Pesticide residues in medicinal plants and phytomedicines

Phytotherapy Research

Volumn 14, Issue 2, 2000, Pages 73-88

  Zuin, Vânia G ^a   Vilegas, Janete H Y ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Chromatographic analysis; Medicinal plants; Pesticide residues; Phytopharmaceuticals; Toxicology

Indexed keywords

CARBAMATE PESTICIDE; ORGANOCHLORINE PESTICIDE; ORGANOPHOSPHATE PESTICIDE; PESTICIDE RESIDUE;

CARCINOGENICITY; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM DISEASE; CHROMATOGRAPHY; HEALTH HAZARD; HERBAL MEDICINE; HUMAN; LAW; MAXIMUM ALLOWABLE CONCENTRATION; MEDICINAL PLANT; MUTAGENICITY; NEUROTOXICITY; PEST CONTROL; PHYTOTHERAPY; REPRODUCTIVE TOXICITY; RESIDUE ANALYSIS; RESPIRATION DEPRESSION; REVIEW; TECHNOLOGY; TERATOGENICITY; TOXICOLOGY; WORLD HEALTH ORGANIZATION;

EID: 0034110103     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1099-1573(200003)14:2<73::aid-ptr577>3.0.co;2-%23     Document Type: Review

References (208)

1. Ahmed, M. T., Ismail, S. M. M., and Mosleh, Y. Y. (1998). Determination of malathion residues in some medicinal plants by liquid chromatography with gas chromatographic/mass spectrometric confirmation. J. AOAC Int. 81, 1023-1025.
2. Alamanni, M. C., Piu, L., and Ginanneschi, R. (1988). Miscele preconfezionate di droghe vegetali: ricerca di residui di pesticidi e controllo microbiologico. Riv. Soc. Ital. Sc. Alim. 17, 515-521.
3. Alamanni, M. C., Piu, L., Luca, G., and Mura, M. (1987a). Sulla presenza di pesticidi clorurati e policlorobifenili in piante medicinali vendute in erboristeria. Riv. Soc. Ital. Sc. Alim. 16, 135-139.
4. Alamanni, M. C., Piu, L., Luca, G., and Mura, M. (1987b). Sulla presenza di pesticidi clorurati e policlorobifenili in miscele preconfezionate di droghe vegetali. Riv. Soc. Ital. Sc. Alim. 06, 139-173.
5. Ali, S. L. (1983a). Bestimmung von Pestizid-Rückständen und toxischen Schwermetallspuren in Arzneidrogen. Pharmaz. Ztg. 128, 2248/14-2252/18.
6. Ali, S. L. (1983b). Bestimmung der pestiziden Rückstände und anderer bedenklicher Verunreinigungen - wie toxische Metallspuren- in Arzneipflanzen. 1. Mitteilung. Pestizid-Rückstände in Arzneidrogen. Pharm. Ind. 45, 1154-1156.
7. Ali, S. L. (1983c). Bestimmung der pestiziden Rückstände und anderer bedenklicher Verunreinigungen - wie toxische Metallspuren- in Arzneipflanzen. 2. Mitteilung. Bestimmung von toxischen Metallspuren in Arzneidrogen. Pharm. Ind. 45, 1294-1295.
8. Ali, S. L. (1985). Bestimmung der Pestizidrückstände und toxischen Metallspuren in Teeaufgüssen aus Arzneidrogen. Pharmaz. Ztg. 130, 73/1927-78/1932.
9. Ali, S. L. (1987). Bestimmung der Pestizidrückstände und toxischen Schwermetallspuren in Arzneidrogen und deren Teeaufgüssen. Pharmaz. Ztg. 132, 7/633-12/638.
10. Allorde, L, and Plumel, M. M. (1984). De la préparation des herbes à celle des plantes médicinales au moyen du four à micro-ondes. Ann. Pharm. Fr. 42, 313-315.
11. Atindehou, E., Robin, A., and Collombel, C. (1981). La chromatographie liquide haute pression appliquée au dosage des insecticides organophosphorés dans les plantes médicinales. Ann. Pharm. Fr. 39, 171-180.
12. Ausher, R. (1997). Implementation of integrated pest management in Israel. Phytoparasitica 25, 119-141.
13. Aziz, N. H., Yousseg, Y. A., El-Fouly, M. Z., and Moussa, L. A. (1998). Contamination of some common medicinal plant samples and spices by fungi and their mycotoxins. Bot. Bull. Acad. Sinica 39, 279-285.
14. Bacci, E., Calamari, D., Gaggi, C., and Vighi, M. (1990). Bioconcentration of organic chemical vapours in plant leaves: experimental measurements and correlation. Environ. Sci. Technol. 24, 885-889.
15. Bagchi, G. D., and Puri, H. S. (1985). Pesticide residues in crude drugs and spices. Indian Drugs 22, 448-454.
16. Bajaj, Y. P. S. (1998). Biotechnology for the improvement of medicinal plants. Acta Hortic. 457, 37-45.
17. Barlow, F. (1985). Chemistry and formulation. In, Pesticide Application: Principles and Practice, ed. by P. T. Haskel, pp. 1-34. Oxford University Press, Oxford.
18. Barnard, C., Daberkow, S., Padgitt, M., Smith, M. E., and Uri, N. D. (1997). Alternative measures of pesticide use. Sci. Total Environ. 203, 229-244.
19. Bauer, R. (1998). Quality criteria and standardisation of phytopharmaceuticals: can acceptable drug standards be achieved? Drug Inf. J. 32, 101-110.
20. Bauer, R., Czygan, F. C., Franz, G., Ihrig, M., Nahrstedt, A., and Sprecher, E. (1993). Qualitätsansprüche an rational anwendbare Phytopharmaka. Dtsch. Apoth. Ztg. 133, 4105-4108.
