Impaired vascular sensitivity to nitric oxide in the coronary microvasculature after endotoxaemia

British Journal of Pharmacology

Volumn 130, Issue 1, 2000, Pages 118-124

  Bogle, Richard G ^a   McLean, Peter G ^b   Ahluwalia, Amrita ^b   Vallance, Patrick ^b  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b NONE

Author keywords

Bradykinin; Endothelium dependent responses; Endotoxin; Nicardipine; Nitrate; Nitric oxide; Nitrite; Perfused rat heart; Sodium nitroprusside

Indexed keywords

BRADYKININ; DEXAMETHASONE; GUANYLATE CYCLASE; N(G) NITROARGININE METHYL ESTER; NICARDIPINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY BLOOD VESSEL; DOSE RESPONSE; ENDOTOXEMIA; ENZYME INDUCTION; INFECTION; INFLAMMATION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

EID: 0034116007     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703267     Document Type: Article

References (40)

1. AMEZCUA, J.L., DUSTING, G.J., PALMER, R.M.J. & MONCADA, S. (1988). Acetylcholine induces vasodilatation in the rabbit isolated heart through the release of nitric oxide, the endogenous vasodilator. Br. J. Pharmacol., 95, 830-834.
2. AMEZCUA, J.L., PALMER, R.M.J., DE SOUZA, B.M. & MONCADA, S. (1989). Nitric oxide synthesised from L-arginine regulates vascular tone in the coronary circulation of the rabbit. Br. J. Pharmacol., 97, 1119-1124.
3. ASSREUY, J., CUNHA, F.Q., LIEU, F.Y. & MONCADA, S. (1993). Feedback inhibition of nitric oxide synthase activity by nitric oxide. Br. J. Pharmacol., 108, 833-837.
4. BAYDOUN. A.R., FOALE, R.D. & MANN, G.E. (1993). Bacterial endotoxin rapidly stimulates prolonged endothelium-dependent vasodilatation in the rat isolated perfused heart. Br. J. Pharmacol., 109, 987-991.
5. BAYDOUN. A.R. & WOODWARD, B. (1991). Effects of bradykinin in the rat isolated perfused heart: role of kinin receptors and endothelium-derived relaxing factor. Br. J. Pharmacol., 103, 1829-1833.
6. BEASLEY, D., COHEN, R.A. & LEVINSKY, N.G. (1990). Endotoxin inhibits contraction of vascular smooth muscle in vitro. Am. J. Physiol., 258, H1187-H1192.
7. BOILLOT, A., MASSOL, J., MAUPOIL, V., GRELIER, R., CAPELLIER, G., BERTHELOT, A. & BARALE, F. (1996). Alterations of myocardial and vascular adrenergic receptor-mediated responses in Escherichia coli-induced septic shock in the rat. Crit. Care Med., 24, 1373-1380.
8. CANNON, T.R., MANN, G.E. & BAYDOUN, A.R. (1998). Mechanisms of acute vasodilator response to bacterial endotoxin in the rat coronary microvasculature. Br. J. Pharmacol., 123, 637-644.
9. COOK, H.T., BUNE, A.J., JANSEN, A.S., TAYLOR, G.M., LOI, R.K. & CATTELL, V. (1994). Cellular localisation of inducible nitric-oxide synthase in experimental endotoxic shock in the rat. Clin. Sci., 87, 179-186.
10. CRIDDLE, D.N., DEWAR, G.H., RADNIKNAM, M., WATHEY, W.B. & WOODWARD, B. (1991). The synthesis, and structure-activity relationships of some long chain acyl carnitine esters on the coronary circulation of the rat isolated heart. J. Pharm. Pharmacol., 43, 636-639.
11. CUNNION, R.E., SCHAER, G.L., PARKER, M., NATANSON, C. & PARILLO, J.E. (1986). The coronary circulation in human septic shock. Circulation, 73, 637-644.
12. DOFFERHOFF, A.S.M., BOM, V.J.J., VRIES-HOSPERS, H.G., DE, VAN INGEN, J., VD MEER, J., HAZENBERG, B.P.C., MULDER, P.O.M. & WEITS, J. (1992). Patterns of cytokines, plasma endotoxin, plasminogen activator inhibitor, and acute-phase proteins during the treatment of severe sepsis in humans. Crit. Care Med., 20, 185-192.
13. FATEHI-HASSANABAD, Z., PARATT, J.R. & FURMAN, B.L. (1996). Endotoxin-induced inhibition of mesenteric vasodilator responses to acetylcholine, bradykinin and post-occlusion hyperaemia in anaesthetised rats. Shock, 6, 371-376.
14. FINKEL, M.S., ODDIS, C.V., JACOB, T.D., WATKINS, S.C., HATTLER, B.G. & SIMMONS, R.L. (1992). Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science, 257, 387-389.
15. 2 in the nitric oxide-independent vasodilator effect of bradykinin in the rat perfused heart. J. Pharmacol. Exp. Therap., 278, 518-526.
16. GREENBERG, S., XIE, J., WANG, Y., CAI, B., KOLLS, J., NELSON, S., HYMAN, A., SUMMER, W.R. & LIPPTON, H. (1993). Tumour necrosis factor-alpha inhibits endothelium-dependent relaxation. J. Appl. Physiol., 75, 2394-2403.
