The isolated major histocompatibility complex class I α3 domain binds β2m and CD8αα dimers

Molecular Immunology

Volumn 37, Issue 3-4, 2000, Pages 141-149

  Whitman, Mary C ^a   Strohmaier, Jason ^a   O'Boyle, Kevin ^a   Tingem, Juanna M ^a   Wilkinson, Yakita ^a   Goldstein, Julia ^a   Chen, Trina ^a   Brorson, Kurt ^a   Brunswick, Mark ^a   Kozlowski, Steven ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

Biochemistry; CD8; MHC; 2 microglobulin

Indexed keywords

BETA 2 MICROGLOBULIN; CD8 ANTIGEN; DIMER; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANTIBODY COMBINING SITE; ANTIGEN FUNCTION; ANTIGEN PURIFICATION; ARTICLE; BINDING SITE; CYTOTOXIC LYMPHOCYTE; LYMPHOCYTE FUNCTION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANTIGENS, CD8; BETA 2-MICROGLOBULIN; BINDING SITES; H-2 ANTIGENS; MUTATION; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

MURINAE;

EID: 0034097884     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(00)00034-1     Document Type: Article

References (50)

1. Alam, S.M., Davies, G.M., Lin, C.M., Zal, T., Nasholds, W., Jameson, S.C., Hogquist, K.A., Gascoigne, N.R., Travers, P.J., 1999. Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. Immunity 10, 227-237.
2. Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennett, W.S., Strominger, J.L., Wiley, D.C., 1987. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329, 512-518.
3. Chakrabarti, A., Matko, J., Rahman, N.A., Barisas, B.G., Edidin, M., 1992. Self-association of class I major histocompatibility complex molecules in liposome and cell surface membranes. Biochemistry 31, 7182-7189.
4. Collins, E.J., Garboczi, D.N., Karpusas, M.N., Wiley, D.C., 1995. The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain. In: Proc. Natl. Acad. Sci. USA, vol. 92, 1218-2121.
5. Connolly, J.M., Hansen, T.H., Ingold, A.L., Potter, T.A., 1990. Recognition by CD8 on cytotoxic T-lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule. In: Proc. Natl. Acad. Sci. USA, vol. 87, 2137-2141.
6. Davis, M.M., Boniface, J.J., Reich, Z., Lyons, D., Hampl, J., Arden, B., Chien, Y., 1998. Ligand recognition by alpha beta T-cell receptors. Annu. Rev. Immunol. 16, 523-544.
7. Elliott, T., 1991. How do peptides associate with MHC class I molecules. Immunol Today 12, 386-388.
8. Fayen, J., Huang, J.H., Meyerson, H., Zhang, D., Getty, R., Greenspan, N., Tykocinski, M., 1995. Class I MHC alpha 3 domain can function as an independent structural unit to bind CD8 alpha. Mol. Immunol. 32, 75-267.
9. Gao, G.F., Tormo, J., Gerth, U.C., Wyer, J.R., McMichael, A.J., Stuart, D.I., Bell, J.I., Jones, E.Y., Jakobsen, B.K., 1997. Crystal structure of the complex between human CD8alpha(alpha) and HLA- A2. Nature 387, 630-634.
10. Garcia, K.C., Scott, C.A., Brunmark, A., Carbone, F.R., Peterson, P.A., Wilson, I.A., Teyton, L., 1996. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature 384, 577-581.
11. Germain, R.N., Margulies, D.H., 1993. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol. 11, 403-450.
12. Goldstein, J., Mostowsky, H., Tung, J., Hon, H., Brunswick, M., Kozlowski, S., 1997. Naive alloreactive CD8 T cells are activated by purified major histocompatibility complex class I and antigenic peptide. Eur. J. Immunol. 27, 871-878.
13. Johnsson, B., Lofas, S., Lindquist, G., 1991. Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors. Anal. Biochem. 198, 268-277.
14. Jones, E.Y., Tormo, J., Reid, S.W., Stuart, D.I., 1998. Recognition surfaces of MHC class I. Immunol. Rev. 163, 121-128.
