Functional dissociation of CD8α's Ig homologue and connecting peptide domains

Journal of Immunology

Volumn 156, Issue 2, 1996, Pages 574-584

  Meyerson, Howard J ^a   Huang, Jui Han ^a   Fayen, John D ^a   Tsao, Hsin Min ^a   Getty, Robert R ^a   Greenspan, Neil S ^a   Tykocinski, Mark L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; CD8 ANTIGEN; CHIMERIC PROTEIN; DECAY ACCELERATING FACTOR; GLYCOSYLPHOSPHATIDYLINOSITOL; IMMUNOGLOBULIN FC FRAGMENT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOCLONAL ANTIBODY; POLYPEPTIDE; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CHIMERA; CONTROLLED STUDY; DISSOCIATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD55; ANTIGENS, CD8; BASE SEQUENCE; BINDING SITES; CARRIER PROTEINS; CHO CELLS; CRICETINAE; GLYCOSYLPHOSPHATIDYLINOSITOLS; HLA-A2 ANTIGEN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

EID: 0029670725     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Miceli, M , and J. Parnes. 1993. Role of CD4 and CD8 in T cell activation and differentiation. Adv. Immunol. 53:59.
2. Dembic, Z , W. Haas, R. Zamoyska, J. Parnes, M. Steinmetz, and H. von Boehmer. 1987. Transfection of the CD8 gene enhances T-cell recognition Nature 326:510.
3. O'Rourke, A., and M Mescher. 1992 CTL activation involves a cascade of signalling and adhesion events. Nature 358:253.
4. + cells. J Immunol. 145:1646
5. Sambhara, S., and R. Miller. 1991. Programmed cell death of T cells signalled by the T cell receptor and the a3 domain of class I MHC. Science 252:1424.
6. Hambor, J. E., D R. Kaplan, and M. L. Tykocinski 1988 Functional consequence of anti-sense RNA-mediated inhibition of CD8 surface expression in a human T-cell clone J. Exp Med 168:1237.
7. - cells whose class I MHC can bind the peptide J Immunol. 152:1103.
8. Letourneur, F., J. Gabert, P. Cosson, D Blanc, J. Davoust, and B. Malissen. 1990. A signaling role for the cytoplasmic segment of the CD8 alpha chain detected under limiting stimulatory conditions. Proc Natl. Acad. Sci. USA 87:2339
9. Zamoyska, R., P. Derham, S. Gorman, P von Hoegen, J. Bolen, A. Veillette, and J Parnes. 1989. Inability of CD8alpha polypeptides to associate with p561ck correlates with impaired function in vitro and lack of expression in vivo. Nature 342:278.
10. Rudd, C E. 1990. CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor. Immunol. Today 11:400.
11. Norment, A., R. Salter, P. Parham, V. Engelhard, and D. Littman. 1988. Cell-cell adhesion mediated by CD8 and MHC class I molecules. Nature 336:79.
12. Leahy, D., R. Axel, and W. Hendrickson. 1992 Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution. Cell 168:1145.
13. Littman, D 1987. The structure of the CD4 and CD8 genes. Annu. Rev. Immunol. 5:561.
14. Sanders, S , R. Fox, and P. Kavathas. 1991 Mutations in CD8 that affect interactions with HLA class I and monoclonal anti-CD8 antibodies J. Exp. Med. 174:371.
15. Giblin, P., D. Leahy, J. Mennone, and P. Kavathas. 1994. The role of charge and multiple faces of the CD8α/α homodimer in binding to major histocompatibility complex class I molecules: support for a bivalent model. Proc. Natl Acad. Sci USA 91 1716.
16. Boursier, J., A Alcover, F. Herve, I. Laisney, and O Acuto. 1993. Evidence for an extended structure of the T-cell co-receptor CD8α as deduced from the hydrodynamic properties of soluble forms of the extracellular region J. Biol. Chem. 268. 2013.
17. Classon, B., M. Brown, D. Garnett, C. Somoza, A. Barclay, A Willis, and A. Williams. 1992 The hinge region of the CD8α chain: structure, antigenicity, and utility in expression of immunoglobulin superfamily domains. Int. Immunol. 4:215.
18. O'Rourke, A., J Rogers, and M. Mescher. 1990. Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling. Nature 346:187.
19. Alcover, A., F. Herve, J -P. Boursier, G. Spagnoli, D. Olive, R Mariuzza, and O. Acuto 1993 A soluble form of CD8 alpha chain expressed in the baculovirus system: biochemical characterization and binding to MHC class I. Mol. Immunol 30 55.
20. Kinch, M , J. Strominger, and C. Doyle. 1993 Cell adhesion mediated by CTM and MHC class n proteins requires active cellular processes J. Immunol. 151.4552.
21. Fayen, J., J H. Huang, H. Meyerson, D. Xiao, R. Getty, N. Greenspan, and M Tykocinski. 1995. Class I MHC alpha 3 domain can function as an independent structural unit to bind CD8 alpha Mol. Immunol 32 267.
