-
1
-
-
0028891614
-
Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers
-
Ahtila S, Kaakkola S, Gordin A et al. (1995) Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers. Clin Neuropharmacol 18:46-57
-
(1995)
Clin Neuropharmacol
, vol.18
, pp. 46-57
-
-
Ahtila, S.1
Kaakkola, S.2
Gordin, A.3
-
2
-
-
0032547507
-
Tolcapone and fulminat hepatitis
-
Assal F, Spahr L, Hadengue A, Rubbia-Brandt L, Burkhard PR (1998) Tolcapone and fulminat hepatitis. Lancet 352:958
-
(1998)
Lancet
, vol.352
, pp. 958
-
-
Assal, F.1
Spahr, L.2
Hadengue, A.3
Rubbia-Brandt, L.4
Burkhard, P.R.5
-
3
-
-
0342355898
-
Diskussion
-
Baas H (1998) Diskussion. Aktuel Neurol 25 [Suppl 4]:282
-
(1998)
Aktuel Neurol
, vol.25
, Issue.SUPPL. 4
, pp. 282
-
-
Baas, H.1
-
4
-
-
0031016506
-
Peripheral and central inhibitors of catechol-O-methyltransferase: Effects on liver and brain COMT activity arid L-Dopa metabolism
-
Brannan T, Prikkhojan A, Yahr MD (1997) Peripheral and central inhibitors of catechol-O-methyltransferase: effects on liver and brain COMT activity arid L-Dopa metabolism. J Neural Transm 104:77-87
-
(1997)
J Neural Transm
, vol.104
, pp. 77-87
-
-
Brannan, T.1
Prikkhojan, A.2
Yahr, M.D.3
-
5
-
-
0031807495
-
Catechol-O-methyltransferase: Variation in enzyme activity and inhibition by entacapone and tolcapone
-
DeSanti C, Giulianotti PC, Pietrabissa A, Mosca F, Pacifici GM (1998) Catechol-O-methyltransferase: variation in enzyme activity and inhibition by entacapone and tolcapone. Eur J Clin Pharmacol 54:215-219
-
(1998)
Eur J Clin Pharmacol
, vol.54
, pp. 215-219
-
-
DeSanti, C.1
Giulianotti, P.C.2
Pietrabissa, A.3
Mosca, F.4
Pacifici, G.M.5
-
6
-
-
0031005861
-
Effects of catechol-O-methyltransferase inhibition on the rates of uptake and reversibility of 6-fluoro-L-Dopa trapping in MPTP-induced parkinsonism in monkeys
-
Doudet DJ, Chan GL, Holden JE, Morrison KS, Wyatt RJ, Ruth TJ (1997) Effects of catechol-O-methyltransferase inhibition on the rates of uptake and reversibility of 6-fluoro-L-Dopa trapping in MPTP-induced parkinsonism in monkeys. Neuropharmacology 36:363-371
-
(1997)
Neuropharmacology
, vol.36
, pp. 363-371
-
-
Doudet, D.J.1
Chan, G.L.2
Holden, J.E.3
Morrison, K.S.4
Wyatt, R.J.5
Ruth, T.J.6
-
7
-
-
0030695512
-
Tolcapone added to levodopa in stable parkinsonian patients: A double-blind placebo-controlled study
-
Tolcapone in Parkinson's Disease Study Group II (TIPS II)
-
Dupont E, Burgunder JM, Findley LJ, Olsson JE, Dorflinger E (1997) Tolcapone added to levodopa in stable parkinsonian patients: a double-blind placebo-controlled study. Tolcapone in Parkinson's Disease Study Group II (TIPS II). Mov Disord 12:928-934
-
(1997)
Mov Disord
, vol.12
, pp. 928-934
-
-
Dupont, E.1
Burgunder, J.M.2
Findley, L.J.3
Olsson, J.E.4
Dorflinger, E.5
-
8
-
-
0031855536
-
Pharmacokinetics and pharmacodynamics after oral and intravenous administration of tolcapone, a novel adjunct to Parkinson's disease therapy
-
Jorga KM, Fotteler B, Heizmann P, Zurcher G (1998) Pharmacokinetics and pharmacodynamics after oral and intravenous administration of tolcapone, a novel adjunct to Parkinson's disease therapy. Eur J Pharmacol 54:443-447
-
(1998)
Eur J Pharmacol
, vol.54
, pp. 443-447
-
-
Jorga, K.M.1
Fotteler, B.2
Heizmann, P.3
Zurcher, G.4
-
9
-
-
0031899068
-
The effect of tolcapone on levodopa pharmacokinetics is independent of levodopa/carbidopa formulation
-
Jorga KM, Fotteler B, Sedek G, Nielsen T, Aitken J (1998) The effect of tolcapone on levodopa pharmacokinetics is independent of levodopa/carbidopa formulation. J Neurol 245:223-230
-
(1998)
J Neurol
, vol.245
, pp. 223-230
