Endotoxin-induced inhibition of mesenteric vasodilator responses to acetylcholine, bradykinin, and post-occlusion hyperemia in anesthetized rats

Shock

Volumn 6, Issue 5, 1996, Pages 371-376

  Fatehi Hassanabad, Zahra ^a   Parratt, James R ^a   Furman, Brian L ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; BRADYKININ; ENDOTOXIN; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANESTHESIA; ANIMAL; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; HEART RATE; HYPEREMIA; MALE; MESENTERIC ARTERY; METABOLISM; RAT; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASODILATATION;

ACETYLCHOLINE; ANESTHESIA; ANIMALS; BLOOD PRESSURE; BRADYKININ; CARDIOVASCULAR SYSTEM; ENDOTHELIUM, VASCULAR; ENDOTOXINS; HEART RATE; HYPEREMIA; MALE; MESENTERIC ARTERIES; NITROPRUSSIDE; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR RESISTANCE; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 0030279912     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199611000-00012     Document Type: Article

References (33)

1. Groeneveld ABJ, Nauta JJP, Thijs LG: Peripheral vascular resistance in septic shock: Its relation to outcome. Intensive Care Med 14:141-147, 1988.
2. Parratt JR, Stockt JC: Nitric oxide as a mediator of the vascular derangements of sepsis and endotoxaemia. In Lamy M, Thijs LG (eds): Mediators of Sepsis. Berlin: Springer, 1992, pp 174-189.
3. Thiemermann C: The role of the arginine nitric oxide pathway in circulatory shock. Adv Pharmacol 28:45-79, 1994.
4. Mitchell JA, Kohlkaas KL, Sorrentino R, Warner TD, Murad F, Vane JR: Induction by endotoxin of nitric oxide synthase in the rat mesentery: Lack of effect on actions of vasoconstrictors. Br J Pharmacol 109:265-270, 1993.
5. Evans T, Carpenter A, Kinderman H, Cohen J: Evidence of increased nitric oxide production in patients with the sepsis syndrome. Circ Shock 41:77-81, 1993.
6. Gray GA, Schott C, Julou-Schaeffer G, Fleming I, Parratt JR, Stoclet JC: An investigation of the effect of inhibitors of the L-arginine pathway on endotoxin-induced vascular hyporeactivity in vitro. Br J Pharmacol 103: 1218-1224, 1991.
7. Thiemermann C, Vane J: Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. Eur J Pharmacol 182:591-595, 1990.
8. Fatehi-Hassanabad Z, Burns H, Aughey EA, et al: Effects of L-canavanine, an inhibitor of inducible nitric oxide synthase, on endotoxin-mediated shock in rats. Shock 6:194-200.
9. Cai M, Sakamoto A, Ogawa R: Inhibition of nitric oxide formation with L-canavanine attenuates endotoxin-induced vascular hyporeactivity in the rat. Eur J Phannacol 295:215-220, 1996.
10. Thiemermann C, Ruetten H, Wu C-C, Vane J: The multiple organ dysfunction syndrome caused by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol 116: 2845-2851, 1995.
11. Guc MO, Gray GA, Furman BL, Parratt JR: Endotoxin-induced impairment of vasodepressor responses in the pithed rat. Eur J Pharmacol 204:63-70, 1991.
12. Sutton ET, Zhou Z, Baker CH, Price JM, Chen Y: Differences in arterial and arteriolar endothelial structure during endotoxin shock. Circ Shock 41:71-76, 1993.
13. Young JS, Headrick JP, Berne RM: Endothelial-dependent and independent responses in the thoracic aorta during endotoxin shock. Circ Shock 35:25-30, 1991.
14. Voss BL, De Bault LE, Blick KE, et al: Sequential renal alterations in septic shock in the primate. Circ Shock 33:142-155, 1991.