22. Engelhard, V., J. Yannelli, G. Evans, S Walk, and M. Holterman 1985 Construction of novel class I histocompatibility antigens by interspecies exon shuffling. J Immunol. 134:4218.
23. Bushkin, Y., D. Posnett, B Pernis, and C. Wang. 1986. A new HLA-linked T cell membrane molecule related to the beta chain of the clonotypic receptor is associated with T3 J. Exp. Med. 164:458
24. 2-microglobulin recognized by mouse monoclonal antibody BBM.1 J. Biol. Chem. 258. 6179.
25. Hogan, K., C. Clayberger, E Bernhard, S. Walk, J. Brock, P. Parham, A. Krensky, and V Engelhard 1989. A panel of unique HLA-A2 mutant molecules define epitopes recognized by HLA-A2-specific antibodies and cytotoxic T lymphocytes. J. Immunol 142.2097
26. Medof, M. E., D Lublin, V M. Holers, D. Ayers, R Getty, J. Leykam, J. Atkinson, and M. Tykocinski. 1987. Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement. Proc. Natl. Acad. Sci. USA 84:2007
27. Horton, R., H. Hunt, S. Ho, J Pullen, and L. Pease. 1989 Engineering hybrid genes without the use of restriction enzymes gene splicing by overlap extension. Gene 77.60
28. Groger, R , D. Morrow, and M. Tykocinski. 1989 Directional antisense and sense cDNA cloning using Epstein-Barr virus episomal expression vectors. Gene 81:285
29. Haver, C. A., R. R. Getty, and M L. Tykocinski. 1989. Epstein-Barr virus episome-based promoter function in human myeloid cells. Nucl. Acids Res. 17:1989.
30. Janknecht, R. G Martynoff, J. Lou, R Hipskind, A. Nordheim, and H. Stunnenberg. 1991. Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus. Proc. Natl. Acad Sci. USA 88:8972.
31. LeGrice, S., and F. Gruninger-Leitch. 1990 Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography Eur J. Biochem. 187 31.
32. Parham, P 1983. Monoclonal antibodies against HLA products and their use in immunoaffinity purification. Methods Enzymol 92 110.
33. Huang, J.-H., R. R Getty, F. V. Chisari, P. Fowler, N S Greenspan, and M L. Tykocmski. 1994. Protein transfer of preformed MHC-peptide complexes sensitizes target cells to T cell cytolysis Immunity 1.607.
34. March, S., I. Parkh, and P. Cuatrecasas. 1974. A simplified method for cyanogen bromide activation of agarose for affinity chromatography. Anal. Biochem. 60:149.
35. Ausubel, F., R. Brent, R. Kingston, D. Moore, J. Seidman, J. Smith, and K. Struhl. 1994. Current Protocols in Molecular Biology. John Wiley and Sons, New York, p. 11.21.
36. Cockett, M., C. Bebbington, and G. Yarronton. 1990. High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification. Biotechnology 8:662.
37. Norment, A., N. Lonberg, E. Lacy, and D. Littman. 1989. Alternatively spliced mRNA encodes a secreted form of human CD8alpha. J Immunol. 142:3312.
38. Weber, M., R. Groger, and M. Tykocinski. 1994. A glycosylphosphatidylinositol-anchored cytokine can function as an artificial adhesin. Exp. Cell Res. 210:107.
39. Huang, J.-H., N. Greenspan, and M. Tykocinski. 1994. Alloantigenic recognition of artificial glycosyl phosphatidylinositol-anchored HLA-A2.1. Mol. Immunol. 31:1017.
40. Tykocinski, M., H.-K. Shu, D. Ayers, E Walter, R. Getty, R. Groger, C. Hauer, and M. E. Medof. 1988. Glycolipid reanchoring of T-lymphocyte surface antigen CD8 using the 3′ end sequence of decay-accelerating factor's mRNA. Proc. Natl. Acad. Sci. USA 85.3555.
41. Watson, S., C. Fennie, and L. Lasky. 1991. Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor-IgG chimaera. Nature 349:164.
42. Sleckman, B., Y. Rosenstein, V. Igras, J. Greenstein, and S Burakoff 1991. Glycolipid-anchored form of CD4 increases intercellular adhesion but is unable to enhance T cell activation. J. Immunol. 147:428.
43. Salter, R., R. Benjamin, P Wesley, S. Buxton, T. Garrett, C Clayberger, A. Krensky, A. Norment, D Littman, and P. Parham. 1990 A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2. Nature 345:41.
44. Potter, T., T Rajan, R Dick II, and J. Bluestone. 1989. Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic lymphocytes. Nature 337:73.
45. Casabo, L., C. Mamalaki, D. Kioussis, and R Zamoyska. 1994. T cell activation results in physical modification of the mouse CD8β chain. J. Immunol. 152.397.
46. Blue, M-L., D Hafler, K. Craig, H. Levine, and S. Schlossman. 1987. Phosphorylation of CD4 and CD8 molecules following T cell triggering. J. Immunol. 139:3949
47. Acres, R. B., P Conlon, D. Mochizuki, and B Gallis. 1987. Phosphorylation of the CD8 antigen on cytotoxic human T cells in response to phorbol myristate acetate or antigen-presenting B cells. J. Immunol. 139:2268.