-
-
Jorga, K.M.1
Fotteler, B.2
Sedek, G.3
Nielsen, T.4
Aitken, J.5
-
10
-
-
0027935135
-
General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase
-
Kaakkola S, Gordin A, Mannisto PT (1994) General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase. Gen Pharmacol 25:813-824
-
(1994)
Gen Pharmacol
, vol.25
, pp. 813-824
-
-
Kaakkola, S.1
Gordin, A.2
Mannisto, P.T.3
-
11
-
-
0028203007
-
Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone
-
Keränen T, Gordin A, Karlsson M et al. (1994) Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone. Eur J Clin Pharmacol 46:151-157
-
(1994)
Eur J Clin Pharmacol
, vol.46
, pp. 151-157
-
-
Keränen, T.1
Gordin, A.2
Karlsson, M.3
-
12
-
-
0031852535
-
Effects of tolcapone, a catechol-O-methyltransferase inhibitor, and sinemet on intestinal electrolyte and fluid transport in conscious dogs
-
Larsen KR, Dajani EZ, Dajani NE, Dayton MT, Moore JG (1998) Effects of tolcapone, a catechol-O-methyltransferase inhibitor, and sinemet on intestinal electrolyte and fluid transport in conscious dogs. Dig Dis Sci 43:1806-1813
-
(1998)
Dig Dis Sci
, vol.43
, pp. 1806-1813
-
-
Larsen, K.R.1
Dajani, E.Z.2
Dajani, N.E.3
Dayton, M.T.4
Moore, J.G.5
-
13
-
-
0030727396
-
Glucuronidation of entacapone, nitecapone, tolcapone, and some other nitrocatechols by rat liver microsomes
-
Lautala P, Kivimaa M, Salomies H, Elovaara E, Taskinen J (1997) Glucuronidation of entacapone, nitecapone, tolcapone, and some other nitrocatechols by rat liver microsomes. Pharm Res 14:1444-1448
-
(1997)
Pharm Res
, vol.14
, pp. 1444-1448
-
-
Lautala, P.1
Kivimaa, M.2
Salomies, H.3
Elovaara, E.4
Taskinen, J.5
-
14
-
-
0031784517
-
No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: A microdialysis study in anaesthezised rats
-
Li YH, Wirth T, Huotari M, Laitinen K, MacDonald E, Männistö PT (1998) No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: a microdialysis study in anaesthezised rats. Eur J Pharmacol 356:127-137
-
(1998)
Eur J Pharmacol
, vol.356
, pp. 127-137
-
-
Li, Y.H.1
Wirth, T.2
Huotari, M.3
Laitinen, K.4
MacDonald, E.5
Männistö, P.T.6
-
15
-
-
84951515357
-
Clinical potential of catechol-O-methyltransferase (COMT) inhibitors as adjuvants in Parkinson's disease
-
Männistö PT (1994) Clinical potential of catechol-O-methyltransferase (COMT) inhibitors as adjuvants in Parkinson's disease. CNS Drugs 1:172-179
-
(1994)
CNS Drugs
, vol.1
, pp. 172-179
-
-
Männistö, P.T.1
-
16
-
-
0023809040
-
Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase
-
Männistö PT, Kaakkola S, Nissinen E, Linden IB, Pohto P (1988) Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase. Life Sci 43:1465-1471
-
(1988)
Life Sci
, vol.43
, pp. 1465-1471
-
-
Männistö, P.T.1
Kaakkola, S.2
Nissinen, E.3
Linden, I.B.4
Pohto, P.5
-
18
-
-
0001722157
-
Long-term safety of entacapone as adjunct ot levodopa in patients with Parkinson's disease
-
Mylylä VV and the Filomen Study Group (1998) Long-term safety of entacapone as adjunct ot levodopa in patients with Parkinson's disease. Mov Dis 13 [Suppl 2]:294
-
(1998)
Mov Dis
, vol.13
, Issue.SUPPL. 2
, pp. 294
-
-
Mylylä, V.V.1
-
19
-
-
0031565076
-
Entacapone, a novel catechol-O-methyltransferase inhibitor for Parkinson's disease, does not impair mitochondrial energy production
-
Nissinen E, Kaheinen P, Penttila KE, Kaivola J, Linden IB (1997) Entacapone, a novel catechol-O-methyltransferase inhibitor for Parkinson's disease, does not impair mitochondrial energy production. Eur J Pharmacol 340:287-294
-
(1997)
Eur J Pharmacol
, vol.340
, pp. 287-294
-
-
Nissinen, E.1
Kaheinen, P.2
Penttila, K.E.3
Kaivola, J.4
