Expression of the angiogenic factor thymidine phosphorylase in human astrocytic tumors

Journal of Cancer Research and Clinical Oncology

Volumn 126, Issue 3, 2000, Pages 145-152

  Takano, S ^a   Tsuboi, K ^a   Matsumura, A ^a   Tomono, Y ^a   Mitsui, Y ^b   Nose, T ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Angiogenesis; Apoptosis; Glioma; Thymidine phosphorylase; Vascular endothelial growth factor

Indexed keywords

ANGIOGENIC FACTOR; BLOOD CLOTTING FACTOR 8; MESSENGER RNA; PROTEIN P53; THYMIDINE PHOSPHORYLASE; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; ASTROCYTOMA; CONTROLLED STUDY; ENDOTHELIUM CELL; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 0034094830     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050024     Document Type: Article

References (45)

1. Ansari B, Coates PJ, Greenstein BD, Hall PA (1993) In situ end-labeling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol 170:1-8
2. Asai K, Hirano T, Kaneko S, Moriyama A, Nakanishi K, Isobe I, Eksioglu YZ, Kato T (1992a) A novel glial growth inhibitory factor, gliostatin, derived from neurofibroma. J Neurochem 59:307-317
3. Asai K, Nakanishi K, Isobe I, Eksioglu YZ, Hirano A, Hama K, Miyamoto T, Kato T (1992b) Neurotrophic action of gliostatin on cortical neurons. J Biol Chem 267:20311-20316
4. Carroll RS, Zhang J, Chauncey BW, Chantziara K, Frosch MP, Black PM (1997) Apoptosis in astrocytic neoplasms. Acta Neurochir 139:845-850
5. Fox SB, Moghaddam A, Westwood M, Turley H, Bicknell R, Gatter KC, Harris AL (1995) Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study. J Pathol 176:183-190
6. Gasparini G, Weidner N, Maluta S, Pozza F, Boracchi P, Mezzetti M, Testolin A, Bevilacqua P (1993) Intratumoral microvessel density and p53 protein: correlation with metastasis in head-and-neck squamous-cell carcinoma. Int J Cancer 55:739-744
7. Giatromanolaki A, Koukourakis MI, Comley M, Kaklamanist L, Turley H, O'Byrne K, Harris AL, Gatter KC (1997) Platelet-derived endothelial cell growth factor (thymidine phosphorylase) expression in lung cancer. J Pathol 181:196-199
8. Griffiths L, Dachs GU, Bicknell R, Harris AL, Stratford IJ (1997) The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo. Cancer Res 57:570-572
9. Guo N, Krutzsch HC, Inman JK, Roberts DD (1997) Thrombospondin 1 and type 1 repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells. Cancer Res 57:1735-1742
10. Haraguchi M, Miyadera K, Uemura K, Sumizawa T, Furukawa T, Yamada K, Akiyama S (1994) Angiogenic activity of enzymes. Nature 368:198-199
11. Heatley MK (1997) A high apoptotic index occurs in subtypes of endometrial adenocarcinoma associated with a poor prognosis. Pathology 29:272-275
12. Hino N, Higashi T, Nouso K, Nakatsukasa H, Tsuji T (1996) Apoptosis and proliferation of human hepatocellular carcinoma. Liver 16:123-129
13. Imazono Y, Takebayashi Y, Nishiyama K, Akiba S, Miyadera K, Yamada Y, Akiyama S, Ohi Y (1997) Correlation between thymidine phosphorylase expression and prognosis in human renal cell carcinoma. J Clin Oncol 15:2570-2578
14. Ishikawa F, Miyazono K, Hellman U, Drexler H, Wernstedt C, Hagiwara K, Usuki K, Takaku F, Risau W, Heldin C (1989) Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 338:557-562
15. Kieser A, Weich HA, Brandner G, Marme D, Kolch W (1994) Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene 9:963-969
16. Kirsch M, Strasser J, Allende R, Bello L, Zhang J, Black PM (1998) Angiostatin suppresses malignant glioma growth in vivo. Cancer Res 58:4654-4659
17. Kitazono M, Takebayashi Y, Ishitsuka K, Takao S, Tani A, Furukawa T, Miyadera K, Yamada Y, Aikou T, Akiyama S (1998) Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase. Biochem Biophys Res Commun 253:797-803
18. Koukourakis MI, Giatromanolaki A, O'Byrne KJ, Comley M, Whitehouse RM, Talbot DC, Gatter KC, Harris AL (1997) Platelet-derived endothelial cell growth facto expressions correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer. Br J Cancer 75:477-481
19. Kubota Y, Miura T, Moriyama M, Noguchi S, Matsuzaki J, Takebayashi S, Hosaka M (1997) Thymidine phosphorylase activity in human bladder cancer: difference between superficial and invasive cancer. Clin Cancer Res 3:973-976
20. Mattern J, Stammler G, Koomagi R, Wallwiener D, Kaufmann M, Volm M (1998) Spontaneous apoptosis in ovarian cancer: an unfavorable prognostic factor. Int J Oncol 12:351-354