15. Kane, K.P., Sherman, L.A., Mescher, M.F., 1991. Exogenous beta 2-microglobulin is required for antigenic peptide binding to isolated class I major histocompatibility complex molecules. Eur. J. Immunol. 21, 2289-2292.
16. Karlsson, R., Fait, A., 1997. Experimental design for kinetic analysis of protein-protein interactions with surface plasmon resonance biosensors. J. Immunol. Methods 200, 33-121.
17. Kern, P.S., Teng, M.K., Smolyar, A., Liu, J.H., Liu, J., Hussey, R.E., Spoerl, R., Chang, H.C., Reinherz, E.L., Wang, J.H., 1998. Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb. Immunity 9, 519-530.
18. Kozlowski, S., Takeshita, T., Boehncke, W.H., Takahashi, H., Boyd, L.F., Germain, R.N., Berzofsky, J.A., Margulies, D.H., 1991. Excess beta 2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules. Nature 349, 74-77.
19. Ljunggren, H.G., Stam, N.J., Ohlen, C., Neefjes, J.J., Hoglund, P., Heemels, M.T., Bastin, J., Schumacher, T.N., Townsend, A., Karre, K., et al., 1990. Empty MHC class I molecules come out in the cold. Nature 346, 476-480.
20. Ljunggren, H.G., Thorpe, C.J., 1996. Principles of MHC class I-mediated antigen presentation and T cell selection. Histol. Histopathol. 11, 267-274.
21. Luescher, I.F., Vivier, E., Layer, A., Mahiou, J., Godeau, F., Malissen, B., Romero, P., 1995. CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature 373, 353-356.
22. Meyerson, H.J., Huang, J.H., Fayen, J.D., Tsao, H.M., Getty, R.R., Greenspan, N.S., Tykocinski, M.L., 1996. Functional dissociation of CD8 alpha's Ig homologue and connecting peptide domains. J. Immunol. 156, 574-584.
23. Moebius, U., Kober, G., Griscelli, A.L., Hercend, T., Meuer, S.C., 1991. Expression of different CD8 isoforms on distinct human lymphocyte subpopulations. Eur. J. Immunol. 21, 1793-1800.
24. Norment, A.M., Littman, D.R., 1988. A second subunit of CD8 is expressed in human T cells. Embo. J. 7, 3433-3439.
25. O'Rourke, A.M., Rogers, J., Mescher, M.F., 1990. Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling. Nature 346, 187-189.
26. Otten, G.R., Bikoff, E., Ribaudo, R.K., Kozlowski, S., Margulies, D.H., Germain, R.N., 1992. Peptide and beta 2-microglobulin regulation of cell surface MHC class I conformation and expression. J. Immunol. 148, 3723-3732.
27. Ozato, K., Evans, G.A., Shykind, B., Margulies, D.H., Seidman, J.G., 1983. Hybrid H-2 histocompatibility gene products assign domains recognized by alloreactive T cells. Proc. Natl. Acad. Sci. USA, vol. 80, 2040-2043.
28. Pedersen, L.O., Hansen, A.S., Olsen, A.C., Gerwien, J., Nissen, M.H., Buus, S., 1994. The interaction between beta 2-microglobulin (beta 2m) and purified class-I major histocompatibility (MHC) antigen. Scand. J. Immunol. 39, 64-72.
29. Pedersen, L.O., Stryhn, A., Holter, T.L., Etzerodt, M., Gerwien, J., Nissen, M.H., Thogersen, H.C., Buus, S., 1995. The interaction of beta 2-microglobulin (beta 2m) with mouse class I major histocompatibility antigens and its ability to support peptide binding. A comparison of human and mouse beta 2m. Eur. J. Immunol. 25, 16-1609.
30. Potter, T.A., Bluestone, J.A., Rajan, T.V., 1987. A single amino acid substitution in the alpha 3 domain of an H-2 class I molecule abrogates reactivity with CTL. J. Exp. Med. 166, 956-966.
31. Reich, Z., Boniface, J.J., Lyons, D.S., Borochov, N., Wachtel, E.J., Davis, M.M., 1997. Ligand-specific oligomerization of T-cell receptor molecules. Nature 387, 617-620.
32. Ribaudo, R.K., Margulies, D.H., 1992. Independent and synergistic effects of disulfide bond formation, beta 2-microglobulin, and peptides on class I MHC folding and assembly in an in vitro translation system. J. Immunol. 149, 2935-2944.
