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This paper describes the finding that human herpesvirus 8 (HHV8) and MCV choose two different ways to interfere with the chemokine system: HHV8 encodes the broad-spectrum chemokine antagonist, vMIP-II, whereas MCV encodes a highly selective CCR8 antagonist, MC148.
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Luttichau B.H., Stine J., Boesen T.P., Johnsen A.H., Chantry D., Gerstoft J., Schwartz T.W. A highly se;ective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum. J Exp Med. 191:2000;171-180. This paper describes the finding that human herpesvirus 8 (HHV8) and MCV choose two different ways to interfere with the chemokine system: HHV8 encodes the broad-spectrum chemokine antagonist, vMIP-II, whereas MCV encodes a highly selective CCR8 antagonist, MC148.
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This paper provides the first evidence that MC148R, found in MCV, is likely to have been acquired from the host.
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Functional comparisons among members of the poxvirus T1/35kDa family of soluble CC-chemokine inhibitor glycoproteins
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This review contains extensive information on the strategies used by MV to subvert the host immune response.
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