21. Bauer, R., and Tittel, G. (1996). Quality assessment of herbal preparations as a precondition of pharmacological and clinical studies. Phytomedicine 2, 193-198.
22. Behrendt, H., and Brüggemann, R. (1993). Modelling the fate of organic chemicals in the soil plant environment: model study of root uptake of pesticides. Chemosphere 27, 2325-2332.
23. Beitz, H. (1989). Aktuelle Aspekte der ökologisch-chemischen Bewertung von Pflanzenschutzmitteln. Z. Chem. 29, 269-276.
24. Bélanger, A. (1989). Residues of azinphosmethyl, cypermethrin, benomyl and chlorotalonil in monarda and peppermint oil. Acta Hortic. 249, 67-73.
25. Benecke, R., Brotka, J., Wijsbeek, J., Franke, J. P., Bruins, A. P., and De Zeeuw, R. A. (1986a). Untersuchung pflanzlicher Drogen auf Rückstände von Organochlorverbindungen. 2. Mitteilung. Identifizierung der Rückstände von DDT und seinen Analogen durch Vergleich von Gaschromatographie an gepackter und Kapillarsäule sowie GC/ MS-Kopplung. Pharmazie 41, 499-501.
26. Benecke, R., Brotka, J., Wijsbeek, J., Franke, J. P., Bruins, A. P., and De Zeeuw, R. A. (1988). Untersuchung pflanzlicher Drogen auf Rückstände von Organochlorverbindungen. 3. Mitteilung. Identifizierung der Rückstände polychlorierter Biphenyle durch Vergleich von Gaschromatographie an gepackter und Kapillarsäule sowie GC/MS-Kopplung. Pharmazie 43, 123-125.
27. Benecke, R., Brotka, J., Wijsbeek, J., and Zeeuw, R. A. (1985). Chemical transformation to avoid interference in the analyses of DDT-type compounds and polychlorinated biphenyls in medicinal plants. HRC & CC. 8, 30-31.
28. Benecke, R., Ennet, D., and Frauenberger, H. (1987). Rückstände von Pflanzenschutzmitteln in Drogen von wildwachsenden Arzneipflanzen. 1. Mitteilung. Pharmazie 42, 869-871.
29. Benecke, R., and Ortwein, J. (1992). Untersuchung pflanzlicher Drogen auf Rückstände von Organochlor-Pestiziden. Pharm. Ind. 54, 726-728.
30. Benecke, R., Ortwein, J., Ennet, D., and Frauenberger, H. (1989). Rückstände von Lindan und DDT in Drogen von wildwachsenden Arzneipflanzen aus forstwirtschaftlich genutzten Waldgebieten. 2. Mitteilung. Pharmazie 44, 562-564.
31. Benecke, R., Thieme, H., and Brotka, J. (1986b). Untersuchung pflanzlicher Drogen auf Rückstände von Organochlorverbindungen. 1. Mitteilung. Gaschromatografische Bestimmung von Rückständen chlororganischer Insektizide. Pharmazie 41, 133-137.
32. Bentson, K. P. (1990). Fate of xenobiotics in foliar pesticide deposits. Rev. Environ. Contam. Toxicol. 114, 125-156.
33. Bisset, N. G. (1994). Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis, pp. 11-41. CRC Press, London.
34. Brennecke, R. (1989). A method for determining residues of the fungicides euparen, euparen M and folicur in plant material and beverages by gas chromatography. Pflanzenschutz-Nachr. 42, 223-284.
35. Brennecke, R. (1991). The use of extraction columns for pesticide residues analysis of plant material and beverages. Fresenius J. Anal. Chem. 339, 399-401.
36. Bruhn, J. G. (1989). The use of natural products in modern medicine. Acta Pharm. Nord. 1, 117-131.
37. Buchholz, H. (1988). Organochlor-Pestizid-Rückstände in schwarzem Tee. Lebensmittelchem. Gerichtl. Chem. 42, 140.
38. Carisano, A., and Rovida, C. (1995). SFE-facilitated detection of pesticide residues in camomile. LC-GC Int. 8, 334-337.
39. Cetinkaya, M. (1988). Organophosphor- und Organochlorpestizidrückstände in Rohkaffee. Dtsch. Lebensm. Rundsch. 84, 189-190.
40. Cetinkaya, M., and Thiemann, W. (1985). Rückstandsanalyse von schwerflüchtigen Organochlorverbindungen in schwarzem Tee. Dtsch. Lebensm. Rundsch. 81, 393-395.
41. Chaigneau, M. (1983). Action de l'oxyde d'éthylène sur des plantes médicinales et des épices: absorption et combinaison. Ann. Pharm. Fr. 41, 385-390.
42. Chaigneau, M. (1986). Sur la combinaison de l'oxyde d'éthylène avec des lignines. Ann. Pharm. Fr. 44, 317-318.
43. Chaigneau, M., and Muraz, B. (1986). Sur des produits résiduels de la désinfection des plantes médicinales par l'oxyde d'éthylène. Ann. Pharm. Fr. 44, 339-346.
44. Chizzola, R., and Franz, C. (1996). Metallic trace elements in medicinal and aromatic plants from Austria. J. Appl. Bot.-Angew. Bot. 70, 52-56.
45. Chourasia, H. K. (1995). Mycobiota and mycotoxins in herbal drugs of Indian pharmaceutical industries. Mycol. Res. 99, 697-703.
46. Cioni, F., and Bartolucci, G. (1994). Metodo multiresiduo per la determinazione di residui di pesticidi in erbe aromatiche ed infusionali essicate. Boll. Chim. Igien. 45, 51-63.
