Gene therapy turns the corner

Nature Medicine

Volumn 6, Issue 6, 2000, Pages 624-626

  Dick, John E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GENE THERAPY; GENE TRANSFER; GENETIC RECOMBINATION; HEMATOPOIETIC STEM CELL; HUMAN; PRIORITY JOURNAL; SHORT SURVEY; STEM CELL;

ANIMALS; FIBRONECTINS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, MDR; GENETIC VECTORS; GERMINOMA; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; RETROVIRIDAE;

EID: 0034097968     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/76188     Document Type: Short Survey

References (11)

1. Dick, JE, Magli, M.-C., Huszar, D., Phillips, R. & Bernstein, A. Introduction of a selectable gene into primitive stem cells capable of long term reconstitution of the hemopoietic system of W/Wv mice. Cell 42, 71-79 (1985).
2. Brenner, M.K. Hematological malignancies. Faseb. J. 11, 640-648 (1997).
3. Abonour, R. et al. Efficient retrovirus-mediated MDR-1 gene transfer into autologous long-term repopulating hematopoietic stem cells. Nature Med. 6, 652-658 (2000).
4. Orkin, S. & Motulsky, A. Report and recommendations of the panel to assess the NIH investment in research on gene therapy. http://www.nih.gov/news/panelrep.html (1995).
5. Cavazzana-Calvo, M. et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288, 669-672 (2000).
6. Larochelle, A. et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy Nature Med. 2, 1329-1337 (1996).
7. Hanenberg, H. et al. Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. Nature Med. 2, 876-882 (1996).
8. Kiem, H.P. et al. Improved gene transfer into baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6, stem cell factor, FLT-3 ligand, and megakaryocyte growth and development factor. Blood 92, 1878-1886 (1998).
9. Hennemann, B. et al. High-efficiency retroviral transduction of mammalian cells on positively charged surfaces. Hum. Gene. Ther. 11, 43-51 (2000).
10. Guenechea, G. et al. Transduction of human CD34+CD38-bone marrow and cord blood derived SCID-repopulating cells (SRC) with third generation lentiviral vectors. Molec. Ther. (in the press).
11. Miyoshi, H., Smith, K.A., Mosier, D.E., Verma, I.M. & Torbett, B.E. Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science 283, 682-686 (1999).