Linden, I.B.5
-
20
-
-
0026671534
-
Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone
-
Nissinen E, Linden IB, Schultz E, Pohto P (1992) Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone. Naunyn Schmiedebergs Arch Pharmacol 346:262-266
-
(1992)
Naunyn Schmiedebergs Arch Pharmacol
, vol.346
, pp. 262-266
-
-
Nissinen, E.1
Linden, I.B.2
Schultz, E.3
Pohto, P.4
-
21
-
-
0030778373
-
Entacapone improves motor fluctuations in levodopa treated Parkinson's disease patients
-
Parkinson Study Group (1997) Entacapone improves motor fluctuations in levodopa treated Parkinson's disease patients. Ann Neurol 42:747-755
-
(1997)
Ann Neurol
, vol.42
, pp. 747-755
-
-
-
22
-
-
0031773064
-
Entacapone enhances the response in parkinsonian patients with motor fluctuations
-
Rinne UK, Larsen JP, Siden A, Worm-Petersen J, Nomecomt Study Group (1998) Entacapone enhances the response in parkinsonian patients with motor fluctuations. Neurology 51:1309-1314
-
(1998)
Neurology
, vol.51
, pp. 1309-1314
-
-
Rinne, U.K.1
Larsen, J.P.2
Siden, A.3
Worm-Petersen, J.4
-
23
-
-
0030042649
-
Entacapone prolongs levodopa respone in a one month double blind study in parkinsonian patients with levodopa related fluctuations
-
Ruottinen HM, Rinne UK (1996) Entacapone prolongs levodopa respone in a one month double blind study in parkinsonian patients with levodopa related fluctuations. J Neurol Neurosurg Psychiat 60:36-40
-
(1996)
J Neurol Neurosurg Psychiat
, vol.60
, pp. 36-40
-
-
Ruottinen, H.M.1
Rinne, U.K.2
-
24
-
-
0027436117
-
The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise
-
Sundberg S, Scheinin M, Illi A, Akkila J, Gordin A, Keränen T (1993) The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise. Br J Clin Pharmacol 36:451-456
-
(1993)
Br J Clin Pharmacol
, vol.36
, pp. 451-456
-
-
Sundberg, S.1
Scheinin, M.2
Illi, A.3
Akkila, J.4
Gordin, A.5
Keränen, T.6
-
25
-
-
0025782688
-
Acute toxicity of three new selective COMT inhibitors in mice with special emphasis on interactions with drugs increasing catecholaminergic neurotransmission
-
Törnwall M, Männistö PT (1991) Acute toxicity of three new selective COMT inhibitors in mice with special emphasis on interactions with drugs increasing catecholaminergic neurotransmission. Pharmacol Toxicol 69:64-70
-
(1991)
Pharmacol Toxicol
, vol.69
, pp. 64-70
-
-
Törnwall, M.1
Männistö, P.T.2
-
26
-
-
0031847116
-
Population pharmacodynamic modeling of levodopa in patients with Parkinson's disease receiving entacapone
-
Trocóniz IF, Naukkarinen TH, Ruottinen HM, Rinne UK, Gordin A Karlsson MO (1998) Population pharmacodynamic modeling of levodopa in patients with Parkinson's disease receiving entacapone. Clin Pharmacol Ther 64:106-116
-
(1998)
Clin Pharmacol Ther
, vol.64
, pp. 106-116
-
-
Trocóniz, I.F.1
Naukkarinen, T.H.2
Ruottinen, H.M.3
Rinne, U.K.4
Gordin A Karlsson, M.O.5
-
27
-
-
0030833203
-
Tolcapone in stable Parkinson's disease: Efficacy and safety of long-term treatment
-
Waters CH, Kurth M, Bailey P et al. (1997) Tolcapone in stable Parkinson's disease: efficacy and safety of long-term treatment. Neurology 49:665-671
-
(1997)
Neurology
, vol.49
, pp. 665-671
-
-
Waters, C.H.1
Kurth, M.2
Bailey, P.3
-
28
-
-
0027417592
-
Identifications of major metabolites of the catechol-O-tranferase inhibitor entacapone in rats and humans
-
Wikberg T, Vuorela A, Ottoila P, Taskinen J (1993) Identifications of major metabolites of the catechol-O-tranferase inhibitor entacapone in rats and humans. Drug Metab Dispos 21:81-92
-
(1993)
Drug Metab Dispos
, vol.21
, pp. 81-92
-
-
Wikberg, T.1
Vuorela, A.2
Ottoila, P.3
Taskinen, J.4
|