21. Moghaddam A, Bicknell R (1992) Expression of platelet-derived endothelial cell growth factor in Escherichia coli and conformation of its thymidine phosphorylase activity. Biochemistry 31:12 141-12 146
22. Moghaddam A, Zhang H, Fan TD, Hu D, Lees VC, Turley H, Fox SB, Gatter KC, Harris AL, Bicknell R (1995) Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc Natl Acad Sci USA 92:998-1002
23. Mukhopadhyay D, Tsiokas L, Sukhatme VP (1995) Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res 55:6161-6165
24. Nakagawa S, Shiraishi T, Kihara S, Tabuchi K (1995) Detection of DNA strand breaks associated with apoptosis in human brain tumors. Virchows Arch 427:175-179
25. Nakagawa H, Yamada M, Fukushima M, Shimizu K, Ikenaka K (1998) In vitro study on intrathecal application of 5-fluoro-2′-deoxyuridine (FdUrd) for meningeal dissemination of malignant tumor. No Shinkei Geka 26:787-794
26. Nakayama Y, Sueishi K, Fukushima T, Oka K, Tomonaga M (1994) Localization of platelet-derived endothelial cell growth factor in human glioblastoma and meningioma. Noshuyo Byori 11:187-191
27. Ng SY, Gunning P, Eddy R, Ponte P, Leavitt J, Shows T, Kedes L (1985) Evolution of the functional human β-actin gene and its multipseudogene family: conservation of non-coding regions and chromosomal dispersion of pseudogenes. Mol Cell Biol 5:2720-2732
28. Nishida M, Hino A, Mori K, Matsumoto T, Yoshikubo TT, Ishitsuka H (1996) Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues. Biol Pharm Bull 19:1407-1411
29. O'Brien TS, Fox SB, Dickinson AJ, Turley H, Westwood M, Moghaddam A, Gatter KC, Bicknell R, Harris AL (1996) Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers. Cancer Res 56:4799-4804
30. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88:277-285
31. Relf M, LeJeune S, Scott PA, Fox S, Smith K, Leek R, Moghaddam A, Whitehouse R, Bicknell R, Harris AL (1997) Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 57:963-969
32. Schiffer D, Cavalla P, Migheli A, Chio A, Giordana MT, Marino S, Attanasio A (1995) Apoptosis and cell proliferation in human neuroepithelial tumors. Neurosci Lett 195:81-84
33. Sotos GA, Grogan L, Allegra CJ (1994) Preclinical and clinical aspects of biomodulation of 5-fluorouracil. Cancer Treat Rev 20:11-49
34. Stevenson DP, Milligan SR, Collins WP (1998) Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesis. Am J Pathol 152:1641-1646
35. Takano S, Yoshii Y, Kondo S, Maruno T, Shirai S, Nose T (1996) Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res 56:2185-2190
36. Takano S, Wadhwa R, Yoshii Y, Nose T, Kaul SC, Mitsui Y (1997) Elevated levels of mortalin expression in human brain tumors. Exp Cell Res 237:38-45
37. Takebeyashi Y, Akiyama S, Akiba S, Yamada K, Miyadera K, Sumizawa T, Yamada Y, Murata F, Aikou T (1996) Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J Natl Cancer Inst 88:1110-1117
38. Tanigawa N, Amaya H, Matsumura M, Katoh Y, Kitaoka A, Aotake T, Shimomatsuya T, Rosenwasser OA, Iki M (1996) Tumor angiogenesis and expression of thymidine phosphorylase/platelet derived endothelial cell growth factor in human gastric carcinoma. Cancer Lett 108:281-290
39. Toi M, Hoshina S, Taniguchi T, Yamamoto Y, Isahitsuka H, Tominaga T (1995) Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer. Int J Cancer 64:79-82
40. Tormanen U, Eerola AK, Rainio P, Vahakangas K, Soini Y, Sormunen R, Bloigu R, Lehto VP, Paakko P (1995) Enhanced apoptosis predicts shortened survival in non-small cell lung carcinoma. Cancer Res 55:5595-5602
41. Ueda M, Ueki K, Kumagai K, Terai Y, Okamoto Y, Ueki M, Otsuki Y (1998) Apoptosis and tumor angiogenesis in cervical cancer after preoperative chemotherapy. Cancer Res 58:2343-2346
42. Usuki K, Gonez LJ, Wernstedt C, Moren A, Miyazono K, Claesson-Welsh L, Heldin CH (1994) Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells. Biochim Biophys Acta 1222:411-414
43. Van Meir EG, Polverini PJ, Chazin VR, Huang HJS, Tribolet N de, Cavenee WK (1994) Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nat Genet 8:171-176
44. Vermeulen PB, Roland L, Mertens V, Marck EV, De Bruijin EA, Van Oosterom AT, Dirix LY (1996) Correlation of intratumoral microvessel density and p53 protein overexpression in human colorectal adenocarcinoma. Microvasc Res 51:164-174
45. Weindel K, Marme D, Weich HA (1992) AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor. Biochem Biophys Res Commun 183:1167-1174