47. Czarnecki, M., and Zalecki, R. (1990). Dobór herbicydów w uprawie Tymianku wlasciwego (Thymus vulgaris L.). Herba Pol. 36, 13-24.
48. Debska, W., and Gnusowski, B. (1980). Propyzamid in medicinal plants. Planta Med. 39, 292.
49. Debska, W., Gnusowski, B., and Zygmunt, B. (1979). Determination of oxycarboxin residues in medicinal plants. Analyst 104, 1191-1194.
50. Debska, W., and Lutomski, J. (1979). Problems of tolerance of medicinal plants - contamination with pesticides. Planta Med. 36, 288.
51. Dorea, H. S., Tadeo, J. L, and Sanchez-Brunete, C. (1996). Determination of organophosphorus pesticide residues in fruits by gas chromatography with ITD and NPD detection. Chromatographia 43, 1996.
52. Dörfler, U., Adler-Köhler, R., Schneider, P., Scheunert, I., and Korte, F. (1991). A laboratory model for determining the volatility of pesticides from soil and plant surfaces. Chemosphere 23, 485-496.
53. Efuntoye, M. O. (1996). Fungi associated with herbal drug plants during storage. Mycopathologia 136, 115-118.
54. El-Keltawi, N. E., and Croteau, R. (1986a). Influence of ethephon and daminozide on growth and essential oil content of peppermint and sage. Phytochemistry 25, 1285-1288.
55. El-Keltawi, N. E., and Croteau, R. (1986b). Influence of phosfon-D and cycocel on growth and essential oil content of sage and peppermint. Phytochemistry 25, 1603-1606.
56. El-Keltawi, N. E., and Croteau, R. (1987). Influence of herbicides and growth regulators on the growth and essential oil content of sage. Phytochemistry 26, 675-679.
57. Ennet, D. (1989). Fremdstoffe in pflanzlichen Arzneimitteln. Pharmazie 44, 383-386.
58. Ennet, D., Hauschild, J., and Pank, F. (1978). Rückstände von Pflanzenschutzmitteln und Mitteln zur Steuerung biologischer Prozesse in Drogen des Arzneibuches der DDR. 1. Mitteilung: Allgemeine Aspekte des Einsatzes von Pflanzenschutzmitteln (PSM) and Mitteln zur Steuerung biologischer Prozesse (MBP) im Arzneipflanzenanbau der DDR. Pharmazie 33, 697-705.
59. Erdelmeier, C. A. J. (1993). Removal of pesticides from plant drugs and extracts using supercritical fluid extraction. Planta Med. 59, A593-A594.
60. Evans, W. C. (1989). Trease & Evans' Pharmacognosy, pp. 126-141. 11th edn, Bailiére-Tindall, London.
61. FAO/OMS (1994). Codex Alimentarius. Residuos de Plaguicidas en los alimentos. FAO/OMS, Roma. Vol. 2.
62. Farmacopéia Brasileira (1996). 4th edn, Atheneu Editora São Paulo, São Paulo.
63. Farnsworth, N. R., Akerele, O., Bingel, A. S., Soejarto, D. D., and Guo, Z. G. (1985). Medicinal plants in therapy. Bull. WHO 63, 965-981.
64. Fehr, D., and Ali, S. L. (1980). Über die Bestimmung von p,p′-DDT und γ-HCH in Flores Chamomillae, Folia Sennae und Fructus Phaseoli. Pharmaz. Ztg. 125, 558-562.
65. Fernández, N., Sierra, M., García, J. J., Diez, M. J., and Terán, M. T. (1993). Organochlorine pesticide residues in black tea, camomile and linden. Bull. Environ. Contam. Toxicol. 50, 479-485.
66. Figura, B., Pluta, J., and Lorenz, K. (1998). Assessment of the level of certain heavy metals in Polish galenic preparations. Pharmazie 53, 458-462.
67. Finkelman, J. (1996). Chemical safety and health in Latin America: an overview. Sci. Total Environ. 188, S3-S29.
68. Friedrich, H., and Büter, H. G. (1974a). Problematik der Anwendung von Pestiziden im Arzneipflanzenbau Untersuchungen an Mentha piperita L. 1. Teil. Grundsätzliche Betrachtung und Ausgangssituation. Dtsch. Apoth. Ztg. 114, 1793-1799.
69. Friedrich, H., and Büter, H. G. (1974b). Problematik der Anwendung von Pestiziden im Arzneipflanzenbau Untersuchungen an Mentha piperita L. 3. Teil. Dtsch. Apoth. Ztg. 114, 1875-1879.
70. Friedrich, H., and Büter, H. G. (1974c). Problematik der Anwendung von Pestiziden im Arzneipflanzenbau Untersuchungen an Mentha piperita L. 3. Teil. Dtsch. Apoth. Ztg. 114, 1980-1987.
71. Friedrich, H., and Büter, H. G. (1975). Problematik der Anwendung von Pestiziden im Arzneipflanzenbau Untersuchungen an Mentha piperita L. 4. Teil. Dtsch. Apoth. Ztg. 115, 179-185.
72. Friedrich, H., and Schneider, D. (1976). Rückstandsproblematik bei der Begasung von Sennae Fructus Angustifoliae des Handels mit Äthylenoxid. Planta Med. 30, 122-132.
73. Gabrio, T., and Ennet, D. (1982). Gaschromatografische Bestimmung der Rückstände von s-Triazinherbiziden in pflanzlichen Drogen. Pharmazie 37, 375-377.
74. Gabrio, T., Ennet, D., and Galetzka, G. (1988). Prüfung von Drogen auf Rückstände von Pflanzenschutzmitteln, Mittel zur Steuerung biologischer Prozesse und Vorratsschutzmitteln. Pharmazie 43, 507-509.