33. Ribaudo, R.K., Margulies, D.H., 1995. Polymorphism at position nine of the MHC class I heavy chain affects the stability of association with beta 2-microglobulin and presentation of a viral peptide. J. Immunol. 155, 3481-3493.
34. Rock, K.L., Gamble, S., Rothstein, L., Gramm, C., Benacerraf, B., 1991a. Dissociation of beta 2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface. Cell 65, 611-620.
35. Rock, K.L., Gramm, C., Benacerraf, B., 1990b. Low temperature and peptides favor the formation of class I heterodimers on RMA-S cells at the cell surface. Proc. Natl. Acad. Sci. USA 88, 4200-4204.
36. Rock, K.L., Rothstein, L.E., Gamble, S.R., Benacerraf, B., 1990. Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides. Proc. Natl. Acad. Sci. USA 87, 7517-7521.
37. Salter, R.D., 1992. Mutant HLA-A201 heavy chains with lowered affinity for beta 2m are transported after growth at reduced temperatures. Hum. Immunol. 35, 40-49.
38. Salter, R.D., Benjamin, R.J., Wesley, P.K., Buxton, S.E., Garrett, T.P., Clayberger, C., Krensky, A.M., Norment, A.M., Littman, D.R., Parham, P., 1990. A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2. Nature 345, 41-46.
39. Santos-Aguado, J., Biro, P.A., Fuhrmann, U., Strominger, J.L., Barbosa, J.A., 1987. Amino acid sequences in the alpha 1 domain and not glycosylation are important in HLA-A2/beta 2-microglobulin association and cell surface expression. Mol. Cell. Biol. 7, 982-990.
40. Saper, M.A., Bjorkman, P.J., Wiley, D.C., 1991. Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J. Mol. Biol. 219, 277-319.
41. Shen, L., Potter, T.A., Kane, K.P., 1996. Glu227 → Lys substitution in the acidic loop of major histocompatibility complex class I alpha 3 domain distinguishes low avidity CD8 coreceptor and avidity-enhanced CD8 accessory functions. J. Exp. Med. 184, 1671-1683.
42. Smith, J.D., Lie, W.R., Gorka, J., Myers, N.B., Hansen, T.H., 1992. Extensive peptide ligand exchange by surface class I major histocompatibility complex molecules independent of exogenous beta 2-microglobulin. Proc. Natl. Acad. Sci. USA 89, 7767-7771.
43. Smith, M.H., Barber, B.H., 1990. The conformational flexibility of class I H-2 molecules as revealed by anti-peptide antibodies specific for intracytoplasmic determinants: differential reactivity of beta 2-microglobulin "bound" and "free" H- 2Kb heavy chains. Mol. Immunol. 27, 169-180.
44. Sun, J., Kavathas, P.B., 1997. Comparison of the roles of CD8 alpha alpha and CD8 alpha beta in interaction with MHC class I. J. Immunol. 159, 6077-6082.
45. Sun, J., Leahy, D.J., Kavathas, P.B., 1995. Interaction between CD8 and major histocompatibility complex (MHC) class I mediated by multiple contact surfaces that include the alpha 2 and alpha 3 domains of MHC class I. J. Exp. Med. 182, 1275-1280.
46. Townsend, A., Bodmer, H., 1989. Antigen recognition by class I-restricted T-lymphocytes. Annu. Rev. Immunol. 7, 601-624.
47. van der Merwe, P.A., Barclay, A.N., 1996. Analysis of cell-adhesion molecule interactions using surface plasmon resonance. Curr. Opin. Immunol. 8, 257-261.
48. Vitiello, A., Potter, T.A., Sherman, L.A., 1990. The role of beta 2-microglobulin in peptide binding by class I molecules. Science 250, 1423-1426.
49. Wyer, J.R., Willcox, B.E., Gao, G.F., Gerth, U.C., Davis, S.J., Bell, J.I., van der Merwe, P.A., Jakobsen, B.K., 1999. T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics. Immunity 10, 219-225.
50. Yokoyama, K., Nathenson, S.G., 1983. Intramolecular organization of Class I H-2 MHC antigens; localization of the alloantigenic determinants and the beta 2m binding site to different regions of the H-2 Kb glycoprotein. J. Immunol. 130, 1419-1425.