15. Baker CH, Sutton ET: Arteriolar endothelium-dependent vasodilation occurs during endotoxin shock. Am J Physiol 264:H1118-H1123, 1993.
16. 2+ mobilization and nitric oxide biosynthesis in cultured endothelial cells. Circ Res 75:659-668, 1994.
17. Umans JG, Wylam ME, Samsel RW, Edwards J, Schumacker PT: Effects of endotoxin in vivo on endothelial and smooth muscle function in rabbit and rat aorta. Am Rev Resp Dis 148:1638-1645, 1993.
18. Schneider F, Bucher B, Schott C, Andre A, Julou-Schaeffer G, Stoclet J-C: Effect of bacterial lipopolysaccharide on function of small rat femoral arterioles. Am J Physiol 266:H191-H198, 1994.
19. Wang P, Ba ZF, Chaudry IH: Endothelium-dependent relaxation is depressed at the macro- and microcirculatory levels during sepsis. Am J Physiol 269:R988-R994, 1995.
20. Pawlik WW, Hottenstein OD, Palen TE, Pawlik T, Jacobson ED: Adenosine modulates reactive hyperemia in rat gut. J Physiol Pharmacol 44:119-137, 1993.
21. Chen RYZ, Ross G, Chyu KY, Guth PH: Role of L-arginine-derived nitric oxide in cholinergic dilation of gastric arterioles. Am J Physiol 265: H2110-H2116, 1993.
22. Pohl U, Lamontagne D, Bassenge E, Busse R: Attenuation of coronary autoregulation in the isolated rabbit heart by endothelium derived nitric oxide. Cardiovasc Res 28:414-419, 1994.
23. Sagach VF, Tkachenko MN: On the mechanism of the involvement of endothelium in reactive hyperemia. Experientia 47:828-830, 1991.
24. Ekkelund U, Bjornberg J, Grande PO, Albert U, Mellander S: Myogenic vascular regulation in skeletal muscle in vivo is not dependent on endothelium-derived nitric oxide. Acta Physiol Scand 144:199-207, 1992.
25. Ward JE, Angus JA: Acute and chronic inhibition of nitric oxide synthase in conscious rabbits: Role of nitric oxide in the control of vascular tone. J Cardiovasc Pharmacol 21:804-814, 1993.
26. Astiz ME, Tilly E, Rackow ED, Weil MH: Peripheral vascular tone in sepsis. Chest 99:1072-1075, 1991.
27. Guc MO, Furman BL, Parratt JR: Endotoxin-induced impairment of vasopressor and vasodepressor responses in the pithed rat. Br J Pharmacol 101:913-919, 1990.
28. Parratt JR, Stoclet JC: Nitric oxide as a mediator of the vascular derangements of sepsis and endotoxaemia. In Lamy M, Thijs LG (eds): Mediators of Sepsis. Berlin: Springer, 1992, pp 174-189.
29. Parratt JR, Stoclet J-C, Fleming I: The role of the L-arginine nitric oxide pathway in sepsis and endotoxaemia with a special reference to vascular impairment. In Schlag G, Redl H (eds): Pathophysiology of Shock, Sepsis and Organ Failure. Berlin: Springer, 1993, pp 575-592.
30. Ruetten H, Southan GJ, Abate A, Thiemermann C: Attenuation of endotoxin-induced multiple organ dysfunction by 1-amino-2-hydroxy-guanidine, a potent inhibitor of inducible nitric oxide synthase. Br J Pharmacol 118:261-270, 1996.
31. Gray GA, Furman BL, Parratt JR: Impairment of vascular reactivity in the rat by endotoxin in vivo but not in vitro. Circ Shock 24:199, 1988.
32. Bouvier C, Guc MO, Furman BL, Parratt JR: Platelet activating factor impairs pressor responses to noradrenaline in the anaesthetized rat but does not mediate endotoxin-induced hyporeactivity. Circ Shock 42:14-19, 1994.
33. Douglas SA, James S, Hiley CR: Endothelial modulation and changes in endothelin pressor activity during hypoxia in the rat isolated perfused superior mesenteric bed. Br J Pharmacol 103:1441-1449, 1991.