75. Gabrio, T., Schlenkrich, H., and Ennet, D. (1990). Prüfung von Drogen auf Rückstände von chlororganischen Pflanzenschutzmitteln (PSM) und polychlorierten Biphenylen (PCB). Pharmazie 45, 209-210.
76. Gentry, A. H. (1993). Tropical forest biodiversity and the potential for new medicinal plants. In, Human Medicinal Agents from Plants, ed. by A. D. Kinghorn and M. L. Balandrin, pp. 12-24. ACS Symposium series, Washington.
77. Gerard, D., Kraus, J., Fröhlingsdorf, B., Jerga, C., and Dallüge, A. (1990). Rückstandsfreier Vorratsschutz für Arznei- und Teedrogen. Dtsch. Apoth. Ztg. 130, 2014-2018.
78. Goldberg, L. (1986). Hazard Assessment of Ethylene Oxide. CRC Press, Boca Raton.
79. Gübeli, T., and Clerc, J. T. (1988). Nachweis von Pestizid-Rückständen in ethanolischen Pflanzenextrakten. Pharm. Acta Helv. 63, 85-89.
80. Gyèresi, Á., Kelemen, H., and Kata, M. (1997). Summary of the chromatographic methods recommended by pharmacopoeias for analysis of medicinal plants and their products. J. Planar Chromatogr. 10, 172-177.
81. Halt, M. (1998). Moulds and mycotoxins in herb tea and medicinal plants. Eur. J. Epidemiol. 14, 269-274.
82. Hapke, H. J. (1982). Zur toxikologischen Bewertung von Kontaminanten in Lebensmitteln: Schwermetalle. Ernähr. Umsch. 29, 251-255.
83. Harvey, J. (1986). Pesticide metabolism in plants. In, Analytical Methods for Pesticides and Plant Growth Regulators, ed. by G. Zweig and J. Sherma, pp. 231-246. Academic Press, New York.
84. Henneberg, M., and Lutomski, J. (1972). Untersuchungsergebnisse mit chlorierten Insektizid-Rückständen in polnischen Handelsdrogen: Fol. Menthae und Flos Chamomillae. Herba Hung. 11, 79-85.
85. Illes, S., Mestres, R., Tourte, J. Campo, M., and Illes, A. (1976). Controle des résidus de pesticides dans les plantes aromatiques et médicinales. Ann. Fals. Exp. Chim. 69, 209-218.
86. Karavaeva, E. N., and Molchanova, I. V. (1998). Accumulation of radionuclides by medicinal plants in the zone of impact from the Beloyarskaya nuclear power plant. Russ. J. Ecol. 29, 357-359.
87. Kips, R. H. (1985). Environmental aspects. In, Pesticide Application: Principles and Practice, ed. by P. T. Haskel, pp. 1-34. Oxford University Press, Oxford.
88. Király, Z. (1996). Sustainable agriculture and the use of pesticides. J. Environ. Sci. Health 631, 283-291.
89. Kirsch, T., Kaffarnik, F., Riederer, M., and Schreiber, L. (1997). Cuticular permeability of three species Prunus laurocerasus L., Ginko biloba L. and Juglans regia L.: comparative investigation of the transport proprieties of intact leaves, isolated cuticular and reconstituted cuticular waxes. J. Exp. Bot. 48, 1035-1045.
90. Koupai-Abyazani, M., Creaser, C. S., and Stephenson, R. (1992). Separation of flavone, flavonol, isoflavone and flavanone aglycones by capillary column gas chromatography. Phytochem. Anal. 3, 80-84.
91. Krstulovic, A. M., and Lee, C. R. (1997). Defining drug purity through chromatographic and related methods: current status and perspectives. J. Chromatogr. B 689, 137-153.
92. Kubiak, R., Müller, T., Maurer, T., and Eichhorn, K. W. (1995). Volatilisation of pesticides from plant and soil surfaces -field versus laboratory experiments. Intern. J. Environ. Anal. Chem. 58, 349-358.
93. Kumar, S., and Roy, A. K. (1993). Occurrence of aflatoxin in some liver curative herbal medicines. Lett. Appl. Microbiol. 17, 112-114.
94. Kwon, S. K., Dicke, W., and Thier, H. P. (1986). Pestizidrückstände in drei Drogen aus Südkorea. Planta Med. 2, 155-156.
95. Lai, S. J., Binder, S. R., Essien, H., and Wen, K. (1995). Identification of western medicines as adulterants in Chinese herbal medicines using a broad-spectrum drug screening HPLC system. J. Liq. Chromatogr. 18, 2861-2875.
96. Lanças, F. M., Barbirato, M. A., Galhiane, M. S., and Rissato, S. R. (1996). Supercritical fluid extraction of chlorothalonil from apples. Chrotnatographia 42, 547-550.
97. Lehotay, S. J., and Valverde-Garcia, A. (1997). Evaluation of different solid-phase traps for automated collection and clean-up in the analysis of multiple pesticides in fruits and vegetables after supercritical fluid extraction. J. Chromatogr. A 765, 69-84.
98. Lino, C. M., and Silveira, I. N. (1996). Contribuiçōes para a presença de residues de pesticidas organoclorados no homem. Rev. Port. Farm. 46, 143-147.
99. Lino, C. M., and Silveira, I. N. (1997a). Extraction and clean-up methods for the determination of organochlorine pesticide residues in medicinal plants. J. Chromatogr. A 769, 275-283.
100. Lino, C. M., and Silveira, I. N. (1997b). Loss of organochlorine pesticide residues during the infusion processes of linden (Tilia cordata Mill.). J. Agric. Food Chem. 45, 2718-2722.
101. Lorusso, S., Camoni, I., and Chiacchierini, E. (1985). Considerazioni sul problema dei residui di pesticidi e metalli pesanti nelle droghe vegetali utilizzate dall'industria farmaceutica. Nuovi Ann. Ig. Microb. 36, 169-180.
