Castoldi, G., Calasanz, M.J., Wong, K.F., Rosenwald, A., Ott, G., Atkin, N.B. & Schlegelberger, B. (2000) A 3cM commonly deleted region in 6q21 in leukemias and lymphomas delineated by fluorescence in situ hybridization. Genes Chromosomes and Cancer, 27, 52-58.