17. HAMILTON, L.C. & WARNER, T.D. (1998). Interactions between inducible isoforms of nitric oxide synthase and cyclo-oxygenase in vivo: investigations using the selective inhibitors, 1400 W and celecoxib. Br. J. Pharmacol., 125, 335-340.
18. HOLHFIELD, T., KLEMM, P., THIEMERMANN, C., WARNER, T.D., SCHROR, K. & VANE, J.R. (1995). The contribution of tumour necrosis factor-alpha and endothelin-1 to the increase of coronary resistance in hearts from rats treated with endotoxin. Br. J. Pharmacol., 116, 3309-3315.
19. KATO, M., YAMAGATA, T., MATSUURA, H. & KAJIYAMA, G. (1997). Bradykinin induced dilation of human epicardial and resistance coronary arteries in vivo: effect of inhibition of nitric oxide synthesis. Heart, 78, 493-498.
20. Gmonomethyl-L-arginine (NMA) restores arterial blood pressure but reduced cardiac output in a canine model of endotoxic shock. Biochem. Biophys. Res. Commun., 178, 1135-1140.
21. KLEMM, P., WARDER, T.D., HOLHFIELD, R., CORDER, R. & VANE, J.R. (1995). Endothelium-1 mediates ex vivo coronary vasoconstriction caused by exogenous and endogenous cytokines. Proc. Natl. Acad. Sci. U.S.A., 92, 2691-2695.
22. G-nitro-L-arginine antagonises endothelium-dependent dilator responses by inhibiting endothelium-derived relaxing factor release in the isolated rabbit heart. Pflügers Arch., 418, 266-270.
23. LEFER, A.M., TSAO, P.S. & MA, X.-L. (1991). Shock-and ischaemia: mechanisms of impairment of endothelium-mediated vasodilatation. Chest, 100, 160S-163S.
24. LEFROY, D.C., CRAKE, T., UREN, N.G., DAVIES, G.J. & MASERI, A. (1993). Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans. Circulation, 88, 43-54.
25. LEONE, A.M., RHODES, P., FURST, V. & MONCADA, S. (1995). Techniques for the measurement of nitric oxide. In: Methods in Molecular Biology. Vol. 41 (ed) Kendall D.A. & S.J. Hill pp. 285-299, Totowa, NJ: Humana Press Inc.
26. LIU, S.F., BARNES, P.J. & EVANS. T.W. (1997). Time course and cellular localisation of lipopolysaccharide-induced inducible nitric oxide synthase messenger RNA expression in the rat in vivo. Crit. Care Med., 25, 512-518.
27. MCDONOUGH, K.H., BRUMFIELD, B.A. & LANG, C.A. (1985). In vitro myocardial performance after lethal and non-lethal doses of endotoxin. Am. J. Physiol., 250, H240-H246.
28. MCKENNA, T.M. (1990). Prolonged exposure of rat aorta to low levels of endotoxin in vitro results in impaired contractility. J. Clin. Invest., 86, 160-168.
29. MINAMIYAMA, Y., TAKEMURA, S., IMAOKA, S., FUNAE, Y., TANIMOTO, Y. & INOUE, E. (1997). Irreversible inhibition of cytochrome P450 by nitric oxide. J. Pharmacol. Exp. Ther., 283, 1479-1485.
30. PARKER, J.L. & ADAMS. H.R. (1993). Selective inhibition of endothelium-dependent vasodilator capacity by Escherichia coli endotoxemia. Circ. Res., 72, 539-551.
31. PARKER, J.L., KELLER, R.S., DEFILY, D.V., LAUGHLIN, H., NOVOTNY, M.J., ADAMS, H.R. (1991). Coronary vascular smooth muscle function in E. coli endotoxemia in dogs. Am. J. Physiol., 260, H832-H841.
32. PARRILLO, J.E. (1993). Pathogenic mechanisms of septic shock. N. Eng. J. Med., 328, 1471-1477.
33. PETROS, A., LAMB, G., LEONE, A., MONCADA, S., BENNETT, D. & VALLANCE, P. (1994). Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc. Res., 28, 34-39.
34. 2+ -independent nitric oxide synthase in the myocardium. Br. J. Pharmacol., 105, 575-580.
35. SCHULZ, R., PANAS, D.L., CATENA, R., MONCADA, S., OLEY, P.M. & LOPASCHUK, G.D. (1995). The role of nitric oxide in cardiac depression induced by interleukin-1 ß and tumour necrosis factor-α. Br. J. Pharmacol., 114, 27-34.
36. SMITH, R.E.A., PALMER, R.M.J. & MONCADA, S. (1991). Coronary vasodilatation induced by endotoxin in the rabbit isolated perfused heart is nitric oxide-dependent and inhibited by dexamethasone. Br. J. Pharmacol., 104, 5-6.
37. G-nitroarginine methylester, on responses to vasodilators of the guinea pig coronary vasculature. Br. J. Pharmacol., 107, 604-609.
38. WANG, P. & CHAUDRY, I.H. (1994). Administration of tumour necrosis factor-α in vivo depressed endothelium-dependent relaxation. Am. J. Physiol., 266, H2535-H2541.
39. WANG, P., ZHENG, F.B.A. & CHAUDRY, I.H. (1995). Endothelium-dependent relaxation is depressed at the macro-and micro-circulatory levels during sepsis. Am. J. Physiol., 269, R988-R994.
40. YOUNG, J.S., HEADRICK, J.P. & BERNE, R.M. (1991). Endothelial-dependent and -independent responses in the thoracic aorta during endotoxic shock. Circ. Shock, 35, 25-30.