102. Lorusso, S., Camoni, I., Muccio, A., and Chiacchierini, E. (1984). Considerazioni sulle tecniche e strumentazioni analitiche applicate al controllo della contaminazione degli alimenti da residui pesticidi. Riv. Soc. It. Alim. 13, 173-185.
103. Luckner, R., and Luckner, M. (1972). Vorschläge zum Deutschen Arzneibuch, 8. Ausgabe, der Deutschen Demokratischen Republik. Der Nachweis von DDT in offiziellen Drogen. Zbl. Pharm. 111, 267-280.
104. Lutomski, J., and Debska, W. (1974). Pesticide residues in medicinal plants in Poland. Residue Rev. 52, 27-44.
105. Lydon, J., and Duke, S. O. (1989). Pesticide effects on secondary metabolism of higher plants. Pestic. Sci. 25, 361-373.
106. Ma, X., Yu, X., Zheng, Z., and Mao, J. (1991). Analytical supercritical fluid extraction of Chinese herbal medicines. Chromatographia 32, 40-44.
107. Maas, G. (1979). Herbicide residues in some medicinal plants. Planta Med. 36, 251.
108. MacIntosh, D. L., Spengler, J. D., Özkaynak, H., Tsai, L., and Ryan, B. (1996). Dietary exposure to selected metals and pesticides. Environ. Health Perspect. 104, 202-209.
109. Matysik, G. (1996). Modified programmed multiple gradient development (MGD) in the analysis of complex plant extracts. Chromatographia 43, 39-43.
110. Mautner, U., Marquard, R., and Vömel, A. (1982). Untersuchungen über Triacin-Rückstande in Thymus vulgaris und Salvia officinalis nach Anwendung der Herbizide Gesagard 50 und Semeron 25. Planta Med. 45, 144.
111. McLean, J. C. (1996). Residue and risks. Plant Prot. Quart. 11, 94-95.
112. Mestres, R., Tourte, J., Campo, M., and Illes, S. (1974). Méthode polyvalente de recherche et de dosage des résidus de pesticides divers dans les matières alimentaires. Ann. Fals. Exp. Chim. 67, 513-526.
113. Mestres, R., Tourte, J., Campo, M., and Illes, S. (1975). Méthode polyvalente de recherche et de dosage des résidus de pesticides divers dans les matières alimentaires. Ann. Fals. Exp. Chim. 68, 81-84.
114. Miellet, A. (1982). Dosage de résidus de pesticides par C.L.H.P. sur plantes médicinales et aromatiques. Ann. Fals. Exp. Chim. 75, 369-375.
115. Molinari, G. P., Del Re, A., Redaelli, C., and Formentini, L. (1981). Determinazione di residui di antiparassitari in camomille: rischi di errore nella ricerca di organoclorurati. Ind. Alim. 20, 91-94.
116. Moltó, J. C., Lejeune, B., Prognon, P., and Pradeau, D. (1994). GC-MS determination of organochlorine pesticides in five medicinal plants. Intern. J. Environ. Anal. Chem. 54, 81-91.
117. Moraes, M. L. L., Vilegas, J. H. Y., and Lanças, F. M. (1997). Supercritical fluid extraction of glycosylated flavonoids from Passiflora leaves. Phytochem. Anal. 8, 257-260.
118. Mortimer, R. D., Weber, D. F., and Sun, W. F. (1995). Analysis of total free and glucose-conjugated pyrethroid acid metabolites in tea infusions as hexafluoroisopropyl esters by gas chromatography with electron capture detection. J. AOAC Int. 78, 846-855.
119. Muccio, A., Barbini, D. A., Generali, T. et al. (1997). Clean up of aqueous acetone vegetable extracts by solid-matrix partition for pyrethroid residue determination by gas-chromatography-electron capture detection. J. Chromatogr 765, 39-49.
120. Muccio, A., Camoni, I., and Vittory, L. G. L. (1981). Indagine sul contenuto di residui di pesticidi clorurati e fosforati in prodotti di erboristeria in commercio in Italia. Nuovi Ann. Ig. Microb. 32, 267-277.
121. Nagayama, T. (1996). Behaviour of residual organophosphorus pesticides in foodstuffs during leaching or cooking. J. Agric. Food Chem. 44, 2388-2393.
122. Nastasa, V., Sirghie, E., and Cuciureanu, R. (1981). Studiul poluarii cu substante fitofarmaceutice (pesticide) a unor plante medicinale de pe teritoriul Moldovei, in ultimii anii. Farmacia 29, 1-5.
123. Nunes, M. J., Camões, M. F., and Fournier, J. (1997). Analysis of organophosphorus, organochlorine and pyrethroid insecticides in medicinal plants. Chromatographia 44, 505-513.
124. Omer, E. A., Nofal, M. A., Lashin, S. M., and Haggag, W. M. E. (1997). Effect of some growth regulators on the growth parameters and oil content of cumin wilt disease incidence under two types of soil. Egypt. J. Hort. 24, 29-41.
125. Pank, F., Buhr, L, and Böhm, H. (1987a). Chemische Unkrautbekämpfung in Arzneipflanzenkulturen. 9. Mitteilung: Mohn (Papaver somniferum L). Pharmazie 42, 467-470.
126. Pank, F., Eichholz, E., and Ennet, D. (1982). Chemische Unkrautbekämpfung in Arzneipflanzenkulturen. 4. Mitteilung: Thymian (Thymus vulgaris L.). Pharmazie 37, 795-797.
127. Pank, F., Eichholz, E., Ennet, D., and Zygmunt, B. (1986). Chemische Unkrautbekämpfung in Arzneipflanzenkulturen. 7. Mitteilung: Pfefferminze (Mentha piperita L.). Pharmazie 41, 47-52.
