Linoleic acid cytotoxicity to bovine lens epithelial cells: Influence of albumin on linoleic acid uptake and cytotoxicity

Ophthalmic Research

Volumn 32, Issue 2-3, 2000, Pages 87-93

  Trimborn, Michael ^a   Iwig, Martin ^a   Glanz, Dagobert ^a   Gruner, Michael ^a   Glaesser, Dietmar ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Albumin; Fatty acid cytotoxicity; Fatty acid uptake; Free fatty acids; Lens epithelial cells

Indexed keywords

ALBUMIN; FATTY ACID; LINOLEIC ACID;

ANIMAL CELL; AQUEOUS HUMOR; ARTICLE; CATTLE; CELL CULTURE; CYTOTOXICITY; EPITHELIUM CELL; LENS EPITHELIUM; NONHUMAN; PRIORITY JOURNAL;

EID: 0034093087     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055595     Document Type: Article

References (21)

1. Glaesser D, Fass U, Gruner M, Thust O, Iwig M, Spindler M: Low concentrations of cis-linoleic acid induce cell damage in epithelial cells from bovine lenses. Eur J Cell Biol 1996;71: 286-292.
2. Glanz D, Glaesser D, Lennarz B, Nguyen N, Iwig M: Low concentrations of cis-linoleic acid induce intracellular calcium rise and cell damage in bovine lens epithelial cells. Nova Acta Leopoldina 1997;75 113-120.
3. Esterbauer H, Schaur RJ, Zollner H: Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991;11:81-128.
4. Fass U, Glaesser D: Linoleic acid cytotoxicity: Lipid peroxidation is not involved. Nova Acta Leopoldina 1997;75:121-127.
5. Fass U: Studien zur Morphologie und Biochemie der Zytotoxizität von cis-ungesättigten Fettsäuren im Vergleich zu Prozessen der Lipidperoxidation an subkultivierten Epithelzellen von Rinderlinsen; PhD thesis, Math.-Naturw.-Techn. Fak., Martin-Luther-Univ., Halle-Wittenberg 1997.
6. 2+-dependent spreading during the activation of resting lens epithelial cells in primary culture. Cell Tissue Kinet 1984;17:557-571.
7. Iwig M, Czeslick E, Müller A, Gruner M, Spindler M, Glaesser D: Growth regulation by cell shape alteration and organization of the cytoskeleton. Eur J Cell Biol 1995;67:145-157.
8. Langner J, Ansorge S, Bohley P, Kirschke H, Hanson H: Intracellular protein breakdown. I. Activity determinations of endopeptidases using protein substrates. Acta Biol Med Germ 1971;34:987-996.
9. Skehan P: Assays of cell growth and cytotoxicity; in Studzinski GP (ed): Cell Growth and Apoptosis. Oxford, University Press, 1995, pp 169-191.
10. Zakim D: Fatty acids enter cells by simple diffusion. Proc Soc Exp Biol Med 1996;212:5-14.
11. Sorrentino D, Stump DD, van Nees K, Simrad A, Schwab AJ, Zhou SL, Goresky CA, Berk PD: Oleate uptake by isolated hepatocytes and the perfused rat liver is competitively inhibited by palmitate. Am J Physiol 1996;270:6385-6392.
12. Fitscher BA, Elsing C, Riedel HD, Gorski J, Stremmel W: Protein mediated facilitated uptake process for fatty acids, bilirubin and other amphipathic compounds. Proc Soc Exp Biol Med 1996;212:15-23.
13. Mangroo D, Trigatti BL, Gerber GE: Membrane permeation and intracellular trafficking of long chain fatty acids: Insights from Escherichia coli and 3T3-L1 adipocytes. Biochem Cell Biol 1995;73:223-234.
14. Stump DD, Nunes RM, Sorrentino D, Isola LM, Berk PD: Characteristics of oleate binding to liver plasma membranes and its uptake by isolated hepatocytes. J Hepatol 1992;16:304-315.
15. Fitz JG, Bass NM, Weisiger RA: Hepatic transport of a fluorescent stearate derivate: Electrochemical driving forces in intact rat liver. Am J Physiol 1991;24:683-691.
16. Stremmel W, Strohmeyer G, Berk PD: Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein. Proc Natl Acad Sci USA 1986; 83:3584-3588.
17. Richieri GV, Anel A, Kleinfeld AM: Interactions of long-chain fatty acids and albumin: Determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 1993;32:7574-7580.
18. Spector AA, Steinberg D, Tanaka A: Uptake of free fatty acids by Ehrlich ascites tumor cells. J Biol Chem 1965;240:1032-1041.
19. Weisiger RA: The role of albumin binding in hepatic organic anion transport; in Tavolini N, Berk PD (eds): Hepatic transport and bile secretion: Physiology and pathophysiology. New York, Raven Press, 1993, pp 171-186.
20. Hennig B, Shasby DM, Fulton AB, Spector AA: Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. Arteriosclerosis 1984;4:489-497.
21. Spiteller G: Linoleic acid peroxidation - the dominant lipid peroxidation process in low lipoprotein - and its relationship to chronic diseases. Chem Phys Lipids 1998;95:105-162.