128. Pank, F., Eichholz, E., Ennet, D., and Zygmunt, B. (1987b). Chemische Unkrautbekämpfung in Arzneipflanzenkulturen. 8. Mitteilung: Melisse (Melissa officinalis L.). Pharmazie 42, 191-195.
129. Pank, F., Eichholz, E., and Hauschild, J. (1978). Chemische Unkrautbekämpfung in Thymiankulturen (Thymus vulgaris L.). Pharmazie 33, 369-371.
130. Pank, F., Eichholz, E., Zygmunt, B., and Hauschild, J. (1981). Chemische Unkrautbekämpfung in Arzneipflanzenkulturen. 3. Mitteilung: Salbei im ersten Anbaujahr (Salvia officinalis L.). Pharmazie 36, 432-435.
131. Pank, F., Eichholz, E., Zygmunt, B., and Hauschild, J. (1983). Chemische Unkrautbekämpfung in Arzneipflanzenkulturen. 5. Mitteilung: Schafgarbe (Achillea millefolium L.). Pharmazie 38, 755-758.
132. Pank, F., and Ennet, D. (1980). Chemische Unkrautbekämpfung in Arzneipflanzenkulturen. 2. Mitteilung: Spitzwegerich (Plantago lanceolata L.). Pharmazie 35, 494-497.
133. Pank, F., and Ennet, D. (1988). Chemische Unkrautbekämpfung in Arzneipflanzenkulturen. 10. Mitteilung: Ringelblume (Calendula officinalis L.). Pharmazie 43, 503-506.
134. Pank, F., Marlow, H., Eichholz, E., Ennet, D., and Zygmunt, B. (1984). Chemische Unkrautbekämpfung in Arzneipflanzenkulturen. 6. Mitteilung: Kümmel (Carum carvi L.). Pharmazie 39, 838-842.
135. Pank, F., Jaruzelski, M., Neubauer, S., and Vekschin, B. S. (1979). Results of a coordinated herbicide check with Digitalis lanata Ehrh carried out 1978 in Czechoslovakia, the GDR, Poland and the USSR. Planta Med. 36, 249-250.
136. Pank, F., Hannig, H. J., Hauschild, J., and Zygmunt, B. (1980). Chemische Unkrautbekämpfung in Arzneipflanzenkulturen. 1. Mitteilung: Baldrian (Valeriana officinalis L.). Pharmazie 35, 115-119.
137. Pank, F., and Neczypor, W. (1978). Untersuchungen zur chemischen Unkrautbekämpfung in Drillkulturen von Wolligem Fingerhut (Digitalis lanata Ehrh.). Pharmazie 33, 677-683.
138. Parodi, B., Caviglioli, G., Bachi, A., Cafaggi, S., and Romussi, G. (1993). Herbal mixtures with claimed slimming activity: determination by TLC and HPLC of illegally added drugs. Pharmazie 48, 678-681.
139. Petersen, J. H., and Jensen, K. G. (1986). Pesticide residues in black tea. Z. Lebensm. Unters. Forrsch. 182, 489-491.
140. Pfleeger, T. G., Fong, A. Hayes, R., Ratsch, H., and Wickliff, C. (1996). Field evaluation of the EPA (Kenaga) nomogram, a method for estimating wildlife exposure to pesticide residues on plants. Environ. Toxicol. Chem. 15, 535-543.
141. Pharmacopée Européenne (1997). Troisième Édition, pp. 121-125. Conseil de l'Europe, Strasbourg.
142. Pharmeuropa (1993). Méthodes d'analyse des résidus de pesticides; Insecticides organophosphorés, organochlorés et pyréthrinoides. 5(3), 195-196.
143. Pifferi, G., and Vitali, R. (1993). Medicines from plants. Chim. Ind. 75, 380-384.
144. Plimmer, J. R. (1996). Analytical chemistry and future of pesticides. J. Environ. Sci. Health B 31, 645-670.
145. Pluta, J. (1988a). Studies on contamination of vegetable drugs with halogen derivative pesticides. Part 1. Changes of concentration of halogen derivatives in herbal raw materials within period of 1980-1984. Pharmazie 43, 121-123.
146. Pluta, J. (1988b). Studies on contamination of vegetable drugs with halogen derivative pesticides. Part 2. Concentration of halogen derivative pesticides in vegetable blends and herbal granulated products produced in Poland in 1980-1984. Pharmazie 43, 348-351.
147. Pluta, J. (1989). Studies on concentration of halogen derivatives in herbal products from various regions of Poland. Pharmazie 44, 222-224.
148. Pluta, J. (1990). Effect of technological factors on concentration of halogen derivative pesticides in some vegetable drugs. Pharmazie 45, 273-275.
149. Raffaelli, A., Moneti, G., Mercati, V., and Toja, E. (1997). Mass spectrometric characterization of flavonoids in extracts from Passiflora incarnata. J. Chromatogr. A. 777, 223-231.
150. Reichling, J. (1979a). Herbicides in camomile cultivation. Herba Hung. 18, 277-291.
151. Reichling, J. (1979b). Herbicides in cultivation of Matricaria chamomila L. 5. Communication. Planta Med. 36, 250-251.
152. Reichling, J., Becker, H., and Vömel, A. (1977). Herbizide im Kamillenanbau (Matricaria chamomilla L.). II. Mitteilung: Einfluβ der Herbizide auf die Zusammensetzung des ätherischen Ölspektrums. Planta Med. 32, 235-243.
153. Reichling, J., Becker, H., Exner, J., and Dräger, P. D. (1979). Vergleichende Untersuchung verschiedener Handeslmuster von Matricariae Flos. Ätherisches Öl, Flavonoide, Cumarine, Phenolcarbonsäuren und Pflanzenschutzmittelrückstände. Pharmaz. Ztg. 124, 1998-2005.
154. Reifenstein, H., and Pank, F. (1975). Triazinrückstände an Arzneipflanzen. Pharmazie 30, 391-393.
155. Reynolds, E. F. J. (1989). Martindale: The Extra Pharmacopoeia. 29th edn pp. 1344-1354. The Pharmaceutical Press, London.
156. Robin, A., Guillot, B., Ferry, S., and Collombel, C. (1978). Étude de la teneur des plantes médicinales en insecticides organochlorés. Plantes Med. Phytot. 12, 130-136.
157. Robin, A., Collombel, C., Ferry, S., and Guillot, B. (1979a). Insecticides organochlorés et plantes médicinales. Lyon Pharm. 30, 175-182.
158. Robin, A., Collombel, C., Ferry, S., and Guillot, B. (1979b). Technique de recherche et de dosage des insecticides organochlorés dans les plants médicinales. Ann. Fals. Exp. Chim. 72, 325-334.
159. Roy, A. K., and Chourasia, H. K. (1990). Mycoflora, mycotoxin producibility and mycotoxins in traditional herbal drugs from India. J. Gen. Appl. Microbiol. 36, 295-302.
160. Ruminska, A. (1965). Die chemische Unkrautbekämpfung und deren Einfluβ auf die Mineralstoffaufnahme, Ertragsqualität der Droge einiger Heil- und Duftpflanzen der Familie Umbelliferae. Herba Hung. 4, 39-57.
161. Sathiyamoorthy, P., Van Damme, P., Oven, M., and Golan Goldhirsh, A. (1997). Heavy metals in medicinal and fodder plants of Negev desert. J. Environ. Sci. Health A 32, 2111-2123.
162. Schilcher, H. (1977). Der Einfluss von Herbiziden auf das Wachstum von Matricaria chamomilla L. und auf die Biosynthese des ätherischen Öles. Biochem. Physiol. Pflanzen 171, 385-390.
163. Schilcher, H. (1982). Rückstände and Verunreinigungen bei Drogen und Drogenzubereitungen. 19. Mitteilung: Zur Wertbestimmung und Qualitätsprüfung von Drogen. Planta Med. 44, 65-77.
164. Schilcher, H. (1983a). Contamination of natural products with pesticides and heavy metals. In, Topics in Pharmaceutical Sciences, ed. by D. D. Breimer and P. Speiser, pp. 417-427. Elsevier Science, New York.
165. Schilcher, H. (1983b). Contamination of natural products with pesticides and heavy metals. Pharm. Int. 7, 191.
166. Schilcher, H. (1985a). Rückstandsbelastung von Drogen und Drogenzubereitungen. Zur Problematik der Pflanzenbehandlungsmittel, Vorratsschutzmittel und Schwermetalle in Drogen und Drogenzubereitungen aus toxikologischer und arzneimittelrechtlicher Sicht. Dtsch. Apoth. Ztg. 125, 47-52.
167. Schilcher, H. (1985b). Rückstandsanalytik bei Drogen und Drogenzubereitungen. Fresenius Z. Anal. Chem. 321, 342-351.
168. Schilcher, H. (1987). Possibilities and limitations of phytotherapy. Pharm. Weekblad 9, 215.
169. Schilcher, H., and Habenicht, M. (1998). Neue Bestimmungs-methode zum Nachweis von Organochlorpestiziden in ätherischen Ölen und Untersuchungsergebnisse von 110 Ätherischöl-Handelsmustern sowie Fertiganeimitteln. Pharm. Ind. 60, 249-252.
170. Schilcher, H., Peter, H., and Wank, H. (1987). Pestizide und Schwermetalle in Arzneipflanzen und Arzneipflanzen-Zubereitungen. Pharm. Ind. 49, 203-211.
171. Schlumpf, R., and Stettler, J. (1981). Die Prüfung auf Pestizide in Arzneipflanzen. Schweiz. Apoth.-Ztg./J. Suisse de Pharmacie 119, 90-92.
172. Schreiber, L., and Schönherr, J. (1993). Mobilities of organic compounds in reconstituted cuticular wax of barley leaves: determination of diffusion coefficients. Pestic. Sci. 38, 353-361.
173. Schroll, R., Bierling, B., Cao, G. et al. (1994). Uptake of organic chemicals from soil by agricultural plants. Chemosphere 28, 297-303.
174. Silva, M. P., and Thiemann, W. (1991). Organochlorine pesticide residues in different grades of Sri Lanka tea. Chem. Mikrobiol. Technol. Lebensm. 13, 89-94.
175. Simon, S. L., and Graham, J. C. (1996). Dose assessment activities in the Republic of the Marshall Island. Health Phys. 71, 438-456.
176. Stahl, E., and Rau, G. (1984). Entfernung von Pestizidrückständen aus Drogen mit überkritischem Kohlendioxid. Planta Med. 50, 171-173.
177. Starr, H., Kiigemagi, U., and Terriere, L. C. (1963) Insecticide residues in peppermint and their distillation with peppermint oil. Agri. Food Chem. 11, 482-486.
178. Suganavam, B. (1996). Risk reduction in pesticide development in developing countries - challenges and opportunities. J. Environ. Sci. Health 631, 307-323.
179. Sullivan, J. H. (1980). Pesticide residues in imported spices. A survey for chlorinated hydrocarbons. J. Agric. Food Chem. 28, 1031-1034.
180. Tekel, J., and Hatrik, S. (1996). Pesticide residue analyses in plant material by chromatographic methods: clean-up procedures and selective detectors. J. Chromatogr. A. 754, 397-410.
181. Tekel, J., Tahotná, S., Pecniková, K., Hollá, M., and Vaverková, S. (1998a). Multiresidual method for determination of the uracil herbicides in plant samples by GC-NPD. Dtsch. Lebensm. Rundsch. 94, 334-336.
182. Tekel, J., Tahotná, S., and Vaverková, S. (1998b). Gas chromatographic method for determination of uracil herbicides in roots of Echinacea angustifolia Moench (Asteraceae). J. Pharm. Biomed. Anal. 16, 753-758.
183. Tekel, J., Vaverková, S., Kovacicová, Hollá, M., and Havránek, E. (1994). A screening method for the determination of the residues of uracil herbicides in Melissa officinalis L. Pharmazie 49, 899-901.
184. Torres, P., and Luque de Castro, M. D. (1996). Interfacing a robotic station with a gas chromatograph for the full automation of the determination of organochlorine pesticide in vegetable. Instrum. Sci. Technol. 24, 57-70.
185. Vaverkova, S., Holla, M., and Tekel, J. (1995a). The effect of herbicides on the qualitative properties of healing plants. 2. Content and composition of the essential oil from Salvia officinalis L. after application of Afalon 50 WP. Pharmazie 50, 143-144.
186. Vaverkova, S., Holla, M., Tekel, J., and Mistrikova, I. (1997). Quality and content of the essential oil from Mentha x piperita after application of Terbacil. Biologia 52, 549-552.
187. Vaverkova, S., Tekel, J., and Holla, M. (1995b). The effect of herbicides on the qualitative properties of healing plants. 3. Content and composition of the essential oil from Melissa officinalis L. after application of Basagran. Pharmazie 50, 835-836.
188. Vilegas, J. H. Y., Lanças, F. M., and Antoniosi Filho, N. R. (1995). High temperature capillary GC analysis of phytopreparations of 'Espinheira Santa' (Maytenus ilicifolia M. and Maytenus aquifolium M. - Celastraceae), a Brazilian antiulcer plant. Chromatographia 40, 341-343.
189. st World Meeting APGI/APV, Budapest, 994-995.
190. Vömel, A., and Mautner, U. (1982). Der Einsatz von Prometryn und Desmetryn bei Thymus vulgaris, Salvia officinalis und Silybum marianum und ihre Auswirkung auf Ertrag und Inhaltsstoffe. Planta Med. 45, 143-144.
191. Vömel, A., Reichling, J., Becker, H., and Dräger, P. D. (1977). Herbizide im Kamillenanbau. I. Mitteilung: Einfluß der Herbizide auf Ertrag und Unkrautbestand; Rückstandsuntersuchungen. Planta Med. 31, 378-389.
192. Wagler, M. (1988). Tendenzen der Reinheitsprüfung von Arzneimitteln. Pharmazie 43, 855-858.
193. Wan, H. (1989). Large-volume spotting apparatus and its application to the semiquantitative determination of organochlorine pesticides in tea. J. Chromatogr. 469, 403-405.
194. Wan, H. (1990). Small-scale method for the determination of organophosphorus insecticides in tea using sulphuric acid as clean-up reagent. J. Chromatogr. 516, 446-449.
195. Wan, H., Xia, H., and Chen, Z. (1991). Extraction of pesticide residues in tea by water during the infusion process. Food Addit. Contam. 8, 497-500.
196. Whitaker, R. J., and Evans, D. A. (1987). Plant production of fine chemicals. Chemtech. 17, 674-679.
197. WHO/PHARM/92.559 (1992). Quality control methods for medicinal plant material, pp. 37-62. WHO/PHARM, Geneva.
198. Wong, M. K., and Koh, L. L. (1986). Mercury, lead and other heavy-metals in Chinese medicines. Biol. Trace Elem. Res. 10, 91-97.
199. Wong, M. K., Tan, P., and Wee, Y. C. (1993). Heavy-metals in some Chinese herbal plants. Biol. Trace Elem. Res. 36, 135-142.
200. Wu, J., and Fan, D. (1992). Gas chromatographic determination of dimethoate residues in Chrysanthemums and soil. J. AOAC Int. 75, 588-590.
201. Yoon, H. R., Lee, E. J., Park, M. K. and Park, J. H. (1998). Sulfuric acid pretreatment for the simultaneous GC screening of organochlorine and organophosphorus pesticides in herbal essential oils. Chromatographia 47, 587-592.
202. Zimmerli, B., and Blaser, O. (1982). Orientierende Untersuchungen zum Übergang von Pestiziden aus Kräutertees in den Aufguß. Mitt. Gebiete Lebensm. Hyg. 73, 174-185.
203. Zongmao, C., and Haibin, W. (1988). Factors affecting residues of pesticides in tea. Pestic. Sci. 23, 109-118.
204. Zongmao, C., and Haibin, W. (1997). Degradation of pesticides on plant surfaces and its prediction - a case study on tea plant. Environ. Monit. Assess. 44, 303-313.
205. Zongmao, C., and Wang, Y. (1996). Chromatographic methods for the determination of pyrethrin and pyrethroid pesticide residues in crops, foods and environmental samples. J. Chromatogr. A 754, 367-395.
206. Zongmao, C., and Xuefen, C. (1990). Chemical control of pests and diseases in tea production in China: progress and strategy. Trop. Agric. 67, 363-367.
207. Zuin, V. G., Airoldi, F. P. S., Nascimento, N. R., Landgraf, M. D., and Rezende, M. O. O. (1999). Determination of pentachlorophenol and hexachlorobenzene in natural waters affected by industrial chemical residues. J. Braz. Chem. Soc. 10, 25-30.
208. Zweig, G., and Aspelin, A. L. (1983). The role of pesticides in developing countries. In, Formulation of Pesticides, ed. by A. R. Khane, pp. 1-13, United Nations, New York.